trigger

Transcriptional Regulatory Inference from Genetics of Gene ExpRession

Bioconductor version: Release (3.4)

This R package provides tools for the statistical analysis of integrative genomic data that involve some combination of: genotypes, high-dimensional intermediate traits (e.g., gene expression, protein abundance), and higher-order traits (phenotypes). The package includes functions to: (1) construct global linkage maps between genetic markers and gene expression; (2) analyze multiple-locus linkage (epistasis) for gene expression; (3) quantify the proportion of genome-wide variation explained by each locus and identify eQTL hotspots; (4) estimate pair-wise causal gene regulatory probabilities and construct gene regulatory networks; and (5) identify causal genes for a quantitative trait of interest.

Author: Lin S. Chen <lchen at health.bsd.uchicago.edu>, Dipen P. Sangurdekar <dps at genomics.princeton.edu> and John D. Storey <jstorey at princeton.edu>

Maintainer: John D. Storey <jstorey at princeton.edu>

Installation

To install this package, start R and enter:

## try http:// if https:// URLs are not supported
source("https://bioconductor.org/biocLite.R")
biocLite("trigger")

Documentation

To view documentation for the version of this package installed in your system, start R and enter:

browseVignettes("trigger")

Details

Package Archives

Follow Installation instructions to use this package in your R session.