splatEstDropout {splatter} | R Documentation |
Estimate the midpoint and shape parameters for the logistic function used when simulating dropout.
splatEstDropout(norm.counts, params)
norm.counts |
library size normalised counts matrix. |
params |
SplatParams object to store estimated values in. |
Logistic function parameters are estimated by fitting a logistic function
to the relationship between log2 mean gene expression and the proportion of
zeros in each gene. See nls
for details of fitting.
SplatParams object with estimated values.