To install this package, start R and enter:

## try http:// if https:// URLs are not supported
source("https://bioconductor.org/biocLite.R")
biocLite("SomatiCA")

In most cases, you don't need to download the package archive at all.

SomatiCA

   

SomatiCA: identifying, characterizing, and quantifying somatic copy number aberrations from cancer genome sequencing

Bioconductor version: 3.2

SomatiCA is a software suite that is capable of identifying, characterizing, and quantifying somatic CNAs from cancer genome sequencing. First, it uses read depths and lesser allele frequencies (LAF) from mapped short sequence reads to segment the genome and identify candidate CNAs. Second, SomatiCA estimates the admixture rate from the relative copy-number profile of tumor-normal pair by a Bayesian finite mixture model. Third, SomatiCA quantifies absolute somatic copy-number and subclonality for each genomic segment to guide its characterization. Results from SomatiCA can be further integrated with single nucleotide variations (SNVs) to get a better understanding of the tumor evolution.

Author: Mengjie Chen <mengjie.chen at yale.edu>, Hongyu Zhao <hongyu.zhao at yale.edu>

Maintainer: Mengjie Chen <mengjie.chen at yale.edu>

Citation (from within R, enter citation("SomatiCA")):

Installation

To install this package, start R and enter:

## try http:// if https:// URLs are not supported
source("https://bioconductor.org/biocLite.R")
biocLite("SomatiCA")

Documentation

To view documentation for the version of this package installed in your system, start R and enter:

browseVignettes("SomatiCA")

 

PDF SomatiCA Vignette
PDF SomatiCAUserGuide.pdf
PDF   Reference Manual

Details

biocViews CopyNumberVariation, Sequencing, Software
Version 2.1.0
In Bioconductor since BioC 2.12 (R-3.0) (3 years)
License GPL (>=2)
Depends R (>= 2.14.0), lars, DNAcopy, foreach, methods, rebmix, GenomicRanges, IRanges, doParallel, mvtnorm
Imports foreach, lars, sn, DNAcopy, methods, rebmix, GenomicRanges, IRanges
LinkingTo
Suggests
SystemRequirements
Enhances sn, SomatiCAData
URL
Depends On Me
Imports Me
Suggests Me
Build Report  

Package Archives

Follow Installation instructions to use this package in your R session.

Package Source SomatiCA_2.1.0.tar.gz
Windows Binary SomatiCA_2.1.0.zip
Mac OS X 10.6 (Snow Leopard) SomatiCA_1.14.0.tgz
Mac OS X 10.9 (Mavericks) SomatiCA_2.1.0.tgz
Subversion source (username/password: readonly)
Git source https://github.com/Bioconductor-mirror/SomatiCA/tree/release-3.2
Package Short Url http://bioconductor.org/packages/SomatiCA/
Package Downloads Report Download Stats

Documentation »

Bioconductor

R / CRAN packages and documentation

Support »

Please read the posting guide. Post questions about Bioconductor to one of the following locations:

Fred Hutchinson Cancer Research Center