Spatial Mixed-Effects Modelling with spicy
9 January 2024
Package
spicyR 1.14.3
Contents
1 Installation
if (!require("BiocManager")) {
install.packages("BiocManager")
}
BiocManager::install("spicyR")# load required packages
library(spicyR)
library(ggplot2)
library(SingleCellExperiment)
library(SpatialExperiment)
library(imcRtools)2 Overview
This guide will provide a step-by-step guide on how mixed effects models can be applied to multiple segmented and labelled images to identify how the localisation of different cell types can change across different conditions. Here, the subject is modelled as a random effect, and the different conditions are modelled as a fixed effect.
3 Example data
Here, we use a subset of the Damond et al., 2019 imaging mass cytometry dataset. We will compare the spatial distributions of cells in the pancreatic islets of individuals with early onset diabetes and healthy controls.
diabetesData_SCE is a SingleCellExperiment object containing single-cell data of 160 images
from 8 subjects, with 20 images per subject.
data("diabetesData_SCE")
diabetesData_SCE
#> class: SingleCellExperiment
#> dim: 0 253777
#> metadata(0):
#> assays(0):
#> rownames: NULL
#> rowData names(0):
#> colnames: NULL
#> colData names(11): imageID cellID ... group stage
#> reducedDimNames(0):
#> mainExpName: NULL
#> altExpNames(0):In this data set, cell types include immune cell types (B cells, naive T cells, T Helper cells, T cytotoxic cells, neutrophils, macrophages) and pancreatic islet cells (alpha, beta, gamma, delta).
4 Mixed Effects Modelling
To investigate changes in localisation between two different cell types, we measure the level of localisation between two cell types by modelling with the L-function. Specifically, the mean difference between the obtained function and the theoretical function is used as a measure for the level of localisation. Differences of this statistic between two conditions is modelled using a weighted mixed effects model, with condition as the fixed effect and subject as the random effect.
4.1 Testing for change in localisation for a specific pair of cells
Firstly, we can test whether one cell type tends to be more localised with another cell type
in one condition compared to the other. This can be done using the spicy()
function, where we include condition, and subject. In this example, we want
to see whether or not Delta cells (to) tend to be found around Beta cells (from)
in onset diabetes images compared to non-diabetic images.
spicyTestPair <- spicy(
diabetesData_SCE,
condition = "stage",
subject = "case",
from = "beta",
to = "delta"
)
topPairs(spicyTestPair)
#> intercept coefficient p.value adj.pvalue from to
#> beta__delta 179.729 -58.24478 0.000109702 0.000109702 beta deltaWe obtain a spicy object which details the results of the mixed effects
modelling performed. As the coefficient in spicyTest is positive, we find
that delta cells cells are significantly less likely to be found near beta cells
in the onset diabetes group compared to the non-diabetic control.
4.2 Test for change in localisation for all pairwise cell combinations
Here, we can perform what we did above for all pairwise combinations of cell
types by excluding the from and to parameters from spicy().
spicyTest <- spicy(
diabetesData_SCE,
condition = "stage",
subject = "case"
)
topPairs(spicyTest)
#> intercept coefficient p.value adj.pvalue
#> beta__delta 1.815458e+02 -48.735693 0.0005033247 0.07169649
#> delta__beta 1.817943e+02 -48.166076 0.0005601288 0.07169649
#> B__unknown 4.327556e-15 11.770938 0.0052338392 0.42051606
#> delta__delta 2.089550e+02 -52.061196 0.0125129422 0.42051606
#> unknown__macrophage 1.007337e+01 -15.826919 0.0207410908 0.42051606
#> unknown__B 0.000000e+00 12.142848 0.0225855404 0.42051606
#> macrophage__unknown 1.004424e+01 -14.471666 0.0244668075 0.42051606
#> B__Th 3.142958e-15 26.847934 0.0245039854 0.42051606
#> otherimmune__naiveTc -9.292508e+00 33.584755 0.0255812944 0.42051606
#> ductal__ductal 1.481580e+01 -8.632569 0.0266935703 0.42051606
#> from to
#> beta__delta beta delta
#> delta__beta delta beta
#> B__unknown B unknown
#> delta__delta delta delta
#> unknown__macrophage unknown macrophage
#> unknown__B unknown B
#> macrophage__unknown macrophage unknown
#> B__Th B Th
#> otherimmune__naiveTc otherimmune naiveTc
#> ductal__ductal ductal ductalWe can also examine the L-function metrics of individual images by using the
convenient bind() function on our spicyTest results object.
bind(spicyTest)
#> imageID condition subject ductal__ductal acinar__ductal
#> 1 P15 Long-duration 6089 3.98231313 -2.539547920
#> 2 Q06 Long-duration 6089 4.54173413 -5.750082801
#> 3 Q20 Long-duration 6089 12.38066538 2.605500710
#> 4 P36 Long-duration 6089 26.39235720 5.224947960
#> 5 P34 Long-duration 6089 12.95818285 -4.590798898
#> 6 Q01 Long-duration 6089 6.99111638 -2.419254923
#> 7 Q32 Long-duration 6089 8.76233308 -4.613796877
#> 8 Q05 Long-duration 6089 10.19642514 -4.800348226
#> 9 Q04 Long-duration 6089 5.11690847 -3.495165661
#> 10 Q24 Long-duration 6089 12.48006145 -6.106493143
#> 11 E34 Non-diabetic 6126 4.77921758 -2.792193685
#> 12 F17 Non-diabetic 6126 1.51878685 -1.777628421
#> 13 E32 Non-diabetic 6126 8.79933987 3.356249820
#> 14 E19 Non-diabetic 6126 8.13955881 0.417289236
#> 15 E17 Non-diabetic 6126 2.83413719 -2.326122613
#> 16 F14 Non-diabetic 6126 6.51660329 -3.668869656
#> 17 E37 Non-diabetic 6126 14.66088038 2.497689525
#> 18 E29 Non-diabetic 6126 7.54855794 1.944926298
#> 19 E42 Non-diabetic 6126 5.00033816 -4.119714304
#> 20 F04 Non-diabetic 6126 4.02371202 -3.249964000
#> 21 M29 Non-diabetic 6134 1.44855110 -1.420023209
#> 22 M05 Non-diabetic 6134 10.65244712 -2.811943812
#> 23 M32 Non-diabetic 6134 17.38535701 -3.222357483
#> 24 L09 Non-diabetic 6134 22.90948116 -5.735460750
#> 25 M16 Non-diabetic 6134 28.24623802 -6.923585736
#> 26 L29 Non-diabetic 6134 24.19992571 7.402151160
#> 27 M15 Non-diabetic 6134 9.89851715 -2.272223688
#> 28 L31 Non-diabetic 6134 23.00110425 -1.581967181
#> 29 M17 Non-diabetic 6134 55.78655554 0.202955662
#> 30 M21 Non-diabetic 6134 20.33454847 3.170877994
#> 31 J16 Long-duration 6180 9.30833803 3.616883687
#> 32 K33 Long-duration 6180 18.81898417 5.553486563
#> 33 J29 Long-duration 6180 4.74358965 -4.038963048
#> 34 K25 Long-duration 6180 2.08019523 -2.229998531
#> 35 K17 Long-duration 6180 8.84427445 0.353066927
#> 36 K34 Long-duration 6180 4.38347569 -4.645643429
#> 37 J07 Long-duration 6180 3.16159258 -3.218935406
#> 38 K09 Long-duration 6180 4.98112085 -1.879401855
#> 39 K26 Long-duration 6180 5.78821361 -5.332797542
#> 40 J31 Long-duration 6180 9.44810912 -3.241704847
#> 41 N25 Onset 6228 6.76164660 -0.359946149
#> 42 N41 Onset 6228 1.66929432 -0.631534995
#> 43 N60 Onset 6228 7.68223599 1.921463220
#> 44 O17 Onset 6228 2.36230335 -2.183800188
#> 45 N55 Onset 6228 6.56177921 5.429939674
#> 46 O11 Onset 6228 3.24689536 -2.510201553
#> 47 O02 Onset 6228 1.96496218 -2.794118368
#> 48 O35 Onset 6228 0.82437314 -2.785428613
#> 49 N52 Onset 6228 -1.14431305 -7.404458994
#> 50 O04 Onset 6228 8.38508606 2.863573165
#> 51 V15 Long-duration 6264 10.60592071 -1.735073100
#> 52 V21 Long-duration 6264 14.43646021 0.333853122
#> 53 V01 Long-duration 6264 12.68216977 -7.015266826
#> 54 W38 Long-duration 6264 27.30806055 -6.676942242
#> 55 W20 Long-duration 6264 7.10341113 -3.307093843
#> 56 W23 Long-duration 6264 12.97847249 -15.123089385
#> 57 V14 Long-duration 6264 24.27925459 -11.530544252
#> 58 V30 Long-duration 6264 4.79657921 -4.948003444
#> 59 W22 Long-duration 6264 5.92124292 -3.157595327
#> 60 W09 Long-duration 6264 13.97962064 -2.081935866
#> 61 Y21 Non-diabetic 6278 12.31477124 -6.577817570
#> 62 X21 Non-diabetic 6278 24.12660016 1.852551246
#> 63 Y15 Non-diabetic 6278 14.76346942 3.777990109
#> 64 X28 Non-diabetic 6278 5.08273188 0.731669199
#> 65 X17 Non-diabetic 6278 15.70340938 6.361374721
#> 66 X10 Non-diabetic 6278 107.73186167 111.907148417
#> 67 Y08 Non-diabetic 6278 11.23503753 4.307427899
#> 68 Y09 Non-diabetic 6278 5.14264786 1.045914775
#> 69 X20 Non-diabetic 6278 15.71617158 3.781752588
#> 70 X11 Non-diabetic 6278 5.79481189 -2.689532194
#> 71 A39 Onset 6362 9.78325895 5.616603244
#> 72 B07 Onset 6362 4.64588222 -2.657780293
#> 73 A25 Onset 6362 0.98205856 -3.295408655
#> 74 A17 Onset 6362 30.88851461 16.053470431
#> 75 B18 Onset 6362 4.14134771 -0.785408832
#> 76 B28 Onset 6362 3.47358534 -2.747168091
#> 77 A16 Onset 6362 29.82495238 12.201065360
#> 78 B10 Onset 6362 12.62857187 3.539927264
#> 79 A09 Onset 6362 3.58824564 -2.606700306
#> 80 A11 Onset 6362 3.58034603 -3.619433989
#> 81 T06 Onset 6380 12.80207877 7.577149787
#> 82 U46 Onset 6380 2.04332003 -4.674763786
#> 83 U27 Onset 6380 0.06683683 -3.988853464
#> 84 T09 Onset 6380 2.87205435 -2.005125153
#> 85 U13 Onset 6380 3.77866070 -1.276568439
#> 86 T38 Onset 6380 -1.68866573 -3.785275397
#> 87 T29 Onset 6380 0.55689368 -2.754952517
#> 88 T40 Onset 6380 1.78704248 -2.082011344
#> 89 T36 Onset 6380 0.88805425 -7.092289171
#> 90 U40 Onset 6380 -0.77153956 -4.356337032
#> 91 S27 Non-diabetic 6386 9.93912920 -4.898497914
#> 92 S11 Non-diabetic 6386 14.49511301 -5.881696382
#> 93 R21 Non-diabetic 6386 14.58349235 -5.156339915
#> 94 R08 Non-diabetic 6386 13.91641482 -3.871867259
#> 95 S32 Non-diabetic 6386 22.52483076 -6.386961434
#> 96 R05 Non-diabetic 6386 7.07056128 -4.064039955
#> 97 R13 Non-diabetic 6386 20.51975792 0.572613414
#> 98 S18 Non-diabetic 6386 3.77696044 -2.396020024
#> 99 R24 Non-diabetic 6386 8.70171762 -2.800561439
#> 100 S35 Non-diabetic 6386 25.46683189 -11.960807085
#> 101 H43 Onset 6414 2.29253726 -2.811016206
#> 102 G32 Onset 6414 18.69218358 2.574126929
#> 103 H33 Onset 6414 1.44839637 -5.871216224
#> 104 H36 Onset 6414 5.91884632 -7.163827183
#> 105 G17 Onset 6414 12.02325628 1.416533678
#> 106 G22 Onset 6414 0.21563887 -3.021132989
#> 107 H12 Onset 6414 -0.51716483 -4.162900030
#> 108 H23 Onset 6414 5.64085651 -3.192847665
#> 109 H38 Onset 6414 7.22328089 0.204139514
#> 110 H16 Onset 6414 6.53260971 -1.570205982
#> 111 C29 Long-duration 6418 -0.48963397 -5.168574355
#> 112 C27 Long-duration 6418 15.19792940 -7.077024163
#> 113 D34 Long-duration 6418 -0.25691911 -5.886275410
#> 114 C30 Long-duration 6418 -3.72759847 -5.591827547
#> 115 D21 Long-duration 6418 4.28986098 -4.177060212
#> 116 D03 Long-duration 6418 19.19567674 1.555127221
#> 117 C13 Long-duration 6418 4.64483616 -3.060585429
#> 118 D11 Long-duration 6418 11.74956224 0.009122844
#> 119 D06 Long-duration 6418 14.17409917 4.401319394
#> 120 D25 Long-duration 6418 3.00511891 -3.523131533
#> neutrophil__ductal unknown__ductal stromal__ductal alpha__ductal
#> 1 -5.39404319 -11.7149625 -4.38106828 -13.7648007
#> 2 -16.90611413 -7.7826513 -4.56896063 2.9280241
#> 3 -29.32244208 -20.9739889 -0.41890112 10.6870003
#> 4 0.59638357 -29.7795961 -25.25015866 26.1004026
#> 5 5.29259896 -1.3980406 -5.39573197 -18.2110738
#> 6 -4.40509594 -9.3718146 -11.07259336 -12.9084965
#> 7 -14.93739708 10.1757219 -14.25054096 -2.4690870
#> 8 -10.38341050 7.4528327 -3.98144658 -12.8237874
#> 9 0.62068749 -1.7898335 -22.60167406 -8.8508743
#> 10 19.59213368 5.9180942 -15.89612469 -3.5432513
#> 11 -2.85870552 -9.9682882 -7.16412458 -17.1679317
#> 12 4.92069976 -5.4421274 -4.59963666 -33.2637043
#> 13 14.18648553 -5.7963680 6.44926344 -45.6799422
#> 14 8.67317218 1.4321604 4.10722141 -32.1927613
#> 15 -0.08746406 8.4900768 -2.62583859 -20.8764696
#> 16 0.93193409 -2.2091716 -3.73377648 -6.5632100
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#> 18 -1.27514579 -2.4739587 -3.05978008 -40.2053515
#> 19 -1.28013351 1.7123739 -2.10100803 -15.3172742
#> 20 1.40620998 -1.4435760 1.32930216 -26.0063463
#> 21 NA -5.4182651 -3.19220118 -30.7112567
#> 22 NA 8.4616429 16.39856658 -21.3808343
#> 23 NA 1.8536798 -9.98817105 -1.8169724
#> 24 NA 14.6703479 11.35866381 -21.6083581
#> 25 32.80673752 10.1915043 14.15481350 -24.2547180
#> 26 NA -10.9958646 -23.12055801 -33.9081020
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#> 51 -6.16866107 -3.1228424 -22.50753397 -0.8904734
#> 52 -14.50704137 -12.6932251 -15.84297973 4.7896599
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#> 68 -3.68766440 -0.3890132 -10.04396839 -29.5314066
#> 69 13.58522364 4.9225199 2.06415963 -56.9622612
#> 70 -6.81280513 -9.1429756 -5.51081059 -2.3971016
#> 71 20.64416392 -3.6894501 2.63220787 -54.5168746
#> 72 9.98736640 -8.7005654 -6.78537281 -21.6951156
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#> 74 5.57302579 6.8048363 20.13610662 -75.1702950
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#> 76 2.58488261 -5.8077898 -9.30470677 -28.9944375
#> 77 1.73831736 5.0957273 7.85950168 -59.4191419
#> 78 6.58750580 -4.0722041 -0.90262748 -44.3911859
#> 79 -3.74403866 -2.3032550 2.22166631 -29.3102029
#> 80 -0.69778919 -3.5644725 -5.07003336 -13.6237076
#> 81 9.40080148 2.1102421 0.08451793 -53.5985445
#> 82 -3.53807446 -5.7752045 -1.13240282 -32.3376469
#> 83 -5.25770238 -14.3869156 -5.17215946 -26.3986995
#> 84 -6.95814179 -9.0760308 -5.18202309 -25.5516116
#> 85 -0.69002036 -5.7748356 -2.19217289 -48.8577124
#> 86 1.86471496 -4.9688208 -6.22046154 -24.5167547
#> 87 3.11345732 -3.5602280 -0.65141242 -36.6658424
#> 88 -13.30078119 -12.3561027 -12.13549228 -3.2465547
#> 89 -5.87251372 -7.6249844 -11.70888225 -10.8758755
#> 90 -5.66636331 -9.0663790 -11.14897205 -18.5987461
#> 91 NA 10.3358743 6.94947474 -37.8236629
#> 92 16.26442506 11.5306273 -2.24050816 -31.1222860
#> 93 NA -8.3899393 15.85801271 21.8625201
#> 94 -47.66177742 11.7015593 -6.93584046 -16.5858806
#> 95 NA -18.3235834 25.74062609 -42.5379693
#> 96 NA -10.8317169 9.61531020 11.0261668
#> 97 NA 9.9203558 -3.50470255 -33.4309678
#> 98 NA -8.2674287 4.37628170 -23.6338366
#> 99 NA -3.1796219 -7.67101640 -28.2850729
#> 100 NA 27.2170847 24.12162521 -26.4323221
#> 101 -48.84985710 -12.8464051 -9.22383018 -34.4147346
#> 102 8.63779046 -8.0538762 -22.04138028 -73.2576955
#> 103 4.30842833 -4.1042375 -1.60240942 -47.1581445
#> 104 7.55989608 -2.0687540 -10.25716914 -27.2817692
#> 105 -3.79259321 -4.2760940 -12.24186016 -19.6505400
#> 106 -13.92578084 -12.9195743 -26.23123737 -52.3660706
#> 107 -18.45261965 -10.3306970 -14.34833116 -46.1509325
#> 108 -24.99097511 -16.7308366 -41.72684813 -60.6549111
#> 109 5.68100875 -12.4425408 -13.84459169 -42.6315282
#> 110 8.24881604 -20.7773894 -16.60106406 -47.3004764
#> 111 -8.86602967 -4.6961659 -15.32752978 -22.3638647
#> 112 -5.61842547 1.2659541 -1.53341588 -25.4649601
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#> 114 -6.06053381 -9.6527532 1.70962858 -24.6667556
#> 115 -21.16687637 -3.9149429 -3.17855173 -43.1735561
#> 116 -27.21330550 -8.6988842 -4.73071117 -38.9119768
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#> 120 -3.25192699 -10.9447976 -3.68032420 -28.0212798
#> endothelial__ductal macrophage__ductal delta__ductal Tc__ductal
#> 1 -7.2619394 -6.3772423 -11.453292 -5.3025334
#> 2 -8.7986126 -5.0543407 2.350429 19.3909683
#> 3 -36.3939917 -4.7949779 3.087641 18.4425369
#> 4 -29.1511445 -11.2622812 24.155941 2.6225554
#> 5 7.9581600 16.4223493 -18.900674 -7.4507093
#> 6 -13.6602351 0.1431831 -16.527774 0.1459792
#> 7 -32.7477913 -13.4904621 5.423427 -14.3427820
#> 8 -3.1209983 -26.9991669 -13.731502 -18.9597461
#> 9 -15.7954445 -14.0424537 -12.158467 -27.0929545
#> 10 -14.6183103 7.2330373 3.422709 31.3988285
#> 11 -5.1933076 -3.8615491 -22.004099 -17.4265264
#> 12 -10.0741606 -6.1390787 -36.913559 -21.7711870
#> 13 -15.5688690 10.0295855 -39.684064 6.8630433
#> 14 -11.9369054 1.4188039 -31.276490 1.8027121
#> 15 -16.7562698 -5.1235899 -41.522487 -0.2267633
#> 16 -10.9674144 -1.3102583 -7.531862 -0.9642048
#> 17 -0.7400364 5.7617966 -65.405238 0.3114809
#> 18 -8.5310026 1.1871176 -35.823427 -10.7058591
#> 19 -6.6113919 -3.1460799 -26.576748 -4.5033781
#> 20 -13.6668207 -4.7186847 -37.851361 -23.4151836
#> 21 -14.5577810 NA -53.299263 5.2933018
#> 22 -13.4890047 NA -16.382754 3.0141596
#> 23 2.3832036 NA -3.836564 6.8284546
#> 24 -7.2509506 59.9236966 -13.486217 1.1088882
#> 25 -5.3886125 NA -42.217650 12.8553949
#> 26 -28.6304241 -17.1037822 -58.663709 8.8598033
#> 27 1.0715004 17.9472990 -11.862850 0.3152381
#> 28 13.4466610 NA -57.119765 3.0752398
#> 29 -13.1552257 -8.0852202 -64.490180 10.7072791
#> 30 -10.8694012 NA -61.984305 1.3751227
#> 31 -5.1479585 8.8850747 -57.086533 0.1422805
#> 32 -23.6648997 4.1392339 -64.436911 -16.9374647
#> 33 -5.6993117 3.8003592 -7.442256 8.6918535
#> 34 -10.2831162 -8.9043966 -52.438227 -10.8523270
#> 35 -36.8582893 3.9267950 -28.114549 -28.9015200
#> 36 -13.1293443 -9.1600452 -16.048628 -14.5906237
#> 37 -7.4273904 -3.0531158 -13.980529 -11.6729957
#> 38 -12.7914452 -2.0736544 -38.538615 -5.1715217
#> 39 -21.3402155 8.7565423 -17.993993 8.2999169
#> 40 -1.5965363 -5.1637596 -38.450612 12.0340122
#> 41 -25.7756320 2.5631637 -62.319972 -13.6268649
#> 42 -9.5984932 -11.6836360 -33.064626 -12.8904984
#> 43 -42.3785152 -1.0529705 5.850599 -15.1439106
#> 44 -3.1519977 1.4908267 -14.242947 -8.8089135
#> 45 -21.1911864 6.5033413 -32.466251 -10.4702459
#> 46 -2.9728688 -7.0836627 -44.042765 -13.7742885
#> 47 -2.5059877 -6.0255006 -17.993889 -3.8290237
#> 48 -5.3337828 4.1122584 -53.255233 -8.6059004
#> 49 0.3405548 -8.2610792 -48.960111 -3.5873275
#> 50 -29.8148498 0.3046943 -11.122116 -24.8327243
#> 51 -12.9083361 10.1238820 9.255150 -1.1482243
#> 52 -16.3541040 -13.0356534 12.280990 -13.8779682
#> 53 -14.9611088 6.0049612 -17.042580 -26.8354560
#> 54 -4.5435491 37.4939001 -34.533829 -0.8305456
#> 55 -9.9732441 -16.8669656 -6.164757 -11.9225469
#> 56 5.0098841 -32.8377345 -9.978138 -19.2499563
#> 57 -10.0514384 3.8908225 -4.448348 -1.2074443
#> 58 -8.2428575 NA -2.009420 -14.4072844
#> 59 -15.4617901 -16.2392715 5.668191 -8.6923163
#> 60 -19.1815600 9.6682217 -29.944640 -7.9966812
#> 61 -26.9753072 -2.6876674 -12.192458 -8.8167083
#> 62 -25.2607312 -28.7525499 -45.584530 7.9816236
#> 63 -26.5071710 -19.9609347 -50.486036 -26.7059589
#> 64 -7.6408816 -16.1305618 -15.273024 -19.7273789
#> 65 0.8805216 22.9956611 -62.401801 -17.9578072
#> 66 -58.8541681 -77.4067116 -116.372096 -77.4770744
#> 67 -4.7141203 -8.2446202 10.009327 8.8678540
#> 68 -0.4097068 -14.2045114 -41.127578 NA
#> 69 -10.4610979 13.3493810 -49.774297 -32.0659259
#> 70 -10.2884577 -9.7845800 1.818068 -1.4058856
#> 71 -9.0340393 6.6929361 -34.459688 7.9100921
#> 72 -12.1468127 0.1111789 -21.120909 -16.6210196
#> 73 -6.9358172 5.1336043 -48.986615 -5.7291463
#> 74 -25.7144812 27.5411998 -85.457513 33.0514320
#> 75 -3.7541765 -7.4407342 -41.335152 -2.1257096
#> 76 -9.8666730 -6.0569637 -33.290844 -3.3682096
#> 77 -15.0049407 7.0716969 -62.448199 13.5748623
#> 78 -18.6102884 5.0127324 -37.847734 -3.9026321
#> 79 4.9133176 -9.1962829 -20.652796 -7.7131461
#> 80 -5.0912697 -5.6345554 -19.279893 -3.3881721
#> 81 0.1215812 6.8233634 -60.678851 4.8591005
#> 82 -9.1698441 -3.0226151 -25.462913 -3.7682411
#> 83 -15.3119739 -8.7373021 -37.140421 -13.5190442
#> 84 -13.2850862 -9.4156158 -22.999679 -6.4606873
#> 85 -8.9725464 -0.8799053 -42.912290 1.2819967
#> 86 -3.9070909 -7.1860469 -17.681945 -6.9082471
#> 87 -3.4848974 -2.8991457 -32.163432 1.4335582
#> 88 -23.7359226 -4.9111150 1.868999 -11.8261149
#> 89 -8.7747096 -11.6834690 -28.005801 -13.8196248
#> 90 -13.6200934 -7.4914297 -21.113370 -1.9192732
#> 91 -12.6652401 NA -41.572798 NA
#> 92 -7.2792216 -29.0540639 -50.029776 -24.1450224
#> 93 -16.0109701 -37.0074030 13.662624 -19.4226694
#> 94 4.7045218 -5.2900959 -34.709098 -32.1424654
#> 95 -11.8136274 -39.8918274 -22.254071 34.4613494
#> 96 2.2130935 -26.1375054 7.005730 -8.4363168
#> 97 -7.6783147 36.5575460 -49.399950 9.2091578
#> 98 -11.0692179 NA -29.170449 -6.4198555
#> 99 -6.7474242 14.8015148 -43.450836 9.0774547
#> 100 12.9065344 -26.9615476 -20.707328 67.4955887
#> 101 -4.4432833 7.1192484 -41.136592 -9.7984239
#> 102 -16.1911159 -7.4582351 -70.683009 -12.9495437
#> 103 -15.7762433 NA -55.008133 -20.2366757
#> 104 -14.4503404 NA -23.600476 -1.7977093
#> 105 -30.4495512 5.0643801 -24.863692 -10.3406318
#> 106 -12.4952452 -14.2072126 -43.218325 -8.0054028
#> 107 -4.1113719 NA -23.939973 -1.6111971
#> 108 -27.9236154 NA -58.785809 -23.8230908
#> 109 -6.7619302 26.6110792 -37.476184 -25.8167865
#> 110 -15.3789240 -15.3151220 -51.486609 -22.3941005
#> 111 -26.7900508 19.2622414 -30.183940 -4.0277857
#> 112 -10.3958178 -5.4864080 -36.779440 -22.8823365
#> 113 -0.9784354 -7.3123717 -36.313894 1.0727139
#> 114 -6.2949926 -2.9487714 -42.223773 -6.1740229
#> 115 -11.2271975 2.2076584 -10.562038 3.9954857
#> 116 -21.7054868 -4.0833514 -51.212084 -4.8979234
#> 117 -10.5338750 1.4179398 -49.487681 -14.9393181
#> 118 -10.7233812 -10.4040842 -39.548536 -20.1825566
#> 119 -42.0732375 -26.3971071 -27.750376 -14.6561151
#> 120 -6.3226418 -18.6647318 -35.519660 -9.0182466
#> Th__ductal otherimmune__ductal gamma__ductal B__ductal naiveTc__ductal
#> 1 6.0523128 -8.80990901 NA NA NA
#> 2 -9.8973569 -52.39504787 -16.9373275 NA NA
#> 3 NA -60.19871211 NA NA NA
#> 4 -21.9740604 -6.29180499 NA NA NA
#> 5 37.8402655 -3.08734782 NA NA NA
#> 6 -24.6617727 -7.80082407 NA -5.984605 NA
#> 7 7.0332403 -37.28632378 NA NA NA
#> 8 0.8000223 -12.23375689 -20.2523946 NA NA
#> 9 NA NA 6.4813951 NA 22.1680344
#> 10 -18.2418669 -1.80578896 NA NA NA
#> 11 -15.2314444 -11.42054909 NA NA NA
#> 12 NA -1.68286022 -18.4020783 NA NA
#> 13 -11.2616552 2.87669839 NA NA NA
#> 14 -8.7693210 3.18503641 NA NA NA
#> 15 -1.0718568 -0.23753657 NA NA NA
#> 16 -13.0231178 -1.98575894 NA NA 14.1367903
#> 17 0.1914142 4.07309924 NA NA -22.6215338
#> 18 13.2151201 -8.28986379 NA NA NA
#> 19 -7.6078164 -5.23436236 NA NA NA
#> 20 -10.7454054 -14.45816955 NA NA NA
#> 21 NA NA NA NA NA
#> 22 -6.9035286 1.80855953 NA NA NA
#> 23 NA -20.90229588 NA NA NA
#> 24 20.1630407 14.29059704 NA NA NA
#> 25 -0.1722034 4.30514399 NA NA NA
#> 26 -23.2763972 -39.40628644 NA NA NA
#> 27 -33.6813355 9.85156742 NA NA NA
#> 28 NA NA NA NA NA
#> 29 25.5295084 12.78737174 -104.2272560 NA -0.7592503
#> 30 NA -22.53071390 NA NA NA
#> 31 -7.1237344 -10.93381511 NA NA NA
#> 32 -34.7020725 -9.04319405 NA NA -50.7643764
#> 33 -5.1546663 -0.21802703 -26.0510898 NA 14.6984655
#> 34 -1.4511477 -19.05805028 NA NA NA
#> 35 -36.0739371 -17.88028666 14.3669215 NA 7.8803164
#> 36 -12.4615821 -8.33424470 NA NA -7.7421097
#> 37 -14.4894837 -0.46103483 5.3826255 NA NA
#> 38 6.6693743 -3.85252663 -41.0861187 NA 7.1128686
#> 39 NA 1.84221512 NA NA NA
#> 40 57.5665678 -1.70497043 NA NA 25.0743981
#> 41 -14.0345603 -17.56867001 NA -4.407471 -53.6391991
#> 42 -15.3008901 -8.38502112 NA -18.943410 -37.4686564
#> 43 -31.5799932 -23.23150640 NA -43.819073 -20.9169123
#> 44 -15.9641698 -8.15507346 -7.8083893 -25.833279 0.3081836
#> 45 -18.7397460 -8.38835665 -26.9542336 -39.324750 -17.2908811
#> 46 -17.0336119 -14.16085758 NA 20.752641 -28.8515808
#> 47 -1.6170880 -5.41480298 NA -28.452855 -7.6086368
#> 48 -2.4698597 0.46894518 NA -8.520104 -23.0863646
#> 49 -12.0166167 0.80125255 NA -3.910610 3.9233615
#> 50 -14.7956792 -23.57106002 NA -49.819096 -33.2482976
#> 51 -25.1205982 -3.14111402 NA NA NA
#> 52 -12.2053359 -15.70673557 0.6583570 -98.113410 -6.6043374
#> 53 -12.9676655 -6.61772695 NA NA -66.8854534
#> 54 -11.1656709 43.24160593 -27.9648655 -27.733500 -20.9909048
#> 55 NA 10.92242450 -62.1493234 NA NA
#> 56 -22.7286076 -28.86093902 NA NA NA
#> 57 -8.5159375 3.30169860 NA NA NA
#> 58 -2.2431381 -13.19832300 NA NA -39.9077019
#> 59 -12.7856212 -16.35303981 -12.3091221 NA NA
#> 60 -53.6818090 -13.79354149 -16.5008766 35.324236 NA
#> 61 -33.3923897 -14.79786807 NA NA NA
#> 62 -15.3033520 -25.21087779 NA NA NA
#> 63 -12.3374662 -18.40689589 NA NA NA
#> 64 -37.6217276 -15.42637445 NA NA NA
#> 65 16.3251603 18.99456767 NA NA NA
#> 66 -84.7492301 -97.82839477 NA NA NA
#> 67 -5.5588604 3.94875077 24.0772156 NA NA
#> 68 -11.9556340 3.45815018 NA NA NA
#> 69 NA 26.34010180 NA NA NA
#> 70 NA -12.26884260 NA NA NA
#> 71 NA 0.16188511 -80.0742312 NA NA
#> 72 -22.0524505 -17.72851424 -22.8130941 -27.714006 -28.1744209
#> 73 -6.6209340 -14.10305372 -56.7111050 NA NA
#> 74 1.4620364 35.41132289 NA NA 2.0058579
#> 75 NA -3.71327598 7.1693670 NA 14.4587978
#> 76 -28.4718483 1.94506471 NA NA 11.5224148
#> 77 -20.0912904 10.78510386 NA NA 34.8678439
#> 78 -16.2428289 -4.94309638 4.7819526 NA -2.4491106
#> 79 -14.1464530 -7.95390947 NA NA -6.7456126
#> 80 -1.9149680 -14.00983982 -11.9796198 NA NA
#> 81 7.7855650 8.66393930 -46.4059944 NA 52.1511588
#> 82 -5.4509869 0.08131269 NA NA -18.9510647
#> 83 -21.0842503 -8.46394834 NA NA NA
#> 84 -13.4520658 -4.67322061 0.2500086 -29.622787 15.4463801
#> 85 -2.0706158 -5.77276958 -32.8651337 NA 9.9866617
#> 86 2.0908215 -10.96386650 NA NA NA
#> 87 -6.5411814 -4.77307213 -29.0641044 NA -2.0940096
#> 88 -29.5921189 -14.86700955 2.1657528 -15.165273 -6.6742166
#> 89 -22.5519846 -4.48479109 NA NA NA
#> 90 -14.7802924 -27.19277334 NA NA NA
#> 91 NA 19.80411096 NA NA NA
#> 92 NA 2.10036614 NA NA NA
#> 93 -10.7383829 1.26958648 NA NA 26.5831406
#> 94 -7.8567459 8.20596907 NA NA NA
#> 95 NA -47.21187428 NA NA NA
#> 96 -34.9940565 5.92778547 NA NA NA
#> 97 5.3071125 5.41469294 NA NA NA
#> 98 -9.3499091 -3.60293231 NA NA NA
#> 99 NA -36.38697381 NA NA NA
#> 100 NA 84.87687724 NA NA NA
#> 101 -0.1687992 -14.36394592 NA NA NA
#> 102 -31.7928858 -16.76672624 NA NA -42.2001483
#> 103 -45.2803590 28.86130893 NA NA NA
#> 104 -33.8879695 -4.84202093 NA NA NA
#> 105 -29.3809566 7.05427956 NA NA -30.9955650
#> 106 -18.4637946 -18.06507838 NA NA NA
#> 107 -68.6940840 -3.66977437 3.5677077 NA -16.8165667
#> 108 -34.6120095 -35.06166979 -43.3859090 NA -43.9153817
#> 109 -29.2217778 -23.67328015 NA -33.927766 -43.1794189
#> 110 -14.8375398 -13.99401817 NA -18.190903 -19.9009609
#> 111 -6.8390788 -10.14219911 NA NA NA
#> 112 -6.6680453 -9.96477929 -31.4256222 NA NA
#> 113 -29.0009212 0.70408005 NA NA NA
#> 114 -0.9958604 -9.25509070 NA NA NA
#> 115 2.7907287 -14.31474074 NA NA NA
#> 116 -20.2435140 -9.43962145 -35.2089636 NA -21.2698373
#> 117 -1.5798395 -15.89242434 NA 1.260101 NA
#> 118 -34.3213833 -25.75435640 NA NA NA
#> 119 -36.4824099 -19.17702630 NA NA NA
#> 120 -19.6523239 NA NA NA NA
#> beta__ductal ductal__acinar acinar__acinar neutrophil__acinar
#> 1 NA -2.90256026 -1.64831157 -1.588798457
#> 2 NA -3.70728165 -1.06831847 -1.441158635
#> 3 NA 3.57230122 7.47147596 -9.047100528
#> 4 NA 5.23279885 7.29456559 1.577727758
#> 5 NA -4.33491263 -1.60525967 -4.067451000
#> 6 NA -3.42382159 1.73894491 2.911082165
#> 7 NA -5.09156723 -3.23034604 -2.853002235
#> 8 NA -4.64485621 -0.77225976 -4.471305737
#> 9 NA -3.93984708 -1.85075761 -3.527461555
#> 10 NA -7.03899867 -3.47082184 -6.873051757
#> 11 -19.735120 -3.31927486 -1.13073407 -1.274120455
#> 12 -41.755229 0.06202724 0.07126727 0.646844750
#> 13 -66.349308 4.47991552 6.91664693 4.363782331
#> 14 -58.474070 -1.20116150 6.94721024 -0.950061602
#> 15 -32.423380 -2.33510209 1.66500724 -0.247452591
#> 16 -14.600638 -5.64810698 -2.38845842 -2.352346139
#> 17 -68.680096 3.03982130 7.69897640 7.967860681
#> 18 -52.441771 1.89008135 5.40714442 3.120939731
#> 19 -21.232407 -3.78744096 2.13194121 -0.020421910
#> 20 -27.918778 -1.48416627 -1.07010938 -2.423960635
#> 21 -50.235593 -0.59137585 0.73309205 NA
#> 22 -24.550867 -3.02310605 3.56470951 NA
#> 23 -6.478699 -4.36850737 0.16921098 NA
#> 24 -20.881091 -5.61137397 7.42075982 NA
#> 25 -29.640884 -6.47881959 3.85859608 -30.841173865
#> 26 -44.590968 4.79764334 8.09871832 NA
#> 27 -16.848433 -1.86855211 1.56582884 9.021841369
#> 28 -41.802304 -1.04092042 1.47460247 NA
#> 29 -67.916033 -0.22664930 7.78547188 14.388876384
#> 30 -61.755296 2.69700951 3.08709080 NA
#> 31 NA 3.54222293 7.28816801 2.582696691
#> 32 NA 5.84757075 5.60334003 0.725786075
#> 33 NA -4.62225367 -1.28192641 1.087296090
#> 34 NA -2.57770126 -0.15846475 -0.679876288
#> 35 NA 0.88652642 1.08143434 -2.251585992
#> 36 NA -3.86339734 -1.14934626 -2.853420679
#> 37 NA -2.99186930 -1.23258065 0.185598821
#> 38 NA -1.55723699 2.32975801 0.609814944
#> 39 NA -4.72646203 0.74293691 -5.185617719
#> 40 NA -2.79913231 2.07996612 -0.096459927
#> 41 -58.501062 -0.55506856 5.53238871 0.896790154
#> 42 NA -0.77247562 0.61746184 -5.144750116
#> 43 -31.500113 0.81077110 5.03039404 -11.412467535
#> 44 NA -2.66814059 -0.93638458 -1.109118308
#> 45 NA 3.37069781 4.16106134 -1.904577967
#> 46 -43.959879 -2.53076439 1.92561256 3.584466291
#> 47 -32.342628 -2.80235805 0.89362156 9.538902934
#> 48 -36.280377 -3.57439125 -1.31913435 8.489029904
#> 49 -36.039482 -7.73251424 6.28788444 NA
#> 50 NA 3.61680931 4.82243586 -0.866016611
#> 51 NA -2.63139683 1.72414221 7.050822706
#> 52 NA 0.39285853 4.16524368 -9.059695066
#> 53 NA -5.84367911 5.84402159 -8.642742510
#> 54 NA -7.31319591 8.69621113 -3.609377260
#> 55 NA -2.81663602 -2.36997442 -9.151374824
#> 56 NA -14.30047282 36.71828053 41.404002523
#> 57 NA -13.51197612 4.23830509 7.906495679
#> 58 NA -7.33816172 4.06582370 -8.767334442
#> 59 NA -4.99865195 -2.75257200 -1.098185672
#> 60 NA -2.70541801 6.38658493 1.056185113
#> 61 -15.729512 -6.21958383 5.31628942 -3.362395700
#> 62 -60.230381 2.39685280 6.22880252 -5.645505376
#> 63 -39.834231 3.50079423 6.84708967 -5.364088507
#> 64 -18.026308 0.54250948 5.60993072 -13.553425587
#> 65 -59.201722 4.49416233 6.75015138 8.974430170
#> 66 NA 111.05286282 118.45059299 -41.873983725
#> 67 1.631180 4.30570376 5.59947070 -0.259227303
#> 68 -30.907929 1.75963114 2.61284265 -4.003658195
#> 69 -58.759133 4.03629447 6.14608865 8.108578271
#> 70 -4.366729 -3.18524993 0.51081147 0.005734523
#> 71 NA 5.50957084 9.61800262 6.182913145
#> 72 NA -2.04835983 0.39102003 -8.809064428
#> 73 -34.171441 -3.54758940 1.84807026 10.445404812
#> 74 -85.655418 17.43033678 22.32401090 2.555069167
#> 75 -45.633806 -0.26889464 1.99877049 8.099937227
#> 76 NA -2.00471562 -0.31259992 -8.946675280
#> 77 -69.227835 12.50322885 21.09909251 18.083707949
#> 78 -68.689256 3.33189063 7.92194142 -2.497687691
#> 79 -40.783897 -2.44076999 3.26356384 0.982678449
#> 80 NA -3.70571026 4.76544260 3.314220595
#> 81 NA 9.60065047 14.10938375 10.348118093
#> 82 -25.538029 -4.54019895 0.63457718 -6.745377715
#> 83 -33.555149 -2.04757463 1.78772006 -2.497825324
#> 84 NA -1.15134454 0.43354699 -4.839225897
#> 85 -39.014338 -2.76448351 2.52373197 3.193220681
#> 86 -26.130906 -5.17865031 -2.07036535 -4.799500140
#> 87 -32.861304 -3.09489792 -1.25762742 -2.811868495
#> 88 NA -3.19428334 -2.68068191 -5.910229845
#> 89 -31.610441 -5.08219048 -2.29869835 -2.243292120
#> 90 -23.245624 -3.78613642 -1.76421373 -2.289521577
#> 91 -29.931107 -5.59089720 -1.64125408 NA
#> 92 -22.315425 -6.20546859 9.83195971 14.499544409
#> 93 14.446471 -5.26329368 -1.31963833 NA
#> 94 -10.244153 -4.11546781 2.97709884 7.388302050
#> 95 -37.535228 -6.98447406 0.23036401 NA
#> 96 2.219440 -4.04879443 -0.76440002 NA
#> 97 -37.493706 0.35789133 6.24836192 NA
#> 98 -29.852871 -2.38220077 1.35621659 NA
#> 99 -30.091114 -2.01416987 -0.23714813 NA
#> 100 -8.781323 -16.13654479 6.60017049 NA
#> 101 -48.737096 -1.79665444 -1.07718221 -5.248676943
#> 102 -76.412778 3.43141967 11.65747984 5.234687783
#> 103 -47.073576 -4.38566127 -3.05616169 -9.689610117
#> 104 NA -9.05648684 1.08590913 -5.795461972
#> 105 -33.768818 0.90080921 5.38283692 7.751030676
#> 106 NA -1.11244749 -0.55105438 -11.943087534
#> 107 -47.739260 -0.59565855 -0.67776202 -18.049954916
#> 108 -60.724407 -2.16457091 -1.49064114 -21.325070262
#> 109 -40.946088 2.53846785 2.77060688 -6.929436843
#> 110 -56.894954 -2.95916802 -0.63967334 1.530052078
#> 111 NA -3.96843634 -2.81065675 -7.421216755
#> 112 NA -6.82396892 1.06786748 -7.476503341
#> 113 2.273108 -4.23337997 -2.32117391 NA
#> 114 NA -4.69035069 -3.91728714 -5.218382975
#> 115 NA -2.93109163 -1.55754090 -15.531966968
#> 116 NA 1.88804236 3.92287006 -17.474304831
#> 117 NA -1.58182134 -0.88553240 -1.515384853
#> 118 NA 0.87995309 2.44451133 0.708673894
#> 119 NA 1.86361668 3.62999540 -50.099319812
#> 120 NA -3.26138545 -1.60873721 -10.312954890
#> unknown__acinar stromal__acinar alpha__acinar endothelial__acinar
#> 1 -12.3050583 -2.72863631 -26.354200 -6.0693053
#> 2 -2.9378631 -5.00027657 -26.450018 -7.3424416
#> 3 -14.8438645 17.92258011 -16.369177 -37.0250701
#> 4 -20.4644051 -17.32356363 -7.324122 -22.9639051
#> 5 -4.6365767 -5.40923404 -24.958414 -12.0162431
#> 6 -1.9097091 -10.28296149 -47.491782 -11.7025267
#> 7 -7.3318518 -13.00642022 -21.092493 -2.1206735
#> 8 -12.2840964 0.28231297 -26.748941 -11.3164440
#> 9 -7.3605603 0.65370765 -20.164998 -8.2071616
#> 10 -5.7272354 -2.72645760 -14.115148 -2.9882592
#> 11 -3.6301446 -4.54666765 -28.725472 -3.5524990
#> 12 -3.2531650 -1.89775089 -34.398355 -0.9505728
#> 13 2.2244181 6.11445345 -49.449317 -9.5303387
#> 14 -10.8136096 -3.54978699 -44.388442 -20.3937696
#> 15 -9.9853480 2.54606636 -34.002992 -4.6046683
#> 16 -2.9210179 -2.30945052 -16.087186 -3.9887987
#> 17 1.5500037 3.26863767 -56.958790 -0.3111759
#> 18 0.3642133 -5.44956795 -47.936741 -6.3799421
#> 19 -1.3365739 -0.96017250 -28.263847 -3.4576166
#> 20 -3.8741427 -4.20465459 -24.542518 -6.0188310
#> 21 -13.1505037 -8.90784434 -44.836216 -17.3355527
#> 22 -11.5054773 -6.18090632 -51.169862 -22.7983357
#> 23 -6.5075448 -0.14417244 -46.876755 -7.9047201
#> 24 -21.2506667 -12.58461573 -74.220668 -22.2968512
#> 25 -21.4207699 -19.45073162 -40.136266 -17.8245022
#> 26 -1.6757642 -6.89248022 -53.413422 -20.8792000
#> 27 -7.2457704 -3.97525307 -45.250951 -7.1574466
#> 28 -1.4849929 -0.29469342 -53.448039 -9.6674277
#> 29 -4.0161921 -21.47121207 -65.817158 -19.6972300
#> 30 -5.7634657 -9.45872578 -40.153667 -6.1696182
#> 31 -0.8081819 -2.19543890 -61.695368 -7.0085342
#> 32 -6.8982809 -15.34545117 -49.229148 -18.8661960
#> 33 -7.4262498 -2.30534869 -17.164561 -11.3468666
#> 34 -8.6796216 -1.50922084 -43.806176 -1.8881257
#> 35 -3.0783885 1.12326894 -19.712020 -18.5321155
#> 36 -2.9615263 -4.49805728 -13.820768 -4.8233854
#> 37 -4.0014152 -3.07277577 -19.450445 -1.6033654
#> 38 -5.3259747 0.49322217 -44.776615 -8.5067903
#> 39 -1.5782152 -0.41273231 -43.097975 0.3541965
#> 40 -4.9960025 3.26243318 -41.539355 -3.6004191
#> 41 -8.1471616 -5.95094038 -56.955266 -13.1638533
#> 42 -4.7941843 -3.67178800 -20.264521 -12.0487414
#> 43 -10.4397704 -3.87345067 -45.333671 -27.7374918
#> 44 -8.8019310 -2.86914209 -19.992049 -2.8245272
#> 45 -4.6541114 2.67115105 -48.394927 -12.2144009
#> 46 -6.3761896 -2.66775516 -38.055482 -4.5365656
#> 47 -6.4357498 -2.30068925 -22.340150 -3.5388832
#> 48 -4.3087351 -0.58768557 -28.108695 -19.0355612
#> 49 -2.7137500 -11.70024050 -48.894069 -6.7422866
#> 50 -7.8374005 3.27456261 -19.898728 -25.2648698
#> 51 -13.2520293 -11.96082920 -41.121151 -20.5536824
#> 52 -13.1704781 -11.58990105 -8.457108 -15.6648058
#> 53 -25.9911320 -3.44300723 -20.312780 -26.0195886
#> 54 -22.9157028 -8.21323469 -63.416949 -22.4306231
#> 55 -6.6724747 -5.46848088 -12.981563 -6.1677451
#> 56 -61.4991459 -35.05664980 -57.545456 -61.5657311
#> 57 -16.1814103 -4.13148180 -48.001146 -17.3698621
#> 58 -18.1206893 11.47395800 -40.490114 -15.7216551
#> 59 -5.5228720 -4.23856075 -21.609361 0.4711098
#> 60 -27.2798530 -11.13687578 -42.412430 -14.9776698
#> 61 -17.8622011 -19.41991979 -10.032306 -39.4177744
#> 62 -4.6031195 -0.85144946 -40.375725 -0.7963965
#> 63 -10.0527026 -1.19115927 -56.975637 -14.4220704
#> 64 -13.9277609 -4.25864984 -38.359565 -10.3045779
#> 65 -4.3112091 0.94688335 -64.539878 1.1676925
#> 66 -44.7202486 -58.05830908 -130.941910 -56.7112388
#> 67 -7.9367056 -0.93737525 -3.872109 4.2876506
#> 68 -1.1606883 -6.97759899 -42.598743 -6.8626043
#> 69 0.4239090 4.96675471 -58.190693 -3.3639096
#> 70 -2.5375380 -9.24033575 -30.333166 0.5067649
#> 71 4.0319655 8.58575707 -70.865528 -3.2779564
#> 72 -5.7173424 -5.77555853 -22.138365 -8.4206647
#> 73 -14.3110862 -1.07991030 -49.744784 -17.3949372
#> 74 3.9719558 10.02048122 -75.127665 -21.5444610
#> 75 -4.5823935 -0.84573072 -37.607936 -3.8847515
#> 76 -0.5171992 -1.65046627 -28.766480 -4.0038750
#> 77 0.0379699 9.26492607 -68.114508 -12.2675785
#> 78 -5.5885704 5.51343959 -47.777935 -16.7885311
#> 79 -5.9783139 0.30893149 -45.807581 -6.0690231
#> 80 -19.2269789 -3.46510025 -31.583881 -9.5155733
#> 81 1.8134802 4.13207298 -62.917705 4.9927060
#> 82 -7.0062999 -2.15655344 -33.105201 -4.4681478
#> 83 -8.7238180 -8.89136684 -26.174596 -1.2838756
#> 84 -5.8781308 -2.52943810 -23.409365 -3.5021995
#> 85 -10.5974873 0.77098340 -58.025667 -7.6551419
#> 86 -10.4135186 -8.90919348 -40.981214 -2.5112042
#> 87 -2.3454118 -2.51041708 -32.424612 -6.2117387
#> 88 -8.9696378 -6.79619173 -25.634180 -17.0064821
#> 89 -1.8883054 -4.95226475 -34.483615 -11.2105171
#> 90 -6.3840790 -3.51954743 -27.426339 -12.3512634
#> 91 -9.5868179 0.30313914 -41.354872 -18.3687412
#> 92 -24.5082555 -0.18636209 -54.226622 -32.0438111
#> 93 -1.5795308 -4.15456178 -13.960457 -9.8764325
#> 94 -11.0398999 -15.67849863 -47.400576 -11.9848398
#> 95 -6.3916840 -6.03080455 -44.921441 -23.2907827
#> 96 1.2523351 -1.10052256 -30.790235 -11.5686751
#> 97 -6.4140526 7.39329280 -58.109387 -24.3743942
#> 98 -7.2899291 -16.09270527 -52.123190 -22.6667128
#> 99 -3.3715541 -3.33400511 -25.503079 -9.1195698
#> 100 -20.7226207 -32.29372329 -60.214467 -29.1998582
#> 101 -7.8347789 -15.13953111 -38.496045 -6.8191560
#> 102 -13.6394538 -17.57408553 -83.210360 -19.8714373
#> 103 -1.6719528 -4.08358386 -24.440052 -9.2030758
#> 104 -15.1395598 -19.18951166 -51.380375 -11.9342112
#> 105 -3.8643124 -13.53740539 -35.031397 -22.5476036
#> 106 -6.4889837 -11.19272685 -43.892506 -7.5216386
#> 107 -7.3613274 -7.05721346 -31.091151 -1.4698308
#> 108 -12.3205020 -20.09245816 -33.793254 -13.8010358
#> 109 -6.2210315 -17.46627643 -18.917853 -3.0670088
#> 110 -11.6213359 -16.11462395 -42.222274 -10.3308884
#> 111 -6.8351778 -4.08750575 -21.428309 -6.5221267
#> 112 -10.4249834 -6.51288979 -33.153851 -5.4290301
#> 113 -2.4443670 -1.33058415 -23.001689 -4.6318231
#> 114 -4.8734622 -7.52594778 -17.199433 -3.2429006
#> 115 -1.6599930 -0.05328494 -18.533195 -7.6728884
#> 116 -7.8868140 -4.18134838 -31.578046 -11.7245651
#> 117 -1.8742361 -3.59563404 -24.594342 -5.1497736
#> 118 -12.5361444 -2.89373996 -15.898087 -1.2584021
#> 119 -18.6430675 -9.20309092 -26.627857 -31.8903475
#> 120 -3.0361252 -5.55156886 -37.472958 0.4620292
#> macrophage__acinar delta__acinar Tc__acinar Th__acinar
#> 1 -4.9163037 -23.259095 -7.48063126 -8.447490038
#> 2 -2.8025283 -28.716750 -1.93943630 -4.566117769
#> 3 7.2587548 -21.825120 10.74303733 NA
#> 4 -6.7082516 -7.561262 16.49545301 -4.935751480
#> 5 -6.5698072 -25.747748 -9.07345511 -17.074868628
#> 6 1.5574932 -42.424366 -25.87571664 16.163161907
#> 7 -5.5929580 -23.391511 -5.75285562 -7.583297310
#> 8 -6.3465955 -31.420624 -8.26031387 -10.652913474
#> 9 -4.5547467 -20.434612 7.10378860 NA
#> 10 -3.9781630 -17.205531 -11.68370172 1.467157461
#> 11 -2.3577819 -32.909388 -2.06431124 2.150477493
#> 12 0.7217382 -47.504493 0.12703517 NA
#> 13 6.2754247 -50.492650 -2.83618783 -15.104317268
#> 14 -0.3486896 -45.820527 -4.75700339 8.363045778
#> 15 6.7332133 -37.711506 -2.27375489 -0.410241552
#> 16 -0.4366333 -32.488523 -3.18873140 1.234808043
#> 17 7.6835923 -66.186619 3.58931341 4.846043471
#> 18 3.4622941 -44.276260 6.01496533 -5.589763403
#> 19 0.8646231 -47.500268 -3.12990091 1.059468668
#> 20 -6.7282725 -37.467195 -4.81641791 -7.569990883
#> 21 NA -70.714573 0.17131854 NA
#> 22 NA -47.019046 -7.03313479 17.145950462
#> 23 NA -51.318561 0.97609616 NA
#> 24 -3.3057317 -65.862666 -8.83447123 -29.054004985
#> 25 NA -49.458648 -9.94278917 -27.263158194
#> 26 -19.8536509 -60.505311 4.72393670 -28.869055625
#> 27 -7.7520070 -46.304682 -2.58562437 -7.480516829
#> 28 NA -60.027634 -1.32893332 NA
#> 29 8.2584418 -70.392677 -6.93943780 -3.232347825
#> 30 NA -51.682111 -8.00543665 NA
#> 31 3.5715722 -59.416061 3.77904556 6.590009632
#> 32 4.3711357 -61.914765 -11.32809419 5.313453139
#> 33 -4.8035780 -17.509405 -4.02591586 -5.548543077
#> 34 -9.4949878 -58.596008 -4.45094956 0.860224780
#> 35 -3.4428066 -23.921257 -8.74193603 -22.684449824
#> 36 -2.2425788 -11.233167 -6.97480653 -9.830026530
#> 37 -3.2350248 -24.411470 -1.17747264 0.077593404
#> 38 -1.1343919 -45.786109 -1.23069826 -7.236037722
#> 39 -10.4229451 -37.302633 -6.41944091 NA
#> 40 -3.6303338 -52.097686 -2.71855125 -22.378450246
#> 41 2.4957924 -71.463359 -8.80026081 0.306994397
#> 42 -4.7983671 -26.434688 -13.16517730 -12.327261514
#> 43 -7.3883548 -14.834880 -12.27136160 -21.555735005
#> 44 -3.9469471 -25.120397 -4.51671281 -8.633108504
#> 45 7.8501813 -52.836126 -3.68670745 -8.728391979
#> 46 2.1675805 -38.855979 -4.23746595 -13.876941165
#> 47 -3.9132638 -9.480951 -10.47339854 -6.934279045
#> 48 -2.9619103 -56.797780 -7.11166226 -4.911682300
#> 49 -36.7978877 -66.868682 -23.40256483 -6.525780572
#> 50 1.9317429 -23.885048 -9.37490196 -4.232251487
#> 51 6.5057194 -29.545479 6.46664503 -16.157849095
#> 52 -15.2205897 -3.480687 -22.49079592 -22.959595241
#> 53 -22.1601094 -25.627711 3.06693926 0.915147464
#> 54 -35.5732444 -44.834661 -8.09322455 5.488800128
#> 55 -6.0554507 -16.121208 -3.29672906 NA
#> 56 -72.1131035 -45.732120 -0.89014661 -27.679229306
#> 57 9.9668736 -45.373970 -14.76366480 -12.661245154
#> 58 NA -31.375814 -40.04670369 -11.313563512
#> 59 -1.4147880 -21.083944 0.91667842 -12.980231759
#> 60 -13.2989274 -41.573275 -10.01790323 -32.771405917
#> 61 -37.8725479 -4.117552 -16.13052204 9.727740733
#> 62 -3.9026437 -38.590392 -1.50905005 -19.581561229
#> 63 -5.5847264 -64.235766 -21.88555662 -13.097099534
#> 64 -13.5343577 -35.573918 -29.56511587 -23.216728205
#> 65 11.2515606 -57.304239 16.77222856 8.581868112
#> 66 -87.4433456 -122.073865 -92.39511115 -98.080442405
#> 67 -8.9445858 -6.051494 7.24025502 2.920852232
#> 68 -2.5364204 -49.695019 NA -18.424271192
#> 69 11.8311618 -43.674915 -25.16293866 NA
#> 70 -1.9012855 -31.428254 2.63364717 NA
#> 71 3.0663606 -50.827204 10.13195783 NA
#> 72 -4.6344690 -22.491336 -11.17278675 -9.939640980
#> 73 0.3120723 -83.229317 -11.40505925 -24.754926526
#> 74 4.0906950 -87.528391 5.30781754 -21.802610604
#> 75 0.7464799 -52.482648 -0.13262813 NA
#> 76 -3.6959057 -31.658242 -6.49713550 -9.711202367
#> 77 18.2939360 -81.340768 18.89905251 29.367122608
#> 78 2.1929802 -44.380708 -5.30779752 -22.231112963
#> 79 3.5157841 -41.175061 -6.57444502 19.456885502
#> 80 -2.8977359 -39.249635 -9.93348394 11.749765538
#> 81 8.1479688 -72.936795 16.44367453 9.401841142
#> 82 -11.0663867 -34.588736 -2.25833534 -6.222826030
#> 83 -1.3490637 -25.861793 -10.02138803 -18.306182759
#> 84 -5.8562009 -20.993337 -7.16520528 -9.473454799
#> 85 -0.8401583 -76.131037 -3.55621230 -3.940345464
#> 86 6.1197188 -35.603825 -17.56144316 5.454994076
#> 87 -3.9147317 -26.790914 1.66260573 -5.889271855
#> 88 -3.6457905 -21.468831 -3.27437908 -12.791040794
#> 89 -4.7672784 -31.906301 -13.43244199 0.008618199
#> 90 -3.6083845 -38.001733 2.50064059 2.627362997
#> 91 NA -58.392359 NA NA
#> 92 22.2302240 -71.207995 -14.39727595 NA
#> 93 -30.8061833 -20.420409 -7.27921477 -17.630999579
#> 94 -11.2107009 -55.556076 10.41081752 -13.762268012
#> 95 5.7945533 -42.400150 -23.64465276 NA
#> 96 11.5137280 -42.517740 -13.53609641 4.307155497
#> 97 4.9540586 -76.306726 -5.60287463 7.679770704
#> 98 NA -53.144034 -20.45779044 -11.557269870
#> 99 -35.3566387 -51.121036 -7.74545845 NA
#> 100 19.6762550 -70.065379 -85.95442783 NA
#> 101 -9.5904464 -39.785640 -9.24533065 -19.191008642
#> 102 -22.7851277 -85.268433 -4.64895748 -35.674168306
#> 103 NA -30.149415 -11.08610545 -15.590965746
#> 104 NA -42.684769 -17.69564849 -10.400425946
#> 105 -34.2663611 -33.856316 -9.42606832 -18.738346887
#> 106 -3.8901263 -36.250004 -4.89980195 -10.314542488
#> 107 NA -2.997677 -7.21974258 -54.847464373
#> 108 NA -34.454333 -14.45307549 -21.082161241
#> 109 -16.1950463 1.628579 -12.39629107 -19.458009508
#> 110 -7.0150533 -41.861165 -15.25586236 -20.580831929
#> 111 -15.7244908 -27.225805 -6.96733048 -5.226084321
#> 112 -1.5040283 -26.323149 -0.06105192 -14.355574938
#> 113 -0.8554307 -27.247880 0.77387277 2.766286101
#> 114 -4.2454883 -22.126047 -4.11716599 -9.770378108
#> 115 -7.4749873 -11.094114 -4.28640633 -6.015588475
#> 116 -3.3766207 -35.864811 -1.95537753 1.204495568
#> 117 -2.7042338 -30.630851 -3.06868917 -8.735547583
#> 118 -1.8315946 -16.582480 1.98793189 -13.543224576
#> 119 -30.0251516 -35.903291 -5.66158067 -18.499305839
#> 120 -4.9541950 -39.086739 1.12416700 0.996351296
#> otherimmune__acinar gamma__acinar B__acinar naiveTc__acinar beta__acinar
#> 1 -1.8693952 NA NA NA NA
#> 2 5.9635783 -16.8111626 NA NA NA
#> 3 -53.9287054 NA NA NA NA
#> 4 -13.2326891 NA NA NA NA
#> 5 -4.8356504 NA NA NA NA
#> 6 1.3693613 NA 5.024367 NA NA
#> 7 -9.2972384 NA NA NA NA
#> 8 -39.5755547 -32.2007721 NA NA NA
#> 9 NA -5.6677733 NA 2.0756715 NA
#> 10 -3.4871238 NA NA NA NA
#> 11 -0.4931674 NA NA NA -31.836002
#> 12 -0.3415218 -27.2252971 NA NA -51.078122
#> 13 -2.1431044 NA NA NA -68.633478
#> 14 2.4388133 NA NA NA -66.176572
#> 15 -7.9515698 NA NA NA -39.762552
#> 16 -5.4535296 NA NA -13.6732570 -24.494390
#> 17 -1.9073572 NA NA 9.7325109 -74.700908
#> 18 5.8815731 NA NA NA -64.233387
#> 19 -2.0168427 NA NA NA -37.510796
#> 20 -7.1600730 NA NA NA -32.168908
#> 21 NA NA NA NA -54.323369
#> 22 -17.8966313 NA NA NA -45.536341
#> 23 3.3913466 NA NA NA -50.029796
#> 24 -38.9807920 NA NA NA -75.181708
#> 25 -39.0117624 NA NA NA -43.759146
#> 26 -26.5725486 NA NA NA -61.778644
#> 27 -4.7524752 NA NA NA -48.742776
#> 28 NA NA NA NA -49.594036
#> 29 10.9418467 -91.0273136 NA 14.2368816 -68.891411
#> 30 -31.1316035 NA NA NA -53.718515
#> 31 2.8971394 NA NA NA NA
#> 32 -4.1945303 NA NA -17.7704444 NA
#> 33 -4.9724963 -12.7201016 NA -6.9493251 NA
#> 34 -2.9153420 NA NA NA NA
#> 35 -9.9294407 -14.7000512 NA 14.2031705 NA
#> 36 -6.2113519 NA NA -6.8379369 NA
#> 37 -1.7467470 -12.0895334 NA NA NA
#> 38 -0.1545851 -61.4387360 NA -8.9336639 NA
#> 39 -5.4390630 NA NA NA NA
#> 40 -3.5508045 NA NA -0.3047958 NA
#> 41 -15.3670532 NA 6.068788 -33.7869085 -64.026437
#> 42 -6.1660225 NA -30.778221 -17.1806990 NA
#> 43 -10.7175358 NA -32.472337 -10.9240173 -50.530607
#> 44 -10.6641386 -20.9382695 -15.951180 9.3490035 NA
#> 45 -2.9552677 -31.5169872 -25.124854 -15.0654487 NA
#> 46 -11.7340352 NA -2.868525 -15.8003286 -39.423005
#> 47 -8.6628698 NA -13.744820 4.2625482 -32.074389
#> 48 -2.4735701 NA -5.586540 -1.4875536 -43.089236
#> 49 -5.4739270 NA -71.197243 -47.1968643 -62.996596
#> 50 -8.8949032 NA -32.984499 -4.7164327 NA
#> 51 0.9072018 NA NA NA NA
#> 52 -12.1400653 2.5321898 -68.941964 -22.5869644 NA
#> 53 -12.6936956 NA NA -45.0899678 NA
#> 54 -40.2947117 -29.6114184 21.639029 9.1633746 NA
#> 55 -10.3708643 -0.4197866 NA NA NA
#> 56 20.5385486 NA NA NA NA
#> 57 -25.8728984 NA NA NA NA
#> 58 -11.8813370 NA NA 22.2249449 NA
#> 59 0.5081638 -24.8664697 NA NA NA
#> 60 -3.9199654 -24.1582628 -5.369521 NA NA
#> 61 7.6054747 NA NA NA -9.811630
#> 62 -10.1229845 NA NA NA -51.480459
#> 63 -19.3228203 NA NA NA -52.588867
#> 64 -11.7610586 NA NA NA -40.957720
#> 65 9.8064958 NA NA NA -59.257182
#> 66 -107.6948750 NA NA NA NA
#> 67 9.9750257 -1.8531882 NA NA -6.988722
#> 68 -0.1446831 NA NA NA -36.897474
#> 69 2.6706290 NA NA NA -59.962170
#> 70 -3.3491387 NA NA NA -33.545834
#> 71 -2.0583632 -88.0712104 NA NA NA
#> 72 -5.6421346 -33.5849056 -15.778183 -0.5151703 NA
#> 73 -18.7293304 -77.9776457 NA NA -58.527139
#> 74 14.8877629 NA NA 14.8213832 -86.449144
#> 75 1.0720792 -10.4555078 NA -7.2847779 -63.788050
#> 76 0.7776317 NA NA -13.5923267 NA
#> 77 9.1943181 NA NA 29.6591692 -80.214581
#> 78 -2.2137243 -14.1140879 NA -6.5688290 -73.110178
#> 79 7.1666162 NA NA -7.0556906 -43.663893
#> 80 8.1129389 -39.6338196 NA NA NA
#> 81 16.4902371 -34.0846302 NA 21.2347009 NA
#> 82 -8.0830037 NA NA -1.7255005 -35.640816
#> 83 -3.7270602 NA NA NA -31.762455
#> 84 -4.2547777 -9.4476005 -35.616293 -17.4681669 NA
#> 85 1.9735158 -58.7651418 NA 7.5923190 -48.835851
#> 86 6.4880981 NA NA NA -34.288428
#> 87 -12.3924361 -32.8190052 NA -5.6977222 -33.001606
#> 88 -5.7669879 -9.3275842 -9.732156 19.2679189 NA
#> 89 -1.2857189 NA NA NA -37.386829
#> 90 -2.7691776 NA NA NA -36.602236
#> 91 -8.5146807 NA NA NA -35.364871
#> 92 -3.3616995 NA NA NA -50.106808
#> 93 -3.6531477 NA NA -13.4609831 -18.911170
#> 94 -6.9483010 NA NA NA -38.628000
#> 95 12.6382022 NA NA NA -44.143904
#> 96 1.9614983 NA NA NA -33.603708
#> 97 -19.0076077 NA NA NA -58.348476
#> 98 1.0623868 NA NA NA -59.630416
#> 99 13.6432160 NA NA NA -39.419748
#> 100 -48.1983677 NA NA NA -60.465148
#> 101 -6.5072876 NA NA NA -43.972373
#> 102 -10.6048397 NA NA -86.0596683 -86.992186
#> 103 -1.7532757 NA NA NA -27.535106
#> 104 -12.0868896 NA NA NA NA
#> 105 -5.8726650 NA NA -42.6604504 -62.858786
#> 106 -6.9855577 NA NA NA NA
#> 107 5.1663157 -0.7938452 NA 13.2571182 -36.951011
#> 108 -24.3666110 -11.8389355 NA -31.0457917 -39.140540
#> 109 -14.3837327 NA -17.316020 -28.4695516 -34.309833
#> 110 -21.3412251 NA -28.783201 -31.8593017 -48.529799
#> 111 -4.4036803 NA NA NA NA
#> 112 3.6047382 -19.3540481 NA NA NA
#> 113 -2.7095914 NA NA NA 9.658050
#> 114 -2.7028597 NA NA NA NA
#> 115 -6.0641984 NA NA NA NA
#> 116 4.2568808 2.5350142 NA -25.1481757 NA
#> 117 -2.0113173 NA -9.735817 NA NA
#> 118 -14.8230807 NA NA NA NA
#> 119 -13.8144700 NA NA NA NA
#> 120 NA NA NA NA NA
#> ductal__neutrophil acinar__neutrophil neutrophil__neutrophil
#> 1 -14.5781733 -9.530412762 -11.8395886
#> 2 -15.2444237 -2.138618771 37.0096910
#> 3 -31.4980561 -13.440284961 53.8502214
#> 4 0.6812866 0.809767190 17.5932569
#> 5 4.0629433 -5.414527082 -30.9686521
#> 6 -10.6805970 -2.905475798 22.1725061
#> 7 -12.9965849 -4.624701599 -6.0852034
#> 8 -8.3722761 -7.540308831 2.7930815
#> 9 -0.1739895 -7.497674142 84.8518775
#> 10 21.9075683 -5.786788113 147.5417370
#> 11 -3.9362085 -2.453110192 -0.1551897
#> 12 1.8810974 -3.966113812 8.3922704
#> 13 14.0777629 2.969535681 39.7213465
#> 14 8.7029564 1.041049550 18.8215141
#> 15 2.9697995 3.595813024 9.7108296
#> 16 -1.6792368 -2.308423582 2.1395365
#> 17 4.4731100 7.768536146 18.6205835
#> 18 -0.5353607 4.049595850 14.8937231
#> 19 -0.8985122 -0.005027529 14.6504658
#> 20 2.5297830 -3.087875249 16.8355214
#> 21 NA NA NA
#> 22 NA NA NA
#> 23 NA NA NA
#> 24 NA NA NA
#> 25 40.8124857 -25.455368605 341.2578795
#> 26 NA NA NA
#> 27 -14.7683100 9.805934651 -170.0000000
#> 28 NA NA NA
#> 29 -15.0173300 19.512954567 -170.0000000
#> 30 NA NA NA
#> 31 -6.9307676 -2.523527590 10.7689621
#> 32 -8.8284734 -1.570947919 5.8830969
#> 33 -4.8125947 0.431482573 9.2042106
#> 34 -1.3052477 3.132425046 29.5693595
#> 35 -2.7338944 -3.285420185 15.6378564
#> 36 -3.9135025 -3.300168409 17.5753739
#> 37 -2.3663307 0.726644483 17.0696003
#> 38 -1.4279689 0.985120748 25.6297454
#> 39 -1.4565602 -5.069838521 105.6691610
#> 40 -8.7257162 -4.779265868 77.0678426
#> 41 7.4231566 5.292261957 -170.0000000
#> 42 1.4369588 -5.064159215 -33.6838748
#> 43 -21.0025016 -10.132767248 -1.5687273
#> 44 2.0018326 0.725689323 11.9050837
#> 45 -7.7211371 -2.547433004 42.4652360
#> 46 -7.7936929 2.408159915 -78.5681048
#> 47 -0.2492917 9.622760711 80.3793739
#> 48 -9.4726891 -5.444151410 -170.0000000
#> 49 NA NA NA
#> 50 -16.5734859 -5.820918233 21.6638638
#> 51 -3.4435441 9.999509535 19.9164296
#> 52 -20.6524309 -14.134309448 15.3849975
#> 53 3.9739698 -9.981029505 -170.0000000
#> 54 13.6787811 2.265019084 263.0648094
#> 55 10.2343919 -17.082939223 176.8615558
#> 56 -19.9545866 41.253795392 -170.0000000
#> 57 -13.6497890 10.007409724 91.7580276
#> 58 -15.2217991 -39.402450597 -170.0000000
#> 59 -32.3828918 -10.393079127 39.8475383
#> 60 -16.9905341 3.365851672 252.2405402
#> 61 -3.6977911 -6.219972271 106.2774041
#> 62 -17.4257247 -7.071118901 48.9814367
#> 63 -17.7890854 -8.384995687 114.3474489
#> 64 -23.4740475 -13.064962986 156.1460199
#> 65 -32.2854291 -17.460825960 -170.0000000
#> 66 -43.9010194 -41.333149905 137.9474053
#> 67 -6.5970513 -2.560842765 72.8801382
#> 68 2.1908328 0.749501697 -170.0000000
#> 69 19.5640629 9.231761027 -170.0000000
#> 70 -16.4909153 -6.813764792 8.5066832
#> 71 23.0983475 9.197806146 135.3573535
#> 72 9.0076363 -9.435009098 72.2237531
#> 73 -18.6100970 10.687872488 141.7428890
#> 74 10.0121840 11.214851034 361.4282523
#> 75 -9.1290718 7.755050148 -79.6417996
#> 76 -2.5999530 -14.142089964 20.6437466
#> 77 -1.7804851 13.154341394 178.5897027
#> 78 -0.2166248 -7.647003066 83.1958488
#> 79 -1.7733743 -0.396497183 86.9195425
#> 80 1.0487571 3.917047442 24.0453902
#> 81 11.2035874 8.420783834 29.0109895
#> 82 -9.6208250 -11.349899258 34.7517849
#> 83 -4.2190113 -3.016290725 2.0138416
#> 84 -6.6008082 -5.617998203 11.8682168
#> 85 -2.1454298 3.463956162 9.0653801
#> 86 -7.5687678 -11.269281150 23.5107480
#> 87 -0.9997181 -6.475243902 7.7838172
#> 88 -16.7481464 -8.414100796 11.5456776
#> 89 -6.6461711 -4.449020500 -4.5587943
#> 90 -7.4846870 -5.369915975 10.9127269
#> 91 NA NA NA
#> 92 25.2874843 22.007020510 -170.0000000
#> 93 NA NA NA
#> 94 -53.6445725 1.186816293 116.0505198
#> 95 NA NA NA
#> 96 NA NA NA
#> 97 NA NA NA
#> 98 NA NA NA
#> 99 NA NA NA
#> 100 NA NA NA
#> 101 -39.8410868 0.936029707 -170.0000000
#> 102 16.0520467 9.822523227 118.0620788
#> 103 -12.8708546 -18.107096994 -170.0000000
#> 104 14.1392978 3.246918561 177.9103784
#> 105 -2.0959324 11.905374780 143.0212199
#> 106 -3.8385963 -3.909803589 -170.0000000
#> 107 -17.4381719 -22.029715890 -170.0000000
#> 108 -47.1524071 -37.801021889 -170.0000000
#> 109 12.2141102 -2.020583716 78.1160090
#> 110 -3.2457256 -6.713405995 -170.0000000
#> 111 -13.1908230 -15.795515583 53.7026942
#> 112 -8.9872648 -11.243182609 -65.0835067
#> 113 NA NA NA
#> 114 -15.4335388 -13.629121706 35.0016114
#> 115 -19.5744955 -23.145836555 163.0569227
#> 116 -26.1546473 -16.376124637 233.6635897
#> 117 -10.5240253 1.020250321 12.1385699
#> 118 12.0898358 -0.563836945 -7.5120334
#> 119 -57.4416434 -49.676069265 254.7817635
#> 120 -8.5197413 -14.959639441 168.0943334
#> unknown__neutrophil stromal__neutrophil alpha__neutrophil
#> 1 6.54110506 24.97203043 -104.849398
#> 2 40.22229731 19.76878652 -93.700579
#> 3 20.27122128 -90.28002954 -81.672096
#> 4 -18.44347571 -10.55618435 -12.289950
#> 5 2.63699643 49.23809320 -34.087430
#> 6 -5.76312016 -42.52120339 -61.548099
#> 7 -21.29954107 6.78523235 -55.716536
#> 8 40.88234107 -11.44591599 -76.277434
#> 9 -13.91946726 112.03367994 -84.514252
#> 10 26.46596060 6.88580204 -46.868174
#> 11 -0.07637219 2.65014187 -28.825658
#> 12 -3.60260610 -9.71696568 -40.953086
#> 13 -0.60352015 30.65514143 -73.221715
#> 14 16.25485901 -17.04983847 -33.670326
#> 15 8.10619297 19.38009554 -40.322502
#> 16 4.44837985 -5.90654297 -33.430424
#> 17 1.25776188 4.79039964 -67.472661
#> 18 3.43059574 -20.13767422 -45.626067
#> 19 6.46099053 1.11190515 -32.915364
#> 20 20.67138055 3.68868552 -8.390300
#> 21 NA NA NA
#> 22 NA NA NA
#> 23 NA NA NA
#> 24 NA NA NA
#> 25 134.23678201 41.69453687 -170.000000
#> 26 NA NA NA
#> 27 0.63931694 -111.06614935 -170.000000
#> 28 NA NA NA
#> 29 -1.67866165 -6.58991097 -170.000000
#> 30 NA NA NA
#> 31 -12.41439563 15.85926945 -43.023166
#> 32 12.83274848 -12.24343499 -34.267615
#> 33 -18.10271090 0.87862649 -17.176642
#> 34 -4.37117283 6.49425814 -59.526655
#> 35 2.49372266 17.50988504 -19.563269
#> 36 -0.75413136 7.58985262 -6.217760
#> 37 2.38386861 3.78298349 -45.579162
#> 38 5.59553641 -3.17478788 -55.098895
#> 39 15.73725459 -8.29140531 -64.440715
#> 40 -1.89232062 -1.20495288 -52.927073
#> 41 54.69552911 -10.59168365 -170.000000
#> 42 13.39355325 -2.86860334 30.734711
#> 43 22.55338601 2.77592732 -75.225884
#> 44 4.28515251 -16.01479508 -7.496115
#> 45 -6.33904181 -8.01436647 -93.399445
#> 46 -34.34859049 4.26262237 -126.696106
#> 47 -15.01495069 -3.86170137 -128.690546
#> 48 -27.35186170 -18.96866423 -81.370179
#> 49 NA NA NA
#> 50 -0.72227311 14.01598169 -75.804749
#> 51 -34.58863230 -27.11742716 -39.868063
#> 52 -10.99128088 24.79806513 -88.990086
#> 53 -5.88366375 -41.13668975 -30.288366
#> 54 -1.81020592 -78.40893158 -170.000000
#> 55 -2.57352083 20.32885377 -23.776934
#> 56 -87.30715999 -41.64701642 -82.240377
#> 57 -32.35507381 26.66072310 -100.277001
#> 58 -115.07132449 -170.00000000 -170.000000
#> 59 10.36351503 -8.62608046 -137.460711
#> 60 -3.51025548 -12.52285494 -120.600404
#> 61 0.98074963 -7.95959236 26.704296
#> 62 20.25910471 9.68243239 -52.006333
#> 63 64.67100306 47.52393419 -114.734413
#> 64 71.46249693 19.24646591 -106.900150
#> 65 125.84505788 19.32947180 -98.008636
#> 66 5.92851410 28.30117073 -59.115344
#> 67 7.20478964 18.81325324 -54.188179
#> 68 11.93323912 -86.06403665 -71.830920
#> 69 -40.28883030 28.46976388 -117.423384
#> 70 -3.19844048 33.61287651 -90.024854
#> 71 -12.26387781 4.19563502 -101.918677
#> 72 -10.63785076 2.84727947 -55.459576
#> 73 2.46623053 30.05714576 -75.434985
#> 74 -49.44651120 44.12242958 -58.654221
#> 75 -26.41111688 -6.41564047 -127.585608
#> 76 -3.78505119 -16.42406484 -30.657299
#> 77 -9.98456714 21.80456632 -109.176695
#> 78 -15.69894755 22.54656930 -118.952890
#> 79 -18.49138817 -4.42410224 -35.022920
#> 80 -34.05137619 30.95189679 -69.365447
#> 81 14.62336952 20.56888901 -103.158846
#> 82 5.18344321 14.51827900 -84.457717
#> 83 11.00810261 -1.07841717 -19.334936
#> 84 -0.79610925 4.58497656 -18.169101
#> 85 -14.59556080 -0.63408394 -91.043931
#> 86 -20.35405267 -46.09556744 -123.872931
#> 87 -8.08007268 -15.14384689 -60.891002
#> 88 0.40387834 -9.38645105 -46.600389
#> 89 -10.04786203 -6.84771729 -23.144521
#> 90 -6.05418860 -0.07415653 -68.420462
#> 91 NA NA NA
#> 92 -27.11640899 -22.81006120 -170.000000
#> 93 NA NA NA
#> 94 53.24322336 126.09013645 -115.041721
#> 95 NA NA NA
#> 96 NA NA NA
#> 97 NA NA NA
#> 98 NA NA NA
#> 99 NA NA NA
#> 100 NA NA NA
#> 101 7.86813130 -121.90407139 19.133263
#> 102 8.95942172 -12.00504753 -56.287457
#> 103 -88.20433271 -90.06681624 -170.000000
#> 104 -14.49640881 -8.01452004 -71.159660
#> 105 12.11908614 22.23298149 -71.365321
#> 106 -24.97861026 -120.27102320 44.589486
#> 107 24.41888320 96.86818692 77.891031
#> 108 -6.36717843 49.70196361 98.536869
#> 109 21.05493526 25.30697490 -102.698780
#> 110 -25.51408057 29.61856064 -70.949023
#> 111 -0.10016339 -36.67702490 -107.507333
#> 112 36.12918826 5.98245213 -83.645002
#> 113 NA NA NA
#> 114 -22.73649642 -31.43626802 -25.945341
#> 115 -24.16678977 -7.79692253 -102.498356
#> 116 21.94706150 0.69340436 -54.230182
#> 117 7.72252992 23.65286204 -33.202176
#> 118 2.22115046 -22.87774492 -48.565761
#> 119 79.17786344 26.15338291 -125.837051
#> 120 -26.66982252 -55.40125263 -73.394410
#> endothelial__neutrophil macrophage__neutrophil delta__neutrophil
#> 1 -21.46326212 -26.8850107 -100.908098
#> 2 -2.93781166 33.3906616 -98.365866
#> 3 -0.96347040 -0.2025680 -53.644558
#> 4 11.12314911 12.5827592 -19.795508
#> 5 30.77705527 20.3441904 -48.675180
#> 6 -26.75690334 7.1648113 -53.151564
#> 7 41.44851670 19.0334633 -61.268152
#> 8 38.16448103 70.1681267 -122.504843
#> 9 69.43381417 113.2067920 -110.216723
#> 10 -17.77412255 97.0048275 -35.021147
#> 11 -6.61713426 11.3682054 -51.927840
#> 12 2.82839602 -10.8090130 -45.031681
#> 13 -26.94490338 40.9391650 -54.669765
#> 14 -11.63947357 18.9839374 -37.598336
#> 15 -4.29519356 11.0296963 -37.500729
#> 16 -1.83019205 -6.2141969 -39.066222
#> 17 -0.49254840 20.6885744 -80.358821
#> 18 1.47344176 16.7619117 -42.991803
#> 19 -0.73278719 10.8150201 -61.302022
#> 20 -15.00406527 23.3852737 -36.256568
#> 21 NA NA NA
#> 22 NA NA NA
#> 23 NA NA NA
#> 24 NA NA NA
#> 25 70.24201823 NA -170.000000
#> 26 NA NA NA
#> 27 17.40750355 -170.0000000 -170.000000
#> 28 NA NA NA
#> 29 -170.00000000 -170.0000000 -170.000000
#> 30 NA NA NA
#> 31 -5.16784337 33.8429685 -49.120927
#> 32 -1.61254068 0.2315746 -55.558693
#> 33 -55.09563530 19.7358978 -14.035673
#> 34 19.09493148 14.4914096 -88.308119
#> 35 11.22795088 8.8278340 -7.288037
#> 36 -9.88554987 7.8453688 -15.543870
#> 37 5.77168062 23.5854589 -78.426358
#> 38 5.60933403 23.2255855 -44.509399
#> 39 -23.74930587 11.1641581 -75.254128
#> 40 -1.36662097 81.5416397 -61.806109
#> 41 -51.15342078 -170.0000000 -170.000000
#> 42 -0.05527194 -23.8099553 6.477632
#> 43 80.96606062 28.5803757 -31.077342
#> 44 -1.59087903 -12.7380476 -50.428268
#> 45 17.28717421 7.5835921 -103.447802
#> 46 30.47309986 -1.6195678 -108.275741
#> 47 -4.68588508 -57.1887794 -42.346573
#> 48 -29.83846656 -170.0000000 -105.817700
#> 49 NA NA NA
#> 50 14.23947462 -12.6544011 -94.165144
#> 51 -113.13726605 -5.4945156 45.620178
#> 52 -36.36448560 14.3161226 -115.819070
#> 53 -41.78920161 -55.0993552 -32.464680
#> 54 -5.25174610 152.7874508 -47.536554
#> 55 -103.09212031 10.9630513 -80.144791
#> 56 -118.70489497 -170.0000000 -74.287797
#> 57 -35.31496613 61.2066985 -122.011548
#> 58 -170.00000000 NA 48.695374
#> 59 -31.54053307 35.0548904 -144.832710
#> 60 10.72963613 26.3039839 -78.789690
#> 61 -32.73259219 -22.7516916 -5.735408
#> 62 -17.21748687 61.2434984 -71.629685
#> 63 67.64351654 119.1882367 -150.440108
#> 64 43.89764364 125.0582244 -126.265877
#> 65 -26.98216407 -170.0000000 -170.000000
#> 66 69.03957543 143.4165955 -51.472421
#> 67 28.32581339 48.1712047 -47.227190
#> 68 -33.10975795 -170.0000000 -170.000000
#> 69 -66.55669091 225.3117355 -115.699105
#> 70 15.83192499 60.0970349 -123.176885
#> 71 -15.51486520 11.2039085 -87.828117
#> 72 -14.59710805 40.2779796 -44.052747
#> 73 -39.66252350 67.9971371 -170.000000
#> 74 12.25231968 55.5217775 -42.063052
#> 75 -9.91849655 32.1401169 -108.092242
#> 76 2.39628051 10.3498293 6.628697
#> 77 9.68363844 74.8885993 -126.806483
#> 78 6.18914104 62.6649484 -115.938444
#> 79 32.56340684 12.8906101 -136.368252
#> 80 -9.86298279 13.6382644 -79.032502
#> 81 13.34410956 32.5644012 -120.062030
#> 82 -25.51324962 26.6295436 -95.357529
#> 83 -4.01045992 18.4160157 -42.825756
#> 84 -2.05417031 13.0273130 -33.598734
#> 85 -13.03204974 9.6362544 -100.680064
#> 86 -4.41307292 -9.4238169 -137.386152
#> 87 -3.86675258 0.5181665 -84.426635
#> 88 9.00603839 -7.7199845 -37.754434
#> 89 -19.01077653 -2.9692014 -46.224740
#> 90 -13.73628729 16.6419967 -72.045088
#> 91 NA NA NA
#> 92 -58.97633811 -170.0000000 -170.000000
#> 93 NA NA NA
#> 94 -96.40275815 170.3532111 -106.950376
#> 95 NA NA NA
#> 96 NA NA NA
#> 97 NA NA NA
#> 98 NA NA NA
#> 99 NA NA NA
#> 100 NA NA NA
#> 101 87.77706505 -170.0000000 -170.000000
#> 102 -32.47186364 -87.3829717 -102.504813
#> 103 59.20244958 NA -170.000000
#> 104 -32.98963029 NA -21.742379
#> 105 -25.74305400 -170.0000000 -9.228358
#> 106 48.46265493 14.0161681 20.907435
#> 107 5.11278437 NA -29.513183
#> 108 71.67702778 NA 90.056028
#> 109 -18.25022407 271.7973812 -170.000000
#> 110 1.90921337 15.8564927 -86.601405
#> 111 -82.85401800 102.5257973 -129.666429
#> 112 19.28890830 18.8526833 -61.502417
#> 113 NA NA NA
#> 114 -3.65651548 6.1150352 -110.768490
#> 115 75.53129834 46.9649356 -142.420717
#> 116 27.61279177 66.1656651 -67.574785
#> 117 14.39563061 25.3782211 -52.616925
#> 118 10.35565579 11.9901102 -86.743716
#> 119 154.09701276 157.8898281 -131.247482
#> 120 41.05285426 89.4562016 -71.654078
#> Tc__neutrophil Th__neutrophil otherimmune__neutrophil gamma__neutrophil
#> 1 -89.0333068 -170.0000000 37.8870837 NA
#> 2 -23.7317931 49.7914290 71.8688702 -95.47454
#> 3 -112.8090311 NA 102.7037841 NA
#> 4 5.6262286 6.7932739 2.1387877 NA
#> 5 -28.7584980 81.4287696 1.9666477 NA
#> 6 -4.3118240 -40.2066651 25.3307593 NA
#> 7 -14.9549745 -2.8255602 43.1335526 NA
#> 8 68.0220609 46.4709148 126.9189076 -58.57859
#> 9 17.6865097 NA NA -94.39900
#> 10 1.2815779 -4.2307061 -62.7707250 NA
#> 11 20.3679663 -16.3045905 -24.4041732 NA
#> 12 -76.4887387 NA -78.0636632 -72.90514
#> 13 -8.8418922 -41.0228858 -11.7033283 NA
#> 14 15.9560050 -59.4301822 -37.5319202 NA
#> 15 2.9532599 -25.8533642 1.3148193 NA
#> 16 5.3030080 -6.0130359 0.6517733 NA
#> 17 14.5851262 -7.8826135 17.2922064 NA
#> 18 34.6616016 -15.4276180 39.3987967 NA
#> 19 3.0864553 6.5043126 17.4776428 NA
#> 20 -20.6228161 -14.1630694 -14.0946667 NA
#> 21 NA NA NA NA
#> 22 NA NA NA NA
#> 23 NA NA NA NA
#> 24 NA NA NA NA
#> 25 108.2575969 -170.0000000 8.1537962 NA
#> 26 NA NA NA NA
#> 27 82.1255688 -170.0000000 -170.0000000 NA
#> 28 NA NA NA NA
#> 29 7.7280481 -170.0000000 209.7307321 -170.00000
#> 30 NA NA NA NA
#> 31 -7.3850594 32.0632547 7.1202596 NA
#> 32 11.3892587 9.4688393 21.9373515 NA
#> 33 15.2177282 -31.5458626 -8.1676276 -48.37564
#> 34 2.1423882 -37.8447498 -21.1612508 NA
#> 35 14.3807814 19.6293416 9.4227244 -89.93158
#> 36 14.8283785 23.7738455 10.0180619 NA
#> 37 44.4435696 53.7270441 35.7463184 14.87015
#> 38 23.6222367 12.8933012 -1.3887702 -39.79107
#> 39 -12.3713243 NA 9.8882900 NA
#> 40 -4.6549293 -49.3638690 -5.2084701 NA
#> 41 -170.0000000 -170.0000000 131.1705922 NA
#> 42 7.1246809 -5.2021051 25.1732453 NA
#> 43 36.3490867 71.4197887 34.3622970 NA
#> 44 12.8799031 -6.4414696 -3.0118827 -95.99719
#> 45 32.9384568 62.3163313 25.7943660 -64.20560
#> 46 -3.5811332 18.2788403 5.6906853 NA
#> 47 -16.6088964 -40.8770623 3.3713660 NA
#> 48 -27.1982008 -61.2881984 -21.5623843 NA
#> 49 NA NA NA NA
#> 50 -37.3113291 80.6902576 -46.7841241 NA
#> 51 10.1705448 -170.0000000 90.5286413 NA
#> 52 17.9458808 23.1465675 26.7941591 -44.87450
#> 53 -19.3739545 -170.0000000 -77.1832358 NA
#> 54 -95.9797164 -170.0000000 -170.0000000 -42.46772
#> 55 3.1060936 NA -5.3388841 -170.00000
#> 56 -30.6505231 -1.8700166 47.3626558 NA
#> 57 -126.6866441 -170.0000000 -78.9054514 NA
#> 58 -59.9675899 -170.0000000 -170.0000000 NA
#> 59 68.4795202 -119.6654209 24.0930605 -170.00000
#> 60 -30.0672395 -55.6321008 -65.2493086 -15.04127
#> 61 91.7847461 -6.9927662 55.8857993 NA
#> 62 45.1875103 85.4092448 105.7351522 NA
#> 63 99.9354874 76.8589918 75.9121108 NA
#> 64 183.3188511 154.2968972 82.4849529 NA
#> 65 -170.0000000 -170.0000000 -170.0000000 NA
#> 66 10.2802386 49.6941815 39.8130011 NA
#> 67 -21.3013920 -73.3749489 -60.9797127 -69.75346
#> 68 NA -170.0000000 -24.8059724 NA
#> 69 -170.0000000 NA 62.9406246 NA
#> 70 -46.0592509 NA 16.7862495 NA
#> 71 42.8259511 NA 22.1743846 -170.00000
#> 72 5.3918441 -32.7607285 -17.8025797 -74.08242
#> 73 -85.8159644 58.0253534 -17.9830977 -170.00000
#> 74 -8.0219464 -50.0035275 25.4371628 NA
#> 75 -3.2618559 NA 57.5904210 -27.13114
#> 76 35.3206030 43.8736727 -2.7740026 NA
#> 77 61.6320902 63.4012826 11.9642263 NA
#> 78 49.1185756 48.2023460 0.3491347 -76.32369
#> 79 28.9183873 -170.0000000 64.7506476 NA
#> 80 -22.1395312 -22.2068523 62.0118152 -105.15009
#> 81 43.5683069 42.2496051 27.2150122 -116.02595
#> 82 8.4917484 -11.2587677 30.8767695 NA
#> 83 -4.5321076 -4.5259256 37.4154504 NA
#> 84 3.9891099 8.6465463 -2.9962808 -36.84336
#> 85 -5.0342441 -17.8328077 18.2065060 -54.19522
#> 86 -22.0615253 -69.7259119 -119.0839017 NA
#> 87 -0.1888904 16.6506656 15.3903530 -52.93509
#> 88 -9.0281889 16.5922089 11.9220171 -14.75616
#> 89 10.2927410 51.4854848 -13.2314696 NA
#> 90 -7.0620968 23.5444537 16.8444002 NA
#> 91 NA NA NA NA
#> 92 -170.0000000 NA -170.0000000 NA
#> 93 NA NA NA NA
#> 94 141.6158132 -27.5394341 -20.2098674 NA
#> 95 NA NA NA NA
#> 96 NA NA NA NA
#> 97 NA NA NA NA
#> 98 NA NA NA NA
#> 99 NA NA NA NA
#> 100 NA NA NA NA
#> 101 -47.0318762 -55.9101800 72.9032187 NA
#> 102 1.7796187 14.5622590 56.7042184 NA
#> 103 -45.3205098 -170.0000000 -170.0000000 NA
#> 104 -7.7541612 -103.0446165 -22.8709534 NA
#> 105 0.4745240 -12.2862089 21.5452412 NA
#> 106 -115.6374527 -18.4657227 -31.6746271 NA
#> 107 75.0707865 46.2579579 71.7040535 -74.19572
#> 108 6.9169621 123.9001129 62.9272431 -46.62629
#> 109 -64.3383836 -41.9158850 -41.0270420 NA
#> 110 10.4571213 0.1650643 22.0171627 NA
#> 111 -68.0462701 47.3766516 0.7096437 NA
#> 112 19.5421219 69.5957019 11.2425856 -170.00000
#> 113 NA NA NA NA
#> 114 15.7455364 -47.1910452 -46.4281337 NA
#> 115 -23.9460052 -37.6365780 -98.2253314 NA
#> 116 14.7821024 5.5233146 -12.2800919 -125.43486
#> 117 11.6077346 -9.5796140 37.1194162 NA
#> 118 -17.2194100 -124.5405782 -42.6645898 NA
#> 119 21.2706155 94.0993660 68.0604121 NA
#> 120 -23.9961316 -130.9905460 NA NA
#> B__neutrophil naiveTc__neutrophil beta__neutrophil ductal__unknown
#> 1 NA NA NA -17.58230072
#> 2 NA NA NA -9.53207654
#> 3 NA NA NA -21.85811959
#> 4 NA NA NA -32.96637999
#> 5 NA NA NA 1.16489968
#> 6 56.10165 NA NA -12.23295461
#> 7 NA NA NA 9.30157809
#> 8 NA NA NA 2.63735979
#> 9 NA 147.121486 NA -1.58856239
#> 10 NA NA NA 6.26645623
#> 11 NA NA -35.901789 -9.60973413
#> 12 NA NA -51.446043 -0.94248468
#> 13 NA NA -94.497958 -3.56965435
#> 14 NA NA -71.148820 -0.79337927
#> 15 NA NA -34.803539 9.32891266
#> 16 NA 20.203147 -20.643634 -4.13977603
#> 17 NA 6.785968 -81.024246 -0.22694013
#> 18 NA NA -53.654819 -3.40692936
#> 19 NA NA -25.444649 1.96520055
#> 20 NA NA -29.634407 0.69931738
#> 21 NA NA NA -1.29044691
#> 22 NA NA NA 7.62085755
#> 23 NA NA NA -2.81691169
#> 24 NA NA NA 16.26417192
#> 25 NA NA -170.000000 12.15137021
#> 26 NA NA NA -12.48481872
#> 27 NA NA -170.000000 2.92418273
#> 28 NA NA NA 9.79506087
#> 29 NA -170.000000 -170.000000 14.77978216
#> 30 NA NA NA 3.83366605
#> 31 NA NA NA 5.89222597
#> 32 NA 31.542915 NA -9.32419965
#> 33 NA -75.301078 NA -1.67156607
#> 34 NA NA NA -10.15638467
#> 35 NA 45.463407 NA -11.05864945
#> 36 NA -15.250212 NA 0.12403281
#> 37 NA NA NA -7.57205461
#> 38 NA -49.767235 NA -3.44341183
#> 39 NA NA NA -1.90061471
#> 40 NA -57.760406 NA -2.69988707
#> 41 272.62840 -170.000000 -170.000000 -7.60547882
#> 42 38.13021 -66.180799 NA -7.20317641
#> 43 98.19445 52.898984 -42.595775 -16.05132774
#> 44 -50.49820 -122.136336 NA -8.59153669
#> 45 72.79251 23.995101 NA -12.00811296
#> 46 -170.00000 96.870125 -108.997687 -6.63291127
#> 47 -170.00000 -79.813982 -118.685740 -8.00498523
#> 48 -170.00000 -170.000000 -136.856403 -3.10454120
#> 49 NA NA NA -5.56332232
#> 50 -25.52272 -19.201018 NA -9.35512019
#> 51 NA NA NA -8.43892866
#> 52 -170.00000 22.694274 NA -11.60286959
#> 53 NA -170.000000 NA 5.66768995
#> 54 -170.00000 -170.000000 NA 8.00848870
#> 55 NA NA NA -6.95407729
#> 56 NA NA NA 4.13436387
#> 57 NA NA NA 3.05262008
#> 58 NA -170.000000 NA -7.28936764
#> 59 NA NA NA -2.67930946
#> 60 -170.00000 NA NA -1.07533375
#> 61 NA NA -63.466045 4.84323925
#> 62 NA NA -73.861095 -10.96887817
#> 63 NA NA -144.330876 -14.79547060
#> 64 NA NA -105.400233 -9.74400800
#> 65 NA NA -99.364045 2.06922930
#> 66 NA NA NA -37.33009787
#> 67 NA NA -52.254077 -10.92718170
#> 68 NA NA -44.261215 -0.30186133
#> 69 NA NA -101.563683 6.00038614
#> 70 NA NA -95.578638 -10.00476718
#> 71 NA NA NA -4.92066472
#> 72 16.19274 -50.454267 NA -8.92996851
#> 73 NA NA -170.000000 -7.03026138
#> 74 NA 312.016063 -52.118290 7.29414724
#> 75 NA 51.331485 -143.450839 -3.85047607
#> 76 NA -54.612994 NA -5.69375378
#> 77 NA -170.000000 -104.700777 7.65724113
#> 78 NA 10.160308 -131.240976 -5.14315117
#> 79 NA -170.000000 -145.850040 -0.88602234
#> 80 NA NA NA -3.93438519
#> 81 NA -10.761516 NA 3.34079412
#> 82 NA 24.675517 -85.857893 -7.27437946
#> 83 NA NA -28.524448 -16.26058004
#> 84 23.80407 28.148227 NA -8.76035901
#> 85 NA -2.237842 -71.815429 -3.55793854
#> 86 NA NA -126.302173 -0.36255876
#> 87 NA 39.390776 -55.906809 -5.18788698
#> 88 54.30799 -71.048391 NA -13.99196334
#> 89 NA NA -45.719837 -4.58752288
#> 90 NA NA -77.302571 -8.66873294
#> 91 NA NA NA 11.68432520
#> 92 NA NA -170.000000 10.06191617
#> 93 NA NA NA -6.61959270
#> 94 NA NA -121.647170 9.77452771
#> 95 NA NA NA -18.45082687
#> 96 NA NA NA -10.72357099
#> 97 NA NA NA 9.92848441
#> 98 NA NA NA -5.36583830
#> 99 NA NA NA -2.07542109
#> 100 NA NA NA 27.53899528
#> 101 NA NA -7.878777 -10.62438761
#> 102 NA -61.631162 -76.560975 -6.52447954
#> 103 NA NA -128.763674 -5.09690871
#> 104 NA NA NA -1.83842459
#> 105 NA 23.453602 -76.746801 -4.45776733
#> 106 NA NA NA -9.48464097
#> 107 NA -170.000000 61.135279 -7.48888452
#> 108 NA -49.427987 78.663727 -15.85120513
#> 109 -143.07951 -170.000000 -170.000000 -7.24015340
#> 110 93.72951 148.446314 -67.896554 -24.37456913
#> 111 NA NA NA -4.84021747
#> 112 NA NA NA 0.20342564
#> 113 NA NA NA -0.09263721
#> 114 NA NA NA -4.34826494
#> 115 NA NA NA -3.65987393
#> 116 NA -104.134465 NA -8.77708955
#> 117 24.76111 NA NA -6.78006920
#> 118 NA NA NA -9.69790508
#> 119 NA NA NA -24.61403819
#> 120 NA NA NA -11.43376370
#> acinar__unknown neutrophil__unknown unknown__unknown stromal__unknown
#> 1 -18.131795395 -6.74739167 62.49387860 7.6465626
#> 2 -6.657451733 37.68517401 1.28568309 11.0414710
#> 3 -14.699175928 24.90733666 5.93273411 -11.2908078
#> 4 -24.591480336 -21.88743757 18.79595234 33.4786369
#> 5 -6.819588216 3.90867573 5.85251644 40.1010301
#> 6 -3.830732761 -1.45085012 5.53824378 16.4208668
#> 7 -8.101724202 -24.13848859 -52.44437217 -25.6947850
#> 8 -16.365774486 30.50590751 71.08791086 6.0932852
#> 9 -8.240413382 -5.02841574 -12.42293820 21.1237651
#> 10 -3.709768370 25.87205238 13.99841307 29.5196608
#> 11 -5.366576076 0.23812576 4.57070909 16.8463301
#> 12 -0.893942689 2.49265003 -0.39872700 22.6618267
#> 13 2.027190769 -1.17387000 1.57460558 1.9126885
#> 14 -12.930198107 15.30957376 33.97636982 -15.8091519
#> 15 -8.740117885 5.97315290 32.93417696 2.3966408
#> 16 -2.610705692 6.06189899 -6.27772154 -10.4681082
#> 17 -1.044551180 -0.99742382 37.98434134 27.5077926
#> 18 -0.422480781 2.95847898 1.24806799 -0.7798563
#> 19 -1.352382859 6.86213509 19.48625192 12.9481412
#> 20 -3.286013903 20.58887026 12.89037720 14.4043608
#> 21 -9.499961205 NA 25.25260054 42.1786377
#> 22 -12.452407688 NA 21.00068873 7.0333751
#> 23 -10.649992087 NA -0.98332656 -22.2024856
#> 24 -21.265265277 NA 42.60402574 30.9157019
#> 25 -21.466177900 128.74806971 66.97338485 68.0901145
#> 26 -1.113804793 NA 44.18070098 45.6683032
#> 27 -7.362500105 -2.28372292 20.85548695 12.5001322
#> 28 -1.433634903 NA -4.64116926 16.0657114
#> 29 -2.620148314 -6.46063441 15.21460172 -8.9329054
#> 30 -3.587827265 NA 16.63356015 -3.2168186
#> 31 -0.640629902 -9.83244426 10.71894714 -7.5006566
#> 32 -4.921083971 15.46748134 10.14870647 5.1819681
#> 33 -5.016224301 -19.18494363 31.52413733 19.0284368
#> 34 -11.018879147 -6.61414555 4.81782217 12.0484735
#> 35 -6.310879209 -1.72554003 12.98041734 18.9034914
#> 36 -2.847268855 -0.50002480 22.87991761 14.9830490
#> 37 -3.689826866 1.86098494 7.89575735 5.0991121
#> 38 -3.376229067 6.86140231 52.72726278 9.2164568
#> 39 -1.026672058 10.86790524 -9.66374008 12.7900958
#> 40 -4.418165390 2.18150437 4.58272385 5.0727652
#> 41 -10.693618663 32.61711216 10.89767386 -1.0623783
#> 42 -5.172737062 13.43361566 2.41827886 3.4676129
#> 43 -10.126984465 22.01613506 20.96050328 -3.2242259
#> 44 -8.282064598 1.04377992 33.61280647 -6.5348518
#> 45 -7.287274145 -9.16881932 4.88439498 -8.5488031
#> 46 -7.078215842 -29.84147892 17.24239439 5.9092643
#> 47 -7.040324794 -8.97334719 16.06136659 0.7765978
#> 48 -4.784921453 1.22028395 -3.77915185 -1.3777723
#> 49 -0.974107560 NA -8.73779218 -4.2304276
#> 50 -8.813798954 -0.33333660 5.13622478 4.9008157
#> 51 -16.163183342 -32.85057076 70.11888677 40.7697930
#> 52 -11.248080910 0.12286336 17.88272554 16.2518441
#> 53 -28.641087516 11.86250169 61.60441237 2.7438480
#> 54 -22.522654115 -2.88737215 52.28051445 14.8401638
#> 55 -8.392586584 14.13781593 2.14193902 14.1470186
#> 56 -61.649189632 -83.95925676 45.84116615 37.2790652
#> 57 -14.207521452 -29.62621441 23.46748941 17.6147301
#> 58 -16.955921304 -94.37102319 22.89088604 -13.5979503
#> 59 -4.831005291 11.94376739 11.76149193 -35.6986285
#> 60 -27.028874066 -0.09500653 86.17878897 26.9579867
#> 61 -18.885937253 3.33658870 39.06337493 31.3067031
#> 62 -3.190950632 18.66237651 7.93456967 -10.3526747
#> 63 -13.779005641 56.54534047 49.17881761 20.2911272
#> 64 -13.806915471 68.71026376 49.95736066 3.4402065
#> 65 -6.465924995 167.84618795 -27.58080597 7.2781465
#> 66 -42.500216148 7.01477313 19.36449703 17.3715369
#> 67 -9.427238536 5.56536258 3.38427078 11.3530038
#> 68 -1.394778855 12.39737035 7.11855164 5.7843562
#> 69 1.353100516 -37.73856463 6.96065950 3.8832199
#> 70 -3.197359248 3.20642167 3.19827095 5.9235638
#> 71 2.215649141 -13.63148286 6.13401752 10.5055506
#> 72 -5.922470484 -12.55497707 11.66468854 6.9641740
#> 73 -15.686027859 9.06579788 20.67157656 -3.0373286
#> 74 3.276004068 -49.54788756 10.36844393 10.6605642
#> 75 -4.153616063 -26.45050035 10.44414889 2.6145824
#> 76 -1.160497637 0.26180050 3.02559785 5.2929716
#> 77 0.707890974 -1.90456873 28.56755124 12.1827854
#> 78 -5.682308873 -12.53775333 7.48476673 -5.2998693
#> 79 -4.775577130 -14.41923524 9.55732670 7.2609036
#> 80 -19.439402524 -35.26117434 29.11778523 -11.8166539
#> 81 1.524864032 13.94927871 22.82470996 16.2660867
#> 82 -6.451841497 6.32420641 0.27529671 3.9473528
#> 83 -12.586356223 9.89731206 19.44703945 6.3327447
#> 84 -5.771194399 -0.11595399 12.67042638 3.3549752
#> 85 -8.769681239 -12.29390326 9.04950667 -12.8296513
#> 86 -5.212088205 -8.35850130 7.65055754 13.5369792
#> 87 -4.935605019 -8.41903102 7.33949318 0.3799160
#> 88 -8.425000930 3.58224393 10.93142947 13.7750558
#> 89 0.002522212 -4.67496090 -12.42755238 2.4637744
#> 90 -7.434737382 -7.75538086 16.99449479 6.7139811
#> 91 -9.438185055 NA -4.43162088 1.5990634
#> 92 -24.464402703 -41.08906485 28.77590420 28.2236652
#> 93 0.527986758 NA 1.79408899 -14.3775252
#> 94 -12.070824466 67.62613886 83.79768163 113.3066949
#> 95 -7.873180452 NA -25.59305633 -12.9980973
#> 96 1.647133600 NA 10.51070721 23.9551559
#> 97 -5.955767237 NA 97.25870518 2.3114862
#> 98 -1.966927722 NA -4.89138313 63.0671760
#> 99 -4.641917302 NA -7.18858066 -8.0660683
#> 100 -16.003699019 NA 21.51358232 60.9322701
#> 101 -5.342808850 6.41790601 19.25621970 39.3506123
#> 102 -12.370962140 5.07484192 23.48008626 21.0164087
#> 103 -4.616330631 -109.85654801 5.37020200 -5.9646971
#> 104 -14.729236747 -14.02266740 5.20570165 13.4994099
#> 105 -4.223017992 7.99016111 2.15376918 6.0172466
#> 106 -4.046900160 -24.13733057 23.13182157 26.7557094
#> 107 -8.151015577 40.19805651 -0.09685349 23.5701431
#> 108 -10.073113431 4.22644179 5.86870210 26.1549224
#> 109 -2.571856082 20.95138393 6.35240564 7.4591850
#> 110 -13.547464436 -25.28671755 17.81766850 29.3020931
#> 111 -7.575893617 11.30190747 -12.51145140 -1.4841444
#> 112 -11.398889954 42.11158422 34.17591640 28.5719642
#> 113 -3.796231860 NA 33.95068422 17.2157183
#> 114 -1.694832094 -8.87562666 -8.48496251 3.8622830
#> 115 -1.916114518 -16.73264815 -10.98223580 6.7503183
#> 116 -8.562863660 26.56740497 43.12453910 4.7702942
#> 117 -3.183683259 2.92230968 19.89794984 9.4084273
#> 118 -15.851160639 0.65791784 11.74276514 -15.2048122
#> 119 -19.297155369 78.58003563 66.39693931 54.2640695
#> 120 -4.194894089 -17.38799112 4.24618786 -7.1003077
#> alpha__unknown endothelial__unknown macrophage__unknown delta__unknown
#> 1 9.0733554 -11.5070497 8.0790097 3.2312432
#> 2 -39.7411039 9.0241562 31.8949116 -42.0626368
#> 3 -44.8873249 24.8507905 -4.5085435 -49.4127593
#> 4 -22.5264661 32.9600199 1.0783672 -21.9665093
#> 5 -33.5730348 34.8019235 21.0539768 -16.1066399
#> 6 -17.6690042 -2.7085866 1.3619573 -32.5090742
#> 7 40.5464396 -61.1400183 0.8989676 59.6462580
#> 8 -27.6739801 47.9831210 12.7995551 -51.9123634
#> 9 31.2366836 15.1944577 12.0946634 32.5591364
#> 10 -15.6308642 -7.4292216 23.0301081 -15.9077520
#> 11 14.2473359 12.9723907 -1.3512592 7.3998919
#> 12 9.6136828 -8.2578698 7.7865292 4.7480411
#> 13 -22.9011200 -15.8323792 6.6777206 -12.3307768
#> 14 5.9390392 15.8361020 28.8731444 8.5644747
#> 15 7.3303510 -24.8734859 -31.0616728 -24.4923478
#> 16 -18.0061599 2.8151926 -13.8657959 -9.1817026
#> 17 -43.1547716 7.6332232 -8.6426172 -42.4149954
#> 18 -23.3645605 5.0369277 0.4674218 -31.1170802
#> 19 -30.8985155 -0.1828191 0.5834401 -50.0775949
#> 20 -4.9792036 -1.6000624 17.1909732 -8.6800519
#> 21 42.2514279 38.8911398 NA 30.2817174
#> 22 19.4710656 21.2167236 NA 30.5279035
#> 23 7.6507252 -9.3435270 NA -8.5294734
#> 24 52.4643015 33.9339562 29.2945580 48.6362993
#> 25 29.7054037 54.5234081 NA 26.3255858
#> 26 -34.1515642 73.9301946 134.5936226 -37.8969407
#> 27 37.3376672 29.2510153 43.7276355 46.1057794
#> 28 -24.9280682 30.4544001 NA -29.3301939
#> 29 -7.1002842 10.9762398 26.2316820 -2.6830010
#> 30 -0.1588341 33.5021979 NA 0.2028878
#> 31 -34.0633297 10.8229371 8.7505948 -27.0579580
#> 32 -36.5066477 -13.6846024 1.2927975 -49.9734010
#> 33 -2.7056796 58.9543695 -12.4462090 -3.0030133
#> 34 20.3912199 4.5115636 5.7724544 25.7883911
#> 35 -16.1793943 -6.1260397 -6.4181448 -21.1725868
#> 36 -1.7994575 -0.2918058 14.7051128 -8.3363065
#> 37 28.9125556 8.5944090 7.2869392 22.5658690
#> 38 -34.1511462 51.0217749 -13.2994088 -21.2407193
#> 39 -30.1396196 8.6141700 1.6714726 -41.7377685
#> 40 0.6937663 3.2218796 -4.5104834 -1.5314549
#> 41 15.3453756 -20.3731718 -45.8564428 8.5040801
#> 42 -15.6749006 9.9459741 6.1441666 -14.8247509
#> 43 -13.0141774 59.6497176 -13.2368131 -12.4827887
#> 44 -1.8084179 22.9076757 0.7807624 10.1743643
#> 45 -10.0697825 2.8484160 -16.1019016 -15.3684180
#> 46 -38.6992424 -9.8054866 12.2455466 -45.2322258
#> 47 16.4592709 10.6400794 -6.8057913 -31.3186129
#> 48 -19.1765367 22.0783806 -21.4088812 -32.3880046
#> 49 8.5173556 7.4394388 -22.5687610 35.1525812
#> 50 -38.0317487 7.9349062 -21.5205151 -40.2200220
#> 51 -21.8342361 7.8320562 -22.3100787 -26.6887261
#> 52 -7.2061855 15.0194071 22.5197507 -33.6129962
#> 53 -13.0866777 33.3743444 41.6209944 -8.1265368
#> 54 -83.6176033 45.9087352 84.5469173 -65.4363703
#> 55 13.4498306 2.9183095 12.0012369 16.2378688
#> 56 19.0288366 49.0533493 68.9470351 11.6797317
#> 57 12.7005971 47.2359660 -38.5353815 11.6614240
#> 58 23.0092716 16.6802385 NA 8.5066456
#> 59 16.4115199 -3.1063837 10.2150137 12.0314423
#> 60 -37.5538578 45.8840278 -1.8784844 -11.7609591
#> 61 -28.3919595 7.8433983 27.8333866 -16.3229011
#> 62 18.4272418 -1.7915308 -12.5009662 21.3659133
#> 63 -32.6118920 40.4240067 57.0312078 -34.6351972
#> 64 -43.1434116 24.1771946 51.8829171 -33.2580372
#> 65 -19.2016519 -17.7678530 -21.7553254 -47.0552163
#> 66 15.2903858 10.2852389 12.9370775 21.4692797
#> 67 -6.8851608 0.7691287 20.8426611 -8.2801088
#> 68 23.4620011 -0.5880146 24.1291002 14.8002881
#> 69 -27.1535305 40.2268492 -37.2253724 -32.8277100
#> 70 -11.7095042 6.9443442 4.8234860 -15.4592192
#> 71 -31.6319938 -0.2007478 3.3463186 -25.1484002
#> 72 -8.7356214 24.4277029 -4.3197047 8.8166985
#> 73 52.5504348 11.6844405 17.7553394 57.0634028
#> 74 -17.1931568 6.3764069 4.7583064 -28.4978152
#> 75 16.8353234 5.8991814 -3.7170780 28.2028964
#> 76 -22.8873265 1.8203920 5.7449195 -20.1267704
#> 77 -10.7621041 10.7771096 8.9471264 -13.3062104
#> 78 9.1432055 14.1402910 -14.2687509 3.7690656
#> 79 -11.7361432 9.6095792 6.6415140 16.8985967
#> 80 37.4523279 13.6898463 5.0351028 39.4931017
#> 81 -45.6899761 11.4068373 13.4192486 -38.9916446
#> 82 0.1219220 -4.1695009 -1.1047774 6.8243380
#> 83 -14.0663528 3.2844830 10.0389885 -30.7659011
#> 84 4.9303109 1.0925198 6.2407984 -9.8977821
#> 85 54.2971858 12.5004302 -6.8347822 16.9189063
#> 86 21.3111036 5.9086054 -48.8862653 33.3102245
#> 87 -26.8891843 13.3150878 -5.0069103 -20.8474146
#> 88 -53.2105613 24.0230105 3.1148672 -35.3181359
#> 89 -4.1022653 6.9451910 -5.6180587 -1.1231088
#> 90 11.4371149 8.5464280 3.4545159 -8.5747967
#> 91 -15.5055838 10.4090180 NA -21.9935799
#> 92 28.9775444 19.6182225 -127.0778249 26.4588425
#> 93 -5.3268395 6.1075891 7.9411529 -4.7134089
#> 94 -52.6948458 36.6408781 79.2118643 -62.6242778
#> 95 37.5374868 35.7004956 15.9806423 5.9959976
#> 96 -34.6706649 10.1319926 -53.5701305 -91.9121519
#> 97 -21.5735668 29.7131596 91.8355793 -20.2198535
#> 98 2.0831712 26.4369408 NA 18.8301789
#> 99 16.8957044 26.3977867 2.3223030 -6.5360272
#> 100 -54.6851533 24.3171057 -27.7581763 -18.4843751
#> 101 11.2209393 -2.0660820 -21.1121553 5.6749010
#> 102 5.6165420 14.8459918 20.2574981 27.5795988
#> 103 -35.6540036 1.0925512 NA -54.1020673
#> 104 37.2543400 16.1752587 NA 51.6697474
#> 105 4.2549232 -15.8169918 -51.5308992 23.6364460
#> 106 -1.9206650 16.9202179 29.9564795 5.9858392
#> 107 17.8934340 -20.9868222 NA -35.3030842
#> 108 33.8540182 14.9399375 NA 38.2805351
#> 109 31.2789357 7.1626360 -34.7891528 55.1125462
#> 110 49.8999409 13.9818630 -16.2928338 70.7687014
#> 111 7.5450802 -6.8781901 27.0787909 1.1155990
#> 112 -54.0782593 14.1133938 17.9463646 -28.5684098
#> 113 -86.4305728 48.9579090 2.0822698 -46.0193600
#> 114 10.2046198 9.1663793 7.6672491 15.0106382
#> 115 -24.3673667 -41.2978861 22.9518603 3.6182168
#> 116 -10.5968628 29.5869189 6.9590609 -18.3529618
#> 117 -9.2899162 8.5838091 -11.0388731 -3.7346345
#> 118 -30.9749548 -6.0525796 -22.4988885 -18.3766922
#> 119 -84.1385630 37.5534652 71.3631283 -92.1519357
#> 120 -24.0308049 19.6193055 19.0404607 -22.8851507
#> Tc__unknown Th__unknown otherimmune__unknown gamma__unknown B__unknown
#> 1 -4.8784417 6.4818378 -46.66879271 NA NA
#> 2 2.7208723 7.6782154 -9.20736655 -62.130154 NA
#> 3 -6.1466356 NA 71.08818583 NA NA
#> 4 -50.2300258 24.3085702 0.91528236 NA NA
#> 5 67.3779709 46.3978409 -33.05216892 NA NA
#> 6 -1.9116164 9.9608514 30.51820421 NA -43.778217
#> 7 -52.8679918 -29.9831609 -28.49621907 NA NA
#> 8 76.5657410 78.4489056 148.23322649 -15.365703 NA
#> 9 -19.9303761 NA NA 72.298722 NA
#> 10 79.4593120 -12.2004422 -3.77964346 NA NA
#> 11 28.3351683 15.7673816 24.16223664 NA NA
#> 12 92.2772512 NA 25.04144352 58.114428 NA
#> 13 15.5652742 1.6348280 45.58407606 NA NA
#> 14 28.1872002 -7.3252492 -52.18455886 NA NA
#> 15 37.9900017 11.3114914 41.06073815 NA NA
#> 16 -8.7092051 -10.9182404 -9.88374867 NA NA
#> 17 22.3748504 17.1940169 29.32952108 NA NA
#> 18 -2.1264267 -7.8031176 -1.34079902 NA NA
#> 19 -13.5460728 28.8906596 6.65798047 NA NA
#> 20 -0.1762644 7.3546613 -19.93652322 NA NA
#> 21 -58.4127667 NA NA NA NA
#> 22 1.5721542 -38.7925879 53.77467605 NA NA
#> 23 16.7513195 NA 65.26679360 NA NA
#> 24 18.6103694 55.7810894 81.36256569 NA NA
#> 25 38.4825552 18.4898921 121.68083039 NA NA
#> 26 40.7036831 135.5203268 162.35484596 NA NA
#> 27 8.0978004 -9.6101197 27.72471529 NA NA
#> 28 21.5913442 NA NA NA NA
#> 29 -0.6628780 17.3077416 -26.35869904 -50.217377 NA
#> 30 25.2512199 NA 87.74302824 NA NA
#> 31 13.1070629 -0.7010630 -3.77828840 NA NA
#> 32 25.4507776 6.5905594 21.10391040 NA NA
#> 33 10.0157143 -8.6613963 24.84660371 34.684117 NA
#> 34 -1.9309601 -12.4670122 -15.93431045 NA NA
#> 35 -13.9121748 -9.8880279 -12.18388754 25.586260 NA
#> 36 -6.3282059 -1.2114518 3.25729476 NA NA
#> 37 20.7437358 18.7661075 14.33516226 7.464281 NA
#> 38 6.9709390 4.5355319 4.88345215 -33.888884 NA
#> 39 4.8027447 NA 10.84184204 NA NA
#> 40 -4.2424154 -102.1489457 2.14212484 NA NA
#> 41 2.1063156 13.7176990 25.11494199 NA 18.734607
#> 42 9.3167727 11.1962188 9.04653359 NA 4.721961
#> 43 19.7310033 46.1440046 31.90449417 NA 68.843028
#> 44 7.4538942 23.4236569 19.73091027 -28.623148 44.244220
#> 45 -2.7843015 -5.7551601 -7.52461493 -8.600175 19.152129
#> 46 -4.3167846 41.1672025 40.44333977 NA -61.009152
#> 47 12.0636573 1.1639906 13.88307437 NA 48.802390
#> 48 5.4339261 -1.8317174 -7.79455976 NA 57.542617
#> 49 -5.5012143 4.1319889 2.61685583 NA -14.624770
#> 50 11.8339882 -12.1209964 14.37476727 NA 16.446930
#> 51 -37.8260291 110.0487573 -20.35558676 NA NA
#> 52 19.2526842 18.1209993 4.91124932 18.290183 54.637422
#> 53 -37.2736491 -85.2650710 12.12434214 NA NA
#> 54 26.9060601 -0.1000049 61.40450909 -48.492605 -49.537934
#> 55 36.6908676 NA 7.99354912 -57.816948 NA
#> 56 8.0529640 35.6467475 -35.78517994 NA NA
#> 57 45.7515872 55.2469757 74.16409269 NA NA
#> 58 52.3466789 51.4617817 22.62055506 NA NA
#> 59 -30.0506285 52.5164070 -10.81007578 14.752131 NA
#> 60 19.4938067 59.9621038 55.84412029 -24.393020 -13.396919
#> 61 66.0375749 -0.6856070 -8.07882034 NA NA
#> 62 12.1676989 48.4576947 35.33107409 NA NA
#> 63 76.5450380 40.5763442 82.92409479 NA NA
#> 64 80.3030631 98.5199967 59.39899853 NA NA
#> 65 -109.4168376 -16.4160973 0.33169872 NA NA
#> 66 19.7968731 12.7393232 -11.98723835 NA NA
#> 67 -0.0117317 -4.0211407 -7.72735296 -35.625913 NA
#> 68 NA -49.8787711 43.63918457 NA NA
#> 69 -5.8896521 NA 11.86730868 NA NA
#> 70 3.9304411 NA 4.30755750 NA NA
#> 71 -1.9163268 NA 1.70604568 -60.758849 NA
#> 72 31.9296763 52.2430346 26.15675259 6.173606 62.115633
#> 73 18.7874075 75.4063536 70.04069151 86.951453 NA
#> 74 22.9287685 -6.8877372 -0.06350675 NA NA
#> 75 18.6240874 NA 0.85462940 20.256078 NA
#> 76 8.3633004 25.0266731 23.60655166 NA NA
#> 77 4.6816649 -38.1924197 12.07503690 NA NA
#> 78 0.2459873 70.0194202 23.44683202 27.109564 NA
#> 79 8.7174654 -10.9524276 -5.29146647 NA NA
#> 80 12.5695800 -74.6946215 -3.32489449 55.812613 NA
#> 81 -7.6231182 -4.1649696 -10.04430540 -62.088006 NA
#> 82 2.1429534 4.4907409 4.28613323 NA NA
#> 83 5.9452884 -4.4225123 46.13918277 NA NA
#> 84 8.8306189 19.8908911 7.53683853 -49.404023 34.729185
#> 85 -4.4964010 26.0351153 8.57411295 -65.732868 NA
#> 86 27.1945081 -29.2314298 -16.02079396 NA NA
#> 87 31.9226153 -19.7738002 10.01910716 -28.125346 NA
#> 88 -15.2333731 32.4534438 -0.04108707 -13.818617 -4.311227
#> 89 0.4712470 -10.5695422 -8.34120076 NA NA
#> 90 -67.1981038 -57.3025952 15.93365383 NA NA
#> 91 NA NA -53.04245553 NA NA
#> 92 -59.5742465 NA -71.19939055 NA NA
#> 93 23.0079951 63.5009236 30.05231195 NA NA
#> 94 -36.9564501 91.1129009 6.89897585 NA NA
#> 95 29.6095705 NA -19.80488469 NA NA
#> 96 -74.3135802 -87.6881808 -12.90458672 NA NA
#> 97 109.9643493 -22.8070449 96.48796032 NA NA
#> 98 -2.5838573 2.1723201 38.26774464 NA NA
#> 99 47.1175361 NA 10.04847158 NA NA
#> 100 48.6503246 NA 80.39479782 NA NA
#> 101 29.0082615 13.0249074 23.00457644 NA NA
#> 102 7.6925773 25.4774956 22.87437360 NA NA
#> 103 -77.0433735 55.1316110 24.12530932 NA NA
#> 104 20.2847870 -38.1523795 1.42508485 NA NA
#> 105 8.6418225 31.1058415 -2.39445836 NA NA
#> 106 20.8759442 12.1168825 8.50841899 NA NA
#> 107 61.2167216 30.9058725 24.27238806 -74.630294 NA
#> 108 9.7737603 26.9491951 20.34535016 -6.757907 NA
#> 109 22.0151765 21.9737610 24.10148302 NA 31.194022
#> 110 35.3500213 24.4147257 33.84932091 NA 73.381721
#> 111 14.0608355 10.8333814 5.96189614 NA NA
#> 112 14.1258896 76.2664828 8.09837637 -19.201156 NA
#> 113 -7.2075393 -10.3391574 22.61600945 NA NA
#> 114 15.3255818 14.6854255 18.82213239 NA NA
#> 115 -2.3155238 -22.4789787 31.69564393 NA NA
#> 116 19.4473773 34.7660922 2.98284040 -55.678567 NA
#> 117 -8.0668878 -12.7639108 13.96931509 NA 58.011864
#> 118 -40.4364825 -2.4147040 3.81884191 NA NA
#> 119 0.1690102 4.2207063 32.17852684 NA NA
#> 120 10.3610466 -25.3196516 NA NA NA
#> naiveTc__unknown beta__unknown ductal__stromal acinar__stromal
#> 1 NA NA -6.1232139 -5.3546104
#> 2 NA NA -6.9277411 -5.9504630
#> 3 NA NA -12.8276896 1.3217331
#> 4 NA NA -28.8728439 -21.4288886
#> 5 NA NA -5.2833382 -0.6019443
#> 6 NA NA -24.5683669 -28.5024703
#> 7 NA NA -8.7086891 -8.3102727
#> 8 NA NA 3.0140293 4.6759420
#> 9 -1.9353698 NA -20.9470281 0.1727052
#> 10 NA NA -17.9630248 -9.7194348
#> 11 NA 7.9410821 -7.8090053 -5.6515648
#> 12 NA -1.9501451 -5.2936341 -2.4919939
#> 13 NA -23.9519583 12.1951859 9.1378838
#> 14 NA -13.6449527 -0.3473257 -7.6288559
#> 15 NA -22.5688435 -2.4438926 2.9950647
#> 16 20.7699773 -10.6972504 -3.4216880 0.6319844
#> 17 -134.8426580 -48.1594270 -3.3835590 0.3824519
#> 18 NA -37.3684294 -3.0040786 -5.4348055
#> 19 NA -39.2687357 -3.1377677 -2.2018798
#> 20 NA -8.1067619 4.8994123 -3.2126124
#> 21 NA 25.3335348 -1.3577105 -8.2395214
#> 22 NA 19.1045522 13.1432008 -8.3655660
#> 23 NA 5.4831952 -6.7676798 5.8262575
#> 24 NA 35.4849843 15.7191945 -8.5589808
#> 25 NA 8.6832913 16.3530533 -20.8012153
#> 26 NA -47.2424727 -20.4667794 -5.4274215
#> 27 NA 30.7831464 12.5171221 -4.3649043
#> 28 NA -20.9212978 -2.5083579 -1.0316335
#> 29 -48.7927824 -7.0114331 -8.4361144 -19.2128362
#> 30 NA -7.8874557 -8.1038434 -5.8820330
#> 31 NA NA -6.8644320 -4.6400637
#> 32 32.6104504 NA -17.0800421 -14.2738211
#> 33 27.4129416 NA -0.4389546 -2.2858440
#> 34 NA NA -11.8413455 -2.1407644
#> 35 3.1923860 NA -7.9011355 -1.1780041
#> 36 -0.2578588 NA -2.0678329 -5.4301670
#> 37 NA NA -11.9131717 -6.5823442
#> 38 9.9869098 NA -7.0311316 -0.4571152
#> 39 NA NA -2.0120830 -3.5535807
#> 40 -57.3964004 NA -1.3776949 0.6303621
#> 41 7.4406404 10.5907959 2.1711716 -1.9853220
#> 42 16.9365862 NA -6.2844541 -2.7151703
#> 43 28.8417700 -17.4279270 -3.5900454 -3.3996017
#> 44 -29.2590124 NA -4.2687145 -1.4252007
#> 45 -11.6279763 NA 2.4292065 2.2952894
#> 46 70.4986352 -46.8032387 -5.1517522 -3.0774888
#> 47 -1.5005151 20.5500560 -2.3697245 -2.9566248
#> 48 13.2911487 -14.6667488 -5.8093589 -4.7935363
#> 49 -24.0721089 13.2817883 -5.6339958 -11.2742582
#> 50 -21.5078916 NA -1.4266971 3.7267186
#> 51 NA NA -19.8828854 -7.5881057
#> 52 12.3428279 NA -17.0645322 -12.2609676
#> 53 11.2265882 NA -12.4411360 -6.3366130
#> 54 32.3689530 NA -21.4918981 -8.9772908
#> 55 NA NA -4.2760396 -0.1391303
#> 56 NA NA -7.7376041 -32.1320571
#> 57 NA NA 5.3342945 -1.5545060
#> 58 -74.6269194 NA -9.4710452 16.2802209
#> 59 NA NA -33.1380154 -10.6257611
#> 60 NA NA -5.0942627 -12.2374880
#> 61 NA -26.7793220 -9.7278695 -24.1163569
#> 62 NA 14.5947089 -2.0181111 -2.6854870
#> 63 NA -33.8508360 -2.3223944 -0.8915768
#> 64 NA -43.9229010 -2.5324272 -3.6308665
#> 65 NA -19.9530212 18.3380598 7.9847319
#> 66 NA NA -52.7956493 -56.1730669
#> 67 NA 1.4860631 -0.3182099 -0.9150283
#> 68 NA 17.2980199 -10.9555999 -7.2363597
#> 69 NA -27.9522645 -0.6116975 4.3815053
#> 70 NA -20.4103854 -8.9958741 -13.1869109
#> 71 NA NA 3.1182206 9.4289462
#> 72 -19.6185230 NA -7.1480834 -6.4439780
#> 73 NA 67.7508976 -2.2814454 0.8370755
#> 74 -40.2225418 -27.2652268 20.9287140 8.2795887
#> 75 -52.3759487 17.8644116 -0.5427617 -1.0659837
#> 76 -21.6801108 NA -9.6222058 -2.6886522
#> 77 12.9104720 -22.1681948 7.9011360 8.4357383
#> 78 -111.1201652 0.1143777 -1.7288712 4.1581998
#> 79 -12.2586446 19.4444142 2.6136849 0.2512686
#> 80 NA NA -4.7938882 -3.9507537
#> 81 -0.5792531 NA -0.1886590 1.3231538
#> 82 37.8594789 1.9258390 -5.4212721 -4.4734320
#> 83 NA 14.3580535 -7.0829955 -11.3527454
#> 84 12.7988329 NA -3.3368398 -1.6211790
#> 85 19.3456082 32.8866158 -6.3468817 -1.9857335
#> 86 NA 50.1962036 -6.0575185 -8.8127531
#> 87 -54.4505569 -19.9355476 -1.3939486 -3.4039965
#> 88 -47.2999121 NA -10.2091242 -3.3428812
#> 89 NA 0.2053701 -4.8781483 1.6955905
#> 90 NA 3.6885445 -8.3379550 -0.1565301
#> 91 NA 3.7150690 10.8677765 3.3153724
#> 92 NA 9.2409221 -13.0449865 -6.9150622
#> 93 103.0838247 -4.7312121 20.1345384 -0.9228909
#> 94 NA -52.3038873 -8.8398711 -16.5580011
#> 95 NA 48.0448592 24.0115863 -2.8808211
#> 96 NA -58.0640239 12.0800797 0.0674691
#> 97 NA -17.8373832 -9.5302993 3.5878986
#> 98 NA 8.0024134 8.8378592 -8.9738807
#> 99 NA -8.6777731 -1.7264972 0.6211322
#> 100 NA -7.0863468 26.4057042 -31.2047275
#> 101 NA 14.8615160 -10.8199541 -17.0351282
#> 102 44.1065178 2.8553626 -18.4031285 -15.9033434
#> 103 NA -45.8833161 4.3188687 -2.1480743
#> 104 NA NA -3.5554575 -12.3715964
#> 105 49.0466590 -0.1638746 -8.8309588 -10.7870735
#> 106 NA NA -20.4520500 -6.4210151
#> 107 -118.0481296 17.1572551 -8.4247777 -6.3966135
#> 108 43.0521192 39.6836153 -31.4287282 -10.2514239
#> 109 24.6714965 19.2894151 -12.2111294 -17.3459993
#> 110 -6.0766249 57.3331888 -11.8360938 -9.2869470
#> 111 NA NA -23.3160172 -15.3211143
#> 112 NA NA -5.9691295 -8.2767119
#> 113 NA -73.7709882 -10.3480713 -0.3687438
#> 114 NA NA -2.2548377 -11.1804464
#> 115 NA NA -0.8118740 -0.5155523
#> 116 11.3501446 NA -5.4604328 -4.5836786
#> 117 NA NA -9.8902678 -5.1115678
#> 118 NA NA -11.1328317 -3.0182979
#> 119 NA NA -19.0148414 -9.6436012
#> 120 NA NA 2.1332687 0.3909635
#> neutrophil__stromal unknown__stromal stromal__stromal alpha__stromal
#> 1 18.1138584 14.5594953 -31.96311506 -69.6950864
#> 2 18.7291295 12.9846125 12.45577494 -50.9740536
#> 3 -104.3806488 -20.1006550 49.07296647 -141.6083919
#> 4 -12.1736915 29.4709874 0.39374757 -13.8229963
#> 5 59.1760140 43.3704581 67.63042300 -110.2782686
#> 6 -51.5655392 11.7235004 -61.91336469 45.1123561
#> 7 15.1532499 -14.5807921 -170.00000000 -48.4445026
#> 8 -2.0403232 16.3208592 -77.52102513 -41.8315998
#> 9 122.6477914 17.0720117 32.55568709 -51.2860876
#> 10 1.3763165 25.4550658 34.56531989 -25.9881546
#> 11 4.7583770 11.7795527 10.55358311 -10.9390594
#> 12 -9.0869568 16.6373799 -26.22811412 5.1514633
#> 13 35.7129461 7.1579825 18.24370183 -74.3524028
#> 14 -20.6286500 -20.4164907 50.85087473 -23.8502973
#> 15 11.8729144 1.8964099 27.57871039 -66.5980449
#> 16 -2.1597601 -6.3959117 17.80873098 -8.8713199
#> 17 2.5934402 28.0838878 7.54421541 -35.5037259
#> 18 -19.3719857 1.7288198 21.92392271 14.0308306
#> 19 0.4091594 12.1020375 12.09954554 -23.0721522
#> 20 4.8833163 15.7152926 16.14193790 -14.0332020
#> 21 NA 38.2021381 -37.52958869 33.2834232
#> 22 NA 7.6549164 -41.01277040 6.2254688
#> 23 NA -17.2797704 -7.26422013 -44.7565887
#> 24 NA 32.7211938 9.45619493 29.6543865
#> 25 36.6390025 68.3164229 53.77708471 34.3249057
#> 26 NA 39.0985901 35.97458231 11.0444964
#> 27 -112.6055863 12.6149160 40.24858010 12.2622274
#> 28 NA 18.7216563 57.94384944 -12.4988323
#> 29 -6.5899110 -8.4576510 36.55170704 59.8786168
#> 30 NA -1.6500197 -83.44583589 20.5385669
#> 31 23.5661862 -11.6844224 15.88861929 -24.5265950
#> 32 -13.7356870 2.4660310 38.63769845 3.5844393
#> 33 4.7378032 15.5804980 1.76633505 -19.8096663
#> 34 5.2698645 6.6931099 1.96074693 -55.1548946
#> 35 13.8513523 17.6019894 32.02470189 -22.2580275
#> 36 9.0304446 16.8151621 35.77747940 -26.5041778
#> 37 2.0231921 2.2761702 1.49942283 -24.5146872
#> 38 -3.5422143 6.4614600 36.80682628 -67.1288415
#> 39 -8.5528573 8.0240510 -21.94135291 -60.3648620
#> 40 3.5217594 1.9769200 7.95242336 -68.6323310
#> 41 -3.3942060 2.0236282 0.89434972 -10.6770764
#> 42 1.2156911 5.6112616 7.52612286 7.5757864
#> 43 4.2373097 -2.5268449 2.43865984 -18.5961045
#> 44 -14.7064159 -6.4183460 -2.60434997 -24.3554052
#> 45 -7.8745947 -4.6465767 9.63429904 -36.0546660
#> 46 10.0204488 7.2542882 9.96994875 -46.6462053
#> 47 -1.5295992 2.2036704 2.05577738 -19.3467692
#> 48 -4.6871173 -2.2046081 2.28761966 -44.0835874
#> 49 NA -6.8338180 -4.54674734 12.8675618
#> 50 16.9234305 7.3424904 12.26311071 -49.2113941
#> 51 -18.9801698 45.6905558 40.93181423 30.8184983
#> 52 32.6571410 13.3207218 10.48782380 12.1677774
#> 53 -41.5177380 4.7122628 37.86801606 4.8268952
#> 54 -61.0865941 12.6984838 30.72223833 40.6082054
#> 55 48.3461278 20.1680882 -70.04869489 4.2564026
#> 56 -27.2462168 40.6316078 54.23881447 -19.7584767
#> 57 30.8582139 15.3858992 -17.64169377 -89.3866702
#> 58 -170.0000000 -12.3968432 -98.91327140 -107.0186526
#> 59 -22.9669075 -44.7772327 35.87342825 -78.6613047
#> 60 -15.3927479 22.8158380 47.62154132 -39.7868630
#> 61 -5.2213432 27.9280728 79.79630178 -69.4892673
#> 62 3.0493962 -10.1001557 26.13974351 -37.6583220
#> 63 53.4991297 26.5987719 30.92488278 -52.6381273
#> 64 16.7337917 3.3134076 18.87826164 -34.1654954
#> 65 24.6521114 16.2724091 -37.30538615 -47.0848760
#> 66 27.4098236 18.3610026 10.99655380 8.9171039
#> 67 21.8360112 13.6223452 36.83705600 0.1339145
#> 68 -78.7290054 5.3695696 -23.49755751 42.5087195
#> 69 44.1352551 -2.4453268 92.76549353 -65.1921518
#> 70 33.3295381 0.9198840 27.33564331 20.6076595
#> 71 2.7597744 13.8056387 18.75620676 -67.1822967
#> 72 1.6989110 6.8323562 7.70042796 -32.8244432
#> 73 35.7124529 -1.5386334 -0.04972765 -36.4279769
#> 74 43.6238735 8.1497658 36.76533136 -60.5469357
#> 75 -8.2948725 1.3097192 17.06415107 -29.0176848
#> 76 -11.3711196 3.6208076 10.11112002 -8.2937851
#> 77 35.6731136 10.9567961 26.12944260 -38.5635738
#> 78 27.5908197 -5.6057788 7.60488989 -57.4164263
#> 79 -4.4660625 8.1246053 13.47518359 -65.1991812
#> 80 28.3043758 -11.8391933 19.45574248 -12.4114459
#> 81 16.5830523 13.2668197 3.59141996 -64.4241109
#> 82 18.6939337 3.7188111 9.13043877 -72.2675051
#> 83 -3.2453042 6.8909046 4.84459874 5.7892592
#> 84 6.0917450 2.5908135 6.87881193 -46.8902298
#> 85 -2.7442025 -16.2600316 -1.51868817 -36.3066327
#> 86 -36.1376758 13.3562805 -21.32688488 37.7563664
#> 87 -15.0825908 1.4554444 6.66786774 -36.6255765
#> 88 -1.0017394 21.7135564 16.70412252 -45.8776921
#> 89 -0.3823412 6.1152725 -8.13386120 -3.3948847
#> 90 5.7715253 8.7707136 5.63974792 -14.5390726
#> 91 NA 0.2314203 31.95276487 -74.0925982
#> 92 -65.5374221 24.8682907 26.52093212 -118.7280363
#> 93 NA -12.3781278 176.96089078 -7.9931875
#> 94 140.3191967 113.5316323 102.15953281 -102.3016673
#> 95 NA -6.9450157 -15.46029902 -102.3079763
#> 96 NA 28.4106065 -170.00000000 -88.9076826
#> 97 NA 7.3324697 96.32901012 -156.1807000
#> 98 NA 72.2405097 103.39104353 3.5223061
#> 99 NA -4.1419200 22.88137415 -89.8942179
#> 100 NA 63.9393682 99.50285378 -66.7497801
#> 101 -120.3522353 30.6911415 68.29068949 24.6512193
#> 102 -14.1629065 23.2605624 37.80225862 32.4850839
#> 103 -65.8284854 3.0933607 -93.27088153 -79.6648081
#> 104 2.3683764 19.8121188 91.66942606 92.3067680
#> 105 21.5667044 8.5331543 26.75013402 0.8988675
#> 106 -115.0542072 26.0031789 65.46681653 44.6453837
#> 107 101.2126208 13.5202604 -0.72343044 5.4140856
#> 108 48.8671241 29.7199977 80.76011292 125.6537489
#> 109 17.9842756 1.7277211 7.91152110 37.1739857
#> 110 23.8867317 34.7416849 49.48765668 56.7063184
#> 111 -18.8201226 -14.1359062 73.64242599 -75.6156011
#> 112 4.5173923 26.0885839 30.50377477 -47.0690947
#> 113 NA 16.0544419 21.77867256 -33.8371869
#> 114 -25.5892078 -4.3330234 -1.20654378 -26.9181601
#> 115 -3.9870324 7.9531513 -1.81137262 -48.1585984
#> 116 1.1320413 4.8138227 26.55088183 -19.3615195
#> 117 20.1480852 9.6535706 31.74719391 -25.0567531
#> 118 -23.8261538 -13.8552398 8.29671146 -21.5687341
#> 119 32.7860180 55.2382873 40.62231697 -53.6472299
#> 120 -51.6021632 -0.4638971 22.95374700 28.4658004
#> endothelial__stromal macrophage__stromal delta__stromal Tc__stromal
#> 1 1.1003580 6.7878632 -98.96249430 -116.46473308
#> 2 -7.1349067 41.8237498 -39.20204870 58.55407886
#> 3 -90.0820124 19.4870875 -146.30025422 91.35180596
#> 4 -7.4070910 -46.6939439 -11.74373245 -22.18344524
#> 5 105.7901457 49.9845949 -144.34367211 281.34196137
#> 6 -9.9031653 -33.3557798 16.42595205 -75.45960146
#> 7 -2.0349453 67.4016103 -104.93397982 -60.61139958
#> 8 -60.3603194 9.9653020 -33.06165024 -47.27286965
#> 9 64.5796214 111.0182755 -80.95149624 -170.00000000
#> 10 5.9180954 2.3820161 -11.36458928 -33.31465505
#> 11 7.0103914 -7.0032393 -15.84305112 26.95421365
#> 12 17.0379846 -3.8798416 -9.25296765 48.64332601
#> 13 0.6231762 41.4215683 -53.36644223 54.61798083
#> 14 -12.3230618 -5.5325124 -24.39715216 -4.58321699
#> 15 -37.0455845 21.7590423 -32.41894153 15.80903771
#> 16 5.0025624 4.1296743 -36.63953256 -7.48401031
#> 17 18.4823638 1.5617725 -52.55401750 32.39781354
#> 18 7.9081886 -6.0120324 2.05558508 -25.52425963
#> 19 -1.6047026 6.9948640 -47.10903782 2.91035415
#> 20 0.6484300 -0.9786096 -32.36309929 -6.14387728
#> 21 35.9067188 NA 4.55243303 36.13436950
#> 22 -8.6159459 NA 2.70591186 -18.37329958
#> 23 70.4231234 NA -73.08740277 -60.32721997
#> 24 21.5112626 65.9151488 12.02765847 32.69578794
#> 25 61.0036606 NA -54.56394551 37.66442251
#> 26 45.0329002 -45.9946266 24.86896289 73.40316863
#> 27 3.6344849 -10.6683594 -16.08008096 9.88549257
#> 28 32.1313501 NA -9.58321364 -24.46891444
#> 29 29.3133404 -115.1510881 44.70008349 15.38367610
#> 30 38.5485125 NA 24.11290808 5.23653619
#> 31 5.6250879 8.9270528 -17.75296530 0.66844115
#> 32 -6.6200229 -22.6983921 3.43788968 12.58557504
#> 33 19.9838147 36.0714516 -38.50699166 0.50295921
#> 34 7.9847769 1.0188961 -57.02716102 13.73663239
#> 35 -26.2342470 4.7587536 -19.92339459 -23.55342508
#> 36 12.0049497 4.6145039 -28.63036299 15.88850353
#> 37 -7.9878157 0.2590868 -25.24601232 -6.33530670
#> 38 2.0687723 15.7883652 -80.94817370 26.30760214
#> 39 8.4054939 9.2533672 -58.03535692 16.53304294
#> 40 -8.7465771 -0.6631145 -104.65885524 4.03294286
#> 41 -8.7021890 -5.4561392 -19.12598643 8.34844612
#> 42 10.8460469 7.1435511 21.45515905 10.43858309
#> 43 -1.8052196 5.4772078 5.03661541 0.95636911
#> 44 2.0842943 3.8843008 -25.17167343 -1.92682679
#> 45 -3.9677522 4.7878589 -34.50214359 -6.22977555
#> 46 -7.9286974 10.8344380 -52.14532507 1.93982044
#> 47 5.4562382 -4.9349656 -14.81371752 -2.41237066
#> 48 -28.0978403 70.7496943 -62.69431830 -8.50807892
#> 49 -18.5167841 15.3444763 -6.84163825 8.18764062
#> 50 -18.8817678 7.3516395 -56.91448129 8.72841730
#> 51 38.0206717 -89.0193623 -17.60313314 21.14314856
#> 52 16.3436959 42.5817262 -37.24252998 31.57859374
#> 53 8.9629834 -28.3939605 2.36598356 -35.83705597
#> 54 12.1651260 -99.2241694 21.88079786 54.56398856
#> 55 -29.4853307 16.8060604 -14.33113267 32.29034574
#> 56 33.1250251 67.6982743 -16.49075729 46.89120620
#> 57 11.5454046 42.0416782 -102.89238229 44.48831862
#> 58 -34.3017393 NA -110.22799712 -89.16468660
#> 59 -19.5026673 34.9949964 -112.35875058 1.28353545
#> 60 22.4258990 -84.0122999 -46.00854720 18.04163276
#> 61 55.8357890 106.5148565 9.25041449 64.47329868
#> 62 0.7626332 97.8550707 -31.28351457 15.08039900
#> 63 18.0970892 63.8033953 -35.07893059 40.41689106
#> 64 25.5409755 44.8098250 -32.71423518 14.87101887
#> 65 4.4635151 -90.8647789 -48.05003512 14.60869186
#> 66 30.2984826 16.7864784 13.74703754 25.72663368
#> 67 40.6655025 33.1311038 0.86214375 52.61849344
#> 68 11.4991242 138.2552027 63.56940011 NA
#> 69 49.0544992 -64.2993670 -55.72477483 15.59626026
#> 70 -0.6795017 125.5402105 -40.78093628 -62.34088922
#> 71 3.2588252 8.1318391 -57.30747567 17.38903782
#> 72 12.8037304 -1.6665159 -10.50357992 24.31702258
#> 73 1.8520600 2.6996683 -32.93165100 -25.13826072
#> 74 -5.5877216 35.2733659 -74.26089236 37.87044553
#> 75 0.4315530 20.1546684 -40.82760530 10.34994331
#> 76 -5.6856269 -2.9048386 -35.51537913 -5.46540794
#> 77 -6.8268303 30.2638434 -48.88079068 27.59141102
#> 78 -6.2439428 29.1616445 -49.22220046 7.45919157
#> 79 10.3663406 -1.8406082 -16.60139883 36.14260230
#> 80 -1.2211666 5.6094198 -7.04655723 23.56703529
#> 81 2.4691420 19.7242290 -54.31806225 17.08838185
#> 82 -36.9726734 13.7228674 -66.85617230 3.44608473
#> 83 -13.9999473 2.2845847 -1.15385393 4.18519092
#> 84 1.6970009 10.1116047 -48.40811610 2.73675443
#> 85 -8.3242185 1.8416163 -50.64500484 0.07570993
#> 86 6.6592611 -30.8460839 20.45929861 31.27486489
#> 87 1.2596159 -5.0350973 -53.04264401 10.88312595
#> 88 22.8107022 -3.8172435 -27.80186289 10.47873723
#> 89 12.8725116 8.3838323 24.15107452 40.01067219
#> 90 4.6665702 15.3980015 -32.79834777 13.84490312
#> 91 42.5735195 NA -73.20864034 NA
#> 92 -20.4916613 -170.0000000 -124.95057166 100.29657005
#> 93 -28.2030138 -170.0000000 12.49138241 5.35288694
#> 94 56.2112739 95.8170669 -120.70078235 -170.00000000
#> 95 -83.9081269 61.4312935 1.45161692 -72.04454795
#> 96 64.2263749 -170.0000000 -103.12956200 -95.23657747
#> 97 -71.0609066 -170.0000000 -170.00000000 -10.18972192
#> 98 23.3646093 NA 11.47276970 -73.34166960
#> 99 18.7672802 122.5637040 -96.87376030 101.98682997
#> 100 5.1708769 94.1562502 -5.48835508 71.27080349
#> 101 -21.5516586 44.7442231 0.01906824 53.06018999
#> 102 20.0641567 42.1527567 71.72831301 19.27466634
#> 103 -38.4266983 NA -71.64945603 18.67660086
#> 104 18.4224157 NA 102.64316817 -24.65301660
#> 105 -7.2214660 -26.3234221 11.75545529 29.89489010
#> 106 10.3487527 7.9534169 41.45284633 21.62488436
#> 107 7.3560049 NA -80.86515602 97.56828215
#> 108 64.5790378 NA 127.08059208 60.80672632
#> 109 -14.4956694 72.8801095 42.82514390 40.35285881
#> 110 53.0184036 79.5725245 56.31060284 75.40828182
#> 111 123.9696597 -40.6285412 -71.33450803 -22.09283233
#> 112 2.0062621 32.8259384 -36.33797671 5.60901183
#> 113 -32.5745128 -18.3820750 -13.67098475 10.92669591
#> 114 -2.4655267 -9.1669323 -40.35346488 -17.94343480
#> 115 3.5107811 2.5517155 -61.33661209 23.40470763
#> 116 7.9776702 17.6154158 -12.66946562 28.02193781
#> 117 10.2560758 2.3603172 -18.41054288 31.72478708
#> 118 -10.8897862 15.7798396 -22.83289183 23.22878662
#> 119 19.0647183 46.6043666 -66.57208570 11.65182380
#> 120 7.0190592 -21.3548975 20.97917622 27.19954551
#> Th__stromal otherimmune__stromal gamma__stromal B__stromal
#> 1 -95.44108915 49.6140260 NA NA
#> 2 90.92648704 -170.0000000 -34.457052 NA
#> 3 NA -170.0000000 NA NA
#> 4 73.65220564 -84.2973691 NA NA
#> 5 -170.00000000 105.9140930 NA NA
#> 6 -66.25449262 -83.9619343 NA -170.000000
#> 7 89.10064945 97.8960106 NA NA
#> 8 28.16007343 -170.0000000 -86.774740 NA
#> 9 NA NA -170.000000 NA
#> 10 -102.51229699 -46.3986305 NA NA
#> 11 36.79968403 13.6845090 NA NA
#> 12 NA 88.9283202 -17.838840 NA
#> 13 -11.38839882 67.1940532 NA NA
#> 14 2.88134055 46.2280785 NA NA
#> 15 -4.89766736 8.7215779 NA NA
#> 16 8.79049602 15.9462867 NA NA
#> 17 15.04016608 21.2982822 NA NA
#> 18 30.24993125 4.4437755 NA NA
#> 19 24.49542474 21.9937602 NA NA
#> 20 19.74858934 -11.6935316 NA NA
#> 21 NA NA NA NA
#> 22 30.82370917 49.8134626 NA NA
#> 23 NA 17.1714091 NA NA
#> 24 51.66578945 73.9376122 NA NA
#> 25 -39.43651735 156.7854436 NA NA
#> 26 35.72444581 80.3388735 NA NA
#> 27 -98.22716713 7.2438480 NA NA
#> 28 NA NA NA NA
#> 29 60.12197852 -30.4492253 94.720702 NA
#> 30 NA 14.2455783 NA NA
#> 31 22.95059568 -27.7783843 NA NA
#> 32 -6.23257678 -9.2124632 NA NA
#> 33 -31.77950411 9.5708531 -85.182027 NA
#> 34 22.51628835 23.7406927 NA NA
#> 35 -13.53692969 -6.2497039 -88.477118 NA
#> 36 -8.00380364 12.5336933 NA NA
#> 37 40.42858889 40.8850658 -56.809877 NA
#> 38 26.59875692 20.8299603 -134.654532 NA
#> 39 NA -0.5594152 NA NA
#> 40 15.99105252 9.2284359 NA NA
#> 41 3.17677379 8.8148733 NA 6.168316
#> 42 13.90179247 -7.0906247 NA -38.356688
#> 43 -2.34631533 1.0746864 NA -17.648306
#> 44 7.64794175 6.1703376 -39.408938 14.452135
#> 45 -19.62721986 5.3088010 -26.721992 -20.515736
#> 46 17.10403509 23.3775593 NA 7.071315
#> 47 3.68779831 1.2687790 NA 31.223541
#> 48 -7.87005157 7.1391156 NA -28.941518
#> 49 -9.09323615 -4.5239638 NA 10.534234
#> 50 1.10809053 3.0259504 NA -36.597240
#> 51 -120.08347525 31.8654884 NA NA
#> 52 22.23933783 23.9706565 -17.231044 38.572639
#> 53 -66.05815365 -19.6224406 NA NA
#> 54 144.91633218 -76.3723767 24.744068 14.637220
#> 55 NA 69.0816332 -13.211233 NA
#> 56 93.73755373 -2.3334021 NA NA
#> 57 -0.06660127 39.7241376 NA NA
#> 58 30.35229581 -23.3979775 NA NA
#> 59 -74.49685095 114.8508079 -74.496851 NA
#> 60 121.30712019 21.9283591 18.850788 -60.118877
#> 61 -18.67835347 44.7039956 NA NA
#> 62 10.60160897 -30.8984006 NA NA
#> 63 19.49119187 51.7738284 NA NA
#> 64 -25.34161839 11.0635502 NA NA
#> 65 -170.00000000 -9.8551278 NA NA
#> 66 45.24522868 27.9011791 NA NA
#> 67 -64.67980009 89.1023547 -115.685983 NA
#> 68 24.43109857 17.5856258 NA NA
#> 69 NA 34.3317198 NA NA
#> 70 NA 2.6713009 NA NA
#> 71 NA 11.0225231 -40.693129 NA
#> 72 44.37548707 23.1524021 -12.050451 38.702915
#> 73 21.57961664 46.4810884 -42.494073 NA
#> 74 14.64822115 73.3492015 NA NA
#> 75 NA 0.8864200 31.829077 NA
#> 76 -4.09185939 7.5173084 NA NA
#> 77 -0.88823042 5.2291442 NA NA
#> 78 -11.40268488 -12.1923101 -19.298277 NA
#> 79 0.84741737 12.9105609 NA NA
#> 80 16.41548209 16.4758504 -59.921267 NA
#> 81 21.19243287 5.0937408 -134.977008 NA
#> 82 -17.20156561 3.9722745 NA NA
#> 83 2.87790782 -0.5222778 NA NA
#> 84 9.44176121 -3.8840632 -37.420040 12.420794
#> 85 -12.66562037 -3.3294324 7.403322 NA
#> 86 13.72793836 -27.6587166 NA NA
#> 87 -1.57404653 -15.0628025 -21.297667 NA
#> 88 48.94965437 -1.5686054 -35.916732 -47.466562
#> 89 35.47473167 -15.1811284 NA NA
#> 90 21.33320665 44.6785739 NA NA
#> 91 NA -39.2374900 NA NA
#> 92 NA 10.1977134 NA NA
#> 93 -11.53406387 72.0693895 NA NA
#> 94 159.77460165 -7.8113735 NA NA
#> 95 NA -68.6239974 NA NA
#> 96 -64.26855389 16.1220249 NA NA
#> 97 -170.00000000 -92.6882893 NA NA
#> 98 -21.12339108 -170.0000000 NA NA
#> 99 NA -1.4667286 NA NA
#> 100 NA -58.2531529 NA NA
#> 101 92.41667865 6.6114263 NA NA
#> 102 67.42523615 29.8315760 NA NA
#> 103 -13.44270428 -83.1629032 NA NA
#> 104 103.43209940 50.1126264 NA NA
#> 105 85.31846474 43.2107695 NA NA
#> 106 102.37376897 26.1921971 NA NA
#> 107 -52.71620362 50.6465716 -118.790459 NA
#> 108 106.79834839 114.1236319 95.055418 NA
#> 109 29.14753871 37.5017312 NA 25.338933
#> 110 68.95816218 79.5798209 NA 167.527237
#> 111 -37.50703312 -29.1225501 NA NA
#> 112 31.89643608 27.6482681 -51.738469 NA
#> 113 -12.85178399 -52.2753674 NA NA
#> 114 54.56905653 -14.4804641 NA NA
#> 115 22.72182311 34.7396414 NA NA
#> 116 -1.61085640 23.4949465 -48.367414 NA
#> 117 89.76405753 41.8653821 NA 18.269615
#> 118 26.48858377 9.9605734 NA NA
#> 119 7.78236992 4.1010175 NA NA
#> 120 -3.77788466 NA NA NA
#> naiveTc__stromal beta__stromal ductal__alpha acinar__alpha
#> 1 NA NA -13.6841706 -26.252035
#> 2 NA NA 4.2418360 -24.660521
#> 3 NA NA 14.0323296 -12.541961
#> 4 NA NA 26.6114389 -6.714998
#> 5 NA NA -18.1012796 -25.255006
#> 6 NA NA -10.6668343 -44.019717
#> 7 NA NA 2.8573459 -15.537228
#> 8 NA NA -11.3707300 -24.638311
#> 9 26.4167683 NA -7.7088611 -18.243189
#> 10 NA NA -1.9023133 -11.452480
#> 11 NA -18.6787837 -13.5752431 -25.630199
#> 12 NA -25.9475601 -30.1102551 -30.657609
#> 13 NA -84.7640336 -43.4337819 -45.915324
#> 14 NA -35.9186984 -31.7855509 -42.997349
#> 15 NA -55.1250473 -18.9577748 -31.246115
#> 16 45.0459032 -25.3992218 -3.5172881 -12.551194
#> 17 -119.2375490 -49.7229259 -57.5486380 -56.680537
#> 18 NA 3.9222717 -39.2365235 -46.477609
#> 19 NA -30.6801793 -15.5483423 -28.255446
#> 20 NA -21.5863720 -23.7621357 -21.654809
#> 21 NA 4.3014920 -27.1382923 -42.155302
#> 22 NA 0.9153587 -19.6509764 -49.009850
#> 23 NA -50.4719044 0.1939512 -43.458126
#> 24 NA 11.7122186 -20.0548902 -72.028067
#> 25 NA -1.5909843 -23.1499490 -38.773736
#> 26 NA 6.2491019 -30.4368150 -50.280608
#> 27 NA -8.2511135 -15.2234664 -44.897468
#> 28 NA -2.1715692 -37.7449465 -51.506994
#> 29 -23.0011930 53.5013223 -49.9907399 -64.463238
#> 30 NA 12.2299009 -42.1688917 -37.124511
#> 31 NA NA -57.6082161 -59.571991
#> 32 9.7832034 NA -54.9239659 -46.554251
#> 33 -75.3010776 NA 10.2928462 -14.641753
#> 34 NA NA -30.7317907 -38.759750
#> 35 1.8015747 NA -14.1776454 -17.929899
#> 36 -32.6530922 NA -15.0809624 -12.638628
#> 37 NA NA -10.2571174 -17.219161
#> 38 -8.6991145 NA -33.3690213 -43.694903
#> 39 NA NA -26.5743671 -38.477824
#> 40 37.3689319 NA -27.5967564 -40.204579
#> 41 7.3591144 -12.0097225 -45.8161660 -52.399674
#> 42 36.9810256 NA -17.0579676 -16.557731
#> 43 -3.9786878 -5.5637557 -20.3051579 -43.135138
#> 44 10.4419941 NA -8.4652107 -17.295221
#> 45 -18.7512821 NA -25.2887205 -44.229873
#> 46 64.1661213 -54.5562060 -33.3923966 -35.909034
#> 47 8.8019467 -11.0931857 -22.0238834 -19.559347
#> 48 -29.6506648 -53.6974518 -22.0220691 -22.184138
#> 49 24.1903350 7.2900027 -19.7766926 -44.442549
#> 50 -36.8471813 NA -15.5674456 -17.448386
#> 51 NA NA 0.9859284 -38.948123
#> 52 33.2078876 NA 6.3488697 -6.315585
#> 53 -23.0040312 NA -28.3355033 -18.781906
#> 54 59.0353989 NA -54.9366633 -63.057224
#> 55 NA NA 1.2761058 -9.005229
#> 56 NA NA -20.2359095 -55.136191
#> 57 NA NA -3.9831869 -44.720917
#> 58 -68.7807895 NA 4.0590517 -36.252088
#> 59 NA NA 1.7064459 -18.827290
#> 60 NA NA -26.6549626 -40.133077
#> 61 NA -61.0950916 -3.3638393 -10.130505
#> 62 NA -56.9810578 -43.9068114 -38.756623
#> 63 NA -46.6053156 -44.7448626 -55.252151
#> 64 NA -41.0470391 -14.5146329 -37.286088
#> 65 NA -22.7834482 -63.3188997 -67.113817
#> 66 NA NA -115.1958124 -129.620975
#> 67 NA 1.5842323 7.8875753 -2.254598
#> 68 NA 44.9232097 -28.4861402 -41.260279
#> 69 NA -56.2682361 -55.9033741 -57.085063
#> 70 NA 3.5656850 -1.1763321 -28.383742
#> 71 NA NA -54.2838140 -70.784644
#> 72 4.7716379 NA -21.0824817 -21.744619
#> 73 NA -37.4854531 -22.7115861 -46.941851
#> 74 0.8731244 -62.1335184 -73.1784907 -73.055969
#> 75 45.8519530 -50.9977841 -26.6566666 -36.366470
#> 76 22.7294105 NA -28.0504728 -27.921949
#> 77 -29.0062022 -54.2732430 -58.5290666 -67.034000
#> 78 -38.9367366 -58.1341856 -42.3233153 -46.208480
#> 79 -78.7158169 -32.4149461 -27.6169866 -43.851346
#> 80 NA NA -11.0916050 -28.103744
#> 81 -35.6110624 NA -52.0146342 -61.062558
#> 82 -45.3117666 -78.9518249 -26.9904700 -27.833156
#> 83 NA 23.3995968 -21.1084298 -22.941063
#> 84 -35.9858339 NA -24.2561192 -21.670937
#> 85 -16.1847860 -39.9517765 -45.8646156 -54.611298
#> 86 NA 47.7892502 -18.8129523 -35.261686
#> 87 -16.5239242 -35.7706237 -35.1548348 -31.005661
#> 88 13.5853352 NA 2.2846241 -19.541430
#> 89 NA 10.7201015 -12.5603817 -33.902725
#> 90 NA -27.9178667 -11.8375693 -20.294464
#> 91 NA -66.8179517 -34.3141379 -37.526040
#> 92 NA -80.4265407 -28.1546043 -52.107242
#> 93 -27.9233285 -111.9974417 24.9579152 -10.108487
#> 94 NA -55.7630429 -15.6321711 -46.284104
#> 95 NA -35.0694484 -38.3449845 -41.161493
#> 96 NA -56.3423021 11.1495699 -33.296506
#> 97 NA -129.8599493 -32.9262798 -57.040028
#> 98 NA -23.8663404 -19.9868262 -46.576538
#> 99 NA -51.4229639 -26.2127080 -23.324046
#> 100 NA 29.2477137 -25.5119068 -58.411212
#> 101 NA 2.7960289 -36.7617890 -38.046935
#> 102 90.7932833 24.0635427 -69.8210856 -80.471457
#> 103 NA -51.5350544 -39.5229098 -17.291677
#> 104 NA NA -18.7153784 -44.791753
#> 105 93.9002716 46.4481818 -15.5631846 -31.610180
#> 106 NA NA -45.6971692 -37.441712
#> 107 -1.4102937 7.1039491 -38.3442114 -23.737573
#> 108 113.5468331 125.1182572 -52.7571166 -26.205108
#> 109 49.2813821 24.6921449 -40.3655465 -16.204159
#> 110 152.4143922 44.0942630 -42.5153499 -36.816314
#> 111 NA NA -13.7898413 -13.240123
#> 112 NA NA -22.8474899 -30.043744
#> 113 NA -113.9482969 -20.8530668 -18.184100
#> 114 NA NA -19.1283792 -12.479435
#> 115 NA NA -38.2292822 -14.207801
#> 116 71.5302062 NA -38.1420640 -30.693987
#> 117 NA NA -33.3688094 -21.283536
#> 118 NA NA -40.9704915 -14.167944
#> 119 NA NA -16.2943263 -22.025657
#> 120 NA NA -24.3376565 -33.467875
#> neutrophil__alpha unknown__alpha stromal__alpha alpha__alpha
#> 1 -104.728090 10.516937 -69.098171 238.77700
#> 2 -90.595983 -38.157811 -48.452179 184.50449
#> 3 -78.873924 -39.275398 -133.274060 169.08204
#> 4 -10.686753 -21.529693 -13.077732 243.89738
#> 5 -38.089537 -33.077323 -111.510585 256.85459
#> 6 -58.228318 -14.781937 45.469040 159.42609
#> 7 -48.719071 46.398052 -33.605403 173.41243
#> 8 -74.802723 -27.082330 -42.265182 187.28964
#> 9 -79.877277 32.395872 -45.364831 141.79511
#> 10 -43.387088 -14.049005 -26.107862 151.16889
#> 11 -24.560317 16.127108 -6.420259 169.01536
#> 12 -37.860790 12.478696 5.715317 142.14179
#> 13 -72.399855 -20.400110 -70.858407 134.47388
#> 14 -33.467749 7.073502 -25.753797 114.41373
#> 15 -36.916394 10.194063 -62.712505 181.10919
#> 16 -29.284200 -13.750353 -2.695338 146.77392
#> 17 -67.058833 -42.669840 -34.662635 170.65135
#> 18 -44.192425 -21.846397 14.884427 188.36117
#> 19 -32.889677 -30.772445 -23.363442 202.09489
#> 20 -6.139572 -2.797573 -10.267848 142.55162
#> 21 NA 42.627021 35.030073 148.14854
#> 22 NA 20.235468 7.450436 182.87918
#> 23 NA 8.732839 -37.171267 180.67956
#> 24 NA 53.079053 30.478236 240.24200
#> 25 -170.000000 30.105826 34.793738 236.92559
#> 26 NA -30.150292 12.335781 148.99801
#> 27 -170.000000 37.545247 12.421249 250.78365
#> 28 NA -23.557544 -11.864880 229.57545
#> 29 -170.000000 -6.663770 60.150150 158.65159
#> 30 NA 2.209313 22.664070 131.24445
#> 31 -41.710450 -32.520408 -22.738681 162.81236
#> 32 -31.897504 -33.963759 5.533046 171.33560
#> 33 -16.310466 -1.092805 -18.597938 119.00962
#> 34 -55.789140 23.080726 -50.108289 179.75673
#> 35 -17.871595 -14.564772 -19.879298 182.79110
#> 36 -4.908594 -1.006199 -25.310997 192.52414
#> 37 -44.364264 30.132201 -24.061392 196.06454
#> 38 -53.907133 -33.425911 -65.956950 245.53786
#> 39 -55.561833 -26.696958 -56.144770 185.81777
#> 40 -51.519392 1.702746 -67.576313 187.29521
#> 41 -170.000000 17.750988 -7.440514 153.07382
#> 42 31.229517 -12.730344 10.647902 190.52907
#> 43 -73.312673 -11.516408 -16.277039 266.05358
#> 44 -4.743278 1.499780 -21.993352 201.47235
#> 45 -88.464566 -7.703091 -32.207414 171.66073
#> 46 -124.612634 -36.642164 -43.237703 263.77753
#> 47 -128.399182 18.561604 -17.014676 175.04380
#> 48 -61.579211 -14.445653 -37.739074 163.25461
#> 49 NA 11.480564 20.754757 154.28294
#> 50 -74.420917 -36.608721 -46.207281 234.36544
#> 51 -38.771795 -21.090322 31.290051 206.56563
#> 52 -84.471072 -5.455586 14.587060 258.44649
#> 53 -23.003046 -11.911419 5.971504 209.81215
#> 54 -170.000000 -83.550404 40.930164 582.74245
#> 55 -9.687874 16.978378 10.912576 140.53514
#> 56 -81.764939 20.896120 -18.774016 185.46827
#> 57 -93.240264 15.742194 -85.660900 191.29602
#> 58 -170.000000 26.830852 -99.796596 200.31725
#> 59 -133.322585 19.480596 -78.592181 191.41758
#> 60 -112.350140 -36.620803 -39.693642 554.06913
#> 61 27.020387 -28.164344 -63.280839 172.14889
#> 62 -49.518929 18.942973 -36.240987 169.98907
#> 63 -115.958892 -31.862129 -52.577508 220.14888
#> 64 -107.162600 -42.757489 -34.262721 230.26167
#> 65 -73.993478 -12.080080 -43.984365 132.24998
#> 66 -58.339014 16.287516 9.487387 242.43586
#> 67 -54.171592 -5.364077 7.071836 -170.00000
#> 68 -70.159110 24.331717 42.558996 277.94422
#> 69 -116.097570 -26.810352 -65.234333 168.28700
#> 70 -86.858937 -10.321787 26.027269 166.66416
#> 71 -102.114366 -31.558738 -67.146255 168.56736
#> 72 -53.693700 -8.394811 -33.303964 232.98371
#> 73 -70.515185 53.400721 -34.755294 175.02013
#> 74 -55.549276 -16.122589 -58.942875 94.25473
#> 75 -127.003578 17.614642 -27.503350 182.29532
#> 76 -29.549797 -22.336548 -7.085453 173.66905
#> 77 -107.697933 -10.256726 -37.714571 101.19097
#> 78 -112.579956 10.631768 -55.264854 131.91097
#> 79 -33.931867 -10.433947 -63.220276 185.32869
#> 80 -65.196971 38.050735 -10.880206 86.58650
#> 81 -100.448565 -44.697671 -62.747807 137.90174
#> 82 -74.337885 3.461250 -63.427978 168.37457
#> 83 -15.667557 -11.961448 9.769062 201.85095
#> 84 -16.143522 7.686954 -44.974625 199.50441
#> 85 -87.741890 55.842214 -33.853341 243.31398
#> 86 -116.048392 25.378852 38.945154 213.64549
#> 87 -59.545086 -26.070499 -34.822370 249.50565
#> 88 -41.379810 -48.693891 -41.064574 186.94657
#> 89 -18.290423 -3.366395 2.900900 128.65217
#> 90 -59.267163 19.571021 -7.934435 110.35608
#> 91 NA -14.690379 -71.846332 205.63922
#> 92 -170.000000 32.536042 -115.927263 175.04335
#> 93 NA -3.592256 2.177163 323.93520
#> 94 -112.501819 -51.867109 -101.448697 288.29419
#> 95 NA 38.295658 -102.307976 196.27248
#> 96 NA -34.427154 -88.907683 191.58442
#> 97 NA -21.225729 -155.630557 182.28916
#> 98 NA 6.425157 5.662622 175.44754
#> 99 NA 18.418416 -87.130557 173.60989
#> 100 NA -53.012385 -66.324879 273.18321
#> 101 27.225489 12.490175 24.572976 213.16606
#> 102 -56.868630 8.115120 34.449302 221.32163
#> 103 -170.000000 -31.213732 -67.047505 153.78535
#> 104 -61.388749 43.113208 92.976736 209.42940
#> 105 -71.459573 7.426339 8.672675 187.92473
#> 106 60.811751 1.992382 50.053157 194.27236
#> 107 77.269418 22.558323 9.192347 161.23937
#> 108 98.241968 36.666449 126.659203 171.68147
#> 109 -93.821057 32.624568 38.456375 247.93085
#> 110 -68.394536 51.608580 58.271483 173.22017
#> 111 -89.985031 12.966414 -69.666456 164.89864
#> 112 -80.827437 -51.169521 -45.750842 267.50757
#> 113 NA -80.387739 -29.709077 179.54534
#> 114 -21.319586 14.006330 -22.463109 137.28714
#> 115 -92.751005 -20.047938 -42.838632 197.89853
#> 116 -53.738353 -9.100907 -19.256359 202.63681
#> 117 -29.902835 -6.306822 -21.783544 205.61675
#> 118 -46.311829 -28.648252 -19.254201 196.25601
#> 119 -119.260613 -79.796019 -48.941180 149.15287
#> 120 -70.933093 -18.599345 30.462300 187.33337
#> endothelial__alpha macrophage__alpha delta__alpha Tc__alpha Th__alpha
#> 1 8.183444e+01 -14.7799149 225.64018 11.862110 -24.8961260
#> 2 4.382388e+01 -83.7122445 195.83809 -144.128965 -120.4857110
#> 3 1.288472e+01 -115.6999951 180.58691 -47.512571 NA
#> 4 -5.507515e+01 -48.9462991 258.02057 -70.027509 -120.6424078
#> 5 7.794573e+00 -15.7626857 265.90464 -170.000000 -170.0000000
#> 6 5.807076e+01 -65.2048484 148.51921 76.839574 -130.7878840
#> 7 -4.454141e+01 -29.9899741 185.53974 84.630364 -170.0000000
#> 8 -1.372252e+02 -81.3100408 208.69259 -149.367647 -75.8192317
#> 9 -2.115469e+01 -98.7184935 130.20797 -120.322711 NA
#> 10 -2.542261e+01 -34.3215963 167.76314 -83.478354 54.0599047
#> 11 2.562107e+01 -27.8636852 189.08124 -76.811844 -59.3260522
#> 12 -7.307151e+01 -36.1543400 169.46129 -49.622312 NA
#> 13 4.429878e+01 -94.2133062 73.61872 -66.140793 28.7980767
#> 14 6.337599e+01 -35.4501327 125.75320 -20.355946 38.3931259
#> 15 6.771391e+01 -102.6033535 95.08070 -60.876412 -98.8914714
#> 16 2.687676e+01 -17.8933679 189.59687 -72.415405 -27.7760950
#> 17 -3.296769e+01 -99.9004797 171.69328 -58.492232 -83.9376611
#> 18 1.238297e+01 -58.7106916 156.25533 -63.547209 -112.4485152
#> 19 3.203555e+01 -31.8168685 235.80590 -7.493262 -63.2993260
#> 20 4.751989e+01 20.9120824 173.45736 -30.941413 -25.2684100
#> 21 7.505839e+01 NA 176.94674 -73.826421 NA
#> 22 8.243585e+01 NA 161.64367 13.574114 -101.4258106
#> 23 1.505221e+01 NA 176.82190 -60.114691 NA
#> 24 7.183002e+01 -170.0000000 158.30271 21.839159 81.7266645
#> 25 4.783071e+01 NA 125.30363 -42.104243 219.1182539
#> 26 2.130162e+01 -142.6783519 148.74731 -88.782439 -142.3685544
#> 27 2.080605e+01 2.4261880 227.00572 -20.465872 69.0284933
#> 28 2.170406e+01 NA 215.32914 -48.471386 NA
#> 29 4.664711e+01 -61.1625647 158.92933 17.203588 -6.0817639
#> 30 -3.285901e+01 NA 138.07066 -33.856301 NA
#> 31 -8.594669e-01 -93.6734900 160.53655 -36.479151 -83.6003893
#> 32 8.083921e+01 -72.7096227 188.08336 -36.281889 -14.9496554
#> 33 -2.769913e+01 -2.8118282 117.48773 -18.567440 -20.4565745
#> 34 -1.515619e+01 18.6497953 209.60070 -27.684042 -121.8985450
#> 35 -7.776051e+00 41.4856969 203.56429 26.673875 0.4538660
#> 36 4.702961e+01 7.4158108 196.41361 26.737116 92.4671987
#> 37 1.479951e+01 -12.9243484 218.50452 -57.938088 -133.3479673
#> 38 1.361214e+01 -58.8949407 240.81347 -50.098654 -77.4044699
#> 39 3.038715e+01 -7.2619689 164.66777 -27.786478 NA
#> 40 -8.211212e+00 -38.0650518 218.12465 -71.048829 -140.5582306
#> 41 6.882638e+01 -51.0394816 184.50128 11.523314 43.0912391
#> 42 -3.727928e+01 47.1100586 207.60119 23.040961 11.9406506
#> 43 -3.108929e+01 -7.3503276 34.72154 -15.986180 -17.7591151
#> 44 -2.058923e+01 -31.6923955 171.99667 -13.147262 -36.1605167
#> 45 -8.800390e-01 -89.1726468 184.90935 -75.877762 -62.8995924
#> 46 4.459782e+01 -84.3076447 275.65078 23.818857 1.9708021
#> 47 -1.761300e+01 -26.9754889 153.31545 26.288444 9.7473029
#> 48 2.997764e+01 -170.0000000 197.98269 14.100342 -0.2382456
#> 49 -6.680262e+00 106.0742972 205.34501 53.421041 33.8708822
#> 50 -6.970120e+01 10.4014159 240.32021 -64.144629 -65.3471958
#> 51 7.016524e+01 -82.2364116 152.96003 -46.058910 -153.1031765
#> 52 -3.866565e+01 -24.6156623 197.52573 -75.332878 -90.5608690
#> 53 -1.064381e+01 9.6895051 203.25442 37.469058 31.2678803
#> 54 -2.268546e+01 -170.0000000 452.99444 -170.000000 -73.5488010
#> 55 6.219828e+01 -66.4578800 148.68505 -55.232787 NA
#> 56 1.654440e+01 -125.8952384 151.23399 -30.320257 -65.3191948
#> 57 6.872501e+00 -130.4060293 193.57292 -69.886868 -47.1915980
#> 58 3.426665e+01 NA 170.97858 -63.578194 -47.2166945
#> 59 1.008431e+01 -47.7472587 177.96157 -129.915418 129.8073319
#> 60 -1.307186e+01 110.4734784 437.50324 -112.816050 -170.0000000
#> 61 -4.659536e+01 -130.9966152 71.53453 -47.811269 -65.0881210
#> 62 2.651827e+01 -137.9032720 154.99872 -50.451850 -170.0000000
#> 63 -6.049712e+00 -126.7455406 220.46824 -29.770773 -61.3873498
#> 64 -1.752284e+01 -60.4559041 193.59310 -40.649333 -145.7028730
#> 65 -3.132351e+01 -136.7565578 123.06464 -135.317471 -47.8391253
#> 66 -2.360316e+00 -24.4869006 243.10532 37.750685 -97.3725375
#> 67 -2.874480e+01 -25.0798299 175.44753 -101.518534 -170.0000000
#> 68 1.987782e+01 -28.2169343 307.16362 NA -56.6441103
#> 69 -1.868384e+01 -93.8230959 141.19527 90.071666 NA
#> 70 -2.575150e+01 -50.8197454 164.45258 -89.563571 NA
#> 71 5.711395e+00 -71.9328365 127.52174 -103.374378 NA
#> 72 3.105125e+00 -58.8177225 133.72982 -51.517378 -29.4192556
#> 73 5.080237e+01 -46.3877293 223.70387 41.207112 63.2091060
#> 74 3.332041e+01 -45.3429938 103.03101 -46.873324 25.0520889
#> 75 2.738125e+01 -111.5058744 175.66909 -24.534248 NA
#> 76 -1.005800e+01 -42.2801225 142.69279 -14.994452 -82.3099671
#> 77 1.838630e+01 -59.7312151 102.60725 -64.528624 -126.3029265
#> 78 3.823487e+01 -98.9011311 132.73885 -71.908711 -51.1980720
#> 79 -8.904473e+00 -59.7202249 72.88348 -52.984717 -170.0000000
#> 80 4.278492e+00 0.7841072 93.89277 26.916673 -144.8876039
#> 81 -2.734955e+01 -98.3134004 137.78601 -103.683552 -101.3254948
#> 82 4.162302e+01 -28.2293885 161.01995 -44.527275 -4.3398069
#> 83 5.947888e+01 -29.5321942 228.83428 81.380831 144.5428089
#> 84 3.205428e+00 -21.4213116 178.40663 -24.578960 -28.4192518
#> 85 6.644993e+01 -49.6987699 263.65706 -68.639885 -7.8478777
#> 86 -1.821920e+01 -149.0252045 226.05476 71.846985 -45.1504353
#> 87 -5.554752e+00 -44.1940285 262.52522 -170.000000 -1.3027080
#> 88 -9.660109e+00 -35.2324080 155.08910 -4.259985 -87.6951089
#> 89 6.486428e+01 20.6435166 158.61849 -40.364590 -170.0000000
#> 90 8.250769e+01 -51.9943289 173.98268 -69.436875 -89.4526209
#> 91 1.136933e+02 NA 202.65953 NA NA
#> 92 8.278764e+01 -127.5007138 208.59259 -51.545071 NA
#> 93 -5.871991e+01 -170.0000000 130.14247 19.703002 74.2106901
#> 94 2.972981e+01 -24.8093557 293.53637 -124.515966 -87.7184295
#> 95 1.200367e+02 13.3989297 169.42918 25.910904 NA
#> 96 9.215270e+01 -170.0000000 220.37810 40.684021 -170.0000000
#> 97 8.953514e+01 -145.6492724 205.00766 -20.659794 -92.9628064
#> 98 7.821437e+01 NA 163.63762 66.986412 13.4475618
#> 99 7.591325e+01 -170.0000000 125.72435 -137.170096 NA
#> 100 1.206881e+02 -170.0000000 222.73610 -29.809028 NA
#> 101 3.614403e+01 -170.0000000 152.04075 -8.284964 23.7028818
#> 102 5.040054e+01 -35.4772092 193.66394 -8.204679 48.7245958
#> 103 6.388010e+01 NA 196.19496 105.358336 144.8309913
#> 104 4.665525e+01 NA 178.76831 42.851345 116.4787626
#> 105 -3.376520e+01 3.0206503 168.85759 -3.292921 -9.5875939
#> 106 1.957797e+01 -46.7150285 181.32478 -26.960309 -50.8192102
#> 107 -1.878121e+01 NA 89.39856 -153.595813 223.0527952
#> 108 8.133061e+01 NA 187.01480 66.590153 123.3553469
#> 109 6.521405e+01 -37.6915253 166.50610 161.339424 189.9324868
#> 110 6.261836e+01 -170.0000000 159.94315 59.316730 104.0408886
#> 111 -3.975305e+01 -127.0883980 194.12228 11.096481 -23.3684450
#> 112 -1.773135e+01 -72.1201868 231.22020 -55.180650 -129.1090979
#> 113 -2.796103e+01 -8.6782129 181.96463 -110.201872 -94.7255887
#> 114 -1.669207e+01 -15.8752107 189.65185 3.552539 -80.3173754
#> 115 -7.483791e+01 -98.2993449 139.10468 -94.879923 -102.9129445
#> 116 -2.493873e+01 -64.2017020 178.42209 9.942975 -38.4335148
#> 117 -8.293134e-03 -79.0015582 216.28357 -11.181387 -88.1041492
#> 118 3.879384e+01 -12.4333722 197.80553 36.969012 59.8841634
#> 119 -6.454638e+01 -121.0767963 163.36807 -49.957995 -59.4050015
#> 120 -1.131221e+02 -53.2973023 188.64804 -37.785488 -55.9173099
#> otherimmune__alpha gamma__alpha B__alpha naiveTc__alpha beta__alpha
#> 1 -152.207243 NA NA NA NA
#> 2 -145.705798 125.148973 NA NA NA
#> 3 -55.170827 NA NA NA NA
#> 4 -41.072359 NA NA NA NA
#> 5 -86.565116 NA NA NA NA
#> 6 -76.145108 NA -139.88990 NA NA
#> 7 3.917422 NA NA NA NA
#> 8 -170.000000 191.302909 NA NA NA
#> 9 NA 6.824421 NA -134.722507 NA
#> 10 -1.121431 NA NA NA NA
#> 11 -148.242323 NA NA NA 172.04511
#> 12 -106.346084 105.640588 NA NA 170.05457
#> 13 -70.447918 NA NA NA 129.71223
#> 14 -35.442441 NA NA NA 128.67380
#> 15 -54.404106 NA NA NA 145.91723
#> 16 -53.404523 NA NA -77.136976 136.03016
#> 17 -45.186308 NA NA -5.306108 170.64325
#> 18 -62.292280 NA NA NA 191.13227
#> 19 -58.839125 NA NA NA 175.07754
#> 20 27.394265 NA NA NA 147.26929
#> 21 NA NA NA NA 163.54146
#> 22 17.032052 NA NA NA 150.12322
#> 23 -170.000000 NA NA NA 189.39609
#> 24 92.634892 NA NA NA 200.22679
#> 25 23.246375 NA NA NA 216.32461
#> 26 -115.842806 NA NA NA 151.60515
#> 27 1.247841 NA NA NA 242.01018
#> 28 NA NA NA NA 196.03850
#> 29 -154.244567 155.137351 NA -170.000000 151.44443
#> 30 -45.382436 NA NA NA 145.30568
#> 31 -15.967752 NA NA NA NA
#> 32 -27.351116 NA NA -15.988792 NA
#> 33 6.422219 -77.993085 NA -32.071609 NA
#> 34 6.329590 NA NA NA NA
#> 35 30.351884 -66.429995 NA -98.641830 NA
#> 36 13.544780 NA NA -54.672378 NA
#> 37 -28.835961 161.925617 NA NA NA
#> 38 -27.974836 293.449886 NA 4.083375 NA
#> 39 -8.910814 NA NA NA NA
#> 40 -32.872171 NA NA -125.994939 NA
#> 41 40.141790 NA -105.87421 114.041936 164.32391
#> 42 -10.689666 NA -98.95261 -12.091274 NA
#> 43 -30.675531 NA -87.45758 -34.777259 211.31219
#> 44 -34.863935 183.863681 -56.64850 -55.760863 NA
#> 45 -64.484723 145.712236 -124.94088 21.817298 NA
#> 46 -66.891480 NA -120.56520 -170.000000 277.97644
#> 47 2.419521 NA 13.74074 -31.299041 185.19703
#> 48 -19.571813 NA -104.04862 -53.373687 162.11347
#> 49 -17.383761 NA 134.51900 88.260192 178.54541
#> 50 -53.814474 NA -66.92596 -14.526349 NA
#> 51 -40.955634 NA NA NA NA
#> 52 -33.231597 215.472438 -170.00000 -61.613271 NA
#> 53 28.231231 NA NA 175.256639 NA
#> 54 -170.000000 246.836074 -170.00000 -170.000000 NA
#> 55 -7.698484 -51.425610 NA NA NA
#> 56 -23.174457 NA NA NA NA
#> 57 -56.217217 NA NA NA NA
#> 58 -97.226251 NA NA -85.207876 NA
#> 59 -132.389576 172.085815 NA NA NA
#> 60 -170.000000 191.660871 134.98106 NA NA
#> 61 -100.551489 NA NA NA 145.39248
#> 62 -64.666869 NA NA NA 181.64059
#> 63 -123.598305 NA NA NA 196.41457
#> 64 -88.880051 NA NA NA 215.25365
#> 65 -125.603114 NA NA NA 123.39395
#> 66 -108.833118 NA NA NA NA
#> 67 31.795477 -22.015526 NA NA 154.34211
#> 68 -47.545643 NA NA NA 252.56898
#> 69 -85.663388 NA NA NA 165.70569
#> 70 -43.485663 NA NA NA 156.10902
#> 71 -9.944703 170.721920 NA NA NA
#> 72 -52.469117 139.444452 -98.53449 -21.015284 NA
#> 73 25.222487 224.682626 NA NA 190.04974
#> 74 -122.355428 NA NA -103.313132 95.86174
#> 75 -51.504691 -13.652110 NA -58.400353 200.38246
#> 76 -100.177496 NA NA -170.000000 NA
#> 77 -33.167396 NA NA -52.499356 92.91137
#> 78 -60.910926 32.333901 NA -18.140933 160.54175
#> 79 -93.963894 NA NA 28.414355 82.02912
#> 80 -34.815458 92.523664 NA NA NA
#> 81 -110.745074 127.815801 NA -73.817069 NA
#> 82 -41.672889 NA NA -6.294317 170.08511
#> 83 -50.253108 NA NA NA 199.84904
#> 84 -43.784301 60.727699 42.92951 -100.158950 NA
#> 85 -53.395613 133.896181 NA -143.700512 193.38644
#> 86 -114.648366 NA NA NA 205.35821
#> 87 42.570488 250.755651 NA 23.324279 233.74509
#> 88 -62.322702 57.142536 -78.81830 -102.027087 NA
#> 89 -105.174350 NA NA NA 151.61476
#> 90 -114.826193 NA NA NA 159.28413
#> 91 21.792365 NA NA NA 184.58552
#> 92 -44.338711 NA NA NA 146.00563
#> 93 33.972302 NA NA -111.997442 35.61538
#> 94 -28.268179 NA NA NA 153.47708
#> 95 -26.632682 NA NA NA 174.41128
#> 96 -98.483298 NA NA NA 169.26912
#> 97 12.525212 NA NA NA 157.97869
#> 98 -22.228571 NA NA NA 172.13693
#> 99 -170.000000 NA NA NA 131.98634
#> 100 -170.000000 NA NA NA 183.17158
#> 101 7.438989 NA NA NA 240.57305
#> 102 23.283905 NA NA 83.819412 231.36303
#> 103 -170.000000 NA NA NA 173.88089
#> 104 32.522088 NA NA NA NA
#> 105 -14.278318 NA NA 90.938965 198.24421
#> 106 32.862536 NA NA NA NA
#> 107 -112.010057 -103.273885 NA -137.477470 164.48320
#> 108 142.188613 88.306639 NA 114.190961 184.84798
#> 109 159.890091 NA 232.42533 307.641452 278.60492
#> 110 83.966904 NA 70.82155 76.505245 173.25904
#> 111 -61.321323 NA NA NA NA
#> 112 -114.719744 170.346445 NA NA NA
#> 113 -30.129548 NA NA NA -170.00000
#> 114 -64.492356 NA NA NA NA
#> 115 42.905765 NA NA NA NA
#> 116 -34.299143 -77.784870 NA 70.332887 NA
#> 117 -76.965987 NA -131.20997 NA NA
#> 118 49.123173 NA NA NA NA
#> 119 -47.214207 NA NA NA NA
#> 120 NA NA NA NA NA
#> ductal__endothelial acinar__endothelial neutrophil__endothelial
#> 1 -12.30485754 -11.11025539 -25.8248513
#> 2 -7.06938959 -6.62858004 -3.0370906
#> 3 -34.80413310 -35.68944674 -2.9089613
#> 4 -32.79524835 -26.89841668 6.9606173
#> 5 3.13846350 -11.66827736 36.9373849
#> 6 -15.02717658 -14.00734161 -22.1679531
#> 7 -25.14147283 2.90570279 55.8393059
#> 8 -8.05307396 -22.06780454 28.1026660
#> 9 -15.71560375 -13.54692806 63.1424866
#> 10 -18.29901511 -8.21551102 -14.5119530
#> 11 -3.17130918 -2.51433074 -4.6705855
#> 12 -11.50636685 -6.41967840 17.3604220
#> 13 -13.07720856 -7.19363308 -25.3815130
#> 14 -11.48807219 -19.71422819 -7.0411465
#> 15 -13.23125773 -0.90954322 -5.1926679
#> 16 -11.91175626 -2.81791414 -1.2686886
#> 17 0.08710605 0.04657797 0.1726729
#> 18 -9.13300916 -7.77135553 -1.4301920
#> 19 -7.42474035 -4.13244567 -1.7053101
#> 20 -16.90414821 -8.46795385 -16.2380528
#> 21 -10.21100896 -13.02416063 NA
#> 22 -9.83177395 -19.58859560 NA
#> 23 3.67097077 -3.06446472 NA
#> 24 -6.85856693 -21.31474820 NA
#> 25 -4.59053461 -16.66034128 64.1921541
#> 26 -31.56416705 -22.40917858 NA
#> 27 -0.54747990 -8.70343874 8.1180308
#> 28 11.89956843 -12.48936936 NA
#> 29 -13.40051112 -20.17480584 -170.0000000
#> 30 -3.68543132 -6.63597760 NA
#> 31 -6.90785627 -9.68238871 -7.8868591
#> 32 -21.75290668 -16.04984489 1.3183691
#> 33 -5.55753985 -10.11949670 -55.3113683
#> 34 -10.41654094 -2.38896456 14.7229676
#> 35 -33.03269564 -13.22875722 11.3294479
#> 36 -12.29882655 -5.14815518 -9.6796172
#> 37 -7.35434170 -2.49227465 6.9385341
#> 38 -12.30440872 -7.66539759 5.5851132
#> 39 -17.65519202 1.84886779 -23.1170607
#> 40 -1.76168891 -4.85687460 1.7689697
#> 41 -25.23976572 -13.18261847 -37.5297740
#> 42 -10.45986389 -13.43005975 -0.7987509
#> 43 -40.74195036 -25.09239296 82.4972024
#> 44 -6.75983701 -7.54271860 -5.0362002
#> 45 -24.17563057 -15.87753717 10.8301236
#> 46 -4.39364960 -5.70705350 30.3308814
#> 47 -3.73455622 -5.17042832 1.7146842
#> 48 -8.28356626 -20.83881621 -45.9844164
#> 49 5.73878920 2.02631518 NA
#> 50 -33.21293240 -28.23998273 14.0478926
#> 51 -14.32366281 -20.42436673 -109.5011484
#> 52 -18.75929068 -18.71150768 -32.6886405
#> 53 -17.40716689 -26.64642433 -28.9976110
#> 54 -3.55259102 -20.83272663 -10.9314040
#> 55 -11.49593774 -9.99785266 -101.4942351
#> 56 -0.58122053 -61.54572733 -120.7721543
#> 57 -12.15513091 -14.49561754 -37.0593224
#> 58 -9.94030724 -17.97302435 -170.0000000
#> 59 -14.44550654 0.30547556 -26.1827421
#> 60 -19.16014621 -15.46215942 10.7566687
#> 61 -24.01621382 -36.07528162 -27.2455230
#> 62 -21.40295606 1.02165374 -9.0788992
#> 63 -26.39291502 -16.50167144 58.3808802
#> 64 -12.71444582 -13.45395553 34.6697480
#> 65 -2.98017806 -1.40798776 -41.2497302
#> 66 -56.31729809 -53.85227793 72.1400716
#> 67 -4.91650290 3.35605573 29.1074442
#> 68 -3.53499127 -11.54731643 -31.7716529
#> 69 -8.92161155 -1.01253566 -66.5566909
#> 70 -13.53643407 -3.27927404 20.3130705
#> 71 -9.73019021 -3.49383687 -19.0587810
#> 72 -10.68103481 -7.38884404 -12.6311423
#> 73 -4.82186082 -14.11688969 -31.1179610
#> 74 -22.94321438 -19.41447351 15.4684180
#> 75 -4.09595748 -4.48893074 -9.7269275
#> 76 -10.07015749 -4.32577554 3.2004224
#> 77 -14.24691677 -11.90375551 12.1523338
#> 78 -20.46677525 -19.01633922 4.3601969
#> 79 1.17752667 -5.83267586 25.8415331
#> 80 -7.53926689 -12.48153619 -21.3902634
#> 81 2.33880209 3.80094008 12.2565542
#> 82 -1.75213110 1.16477761 -12.9337305
#> 83 -15.75695855 -3.31025655 -7.1353552
#> 84 -13.63931317 -5.21257727 -1.9696356
#> 85 -7.24843276 -6.47483854 -13.6695451
#> 86 -1.55026182 -0.46447952 4.2866425
#> 87 -7.42657770 -9.96840830 -3.3030358
#> 88 -21.61547081 -15.35214110 14.2097942
#> 89 -8.10649961 -8.19108086 -12.6426129
#> 90 -10.49344527 -7.91566849 -2.6551544
#> 91 -8.67946676 -14.63050782 NA
#> 92 -6.83225766 -30.90261897 -63.3088885
#> 93 -14.16843758 -8.81977091 NA
#> 94 4.34025359 -11.88734703 -86.5046000
#> 95 -5.80869451 -18.29615677 NA
#> 96 2.09818029 -11.75310371 NA
#> 97 -7.54362873 -23.83987419 NA
#> 98 -10.27187067 -22.71550376 NA
#> 99 -1.61717136 -6.22400187 NA
#> 100 7.48925712 -26.69925546 NA
#> 101 -2.69928963 -5.49896088 86.0188410
#> 102 -14.50605780 -18.26475513 -34.0303961
#> 103 -16.75954095 -11.23968851 33.6623566
#> 104 -12.29986715 -9.22213513 -32.2137592
#> 105 -29.52873194 -20.67073999 -35.7453157
#> 106 -11.08739397 -5.76249073 40.5460787
#> 107 -2.89661598 -4.27905086 10.3712200
#> 108 -28.94489217 -15.18709151 59.3678765
#> 109 -5.14220267 -4.34376087 -26.6976172
#> 110 -13.60746972 -8.59221505 1.0510197
#> 111 -30.74044172 -21.18999728 -75.7961083
#> 112 -12.24523573 -6.90948374 22.7862586
#> 113 -2.95047933 -8.34575710 NA
#> 114 -5.30794306 -2.41279729 15.7736620
#> 115 -17.30898925 -15.49875609 74.7087916
#> 116 -21.02658530 -10.95313171 35.9966949
#> 117 -6.25477102 -2.98406756 13.5533595
#> 118 -19.61338096 -6.72951534 9.6045061
#> 119 -41.59671488 -32.24599237 163.0833574
#> 120 -11.87351757 -4.49874046 43.0117381
#> unknown__endothelial stromal__endothelial alpha__endothelial
#> 1 -13.9184792 -4.3624848 81.8502527
#> 2 13.5286468 -8.6015609 41.6243411
#> 3 20.7375118 -78.2547955 12.1806282
#> 4 37.4915546 -3.0508685 -55.2505193
#> 5 35.8196419 115.6790141 7.0950807
#> 6 -3.1116685 -2.3432109 56.8016904
#> 7 -51.7765554 -3.5685372 -53.5523329
#> 8 63.1048271 -72.0874381 -142.3786152
#> 9 11.4705447 58.7718889 -21.7566746
#> 10 -7.2361136 16.4222991 -31.0368807
#> 11 15.5311637 12.8475716 23.3588915
#> 12 -13.6015306 8.1194392 -73.6060352
#> 13 -13.7873358 3.6688210 41.8821037
#> 14 21.9988347 -9.7196900 62.0096765
#> 15 -24.4702326 -34.7946082 65.5817429
#> 16 3.4748108 3.3631663 23.3575027
#> 17 7.6207577 16.9951242 -33.2123815
#> 18 2.8823466 5.0770595 11.5408036
#> 19 -0.7550022 -1.7880670 31.1301371
#> 20 -1.1752425 -2.4800952 46.6822830
#> 21 41.5759804 40.3202201 74.7680238
#> 22 23.8678916 -4.6973900 81.6241826
#> 23 -2.6609075 70.0696143 11.5588202
#> 24 33.7231848 19.4749121 71.2265955
#> 25 54.7930784 60.1312422 47.4638474
#> 26 67.2304155 43.5155030 19.3364823
#> 27 27.4667454 2.8529658 20.6358808
#> 28 30.7397005 31.1979340 20.8785343
#> 29 9.8574500 27.9087873 46.2836547
#> 30 34.4947553 25.2531877 -35.9467826
#> 31 6.9685678 2.7222537 -1.5329461
#> 32 -12.3921410 -4.5428413 79.9596539
#> 33 54.9265949 19.9977702 -28.3724317
#> 34 10.9727999 14.3647724 -19.0118916
#> 35 -3.2160929 -27.7632522 -10.1980554
#> 36 -0.3338098 11.7115070 46.6954165
#> 37 7.4742273 -5.3381526 12.2686611
#> 38 45.5311474 5.3588475 13.1087240
#> 39 12.4831886 10.3987597 28.8392171
#> 40 0.7292008 -9.0716922 -9.4242270
#> 41 -16.5230754 -11.2218086 67.7400166
#> 42 10.4751250 7.4225873 -39.9439387
#> 43 62.1039804 -1.2491096 -31.7749355
#> 44 18.6705196 -4.2816435 -23.9178310
#> 45 5.4886129 -6.4816433 -3.1033331
#> 46 -9.7731926 -7.4020827 43.5409116
#> 47 10.7398795 4.1701816 -19.0669924
#> 48 18.7202774 -27.7366967 28.4520334
#> 49 15.3176130 -17.0193466 -14.8132650
#> 50 8.6739305 -20.4962271 -70.5770882
#> 51 9.4082083 34.1475749 69.1890176
#> 52 11.8254584 17.2044155 -39.2238448
#> 53 31.9664106 5.3800965 -11.6884322
#> 54 47.0061243 14.2329535 -23.7270928
#> 55 -3.0958931 -43.8336935 61.4386719
#> 56 49.9899784 25.7125022 16.1211340
#> 57 45.4153855 16.7531490 1.6205675
#> 58 15.4705399 -43.1261292 29.9897234
#> 59 -5.4919433 -24.1132311 7.6085997
#> 60 46.6907109 23.1653531 -14.6057867
#> 61 6.5692535 54.7983188 -46.5343055
#> 62 -2.0536447 3.1558254 25.9234838
#> 63 40.0769985 14.3423602 -6.5561669
#> 64 19.3107758 26.2339720 -14.8537531
#> 65 -22.7301679 -5.3781350 -24.6408559
#> 66 10.8565314 33.4009029 -3.2852522
#> 67 2.3144546 41.5782894 -31.4235487
#> 68 -3.4059100 3.7151734 19.4646010
#> 69 39.8945589 50.3512197 -18.3959696
#> 70 3.2748931 -1.8231508 -26.6977801
#> 71 2.7220900 2.2908813 5.8189684
#> 72 25.2518965 14.3960858 2.7821288
#> 73 12.2335225 3.6081051 49.7755107
#> 74 8.1027764 -2.3078175 33.1158746
#> 75 4.3936833 0.6960687 26.2570647
#> 76 2.4721908 -1.9582531 -10.7288199
#> 77 9.9737171 -5.7831530 18.0044741
#> 78 14.0054786 -9.1320529 36.8034662
#> 79 9.0482791 9.0236538 -11.1516622
#> 80 14.6842987 -5.2475692 2.7919118
#> 81 9.0958071 5.3674382 -28.0228094
#> 82 -0.2899378 -29.3685710 38.4283341
#> 83 1.3081978 -14.1354741 58.9279776
#> 84 -1.7777929 -0.3734988 0.5393326
#> 85 12.9696799 -7.2572126 66.1386331
#> 86 2.9567950 5.2275551 -25.4963635
#> 87 16.7612291 -3.7314067 -6.2277956
#> 88 27.9240568 19.0853226 -14.2144059
#> 89 9.1767101 11.1908878 61.2164202
#> 90 15.6522038 8.2157034 80.7188730
#> 91 13.7517593 40.6439620 113.7660925
#> 92 20.2763456 -13.3097637 81.0917197
#> 93 6.2537520 -31.8466572 -60.6131667
#> 94 35.7165592 49.7705708 29.4993961
#> 95 37.3156696 -82.9653834 119.3201837
#> 96 12.1985874 57.6233314 93.4468193
#> 97 29.9180439 -69.6416084 89.4601157
#> 98 26.2909863 24.8766232 77.2918186
#> 99 32.8703956 17.1304810 74.9878900
#> 100 20.9818560 8.5873012 120.4075839
#> 101 -2.5935967 -20.2008977 34.4864705
#> 102 14.9772252 18.1476354 46.3909292
#> 103 9.5472571 -40.2110153 61.4169103
#> 104 18.4627480 13.5785930 37.2503764
#> 105 -14.4705384 -12.0465440 -35.1031398
#> 106 17.3132302 11.1559405 12.1867030
#> 107 -25.3251041 5.2256067 -24.9558782
#> 108 13.2619837 62.3045251 79.0095332
#> 109 2.8597561 -16.2522567 63.9050267
#> 110 16.3722976 54.2695311 61.1698130
#> 111 -11.3356242 71.5671527 -44.8814038
#> 112 11.7305416 2.1296664 -18.2945721
#> 113 44.1232376 -32.0456065 -36.6932695
#> 114 5.2564358 2.8977254 -27.5799273
#> 115 -45.6819140 -0.7438961 -87.2937003
#> 116 31.4334524 9.2655156 -25.5967289
#> 117 9.8581454 12.6930071 -3.4942143
#> 118 -12.1358485 -9.0619608 37.4952319
#> 119 41.5163236 12.0090669 -72.3221025
#> 120 7.0213756 -2.0908257 -120.6559834
#> endothelial__endothelial macrophage__endothelial delta__endothelial
#> 1 35.4888389 -9.2786905 88.7677008
#> 2 50.8677500 23.2251583 47.2846005
#> 3 51.4502316 -27.3226842 28.3392434
#> 4 78.2014119 19.1578769 -46.4938110
#> 5 72.4801204 52.0194386 20.6081872
#> 6 -1.8405077 -17.8557056 62.3880830
#> 7 84.1682520 38.0116028 -115.8052109
#> 8 43.0255720 52.3170562 -148.4250038
#> 9 179.9076318 126.6089128 -26.1018676
#> 10 72.4849056 12.9135347 -24.6515909
#> 11 -27.8479103 9.2250712 23.8012923
#> 12 -17.3400910 19.0060033 -54.2276982
#> 13 30.0511242 -29.6064063 36.6326024
#> 14 19.6878347 13.1040485 63.3827455
#> 15 13.0311037 -10.1176894 0.6273626
#> 16 -1.8458187 -6.2529485 6.0238579
#> 17 36.4327062 0.4227167 -28.6897508
#> 18 77.1127851 -17.6005863 3.3244429
#> 19 17.8768384 -3.7257295 78.6171377
#> 20 -0.8116326 -15.1742157 56.2846848
#> 21 29.6474514 NA 74.3105059
#> 22 89.9218743 NA 62.7654197
#> 23 30.2515213 NA -17.8180511
#> 24 67.1559315 -133.9838851 63.6457160
#> 25 56.3013196 NA 41.2057255
#> 26 130.5387366 31.5638076 39.0215367
#> 27 45.4078736 60.4357016 32.8540103
#> 28 34.7364156 NA 32.7769303
#> 29 37.4124119 -45.6866408 62.2438768
#> 30 69.0161938 NA -19.0130027
#> 31 22.5585720 -2.8620380 0.6856908
#> 32 35.3523738 -22.2956042 79.1850398
#> 33 137.5379117 3.6539664 -23.1279491
#> 34 -11.0892430 4.1884784 -50.3175872
#> 35 137.7249115 -28.3136988 -21.9127216
#> 36 47.6521293 -1.8454358 18.8981554
#> 37 -9.4161678 26.5462589 6.8900168
#> 38 48.6968289 2.4974401 33.8169040
#> 39 -15.0653825 -22.7783633 -25.3887385
#> 40 27.0757932 7.4822450 -20.0680032
#> 41 9.0302935 24.5947579 86.4049299
#> 42 42.3618233 -37.9111557 -53.8388464
#> 43 163.5385702 -16.5752423 -46.3949645
#> 44 20.8535957 20.3526411 -21.3471728
#> 45 28.5884742 -5.2514333 -0.6376168
#> 46 14.5235402 -26.7262776 31.1887323
#> 47 -7.5131190 -8.4425064 6.0422796
#> 48 22.0492054 -170.0000000 41.9631410
#> 49 7.8337441 -38.3722871 -50.7777199
#> 50 80.6655515 -14.1486477 -79.7041857
#> 51 88.4968329 -15.8648704 19.5662508
#> 52 86.8474750 -11.1517904 -22.5801625
#> 53 182.1534753 -25.7841796 -21.1229465
#> 54 87.8933447 117.6041019 -13.4067729
#> 55 -49.3369601 -34.1552222 82.5982933
#> 56 56.0803547 91.4651918 7.6057035
#> 57 59.1973614 -71.4748619 -6.3648437
#> 58 -43.2208941 NA -9.5685354
#> 59 -88.4527331 15.9952377 4.3379631
#> 60 75.7167225 -89.8485999 -9.7422114
#> 61 223.7718218 133.6850992 -42.5643909
#> 62 76.2202291 -4.7719455 32.4951565
#> 63 98.8864978 50.9676602 -8.6231590
#> 64 54.3435086 7.6047663 -20.1614000
#> 65 -45.8777912 -5.6715619 -31.1024657
#> 66 60.7943447 54.4442947 2.3734200
#> 67 53.7432302 45.3522840 -24.7626703
#> 68 -22.3389497 14.1060384 31.7283904
#> 69 108.2737975 -141.8462973 4.7103817
#> 70 0.6947936 -33.9181991 -62.8572125
#> 71 17.4899331 10.4736184 -2.2029328
#> 72 45.1236152 -22.8420319 -11.9731017
#> 73 -30.1226567 -11.7902467 65.8466259
#> 74 15.8625737 -27.7879906 36.5886125
#> 75 5.8060110 -24.6095974 10.4095011
#> 76 9.1719628 -8.5207915 9.8081171
#> 77 67.1304741 -33.3140889 20.0076755
#> 78 21.1432206 -22.9822751 25.9501187
#> 79 14.2047231 -4.2248520 -18.6812800
#> 80 2.2663172 1.9871861 8.5472524
#> 81 -1.6339648 2.5357087 -23.9754523
#> 82 20.5299208 0.3784760 28.2653024
#> 83 27.7035120 1.1808103 114.5679416
#> 84 44.6004475 11.1880236 -5.2873021
#> 85 0.4985272 -4.3562197 36.3228714
#> 86 -5.0577405 -83.6964238 -36.2037076
#> 87 6.8061790 -0.3124974 -4.1851721
#> 88 61.2599245 1.4303273 -36.4663312
#> 89 -1.4975507 2.2311028 66.5349809
#> 90 70.2842670 -5.8404610 84.5359419
#> 91 45.8332469 NA 119.4467193
#> 92 35.0700709 -85.6452388 96.6122124
#> 93 92.9615946 243.4199220 -0.4627787
#> 94 68.1989093 10.1505074 19.8567845
#> 95 113.8539308 -66.1567359 97.8478654
#> 96 70.3097533 -85.0574028 126.5277351
#> 97 53.1837018 -27.1544305 95.6940117
#> 98 31.0131873 NA 92.8915673
#> 99 32.8049436 -170.0000000 39.3922934
#> 100 52.0269087 -35.1128363 125.1487412
#> 101 14.5526476 15.3486133 57.7317825
#> 102 28.0639196 34.7986844 47.2747822
#> 103 6.2659001 NA 63.7164661
#> 104 20.2187640 NA 34.3671595
#> 105 97.9216180 81.0728389 -19.3573033
#> 106 1.1011774 46.8415079 10.6185881
#> 107 -18.5658479 NA -80.9830380
#> 108 18.2013676 NA 92.1361334
#> 109 17.8713884 -25.6900250 -29.6672559
#> 110 54.1763588 -88.8855765 37.2487966
#> 111 69.0175076 -32.1753709 -71.6200643
#> 112 14.5133829 8.9825566 -8.9646202
#> 113 23.5156557 -43.7191652 -23.1508140
#> 114 -31.5022493 -17.7677839 -25.2290278
#> 115 81.8292388 -13.9280617 -121.2874313
#> 116 67.6628956 20.8361486 -24.4117635
#> 117 95.9885484 -9.7744854 13.8659015
#> 118 57.0313949 25.9472388 39.3647717
#> 119 125.9254164 103.2419359 -64.8775257
#> 120 -37.0713333 25.6260534 -93.3238337
#> Tc__endothelial Th__endothelial otherimmune__endothelial gamma__endothelial
#> 1 -100.3414002 65.1336208 30.96840807 NA
#> 2 -22.2961459 -54.1666704 -90.65546722 11.602562
#> 3 -109.6742086 NA 96.72420513 NA
#> 4 -30.1414654 -27.9555031 -81.94135852 NA
#> 5 190.4382844 15.6886306 69.80378785 NA
#> 6 -17.6621450 -9.3332039 -43.37535981 NA
#> 7 12.5061515 13.2118262 -48.35546800 NA
#> 8 39.1242560 25.5490486 131.83838777 -60.219457
#> 9 70.3363828 NA NA -170.000000
#> 10 -64.7096870 -65.4497943 -10.41121659 NA
#> 11 20.7977815 5.3943476 -23.36740755 NA
#> 12 -170.0000000 NA -95.23568401 -113.791962
#> 13 -41.9358338 22.3397502 -19.02175622 NA
#> 14 -20.4380910 -5.9903597 -40.01523719 NA
#> 15 -14.3043857 14.9866996 -45.01577548 NA
#> 16 5.2163313 -28.9549655 3.35950094 NA
#> 17 -2.0325890 62.1194442 24.38837863 NA
#> 18 -15.0143754 -58.8745422 2.85737461 NA
#> 19 -17.5697090 -16.0938829 -10.68086801 NA
#> 20 6.7955341 6.5588194 23.74730008 NA
#> 21 -35.4409167 NA NA NA
#> 22 10.6617913 -56.3209008 -7.82476483 NA
#> 23 5.2535288 NA -55.08677347 NA
#> 24 5.7929302 52.7639475 -0.04633072 NA
#> 25 18.7172749 34.5031518 100.20875663 NA
#> 26 -5.1730170 56.8040276 64.61963122 NA
#> 27 45.5102172 12.7583675 29.84956838 NA
#> 28 -22.1110727 NA NA NA
#> 29 12.1646914 44.6387474 -74.34610256 52.644979
#> 30 92.4628392 NA 187.12029230 NA
#> 31 -22.5113572 38.9534330 -52.71930656 NA
#> 32 2.2619144 -1.4618233 1.65346300 NA
#> 33 -6.5553663 -52.9088421 29.50884615 -82.414204
#> 34 0.7561767 -45.9618891 0.37395860 NA
#> 35 95.7192542 116.9957819 58.41534336 -90.500834
#> 36 29.4721149 49.5088993 25.50298504 NA
#> 37 9.6938386 -0.5705015 5.76441265 -18.882978
#> 38 4.1172034 4.4985356 5.63426589 -1.313312
#> 39 -16.7556806 NA 5.52168058 NA
#> 40 9.5099167 -75.0928484 -14.60870855 NA
#> 41 -4.7406102 -7.3374754 19.91850594 NA
#> 42 19.5736395 20.8150160 -6.90231652 NA
#> 43 42.8725246 102.1551444 73.21761915 NA
#> 44 -28.9354322 2.1802412 17.66360914 -86.180762
#> 45 11.8093366 25.7706295 1.97743807 19.343795
#> 46 -5.3378908 8.7738120 12.36922973 NA
#> 47 -20.5824119 -0.8630159 13.97890219 NA
#> 48 32.9461244 2.2156784 -16.76787782 NA
#> 49 -11.3369023 3.5955096 19.63022796 NA
#> 50 33.5082739 -1.1854005 33.95340524 NA
#> 51 -90.2619688 51.1622315 20.88316149 NA
#> 52 39.5135778 20.4339240 10.70404488 -138.880288
#> 53 -6.5752062 -89.2559643 71.88114780 NA
#> 54 45.7442950 -23.0213807 85.41112814 -32.995856
#> 55 -46.6633713 NA -38.43876657 -50.901790
#> 56 12.9776839 24.8487734 -30.25967722 NA
#> 57 59.5088912 88.6054992 148.25273609 NA
#> 58 32.1121170 -42.6019609 4.41759926 NA
#> 59 -44.9509853 24.8629888 21.18469494 -71.144849
#> 60 53.7460938 56.4839589 56.16408010 -15.818078
#> 61 -21.5956865 -64.6654552 -11.24196290 NA
#> 62 -7.1923180 -119.9493018 -4.57685815 NA
#> 63 69.0439612 -5.0346583 49.34565154 NA
#> 64 25.0251684 28.7666390 -4.59344238 NA
#> 65 10.6096485 -20.4450585 1.68987286 NA
#> 66 29.9712957 36.0635928 17.57956712 NA
#> 67 6.2780644 -8.2771025 28.15489818 -104.408469
#> 68 NA 101.0504696 23.82820469 NA
#> 69 20.1742328 NA -17.37729186 NA
#> 70 2.7486583 NA -35.71591676 NA
#> 71 -8.7616029 NA -10.73068519 -19.599427
#> 72 46.3760007 65.7107154 53.43260579 -41.336546
#> 73 17.3070807 -45.8787190 -34.03194910 65.837824
#> 74 -27.0847474 -1.3487653 -25.64035237 NA
#> 75 -13.3360472 NA -14.37335998 -1.258981
#> 76 -2.3255328 28.1450964 8.97236583 NA
#> 77 -5.0700395 100.4680186 41.92497072 NA
#> 78 -6.3808118 98.0502795 25.62699233 -21.530535
#> 79 4.1621007 -16.4115877 -20.03914072 NA
#> 80 8.3631008 -23.8800677 -17.59155599 28.971327
#> 81 18.1770794 0.5249892 -7.79024428 -104.904841
#> 82 3.5611817 10.0137183 -10.23949723 NA
#> 83 18.7505869 69.2999817 -58.97522449 NA
#> 84 52.8443883 23.3675540 25.48465854 -18.280407
#> 85 -0.9760583 -8.5143127 13.60290112 38.942356
#> 86 14.2311488 12.6907082 -78.20969847 NA
#> 87 25.5638446 -24.1389681 19.78136299 -6.515564
#> 88 -2.2794815 39.6760074 36.71464432 -26.343976
#> 89 21.4602314 -53.7820783 -28.91213761 NA
#> 90 -16.4423703 19.6558008 -37.13932628 NA
#> 91 NA NA -43.67141360 NA
#> 92 22.4147005 NA 23.99563304 NA
#> 93 61.3629883 98.7071625 -13.44514154 NA
#> 94 -81.4426677 31.2319918 -40.14026918 NA
#> 95 29.6561745 NA -107.42937278 NA
#> 96 58.0442973 35.0283933 43.35392303 NA
#> 97 42.2483644 -50.2047061 31.72874135 NA
#> 98 17.4872632 49.8485385 -47.95796103 NA
#> 99 23.0436637 NA -85.73336428 NA
#> 100 10.1363788 NA 15.26687934 NA
#> 101 -31.5958916 -16.2438772 13.27618097 NA
#> 102 1.4756094 33.1672476 17.46611164 NA
#> 103 38.7048850 58.7243051 -26.79492187 NA
#> 104 16.5083877 15.5539504 0.60635358 NA
#> 105 1.9235757 -7.3441848 -22.35084987 NA
#> 106 -3.6426736 15.4008082 19.14246697 NA
#> 107 1.5910422 -45.1434098 -17.78329184 -76.456598
#> 108 26.1876852 80.3882870 67.40854540 19.278698
#> 109 37.5488538 61.6504797 45.60224460 NA
#> 110 36.0435600 53.7806144 50.82450489 NA
#> 111 -9.4890523 -16.3261824 -19.77181233 NA
#> 112 1.3945538 54.0501862 3.02232186 -20.203483
#> 113 -9.9566827 -97.4637623 6.72213985 NA
#> 114 22.6739369 -28.4743870 -25.04187747 NA
#> 115 15.2526095 51.4405670 -42.48726869 NA
#> 116 -3.0201466 26.9172021 6.62165423 -71.433248
#> 117 23.6633055 31.4634477 53.51242769 NA
#> 118 39.8351017 -42.0229412 8.92417565 NA
#> 119 20.1433033 84.5975049 36.78535835 NA
#> 120 8.7191425 12.0872043 NA NA
#> B__endothelial naiveTc__endothelial beta__endothelial ductal__macrophage
#> 1 NA NA NA -8.0773492
#> 2 NA NA NA -2.5564916
#> 3 NA NA NA -17.4376830
#> 4 NA NA NA -11.4263765
#> 5 NA NA NA 20.4555661
#> 6 -107.02021 NA NA 1.2927269
#> 7 NA NA NA -19.3504401
#> 8 NA NA NA -30.1439109
#> 9 NA 49.517648 NA -14.7950239
#> 10 NA NA NA 8.9733480
#> 11 NA NA 15.106170 -1.9164101
#> 12 NA NA -55.982198 -3.2340639
#> 13 NA NA 24.513100 11.8918540
#> 14 NA NA 52.004672 1.5701207
#> 15 NA NA 38.515007 -8.4357563
#> 16 NA -65.236379 64.124657 -2.8024424
#> 17 NA 12.442883 -36.942986 5.0203813
#> 18 NA NA -1.854156 1.7037401
#> 19 NA NA 28.718921 -2.9172351
#> 20 NA NA 40.741050 -3.1795032
#> 21 NA NA 36.126280 NA
#> 22 NA NA 59.037700 NA
#> 23 NA NA -9.479576 NA
#> 24 NA NA 55.596925 68.9232262
#> 25 NA NA 29.653027 NA
#> 26 NA NA 25.127422 -22.5117137
#> 27 NA NA 21.929940 17.5037767
#> 28 NA NA 24.966053 NA
#> 29 NA -87.634286 49.094210 -5.3027210
#> 30 NA NA -46.125820 NA
#> 31 NA NA NA 14.1326776
#> 32 NA 0.226053 NA 3.5717999
#> 33 NA 64.498188 NA 3.8644351
#> 34 NA NA NA -10.2288006
#> 35 NA -62.620935 NA 6.3355043
#> 36 NA 21.819402 NA -8.9005902
#> 37 NA NA NA -1.4197147
#> 38 NA -9.184260 NA -1.7636806
#> 39 NA NA NA 12.1930288
#> 40 NA -32.360971 NA -4.5057066
#> 41 -35.28871 29.863403 64.473906 -18.6799668
#> 42 89.42555 19.515695 NA -14.5770510
#> 43 155.57740 50.847670 -13.845538 -1.8362575
#> 44 17.25989 28.321297 NA -0.6838258
#> 45 63.09824 42.519871 NA 0.5736911
#> 46 14.56939 -80.948354 30.927904 -3.0837026
#> 47 -110.95939 58.250958 -21.050593 -7.9024797
#> 48 48.10597 24.774335 65.228001 -33.2301292
#> 49 -35.61345 -31.059719 -15.971414 2.6885515
#> 50 102.89942 45.729970 NA 0.6878340
#> 51 NA NA NA -1.6834610
#> 52 232.63517 25.363829 NA -11.9490071
#> 53 NA 217.370536 NA 0.1523688
#> 54 -58.45763 -93.918268 NA 46.5391250
#> 55 NA NA NA -23.2400755
#> 56 NA NA NA -40.3200018
#> 57 NA NA NA 4.0635369
#> 58 NA 35.622715 NA NA
#> 59 NA NA NA -21.8744416
#> 60 -111.58615 NA NA -16.5805033
#> 61 NA NA -46.636876 3.2597628
#> 62 NA NA 16.341706 -21.8915778
#> 63 NA NA -19.194123 -18.7792642
#> 64 NA NA -21.519980 -12.4649510
#> 65 NA NA -30.406835 37.7293685
#> 66 NA NA NA -73.5463896
#> 67 NA NA -16.651819 -11.3471182
#> 68 NA NA 27.795757 -20.7481760
#> 69 NA NA -20.538084 17.2148353
#> 70 NA NA -27.199487 -19.9124842
#> 71 NA NA NA 5.0784270
#> 72 100.45822 -45.616424 NA -1.0041983
#> 73 NA NA 76.634963 9.6717891
#> 74 NA 62.863798 26.450840 31.0275373
#> 75 NA 29.395734 3.902878 -9.4748064
#> 76 NA -12.199779 NA -3.5360373
#> 77 NA -58.766427 3.249350 5.9910983
#> 78 NA -75.194459 36.151417 -1.3283430
#> 79 NA -170.000000 -57.868960 -14.1753421
#> 80 NA NA NA -2.3735262
#> 81 NA 71.084920 NA 5.4594984
#> 82 NA 5.315110 30.259831 -3.0467744
#> 83 NA NA 44.935967 -10.6181045
#> 84 27.03050 -37.418701 NA -8.6211740
#> 85 NA -59.594835 33.126373 -0.3626549
#> 86 NA NA -22.682312 -21.7426037
#> 87 NA -36.581803 -10.424564 -4.3016689
#> 88 -10.68089 -120.187538 NA -2.2312269
#> 89 NA NA 65.706810 -11.8540017
#> 90 NA NA 47.535080 -9.0427247
#> 91 NA NA 83.398323 NA
#> 92 NA NA 65.808029 -20.9631349
#> 93 NA 33.645810 -7.630958 -29.5970911
#> 94 NA NA 5.058287 -10.1829587
#> 95 NA NA 89.702490 -31.8847207
#> 96 NA NA 69.793549 -54.7026364
#> 97 NA NA 79.622154 38.2351597
#> 98 NA NA 78.312107 NA
#> 99 NA NA 36.736479 -21.6421712
#> 100 NA NA 66.419421 -24.5006783
#> 101 NA NA 35.774654 -3.6766817
#> 102 NA 88.849824 32.564459 -7.7309327
#> 103 NA NA 40.312425 NA
#> 104 NA NA NA NA
#> 105 NA -27.917621 -62.827873 3.9289264
#> 106 NA NA NA -8.2994560
#> 107 NA 45.052425 -37.058365 NA
#> 108 NA 120.830639 94.199245 NA
#> 109 72.14515 78.179364 82.586475 30.1633289
#> 110 93.21616 76.248619 37.515457 -24.4233145
#> 111 NA NA NA 13.5542792
#> 112 NA NA NA -6.7672197
#> 113 NA NA -19.971274 -9.2484758
#> 114 NA NA NA -2.9307985
#> 115 NA NA NA -5.2537092
#> 116 NA -39.990750 NA -5.4580728
#> 117 30.45199 NA NA 1.3471069
#> 118 NA NA NA -10.5838166
#> 119 NA NA NA -32.2232716
#> 120 NA NA NA -18.9764259
#> acinar__macrophage neutrophil__macrophage unknown__macrophage
#> 1 -6.1847827 -23.897482 13.0223391
#> 2 -2.7752777 34.147515 37.3336689
#> 3 -6.3427379 -12.227183 -11.7625047
#> 4 -7.0329038 12.907356 1.0220296
#> 5 -4.9729729 22.016237 22.8201417
#> 6 0.3361383 15.342774 -0.9572295
#> 7 -11.4288568 20.421431 2.8799067
#> 8 -11.1984598 73.007229 16.6726435
#> 9 -8.5460798 116.897732 6.5447326
#> 10 -5.3237893 100.484303 19.6475783
#> 11 -1.6217650 14.493431 2.7440772
#> 12 2.5590303 3.736855 8.2126253
#> 13 4.7685992 40.172351 5.1579552
#> 14 -3.1138780 23.468096 37.3892386
#> 15 1.7871142 4.638543 -34.4936616
#> 16 -0.9276615 -8.322194 -17.0440666
#> 17 6.4187749 18.777023 -6.4228963
#> 18 3.8458407 15.302198 1.4082791
#> 19 0.4615507 10.634743 -0.5858286
#> 20 -6.2286399 25.247140 17.6344457
#> 21 NA NA NA
#> 22 NA NA NA
#> 23 NA NA NA
#> 24 -1.0854270 NA 33.6260335
#> 25 NA NA NA
#> 26 -27.7737835 NA 131.9038859
#> 27 -10.4353840 -170.000000 38.3177362
#> 28 NA NA NA
#> 29 17.2860457 -170.000000 34.2013424
#> 30 NA NA NA
#> 31 7.1111108 44.995140 13.6372065
#> 32 4.4558154 6.496444 1.6618287
#> 33 -4.7439679 17.607721 -10.7533095
#> 34 -9.5058801 10.640286 4.1484953
#> 35 -1.1956003 16.311470 -0.9534490
#> 36 -2.7319003 6.466715 13.5592995
#> 37 -2.6190361 23.518123 6.9601637
#> 38 -1.6079675 21.122394 -12.8622778
#> 39 -7.7966516 15.816766 1.0056179
#> 40 -5.6961254 87.432451 -5.9331740
#> 41 -18.3847514 -170.000000 -54.7603284
#> 42 -5.5708682 -24.705564 6.0936035
#> 43 -9.0811962 20.381577 -14.4236198
#> 44 -4.8483115 -13.687089 -1.0381434
#> 45 4.7025719 0.473388 -17.1233337
#> 46 5.5977651 13.749867 16.7578023
#> 47 -5.7625741 -49.065495 -7.8684606
#> 48 -36.0167235 -170.000000 -56.5316487
#> 49 -28.1231081 NA -13.9384366
#> 50 2.1360126 -11.320808 -18.5910610
#> 51 -6.9142380 -39.128726 -23.0888763
#> 52 -14.4550908 15.436009 20.6376073
#> 53 -23.3798910 -57.315763 32.6692097
#> 54 -26.5370851 152.787451 89.8992412
#> 55 -12.3088360 22.348030 12.2064459
#> 56 -71.6120845 -170.000000 83.8709576
#> 57 14.8785034 55.692463 -38.3568616
#> 58 NA NA NA
#> 59 -3.8205570 51.027499 8.1294560
#> 60 -24.7482349 34.043467 -23.5117365
#> 61 -38.3126919 -29.572838 25.6416916
#> 62 -2.8073958 50.445928 -10.0442630
#> 63 -6.4591625 123.695076 68.8613828
#> 64 -12.1086398 128.835861 57.8034633
#> 65 21.8045344 -170.000000 -7.7315628
#> 66 -83.0358172 148.508565 15.1608269
#> 67 -11.8063176 50.284305 21.3122106
#> 68 -6.1155001 -170.000000 25.3823424
#> 69 13.4102962 210.424371 -32.9603653
#> 70 -10.2871012 59.181312 -6.9075691
#> 71 1.4275848 8.246394 3.2341454
#> 72 -5.8877850 39.234122 -2.2389870
#> 73 10.0455669 97.372671 24.5456920
#> 74 4.8099659 63.625162 7.0281476
#> 75 -3.8583737 22.563044 -8.9938099
#> 76 -1.5015319 14.085541 5.0847201
#> 77 12.1261980 98.036808 8.4709056
#> 78 -1.7313162 60.417886 -17.4519754
#> 79 -2.8921535 10.951339 3.2480899
#> 80 0.1256478 9.674068 7.9798913
#> 81 4.4776932 27.505380 12.1831579
#> 82 -9.7712242 35.561433 2.6850545
#> 83 -5.4610227 15.535448 10.3170939
#> 84 -6.2477088 12.996777 3.9926377
#> 85 1.5040437 13.020862 -8.0559599
#> 86 -7.2160343 -16.184963 -57.9063658
#> 87 -6.0805257 2.061075 -3.4211747
#> 88 -1.4667470 -1.810203 6.7928892
#> 89 -5.9700557 -3.855349 -6.8463928
#> 90 -6.4728844 15.943980 -0.2414771
#> 91 NA NA NA
#> 92 27.8816524 -170.000000 -130.8874271
#> 93 -22.8873843 NA 18.2108675
#> 94 -12.5685965 174.230426 71.1177121
#> 95 13.9225010 NA 22.9589887
#> 96 -21.1189604 NA -67.8439773
#> 97 7.3946487 NA 92.7458100
#> 98 NA NA NA
#> 99 -60.7545523 NA -33.3497233
#> 100 22.6264123 NA -28.3945844
#> 101 -17.3335591 -170.000000 -25.1688345
#> 102 -23.3298944 -89.036399 20.8912348
#> 103 NA NA NA
#> 104 NA NA NA
#> 105 -28.7474371 -170.000000 -52.8876696
#> 106 -0.4643030 12.880825 27.6599026
#> 107 NA NA NA
#> 108 NA NA NA
#> 109 -15.4405463 264.115479 -39.1688929
#> 110 -20.7168077 -33.681965 -26.6406000
#> 111 -34.3095224 69.086950 10.4688110
#> 112 -2.4455195 15.994575 16.6044331
#> 113 -10.9317707 NA 14.8753096
#> 114 -3.7690970 8.359182 4.9374386
#> 115 -16.6231525 41.388695 9.2966173
#> 116 -3.5191976 69.150982 5.2212090
#> 117 -2.9248053 21.628835 -11.6564286
#> 118 -2.7340182 20.370926 -18.0457831
#> 119 -31.1000360 156.001805 72.4723043
#> 120 -7.0029328 67.532707 19.6815543
#> stromal__macrophage alpha__macrophage endothelial__macrophage
#> 1 6.0934788 -14.3950137 -1.1802479
#> 2 39.3117426 -87.7083434 27.6831277
#> 3 12.0352771 -120.1453756 -30.4223154
#> 4 -45.5536831 -50.4455464 19.8162008
#> 5 55.3969008 -17.4756993 56.5439724
#> 6 -21.6368918 -69.9166097 -19.6060805
#> 7 52.1164509 -37.6167730 25.7738483
#> 8 5.9707786 -84.9606485 54.0689929
#> 9 104.0524403 -102.9741385 138.7268802
#> 10 8.1279205 -36.3302667 14.4810340
#> 11 1.0358401 -31.9075626 5.7894041
#> 12 0.2689266 -38.0348701 43.9708433
#> 13 35.4930069 -99.3992177 -31.4323620
#> 14 -2.0923587 -36.8555718 13.3643872
#> 15 18.3386597 -105.4776206 -15.8304818
#> 16 2.9281702 -21.1601514 -5.8452642
#> 17 4.0411316 -100.8531282 -1.1346638
#> 18 -6.2347515 -59.6691950 -14.9988733
#> 19 5.6672933 -32.1758900 -3.5497862
#> 20 -2.5150941 18.1618419 -14.3782972
#> 21 NA NA NA
#> 22 NA NA NA
#> 23 NA NA NA
#> 24 62.2567054 -170.0000000 -133.9838851
#> 25 NA NA NA
#> 26 -36.7425564 -147.5420288 37.4926462
#> 27 -17.5421715 0.6190431 59.4681092
#> 28 NA NA NA
#> 29 -115.5299703 -61.9143857 -36.4437390
#> 30 NA NA NA
#> 31 13.6300641 -95.0449953 11.2319508
#> 32 -25.4022064 -75.7514378 -21.1369838
#> 33 32.4392567 -3.1817784 3.6693288
#> 34 1.6154377 13.8864191 1.8279503
#> 35 12.8011092 40.3714277 -27.0658912
#> 36 4.6644528 6.5213820 -2.0704694
#> 37 4.1528258 -13.5217673 24.3529553
#> 38 15.1819610 -60.3990180 0.9320403
#> 39 8.9887966 -12.1164092 -27.7412699
#> 40 -0.3902364 -39.2407962 9.7084958
#> 41 -28.7728971 -51.6245632 13.4989444
#> 42 5.9668468 45.2381880 -37.5906390
#> 43 2.6847106 -9.4981849 -22.9464151
#> 44 2.9642434 -35.8967320 26.5497155
#> 45 2.2817942 -94.8313199 -3.2824410
#> 46 14.8986600 -84.5505322 -22.6706246
#> 47 -9.0336346 -29.4637456 -4.6104475
#> 48 35.0557553 -170.0000000 -170.0000000
#> 49 28.4481042 106.6330981 -24.6054027
#> 50 8.3756650 8.4754689 -7.2373286
#> 51 -89.0193623 -83.4711379 -12.7905797
#> 52 43.0234055 -25.7995512 -8.3370682
#> 53 -29.8764160 9.4735535 -36.2877544
#> 54 -96.8779933 -170.0000000 121.3235544
#> 55 -1.5900166 -75.9798938 -20.1316847
#> 56 82.8046961 -132.2155961 107.3275780
#> 57 37.1795881 -132.7045230 -68.8854138
#> 58 NA NA NA
#> 59 32.6810496 -52.2598569 17.2584969
#> 60 -93.0166431 106.9985305 -99.7435145
#> 61 106.6438864 -131.1744652 132.2732410
#> 62 123.8079485 -138.9555824 -2.7785693
#> 63 62.9344887 -128.5651245 59.9779326
#> 64 48.3455287 -61.1085012 16.3273051
#> 65 -85.9700714 -139.4856222 10.7655684
#> 66 18.1492799 -24.7045048 57.6560488
#> 67 31.1163582 -26.3022519 42.7214364
#> 68 125.9808475 -28.5275823 13.4071523
#> 69 -75.3073287 -96.6854120 -141.7972539
#> 70 133.1884482 -56.2536727 -41.4922035
#> 71 6.3183278 -71.8616837 9.2090497
#> 72 0.2455504 -60.7684331 -23.0996343
#> 73 9.1881319 -48.6420930 -12.6127054
#> 74 41.3199869 -46.7763497 -26.8393348
#> 75 13.1021109 -114.7991961 -26.7320797
#> 76 -1.0004496 -43.8716717 -5.9680698
#> 77 27.2167868 -60.0946322 -35.9624170
#> 78 23.5687210 -100.8260031 -22.0878949
#> 79 -12.2433333 -61.4455254 -9.1531208
#> 80 4.9560717 -0.3611479 6.7245193
#> 81 19.8589025 -100.2385890 -1.3696774
#> 82 17.9884599 -36.6704506 -5.5772241
#> 83 -2.3316500 -32.2008253 -1.4338708
#> 84 8.5233119 -23.3414818 12.5592623
#> 85 6.8022600 -52.0261709 -2.5436460
#> 86 -29.8825756 -151.0485102 -93.7436362
#> 87 -3.1278093 -46.4655181 -0.5938307
#> 88 -8.3567100 -42.6934721 -2.5063159
#> 89 3.5758662 21.2798867 -0.5594978
#> 90 8.8735758 -60.3548481 -11.0829358
#> 91 NA NA NA
#> 92 -170.0000000 -132.1509096 -75.9216853
#> 93 -170.0000000 -170.0000000 254.9369740
#> 94 81.9917462 -24.8093557 8.3235647
#> 95 65.4192067 13.2181589 -65.3568761
#> 96 -170.0000000 -170.0000000 -108.1857432
#> 97 -170.0000000 -145.6492724 -27.0030242
#> 98 NA NA NA
#> 99 79.3870370 -170.0000000 -170.0000000
#> 100 94.1562502 -170.0000000 -40.4411885
#> 101 48.7400877 -170.0000000 -7.4170042
#> 102 37.6467722 -39.1614429 34.2099578
#> 103 NA NA NA
#> 104 NA NA NA
#> 105 -34.4565076 -23.1270975 80.5697288
#> 106 9.7846887 -53.8899973 45.7828338
#> 107 NA NA NA
#> 108 NA NA NA
#> 109 80.9705100 -53.4308679 -29.5621347
#> 110 32.9630932 -170.0000000 -110.2860020
#> 111 -51.4329676 -138.7455006 -51.1286398
#> 112 31.2246319 -72.2190816 7.7863076
#> 113 -39.6578052 -8.6782129 -41.2849452
#> 114 -1.5261537 -19.4384719 -16.0098822
#> 115 -11.7068897 -103.0865636 -17.9981160
#> 116 16.4081603 -63.9941714 19.3231280
#> 117 3.3155160 -82.7619254 -10.1064469
#> 118 22.8706932 -14.4335519 38.7200571
#> 119 43.0553574 -128.5307953 94.5592369
#> 120 -25.3350787 -57.7122201 22.3708203
#> macrophage__macrophage delta__macrophage Tc__macrophage Th__macrophage
#> 1 8.4331995 -8.787409 36.4128610 49.266334
#> 2 24.5288247 -101.970139 56.5484541 6.279918
#> 3 64.7003697 -110.133226 -43.3312138 NA
#> 4 26.9742634 -37.010156 26.0273858 9.872550
#> 5 10.5897389 1.438669 56.8172302 110.595565
#> 6 17.1058033 -63.568675 25.3355989 -45.702360
#> 7 5.3698424 -66.729452 -25.1525948 -28.193784
#> 8 88.5996591 -128.220199 76.4154998 -11.600120
#> 9 118.6267664 -115.642402 53.7105870 NA
#> 10 50.8890348 -43.742650 -31.2435609 -50.221209
#> 11 19.4210763 -59.228751 45.6894731 -11.129191
#> 12 24.7601286 -75.743058 26.1426140 NA
#> 13 27.3635287 -54.091049 25.6886162 -57.705776
#> 14 56.1377258 -38.342606 55.1221002 -56.672126
#> 15 20.8960044 -60.270288 -6.2349734 -35.383401
#> 16 6.0149224 -39.363120 -6.2843381 -19.790314
#> 17 37.3771589 -112.641447 9.7175572 14.142521
#> 18 19.2635553 -63.402686 9.1146909 3.616061
#> 19 0.6778548 -40.310328 14.8679751 21.409277
#> 20 3.6592245 7.134360 0.7881133 8.463116
#> 21 NA NA NA NA
#> 22 NA NA NA NA
#> 23 NA NA NA NA
#> 24 -170.0000000 -119.690508 -31.8299477 -170.000000
#> 25 NA NA NA NA
#> 26 -170.0000000 -170.000000 -32.0749065 490.997169
#> 27 -170.0000000 -72.366580 86.8189922 -170.000000
#> 28 NA NA NA NA
#> 29 -170.0000000 -67.779923 -44.6843689 -170.000000
#> 30 NA NA NA NA
#> 31 -46.2765728 -80.246636 31.7345376 71.319673
#> 32 28.6711298 -100.423760 -4.7008847 8.814867
#> 33 -7.9106007 13.685220 -3.7303478 -14.922468
#> 34 -41.3105397 -48.112252 1.0656146 -37.377434
#> 35 13.5220237 70.269661 -3.1225128 3.421175
#> 36 24.3474711 -3.933112 13.0055300 -23.652644
#> 37 14.2156300 -20.484414 16.2611897 32.743149
#> 38 36.0972432 -87.298929 9.2035230 43.906268
#> 39 25.6619167 4.528524 5.4631468 NA
#> 40 56.8419107 -50.702762 15.6131507 54.431330
#> 41 -0.3476303 -26.983078 -40.6822951 -79.691853
#> 42 -3.1256984 32.222197 18.8208899 2.751710
#> 43 61.0006319 11.885589 -0.1184748 -53.683087
#> 44 3.2580282 -25.606648 -17.1669754 11.016918
#> 45 -31.7533736 -103.395542 -11.8536180 -42.185230
#> 46 17.1880553 -75.489405 7.8738016 19.239423
#> 47 3.0131060 -16.474896 11.6554981 16.298838
#> 48 -170.0000000 -170.000000 -22.8553469 -170.000000
#> 49 -59.1823416 87.549561 69.3734990 -6.256121
#> 50 -27.9855325 -6.414229 -13.9120550 -8.119673
#> 51 -170.0000000 -111.850207 -170.0000000 -87.222808
#> 52 74.7947340 -80.175141 80.1715645 42.564331
#> 53 -47.1887708 -21.209574 -7.3737089 -170.000000
#> 54 -170.0000000 -81.155678 -76.8192892 -170.000000
#> 55 -0.1933452 -89.120375 -32.5659626 NA
#> 56 -170.0000000 -109.466287 227.8681584 173.103538
#> 57 43.0147574 -112.695962 -25.0998092 -170.000000
#> 58 NA NA NA NA
#> 59 0.6526612 -74.898400 0.4249696 -44.357296
#> 60 -170.0000000 -13.088537 -170.0000000 -170.000000
#> 61 166.5584144 -106.274149 -27.5982704 -170.000000
#> 62 49.8800367 -100.702284 -58.5028396 245.652724
#> 63 137.2431455 -133.406793 91.9137660 -47.161085
#> 64 70.0481342 -69.212200 130.2499521 96.466757
#> 65 -170.0000000 -170.000000 -170.0000000 17.192544
#> 66 109.5702113 -10.683269 65.7117061 36.280238
#> 67 23.2742588 -170.000000 -39.9161770 -170.000000
#> 68 151.9926079 16.995548 NA -170.000000
#> 69 -26.8806663 -107.298727 -170.0000000 NA
#> 70 108.6011090 -121.641295 -18.6062196 NA
#> 71 30.8347059 -82.213276 24.9909093 NA
#> 72 40.4478912 -63.590900 46.1848065 -15.977635
#> 73 -170.0000000 -98.338545 -7.1992598 -45.878719
#> 74 -26.7021060 -66.645130 73.2176379 133.019083
#> 75 53.5343932 -125.582753 64.0230946 NA
#> 76 26.8227294 3.040384 34.8837997 25.306088
#> 77 -30.5958166 -104.917557 32.2476846 -54.869869
#> 78 44.5553199 -126.180848 42.5701269 -25.299041
#> 79 -8.6732970 -44.476250 -37.3439894 31.700479
#> 80 -12.2042318 -11.960045 34.2706616 -58.997353
#> 81 23.8672336 -79.242021 32.1905232 31.791842
#> 82 25.1416411 -49.107558 11.0715310 4.620327
#> 83 24.7281894 -36.936791 -5.7556873 -20.502146
#> 84 16.6875702 -37.362754 -3.4519278 18.783902
#> 85 15.9503475 -68.333240 30.9540846 3.536959
#> 86 84.4972845 -170.000000 -74.0616545 -28.584259
#> 87 7.3803368 -70.077738 -46.1053407 13.365208
#> 88 1.7911457 -28.660181 2.1435094 9.736432
#> 89 10.3945411 21.641513 22.6876537 -29.724452
#> 90 8.0445291 -52.909776 35.5888459 12.806467
#> 91 NA NA NA NA
#> 92 13.3033897 -170.000000 -170.0000000 NA
#> 93 279.2858843 -170.000000 171.1415226 449.818153
#> 94 -85.5280348 -74.761225 -30.5327505 101.186664
#> 95 -70.0911058 -84.375610 -170.0000000 NA
#> 96 -170.0000000 -170.000000 -170.0000000 -170.000000
#> 97 -170.0000000 -170.000000 71.8694515 -170.000000
#> 98 NA NA NA NA
#> 99 -170.0000000 -170.000000 156.6133915 NA
#> 100 -170.0000000 -170.000000 -170.0000000 NA
#> 101 -170.0000000 -170.000000 37.7645100 121.125941
#> 102 -23.0264974 33.834510 2.4953048 84.229923
#> 103 NA NA NA NA
#> 104 NA NA NA NA
#> 105 215.7611034 -110.748513 -1.0042836 -77.474381
#> 106 -67.9475060 -42.447669 -26.2276279 -94.232861
#> 107 NA NA NA NA
#> 108 NA NA NA NA
#> 109 -170.0000000 -170.000000 -101.9466360 -49.334204
#> 110 -170.0000000 -170.000000 40.7457470 -170.000000
#> 111 -170.0000000 -170.000000 -16.9360760 -53.727460
#> 112 55.1229296 -100.223859 7.6286398 62.831175
#> 113 -170.0000000 5.093862 -60.9175126 -170.000000
#> 114 -7.9007570 -75.940453 6.9997636 4.554984
#> 115 11.3631101 -65.192690 -1.7985763 24.476929
#> 116 30.1292896 -62.825119 24.9277679 5.378632
#> 117 68.7565014 -80.880728 20.8179242 -45.299926
#> 118 11.3260301 -88.034590 64.1141136 -54.790898
#> 119 81.1077707 -132.095155 -5.9097666 11.787553
#> 120 -40.7444130 -49.849247 -7.5831784 2.491386
#> otherimmune__macrophage gamma__macrophage B__macrophage naiveTc__macrophage
#> 1 32.9208600 NA NA NA
#> 2 -95.9511970 -108.43718046 NA NA
#> 3 -55.8624526 NA NA NA
#> 4 -3.7764433 NA NA NA
#> 5 8.8763627 NA NA NA
#> 6 20.8236997 NA 37.136252 NA
#> 7 42.9488838 NA NA NA
#> 8 173.6324012 -111.50726836 NA NA
#> 9 NA -125.55079292 NA 77.852093
#> 10 -16.3847934 NA NA NA
#> 11 43.7932176 NA NA NA
#> 12 99.4692254 0.09316316 NA NA
#> 13 -13.5266478 NA NA NA
#> 14 -86.9689783 NA NA NA
#> 15 -10.5935533 NA NA NA
#> 16 -9.0463602 NA NA 2.117914
#> 17 15.3642189 NA NA 4.104604
#> 18 47.4579709 NA NA NA
#> 19 16.6851137 NA NA NA
#> 20 -27.2382013 NA NA NA
#> 21 NA NA NA NA
#> 22 NA NA NA NA
#> 23 NA NA NA NA
#> 24 185.1095312 NA NA NA
#> 25 NA NA NA NA
#> 26 322.3147516 NA NA NA
#> 27 38.4747130 NA NA NA
#> 28 NA NA NA NA
#> 29 -170.0000000 -170.00000000 NA -170.000000
#> 30 NA NA NA NA
#> 31 15.2610920 NA NA NA
#> 32 13.1143677 NA NA -24.106062
#> 33 -0.4650828 -81.63610716 NA -57.111392
#> 34 6.6548744 NA NA NA
#> 35 10.7674723 -170.00000000 NA -12.127032
#> 36 17.3263733 NA NA 44.557193
#> 37 7.1369450 -25.34524989 NA NA
#> 38 19.6943906 -97.05432559 NA -19.037519
#> 39 38.2430695 NA NA NA
#> 40 17.4228143 NA NA 47.046746
#> 41 -109.1349097 NA -170.000000 -170.000000
#> 42 18.3592258 NA -91.312576 -42.847966
#> 43 -22.7964581 NA -34.355539 -62.592342
#> 44 24.5019448 -53.88894842 -10.441074 72.993366
#> 45 -6.6720635 -113.94399569 -12.325051 -56.019216
#> 46 49.9848158 NA -82.713660 -93.638844
#> 47 36.1493285 NA 5.831471 7.771608
#> 48 43.2911776 NA -170.000000 -170.000000
#> 49 -2.4449234 NA 45.075982 164.118418
#> 50 11.1266866 NA -21.210706 -73.645551
#> 51 -5.0987676 NA NA NA
#> 52 77.2485888 -32.93188528 -170.000000 92.102197
#> 53 15.8352657 NA NA -170.000000
#> 54 -42.4070569 -78.44198856 -170.000000 -170.000000
#> 55 -14.3662000 -23.89634053 NA NA
#> 56 32.7363008 NA NA NA
#> 57 -99.2623599 NA NA NA
#> 58 NA NA NA NA
#> 59 40.0791141 -128.11909863 NA NA
#> 60 -170.0000000 -49.32812795 -170.000000 NA
#> 61 -100.3315320 NA NA NA
#> 62 50.7301483 NA NA NA
#> 63 43.2619900 NA NA NA
#> 64 61.8156258 NA NA NA
#> 65 168.2429798 NA NA NA
#> 66 51.3540026 NA NA NA
#> 67 -41.5995306 -170.00000000 NA NA
#> 68 78.6530076 NA NA NA
#> 69 -110.7528659 NA NA NA
#> 70 -16.6998408 NA NA NA
#> 71 7.3278085 8.87797055 NA NA
#> 72 -23.4245146 -79.18655117 7.342506 -10.015084
#> 73 -170.0000000 -98.33854502 NA NA
#> 74 71.3957371 NA NA -2.870551
#> 75 66.0591348 -67.54343127 NA -27.191234
#> 76 -103.3308062 NA NA -170.000000
#> 77 25.4364816 NA NA -170.000000
#> 78 11.3060095 -79.50656043 NA -170.000000
#> 79 20.3746318 NA NA 29.711378
#> 80 38.4562026 -4.90756852 NA NA
#> 81 7.7963830 -134.01729672 NA -97.780615
#> 82 23.8912998 NA NA -18.404868
#> 83 25.7555072 NA NA NA
#> 84 -9.2671119 -55.86103877 57.582328 18.340551
#> 85 14.7660991 -32.95528594 NA -4.987718
#> 86 157.2636484 NA NA NA
#> 87 0.5010418 -56.79707879 NA -60.800396
#> 88 -4.3039562 -16.95503926 -29.236580 -57.003296
#> 89 -26.3212117 NA NA NA
#> 90 23.8141765 NA NA NA
#> 91 NA NA NA NA
#> 92 -170.0000000 NA NA NA
#> 93 107.5062928 NA NA -170.000000
#> 94 58.3323620 NA NA NA
#> 95 -4.4536810 NA NA NA
#> 96 -49.6332214 NA NA NA
#> 97 -27.8630103 NA NA NA
#> 98 NA NA NA NA
#> 99 -170.0000000 NA NA NA
#> 100 -170.0000000 NA NA NA
#> 101 -100.5330712 NA NA NA
#> 102 10.0203201 NA NA 240.623478
#> 103 NA NA NA NA
#> 104 NA NA NA NA
#> 105 46.3728698 NA NA -170.000000
#> 106 -31.7154052 NA NA NA
#> 107 NA NA NA NA
#> 108 NA NA NA NA
#> 109 -105.6016089 NA -170.000000 -170.000000
#> 110 47.7932379 NA -170.000000 -170.000000
#> 111 -56.8017401 NA NA NA
#> 112 26.1221648 -71.67920936 NA NA
#> 113 86.4209072 NA NA NA
#> 114 19.2649218 NA NA NA
#> 115 -35.6368996 NA NA NA
#> 116 36.9059595 -111.57618852 NA -89.084989
#> 117 16.7553688 NA 2.381106 NA
#> 118 19.7701262 NA NA NA
#> 119 37.8395839 NA NA NA
#> 120 NA NA NA NA
#> beta__macrophage ductal__delta acinar__delta neutrophil__delta
#> 1 NA -9.278269 -21.597642 -90.920667
#> 2 NA 4.053296 -26.458669 -95.354305
#> 3 NA 5.881493 -19.089899 -48.967043
#> 4 NA 24.671189 -7.081917 -19.300067
#> 5 NA -17.868234 -25.093638 -48.625761
#> 6 NA -16.499864 -43.396130 -57.340822
#> 7 NA 12.850718 -17.168297 -55.975129
#> 8 NA -12.656785 -29.279671 -121.455330
#> 9 NA -10.878732 -17.921546 -105.051432
#> 10 NA 5.063059 -15.504155 -32.159056
#> 11 -48.123343 -18.311259 -29.917647 -48.415546
#> 12 -54.149748 -34.615084 -44.751810 -43.797726
#> 13 -108.359733 -36.946767 -47.283693 -49.575838
#> 14 -58.616367 -32.516122 -47.479544 -41.597804
#> 15 -63.920224 -39.580002 -35.461735 -35.258321
#> 16 -41.120834 -4.811899 -29.863248 -35.809952
#> 17 -111.255252 -65.147510 -66.031792 -80.106391
#> 18 -68.426152 -35.088747 -43.419036 -41.769628
#> 19 -39.934779 -25.837292 -46.447543 -59.743657
#> 20 -14.233757 -35.198471 -34.924104 -33.886932
#> 21 NA -51.356963 -68.365845 NA
#> 22 NA -14.045114 -44.943117 NA
#> 23 NA -1.737700 -47.898810 NA
#> 24 -132.802716 -11.540341 -63.523166 NA
#> 25 NA -40.585244 -48.163211 -170.000000
#> 26 -170.000000 -54.874792 -57.818508 NA
#> 27 -16.423918 -11.698689 -45.834268 -170.000000
#> 28 NA -56.084511 -58.822094 NA
#> 29 -30.152931 -63.809001 -69.382973 -170.000000
#> 30 NA -58.081291 -48.638728 NA
#> 31 NA -55.103270 -57.236803 -48.287958
#> 32 NA -62.167822 -59.673287 -54.522654
#> 33 NA -5.967054 -15.045964 -12.427502
#> 34 NA -50.269658 -56.081325 -87.440020
#> 35 NA -26.108404 -22.261103 -5.455860
#> 36 NA -15.259385 -10.456683 -14.802182
#> 37 NA -11.646494 -20.831202 -77.056636
#> 38 NA -37.019685 -44.184617 -43.575641
#> 39 NA -12.122207 -30.765060 -64.454343
#> 40 NA -37.884413 -51.408914 -59.910031
#> 41 -59.625602 -59.117206 -68.420446 -170.000000
#> 42 NA -29.344950 -22.760789 6.996970
#> 43 -36.566306 2.809353 -15.837296 -26.720078
#> 44 NA -12.506904 -23.442256 -50.517740
#> 45 NA -28.949373 -48.971972 -98.958375
#> 46 -82.537767 -42.464086 -37.261084 -104.100873
#> 47 -4.259231 -15.303295 -5.119019 -41.403296
#> 48 -170.000000 -50.696289 -53.089387 -98.431000
#> 49 93.787581 -39.484729 -61.813440 NA
#> 50 NA -8.015317 -20.972991 -93.744658
#> 51 NA 11.425914 -27.285746 48.547788
#> 52 NA 14.646862 -0.288775 -114.733572
#> 53 NA -13.698466 -25.515912 -24.735520
#> 54 NA -32.254148 -43.652918 -44.775039
#> 55 NA -2.178066 -11.239251 -71.909975
#> 56 NA -8.166558 -42.954515 -73.355738
#> 57 NA -2.242288 -41.953125 -116.108103
#> 58 NA 1.154267 -30.015420 92.042402
#> 59 NA 9.923412 -17.145009 -143.204621
#> 60 NA -28.638889 -39.761938 -76.469448
#> 61 -135.567050 -11.700616 -3.124817 -4.593529
#> 62 -110.377182 -42.037315 -36.337972 -71.260913
#> 63 -129.184196 -49.992482 -63.549657 -150.440108
#> 64 -75.369609 -13.330191 -33.432052 -126.265877
#> 65 -170.000000 -61.910379 -58.224447 -170.000000
#> 66 NA -114.620810 -120.748876 -51.453680
#> 67 -24.083958 12.970208 -3.337325 -43.581774
#> 68 15.729926 -40.203148 -48.200757 -170.000000
#> 69 -82.809113 -50.174005 -44.140059 -114.329810
#> 70 -64.597952 2.646107 -30.149895 -120.917369
#> 71 NA -34.345790 -50.753972 -88.011333
#> 72 NA -18.263496 -19.321313 -41.163654
#> 73 -62.507818 -48.682453 -82.833932 -170.000000
#> 74 -53.085038 -83.457652 -86.020732 -37.239549
#> 75 -129.239102 -40.424881 -51.420104 -101.793976
#> 76 NA -31.668159 -29.184524 8.191908
#> 77 -73.454211 -68.167096 -80.798509 -123.520470
#> 78 -106.907515 -35.080152 -42.257503 -107.796630
#> 79 -6.047170 -19.146434 -40.069338 -133.909802
#> 80 NA -17.914801 -37.372326 -77.389894
#> 81 NA -60.784332 -73.400960 -119.116105
#> 82 -41.328460 -21.062537 -29.500455 -87.319963
#> 83 -23.047056 -36.077893 -24.335043 -40.558583
#> 84 NA -21.740240 -19.505488 -30.830332
#> 85 -43.775737 -37.327800 -72.044483 -90.490700
#> 86 -128.501552 -11.855580 -29.215315 -133.082240
#> 87 -45.084723 -31.120162 -25.616776 -83.849377
#> 88 NA 8.438776 -14.501215 -30.998423
#> 89 6.859682 -20.711812 -23.332676 -36.979147
#> 90 -53.131591 -17.166792 -33.537796 -66.504684
#> 91 NA -38.871993 -55.226176 NA
#> 92 -156.041945 -48.375466 -69.784228 -170.000000
#> 93 -130.894683 16.966742 -17.070244 NA
#> 94 19.420042 -33.598892 -54.056918 -100.109087
#> 95 -12.265690 -21.187695 -41.883288 NA
#> 96 -170.000000 7.967018 -41.942904 NA
#> 97 -93.695260 -49.264124 -75.942338 NA
#> 98 NA -26.561992 -48.932496 NA
#> 99 -96.891250 -42.816773 -50.443133 NA
#> 100 -142.429823 -18.008671 -67.056883 NA
#> 101 -170.000000 -40.263277 -39.092545 -170.000000
#> 102 -42.093063 -68.651039 -83.588430 -102.533141
#> 103 NA -48.402009 -23.780250 -170.000000
#> 104 NA -13.278780 -34.848468 -7.083123
#> 105 19.972372 -21.842475 -31.093755 -8.663953
#> 106 NA -37.175381 -30.739117 31.707520
#> 107 NA -14.714933 3.385946 -43.319021
#> 108 NA -50.134045 -26.395751 89.796582
#> 109 -170.000000 -33.581359 5.157914 -170.000000
#> 110 -170.000000 -46.643432 -36.090906 -83.784905
#> 111 NA -22.748830 -19.754420 -118.506247
#> 112 NA -35.313374 -23.764756 -47.140544
#> 113 -21.701133 -35.743555 -26.612184 NA
#> 114 NA -36.628978 -15.852697 -100.180669
#> 115 NA -8.072338 -9.223524 -142.027545
#> 116 NA -50.046612 -34.695056 -67.186500
#> 117 NA -47.421153 -28.233697 -49.743557
#> 118 NA -38.374649 -15.351026 -83.624985
#> 119 NA -24.419690 -32.655266 -123.904682
#> 120 NA -32.074085 -35.894504 -69.227132
#> unknown__delta stromal__delta alpha__delta endothelial__delta
#> 1 5.385863 -95.12832219 225.78895 88.6871463
#> 2 -41.193910 -35.94856144 195.69972 49.4184751
#> 3 -44.526174 -140.04964588 180.77040 30.2449881
#> 4 -21.572384 -10.70285381 258.08864 -46.5902750
#> 5 -15.360494 -143.59052157 265.90464 20.9854683
#> 6 -32.645499 16.42595205 148.51189 63.8344311
#> 7 67.247189 -93.41440733 186.10164 -111.7294369
#> 8 -51.265362 -33.06165024 208.80356 -145.6882657
#> 9 33.288151 -73.73134752 130.03945 -26.1040599
#> 10 -15.047593 -10.68374695 167.82515 -22.2318211
#> 11 8.584696 -9.32867822 189.04138 25.6342558
#> 12 7.667381 -8.01860209 169.46129 -53.7785224
#> 13 -10.894402 -46.44249379 73.63551 37.5620836
#> 14 8.521224 -24.92268349 128.12266 63.8155782
#> 15 -23.257545 -30.16684421 95.08070 3.9674821
#> 16 -7.050855 -34.45322184 189.59773 7.6726829
#> 17 -42.270463 -52.32975058 171.69589 -28.3822880
#> 18 -30.158774 2.66767213 156.27635 3.7101096
#> 19 -47.978892 -46.98508584 235.80590 78.8116478
#> 20 -6.494331 -27.46270770 173.74404 57.5874362
#> 21 31.406928 6.13195891 176.94674 74.9329618
#> 22 31.785085 4.94653149 161.64367 63.1352395
#> 23 -7.793711 -66.95956746 176.82190 -13.6753196
#> 24 49.246930 12.94447833 158.32949 64.2263017
#> 25 26.588686 -53.64805100 125.30363 41.2116524
#> 26 -35.571884 26.10642428 148.78752 39.9700512
#> 27 46.430493 -15.92061617 227.00572 33.0198721
#> 28 -28.570508 -9.34056315 215.33323 32.9346748
#> 29 -2.340434 44.91614216 158.92933 62.3774460
#> 30 2.790928 24.75113539 138.17100 -15.4023550
#> 31 -25.656068 -14.50092237 160.53655 1.5001933
#> 32 -48.335464 5.07402666 188.08480 79.4026108
#> 33 -2.021749 -37.58827672 117.56177 -23.2338083
#> 34 28.897042 -53.62088943 209.70966 -47.8947627
#> 35 -20.305498 -18.52739346 203.59470 -18.4743415
#> 36 -6.521402 -28.22787218 196.07799 21.6943587
#> 37 23.833894 -24.05859605 218.71644 10.9781581
#> 38 -19.776697 -79.41813088 240.83237 34.8416914
#> 39 -37.957680 -52.99541381 164.77916 -24.3442713
#> 40 -1.233282 -104.14587028 218.13105 -19.5641210
#> 41 10.566646 -16.96549818 184.50128 86.9720164
#> 42 -11.640248 24.53529926 207.60119 -51.4092092
#> 43 -18.320486 -1.67282521 26.88237 -47.1411381
#> 44 9.621624 -25.86781225 171.77714 -20.7107437
#> 45 -13.592098 -31.06808449 184.90935 0.6803479
#> 46 -44.436578 -50.23272411 275.65419 31.9991310
#> 47 -27.252670 -11.21147857 153.23886 10.0983821
#> 48 -29.065382 -60.39726396 198.75390 42.2689790
#> 49 38.623928 0.63214554 206.16990 -41.7188617
#> 50 -38.439215 -54.99652235 240.21181 -79.1335036
#> 51 -26.174710 -17.34103593 152.96003 19.9880492
#> 52 -30.992697 -33.88829042 197.53711 -21.2361122
#> 53 -6.205116 5.18857142 202.63558 -21.0582895
#> 54 -62.822892 22.26126482 452.99444 -7.1871722
#> 55 22.340410 -9.68394146 147.60069 84.9067519
#> 56 12.747702 -16.99842816 151.50494 10.3341280
#> 57 13.553185 -100.01237757 193.62998 -3.2108376
#> 58 9.704777 -103.38593215 170.95653 -6.8253906
#> 59 14.997842 -112.32932827 177.95546 5.3888629
#> 60 -11.206100 -45.56648828 437.57091 -8.9463133
#> 61 -16.465254 11.62224766 71.53453 -43.3320854
#> 62 21.897740 -30.54703759 154.86378 33.2889315
#> 63 -34.389819 -34.98203267 220.50230 -8.4494440
#> 64 -31.986079 -31.01893910 193.28599 -18.1768399
#> 65 -47.735921 -47.24268621 118.66472 -32.4062751
#> 66 22.021133 13.99745991 243.07589 2.8155600
#> 67 -6.958514 6.04626098 175.44753 -23.0099937
#> 68 16.076530 63.60249944 307.16362 31.8719800
#> 69 -34.237235 -57.60653936 141.22284 0.0849387
#> 70 -14.809115 -38.95988398 164.47040 -62.4376701
#> 71 -24.798097 -57.85717266 127.50600 -2.5180025
#> 72 10.991389 -9.78112999 133.76180 -10.2564549
#> 73 57.101839 -32.62684127 223.71036 65.8466259
#> 74 -27.702230 -73.10388925 103.05725 36.8885967
#> 75 28.514105 -40.03948982 175.67361 11.0256907
#> 76 -18.492307 -34.00392710 142.70250 11.9535147
#> 77 -16.386503 -50.96703979 102.62078 19.0339266
#> 78 5.948157 -46.18060918 132.78835 28.3235880
#> 79 16.215144 -16.09791348 72.84967 -8.0685272
#> 80 39.734667 -6.87025465 94.59561 9.4366264
#> 81 -39.284624 -57.83782560 137.78605 -24.4141908
#> 82 10.843547 -58.47286917 161.10509 32.2199244
#> 83 -29.248846 -0.53690957 228.85649 115.1677919
#> 84 -7.102607 -46.12054762 178.53447 -2.8984560
#> 85 18.941746 -50.21241268 264.29693 37.0700829
#> 86 36.913018 23.30437984 226.05848 -28.2904694
#> 87 -19.727286 -50.91224400 262.52569 -3.3288035
#> 88 -29.680794 -22.37147470 155.42925 -34.1154794
#> 89 5.956375 31.82044489 158.56297 69.6227506
#> 90 -7.233692 -26.72195153 174.88974 86.8832623
#> 91 -21.993580 -71.07263832 202.78645 119.4488761
#> 92 29.398095 -123.38358163 208.60145 97.6915975
#> 93 -1.553466 12.49138241 128.49391 -0.1081038
#> 94 -61.441715 -120.70078235 293.59283 20.2037466
#> 95 6.269154 -5.96136514 169.44217 98.4752911
#> 96 -91.912152 -103.12956200 220.37810 126.5277351
#> 97 -20.122344 -170.00000000 205.01633 95.8022037
#> 98 22.233658 14.89027519 163.67859 93.9882973
#> 99 -6.144178 -96.57086467 125.72435 39.7796447
#> 100 -13.291372 -5.09238846 222.73610 126.5543712
#> 101 6.015442 0.01906824 152.04075 57.9532515
#> 102 30.297336 72.42070021 191.29498 50.7648745
#> 103 -50.610319 -57.72042640 196.59977 65.6557024
#> 104 59.516160 102.76016698 178.80804 43.5236838
#> 105 26.215975 18.16130557 170.53797 -17.4429895
#> 106 9.233973 45.55694293 181.22544 15.3254263
#> 107 -36.906166 -82.85096016 83.77768 -71.6391831
#> 108 42.114522 128.11065392 187.61892 94.2476048
#> 109 59.529502 45.02120597 166.50610 -28.1587594
#> 110 72.802698 57.19267559 160.03119 39.0002841
#> 111 6.113100 -67.59053407 194.33973 -68.8622945
#> 112 -25.971977 -35.17686293 231.19019 -8.0221093
#> 113 -55.644786 -11.64847470 182.24269 -27.8187864
#> 114 21.752184 -36.20605924 190.83824 -13.7717006
#> 115 5.926288 -57.90883964 138.41113 -117.0253747
#> 116 -17.252500 -12.37249977 178.74822 -23.8095419
#> 117 -2.053631 -17.16792508 216.53809 17.5467152
#> 118 -16.380239 -20.56880223 197.84108 40.4240822
#> 119 -88.517686 -62.45246526 163.34674 -58.7693874
#> 120 -20.465693 20.39516035 188.71895 -88.0573254
#> macrophage__delta delta__delta Tc__delta Th__delta otherimmune__delta
#> 1 -7.678982 221.251370 -42.1493227 69.660358 -170.000000
#> 2 -98.358748 213.563636 -139.3379886 -110.169213 -170.000000
#> 3 -106.276076 201.805679 -107.7314233 NA -39.784355
#> 4 -36.425284 265.232370 -59.5678484 -96.280685 -44.153258
#> 5 2.909563 274.234728 -170.0000000 -170.000000 -86.470860
#> 6 -69.252375 135.565523 73.7073486 -170.000000 -85.830066
#> 7 -60.963924 209.585186 26.8259910 -170.000000 -55.721274
#> 8 -127.984799 259.213599 -170.0000000 -119.864239 -170.000000
#> 9 -114.050430 159.694750 -100.7166894 NA NA
#> 10 -41.733847 183.534955 -43.5176217 69.069182 12.592778
#> 11 -54.739659 193.776342 -83.5370946 -16.770460 -170.000000
#> 12 -73.395731 183.616964 -55.6235985 NA -125.831269
#> 13 -48.727345 167.654593 -3.6988727 23.577896 -113.350621
#> 14 -40.824863 150.544546 -8.8090209 36.088237 -60.510295
#> 15 -57.963704 220.866966 -62.8820703 -170.000000 -38.040704
#> 16 -35.508677 310.719096 -152.1601267 -135.041234 -137.428997
#> 17 -111.176396 189.675970 -63.0508716 -87.797652 -78.723405
#> 18 -62.264770 166.504429 -36.1352934 -124.801005 -98.790319
#> 19 -40.169975 366.276203 -7.5001929 -91.528879 -60.242586
#> 20 9.845758 205.195196 -17.9759547 -27.770479 74.877762
#> 21 NA 249.971054 -79.0922023 NA NA
#> 22 NA 121.459532 10.0751886 -90.323992 -8.244298
#> 23 NA 188.852307 -56.7191646 NA -170.000000
#> 24 -114.643716 189.231824 27.0399353 96.976259 53.829507
#> 25 NA 454.930465 -82.3278958 -25.394435 53.745215
#> 26 -170.000000 176.003790 -79.0380523 -170.000000 -170.000000
#> 27 -70.538322 274.412908 -55.7875143 253.315736 -16.462728
#> 28 NA 269.043487 -60.9312448 NA NA
#> 29 -67.068902 181.865716 -1.1525705 -67.779923 -170.000000
#> 30 NA 154.965034 -51.6872628 NA -12.506746
#> 31 -79.023861 153.005484 -39.2708347 -90.397885 -24.676839
#> 32 -97.622605 221.929736 -68.9057415 -56.604237 -58.265844
#> 33 13.853031 205.087521 -26.8791740 -20.584379 -29.144564
#> 34 -44.447522 84.615202 -36.9484564 -170.000000 20.618759
#> 35 71.567296 79.411931 42.0784552 -14.239733 23.406831
#> 36 -1.766660 202.032847 -9.9760408 30.596720 19.894120
#> 37 -19.949599 260.048952 -77.4246394 -170.000000 -49.291048
#> 38 -85.360175 255.422236 -60.7850302 -79.106729 -6.550110
#> 39 10.419538 104.717841 -36.3753059 NA -4.628110
#> 40 -50.645709 249.311505 -132.7828204 -170.000000 -66.487326
#> 41 -26.959126 214.608157 0.1629432 15.665622 37.221627
#> 42 33.727296 176.652216 32.6918600 34.541030 -18.524908
#> 43 -8.491114 -170.000000 -10.6176753 -41.883181 -21.929359
#> 44 -24.893320 157.988005 -35.4642937 -24.686262 -27.246752
#> 45 -97.227167 190.185234 -92.4972445 -80.850288 -68.643130
#> 46 -73.968872 242.065151 23.2389856 16.717201 -100.088969
#> 47 -9.755284 323.969165 -58.1352897 -43.125485 -62.601133
#> 48 -170.000000 194.912170 -13.2009709 -50.680333 -22.335729
#> 49 90.607277 -170.000000 53.9356796 51.489226 -37.917938
#> 50 -4.010019 226.460194 -84.3823831 -95.329732 -70.432485
#> 51 -111.850207 266.177263 100.2558172 -170.000000 1.419663
#> 52 -78.508806 269.836344 -56.7559329 -51.915427 14.945456
#> 53 -19.369921 219.785677 52.7155359 -27.988402 8.536232
#> 54 -73.717366 395.983795 -113.8099172 33.297629 -99.762396
#> 55 -79.655086 156.163864 -58.5852119 NA -4.704982
#> 56 -99.340556 110.874872 -31.5341199 -87.723140 -4.466615
#> 57 -108.655979 180.234550 -60.9812605 -170.000000 -136.967409
#> 58 NA 136.713684 -74.6574207 -79.677174 -102.339900
#> 59 -70.682087 237.487796 -93.6550142 8.593568 -170.000000
#> 60 -8.807224 408.539600 -116.2850325 -170.000000 -130.856017
#> 61 -107.398436 229.130513 -82.0927689 -21.646925 92.736479
#> 62 -99.376701 185.087943 -65.6054312 -170.000000 3.179585
#> 63 -132.359880 249.831579 -13.5271557 -64.855994 -130.500035
#> 64 -67.918550 202.794101 -35.8765877 -170.000000 -93.310915
#> 65 -170.000000 117.056069 -75.4145681 -103.817441 -95.852984
#> 66 -10.591099 267.294302 23.3523359 -104.341657 -119.672323
#> 67 -170.000000 180.961993 -29.1826950 -170.000000 -83.634787
#> 68 17.274635 335.684406 NA -58.229585 5.537019
#> 69 -100.216429 174.473121 111.2429144 NA -90.420024
#> 70 -120.654019 -37.564231 -93.1118963 NA -170.000000
#> 71 -83.147534 163.514388 -82.3258251 NA -51.530176
#> 72 -61.668482 250.268853 -45.4595101 -47.499603 -43.599522
#> 73 -98.213712 181.067998 2.2090783 26.252977 5.533999
#> 74 -66.645130 120.485901 -67.2059477 -15.432914 -140.169948
#> 75 -121.022341 281.540774 -63.0694160 NA -68.029574
#> 76 6.276224 207.721067 14.8139774 -13.837442 -89.337479
#> 77 -110.596819 202.141378 -81.9843431 -170.000000 -77.779404
#> 78 -122.445026 142.565510 -95.6270918 -68.493771 -63.692560
#> 79 -40.927655 237.382671 38.6084972 -170.000000 -27.177281
#> 80 -11.984393 118.912911 3.0038282 -136.413802 -51.987948
#> 81 -79.968943 205.961690 -102.1764168 -126.336032 -124.624885
#> 82 -43.037631 154.002094 -61.1070795 -9.792367 -77.880599
#> 83 -35.349345 -8.840156 68.8238233 188.965426 -170.000000
#> 84 -35.146822 243.365199 -57.2387164 -37.976783 -91.251137
#> 85 -65.420131 278.582487 -89.0381593 -54.899027 -87.797568
#> 86 -170.000000 115.963629 13.2351805 -16.691942 -78.209698
#> 87 -68.687676 175.763610 -170.0000000 -28.359259 -4.266132
#> 88 -22.752694 134.142658 6.4370272 -90.140392 -63.907260
#> 89 25.233809 160.111317 39.8741494 -71.996443 -64.323359
#> 90 -49.039005 206.562235 -75.9318101 -82.998887 -170.000000
#> 91 NA 102.380991 NA NA -19.008459
#> 92 -170.000000 220.306008 -54.8825011 NA -13.782520
#> 93 -170.000000 220.538065 -106.0067040 -42.170170 54.984692
#> 94 -74.761225 311.104017 -129.5196035 -135.140189 -35.711123
#> 95 -84.375610 110.599173 66.2363715 NA -170.000000
#> 96 -170.000000 208.276321 -2.8239050 -20.473155 -70.315437
#> 97 -170.000000 232.519394 -36.2745895 -107.330647 16.714047
#> 98 NA 186.211491 31.9234747 -10.615277 -43.280829
#> 99 -170.000000 236.181575 -170.0000000 NA -170.000000
#> 100 -170.000000 54.075341 57.3495017 NA -170.000000
#> 101 -170.000000 -170.000000 -75.0473560 -55.910180 58.178531
#> 102 37.209023 295.291326 23.9039620 54.876894 21.311498
#> 103 NA 167.738562 99.8839921 136.196837 -170.000000
#> 104 NA 183.413095 26.4007771 38.769162 77.288521
#> 105 -97.478621 203.175304 14.0942045 32.013813 -27.630957
#> 106 -39.344063 173.263322 -42.5069944 -69.596560 38.065263
#> 107 NA -170.000000 -170.0000000 83.361957 98.730937
#> 108 NA 123.136315 82.4102059 134.468926 134.766870
#> 109 -170.000000 -170.000000 156.4578665 152.581087 91.725339
#> 110 -170.000000 62.831680 54.2920007 83.374327 36.989609
#> 111 -170.000000 171.923676 -9.2767417 -28.688846 -91.814918
#> 112 -100.507543 219.668470 -33.5592877 -75.408341 -94.839137
#> 113 5.093862 197.826474 -135.8411589 -110.774410 -9.627724
#> 114 -71.235157 191.298664 -17.6649548 -111.082735 -65.882971
#> 115 -60.667630 145.588849 -99.7332459 -135.579711 -84.144749
#> 116 -62.272791 266.188447 13.0297947 -38.611837 -33.455227
#> 117 -77.029390 239.750599 -12.1382733 -66.949569 -95.402071
#> 118 -83.865383 267.446067 -9.9617258 -5.167382 -39.722533
#> 119 -124.852479 182.442510 -75.0167845 -77.170829 -55.622528
#> 120 -46.968694 192.343620 -63.5226070 -73.514494 NA
#> gamma__delta B__delta naiveTc__delta beta__delta ductal__Tc
#> 1 NA NA NA NA -5.53358751
#> 2 40.79880 NA NA NA 10.46390456
#> 3 NA NA NA NA 9.21045481
#> 4 NA NA NA NA 2.18411079
#> 5 NA NA NA NA -4.93767349
#> 6 NA 26.137973 NA NA 4.15576444
#> 7 NA NA NA NA -7.16191732
#> 8 204.81771 NA NA NA -26.29344464
#> 9 13.06916 NA -170.00000 NA -26.38978698
#> 10 NA NA NA NA 33.64088115
#> 11 NA NA NA 182.07019 -19.93191624
#> 12 153.78960 NA NA 188.59769 -10.69521401
#> 13 NA NA NA 128.62553 5.71847161
#> 14 NA NA NA 119.27182 1.87839329
#> 15 NA NA NA 164.73058 -0.71896620
#> 16 NA NA -170.00000 194.70267 -3.31234230
#> 17 NA NA 28.32468 191.50174 2.97434403
#> 18 NA NA NA 183.12347 -11.92613625
#> 19 NA NA NA 225.31008 -5.93396158
#> 20 NA NA NA 180.42014 -21.80722088
#> 21 NA NA NA 199.66181 -3.56226747
#> 22 NA NA NA 152.15487 3.24469273
#> 23 NA NA NA 192.82198 8.00452920
#> 24 NA NA NA 173.07569 2.22800153
#> 25 NA NA NA 230.24802 10.55817005
#> 26 NA NA NA 165.83163 9.23329500
#> 27 NA NA NA 238.80529 -0.05300528
#> 28 NA NA NA 220.63109 5.32917543
#> 29 240.89708 NA -170.00000 153.58663 12.99079747
#> 30 NA NA NA 157.36108 8.26322580
#> 31 NA NA NA NA 3.58819465
#> 32 NA NA -116.97961 NA -8.27538843
#> 33 18.71169 NA -170.00000 NA 8.91085212
#> 34 NA NA NA NA -9.55262404
#> 35 -170.00000 NA -170.00000 NA -25.14690099
#> 36 NA NA -62.40166 NA -16.17140213
#> 37 152.85502 NA NA NA -14.62679975
#> 38 236.03709 NA 82.68620 NA -5.75955069
#> 39 NA NA NA NA 14.73724994
#> 40 NA NA -170.00000 NA 15.46302732
#> 41 NA -121.753256 30.07923 174.79549 -12.94676943
#> 42 NA -95.414466 13.52815 NA -12.67158723
#> 43 NA -20.678433 -68.51915 54.25233 -12.91896977
#> 44 210.88765 -20.993845 -72.65463 NA -5.28600532
#> 45 117.68624 -134.501332 -20.59519 NA -11.22477451
#> 46 NA -170.000000 -170.00000 296.76538 -11.20666042
#> 47 NA -170.000000 -43.49546 108.75911 -3.83872250
#> 48 NA -170.000000 -170.00000 230.68660 -7.48169040
#> 49 NA 16.221980 117.35776 215.35492 0.63105674
#> 50 NA -76.579998 -52.36427 NA -25.08692736
#> 51 NA NA NA NA -1.10691877
#> 52 210.67418 -170.000000 -29.11808 NA -14.51248498
#> 53 NA NA 136.18619 NA -25.23322660
#> 54 227.20088 -170.000000 -29.52479 NA -0.17445694
#> 55 -4.72268 NA NA NA -11.81596581
#> 56 NA NA NA NA -21.10360670
#> 57 NA NA NA NA -0.66823935
#> 58 NA NA -104.32030 NA -15.37685886
#> 59 56.50561 NA NA NA -7.75304151
#> 60 185.92087 -3.570260 NA NA -10.64660282
#> 61 NA NA NA 117.85965 -0.98519032
#> 62 NA NA NA 198.20622 -4.53031475
#> 63 NA NA NA 207.07159 -30.66463227
#> 64 NA NA NA 227.99779 -15.59533372
#> 65 NA NA NA 118.78229 -23.59063494
#> 66 NA NA NA NA -74.79746175
#> 67 -170.00000 NA NA 199.97358 9.41983252
#> 68 NA NA NA 279.58459 NA
#> 69 NA NA NA 133.64928 -29.08092241
#> 70 NA NA NA 178.84491 -3.02443768
#> 71 14.48649 NA NA NA 8.46214879
#> 72 370.64005 1.042058 -115.32848 NA -17.99202267
#> 73 335.92735 NA NA 284.76827 -1.76081533
#> 74 NA NA -73.50777 104.93175 37.88173170
#> 75 159.75451 NA -87.00069 271.75101 -0.11961234
#> 76 NA NA -170.00000 NA -3.57151196
#> 77 NA NA -68.84951 109.40773 17.35745408
#> 78 34.01704 NA -46.19750 149.05575 -9.60076343
#> 79 NA NA -33.38720 278.88083 -2.77085573
#> 80 127.09382 NA NA NA -2.84032363
#> 81 -33.63694 NA -115.26228 NA 8.04010814
#> 82 NA NA -27.00087 168.26474 0.14161972
#> 83 NA NA NA 229.08007 -12.51519559
#> 84 116.19637 -48.223160 -170.00000 NA -5.95213892
#> 85 341.25823 NA -170.00000 210.54854 0.96180765
#> 86 NA NA NA 199.30733 2.61490273
#> 87 158.03688 NA -31.35530 221.03708 8.09758793
#> 88 127.68064 -79.263277 -79.88587 NA -6.21153952
#> 89 NA NA NA 179.11819 -1.29149825
#> 90 NA NA NA 190.28287 10.17305478
#> 91 NA NA NA 203.40937 NA
#> 92 NA NA NA 168.52016 -13.00642474
#> 93 NA NA -40.30234 218.03450 -17.83733690
#> 94 NA NA NA 182.02729 -44.06400836
#> 95 NA NA NA 151.71545 51.90722818
#> 96 NA NA NA 214.99285 -9.12253345
#> 97 NA NA NA 198.94867 8.58210708
#> 98 NA NA NA 181.66619 0.59532930
#> 99 NA NA NA 193.84539 10.75295635
#> 100 NA NA NA 172.27519 76.24232690
#> 101 NA NA NA 249.55075 -11.96528739
#> 102 NA NA 133.29178 174.21191 -10.78941582
#> 103 NA NA NA 185.61340 -10.51290209
#> 104 NA NA NA NA -3.04217560
#> 105 NA NA 148.09697 156.44547 -10.18558966
#> 106 NA NA NA NA -4.11458142
#> 107 70.36026 NA -170.00000 71.43623 4.94746574
#> 108 101.61275 NA 139.73915 177.59855 -12.88932923
#> 109 NA 184.410141 250.13733 30.65347 -23.44784401
#> 110 NA 31.444792 80.32541 197.00806 -21.27105725
#> 111 NA NA NA NA 2.63390202
#> 112 182.22738 NA NA NA -23.85173016
#> 113 NA NA NA -84.37961 -2.54865077
#> 114 NA NA NA NA -2.30974472
#> 115 NA NA NA NA 8.53584513
#> 116 -50.98136 NA 37.50785 NA -4.07962885
#> 117 NA -137.398880 NA NA -15.80463603
#> 118 NA NA NA NA -14.02889557
#> 119 NA NA NA NA -14.92280675
#> 120 NA NA NA NA -14.58029861
#> acinar__Tc neutrophil__Tc unknown__Tc stromal__Tc alpha__Tc
#> 1 -7.6201070 -82.1745211 0.6798694 -116.0640474 11.2026951
#> 2 -17.8143844 -45.7999271 -0.2599065 33.9827876 -148.9775098
#> 3 3.5354275 -128.4805048 -13.5356377 103.9261555 -62.1340830
#> 4 15.0599310 0.2965594 -47.9293854 -18.0186730 -70.0275092
#> 5 -2.6930610 -8.9633943 77.6982419 300.3531215 -170.0000000
#> 6 -24.9503536 11.7477079 -4.8387027 -75.4596015 74.5929950
#> 7 3.2647769 -0.7238378 -42.6782685 -42.7781485 85.2179784
#> 8 -17.7703831 63.3632300 67.4552148 -43.7815933 -153.3801384
#> 9 11.1934831 35.6659093 -8.8393681 -170.0000000 -124.5636552
#> 10 -5.0288255 2.7767649 81.8071752 -34.3760156 -86.2222152
#> 11 -4.6250277 20.7473787 23.9806289 32.0354109 -78.6854819
#> 12 7.5242977 -75.8257314 92.6876038 65.1705489 -55.4424734
#> 13 -3.0608554 -10.9782102 12.9539432 44.9836865 -73.9016598
#> 14 -2.4138075 18.8465311 38.5245310 -10.5481103 -21.6256672
#> 15 -3.8272774 -5.0995919 40.0412925 17.8488097 -63.4553107
#> 16 -3.4713893 3.0820926 -5.8760617 -7.6827298 -73.8339435
#> 17 3.7475321 14.0216955 27.1347879 36.6318514 -59.6678401
#> 18 5.4041274 31.2963593 -3.1501262 -29.4964788 -64.2458758
#> 19 -3.8427735 3.4013165 -13.1798984 3.3952886 -4.4121178
#> 20 -2.2812963 -15.4642071 -1.6582644 -5.4544434 -34.3771310
#> 21 -0.1578146 NA -61.6435635 29.3349345 -80.4713406
#> 22 -5.4648743 NA 4.3939628 -20.8897693 12.2861578
#> 23 -0.1645194 NA 22.2381646 -67.6178482 -61.7890782
#> 24 -6.7497642 NA 18.9378143 32.6532335 20.4591918
#> 25 -10.7992381 100.5685036 36.7224799 24.3236791 -43.2558392
#> 26 9.0598588 NA 33.1121607 75.9729334 -94.1761062
#> 27 -3.6112430 71.9107288 6.7664642 7.5610412 -20.9319040
#> 28 -1.2246998 NA 22.1936940 -25.9456864 -49.4013482
#> 29 -5.7420188 -26.8791592 0.2373080 15.4140812 16.2611469
#> 30 -6.6742225 NA 26.7421685 -5.7792742 -38.6573805
#> 31 5.7866346 -1.3355756 17.5879583 8.9822190 -38.9141929
#> 32 -6.2659985 18.1536823 28.2519187 15.2136624 -38.2470869
#> 33 -1.4071952 17.8210452 9.1584841 -1.4819575 -19.9968250
#> 34 -2.7103414 7.3636940 3.0865393 17.0183585 -37.0498604
#> 35 -4.1420497 19.2856387 -9.3822173 -24.3864622 25.2900665
#> 36 -8.8872106 14.6918731 -8.3091523 14.1696433 25.7523121
#> 37 -4.1428237 42.4535312 15.1208717 -7.1475879 -62.2929054
#> 38 -2.5914060 20.3536343 2.6177904 25.8740423 -52.8361918
#> 39 -1.4246237 -7.4750486 7.3331048 25.5411539 -33.1367792
#> 40 -2.6743164 -5.0926088 -4.4444098 3.1021025 -75.7019892
#> 41 -8.9354045 -170.0000000 2.4707900 7.0401613 7.5609602
#> 42 -12.3580744 7.1962125 11.8646909 11.5781697 19.7074810
#> 43 -9.2236432 37.1845230 21.2645127 2.2679003 -17.6009729
#> 44 0.6486624 15.3260947 14.7976578 0.8315970 -13.6225390
#> 45 -4.0927189 34.7043907 -0.8371728 -5.4682135 -81.7878083
#> 46 -1.8257118 -1.4516961 -1.0477951 5.7504318 21.1254990
#> 47 -10.1664617 -10.0631949 13.1906077 -3.1058844 24.2043267
#> 48 -3.9725246 -1.9708987 7.0140382 -0.9629725 10.9973769
#> 49 -20.3798284 NA -4.4542341 11.1677587 48.1088568
#> 50 -10.5549937 -39.5016488 13.5949342 1.3169742 -67.6073207
#> 51 6.4712611 11.1278703 -40.0015045 21.1431486 -46.5382477
#> 52 -22.3317132 24.7555886 17.9679610 31.0116602 -76.8144017
#> 53 3.3203864 -19.3739545 -32.2851840 -35.7260502 37.4761185
#> 54 -8.7988606 -93.1743927 24.9762292 52.4353122 -170.0000000
#> 55 -3.6434784 22.9671555 43.0917123 37.3692677 -56.5357616
#> 56 -3.0806603 -32.7829314 17.4486966 51.3945028 -32.7574185
#> 57 -11.3536150 -129.8918061 47.0070273 54.0577411 -74.9775108
#> 58 -39.9152450 -13.2294129 47.7459748 -81.7692417 -74.8264240
#> 59 5.6320534 82.8609809 -30.3406076 23.0615136 -135.4782772
#> 60 -13.6264193 -28.2723411 21.0510911 10.6264904 -112.8160504
#> 61 -14.1756721 96.4893908 71.3888749 74.9663002 -49.7034804
#> 62 -7.3860072 42.9255672 13.4583451 -3.4703217 -50.4506825
#> 63 -26.1988571 95.8578692 77.1644123 31.7071666 -29.4938096
#> 64 -29.4922632 181.0527759 84.8087819 18.3310892 -41.4856544
#> 65 12.7008663 -170.0000000 -118.8951272 -3.0142444 -141.1091581
#> 66 -88.3335911 7.4623534 20.1583538 27.2669713 37.5364189
#> 67 6.8150379 -14.1780065 5.9963364 55.4452910 -105.4641960
#> 68 NA NA NA NA NA
#> 69 -20.3410890 -170.0000000 -1.9393638 20.8917559 89.9128688
#> 70 2.5042948 -47.8984169 3.5602682 -51.8028568 -90.5512787
#> 71 10.8300640 40.5369573 0.5005715 16.3506611 -102.9999885
#> 72 -11.4346868 2.0335623 32.0353089 18.8326429 -52.0555422
#> 73 -6.4148603 -86.4458900 19.4163147 -23.6919489 39.7691392
#> 74 9.7552646 -8.3569511 26.1703419 37.3260366 -48.6602218
#> 75 1.0180146 -3.0113737 19.3695863 11.5189816 -25.2213898
#> 76 -6.1664114 35.9359806 8.2031931 -7.3146985 -15.2884634
#> 77 21.3642898 66.2099221 4.8085971 31.8705384 -66.4973579
#> 78 -10.6292440 50.6234033 -2.9109450 5.6476792 -75.8170401
#> 79 -5.1301264 23.4926462 8.1803699 37.0185828 -54.7049556
#> 80 -7.9132207 -28.0993684 14.0009592 26.6537283 27.5973960
#> 81 17.4188073 44.2773221 -7.1126501 19.3568451 -106.7178956
#> 82 2.1415254 13.8997683 6.4525466 8.5640219 -51.0189637
#> 83 -9.7521630 -4.4910785 4.4584469 2.9748326 79.6808465
#> 84 -8.8188658 3.2797781 9.0223152 -0.1130547 -26.8842464
#> 85 -0.3285796 -5.0654818 -5.1691352 5.6450155 -69.4961950
#> 86 -7.7741657 -8.3346741 31.0870712 30.4734140 61.7970348
#> 87 6.9880767 14.4672125 38.6543170 19.7611717 -170.0000000
#> 88 3.8898631 2.1835676 -7.0670401 15.8142825 -12.3423090
#> 89 -0.9200325 25.1534224 7.0026953 46.3065927 -37.5072410
#> 90 13.7086232 6.9740629 -62.7515199 20.3312194 -76.0400815
#> 91 NA NA NA NA NA
#> 92 -1.3850693 -170.0000000 -55.2947852 100.2965701 -56.4527289
#> 93 -7.4668375 NA 23.8996007 -19.5581595 17.8823578
#> 94 -3.6363839 143.8558253 -52.7018277 -170.0000000 -117.7414722
#> 95 -15.4255590 NA 28.4763481 -60.4183029 21.5175837
#> 96 -12.7336487 NA -75.8251705 -95.2365775 40.6840207
#> 97 -4.5413753 NA 110.6408103 -2.6015465 -21.0472847
#> 98 -9.5707004 NA 5.0114236 -71.8023916 66.0418313
#> 99 -13.4866489 NA 54.0197571 102.7979207 -144.1459700
#> 100 -74.9129461 NA 59.5795885 71.0055978 -30.7774319
#> 101 -11.8315514 -46.5615851 26.8956722 65.2576212 -9.1144113
#> 102 -4.1158206 1.0257363 8.2393033 19.5948387 -11.5469712
#> 103 -1.0609605 -5.2903733 -73.8541505 28.6192707 101.5353324
#> 104 -14.6673922 -14.7459765 17.3374753 -29.6666019 35.7230712
#> 105 -9.2098287 -6.2267503 9.1235763 26.9771279 -7.6839081
#> 106 -3.0615045 -110.6517608 19.7271237 20.2069087 -32.4190003
#> 107 -8.6377740 119.8183198 54.9329703 120.4448129 -155.2736353
#> 108 -5.6081496 3.1063522 16.0694122 58.5465166 64.4746210
#> 109 -10.5686761 -65.2822149 21.9274616 42.8668065 161.3301731
#> 110 -12.0848644 18.2539987 38.9373050 70.9616135 58.5269306
#> 111 -4.6830760 -54.5469699 23.0508709 -4.6388065 3.7457320
#> 112 -1.8590827 23.3241905 10.5020388 8.6493965 -60.9399513
#> 113 -3.6715314 NA -14.2292892 9.2428083 -112.9973951
#> 114 -2.2675451 39.0456796 13.7720145 -12.4984757 -0.4894242
#> 115 -2.3640595 -31.6056272 -3.1014896 19.5047097 -104.8040361
#> 116 -1.4383946 14.4219070 21.4818996 27.8511092 9.2888469
#> 117 -3.6325441 6.5296670 -6.1841229 32.8569222 -13.3884683
#> 118 6.4973964 -15.7675230 -35.8049802 30.4713398 35.2543181
#> 119 -4.6053895 35.4405263 6.2750180 12.2902112 -58.4325303
#> 120 -3.6952179 -38.1038876 -4.4599698 13.5515441 -39.7974135
#> endothelial__Tc macrophage__Tc delta__Tc Tc__Tc Th__Tc
#> 1 -84.7186229 38.0641619 -42.1493227 62.8101245 197.135629
#> 2 -28.1930005 32.1027309 -146.4757122 260.9506756 196.158281
#> 3 -112.2535739 -42.7527916 -114.3531475 -170.0000000 NA
#> 4 -29.5401899 26.3350690 -59.5678484 3.1683304 197.824456
#> 5 188.5112057 52.8329773 -170.0000000 290.5824139 -170.000000
#> 6 -12.3326499 23.6715106 73.7073486 -170.0000000 -170.000000
#> 7 24.7197003 -4.7130230 26.9964885 2.7337663 41.554794
#> 8 17.3817697 59.8680931 -170.0000000 -67.5892112 38.053673
#> 9 117.7532096 84.9083869 -107.0331991 -170.0000000 NA
#> 10 -63.9308653 -31.8780319 -45.9772449 178.7802201 -44.243064
#> 11 11.0708806 40.5278333 -84.3420828 84.4934683 71.058662
#> 12 -170.0000000 37.5722993 -61.1536028 -170.0000000 NA
#> 13 -48.4596159 26.1613602 -5.4804189 129.5596398 -5.343506
#> 14 -16.6846428 64.9731809 0.6295591 -13.6088275 -48.847406
#> 15 -21.2387572 -6.9211648 -66.1816740 12.5944204 79.079820
#> 16 -3.7479916 -6.0135239 -152.1601267 23.1202828 -31.741219
#> 17 4.9802664 17.8942507 -63.9058168 121.3455295 -18.685754
#> 18 -13.4969491 13.0938147 -36.7166145 67.5938573 -38.919719
#> 19 -18.3249139 14.0591501 -7.5509600 52.7481482 13.515493
#> 20 3.3515235 -0.2933883 -19.5171437 78.7921533 81.447620
#> 21 -40.4753677 NA -86.6497873 -170.0000000 NA
#> 22 7.9975012 NA 9.6531301 -21.4425430 -80.451898
#> 23 0.3762360 NA -58.4457210 -52.9058215 NA
#> 24 7.8137240 -34.1980572 25.3313381 1.3053315 90.660923
#> 25 18.7371697 NA -84.6731601 11.7649719 20.454419
#> 26 -6.9430248 -39.2868594 -84.0043134 54.6297789 46.852606
#> 27 45.2973845 85.1871311 -56.1589390 34.8915805 -170.000000
#> 28 -17.0456937 NA -61.0114754 7.1054046 NA
#> 29 14.0640088 -50.2746639 -2.3898860 -7.0462525 59.693886
#> 30 92.4748377 NA -59.2059033 13.6130231 NA
#> 31 -18.8340680 29.9530371 -41.6927107 54.3471637 2.951179
#> 32 1.7274863 -2.6970141 -69.7484118 91.0604253 65.631785
#> 33 -6.0608819 -3.1082984 -26.7996165 -1.3877066 -31.394023
#> 34 6.0449236 1.9584733 -38.5398612 -5.2746996 37.521605
#> 35 100.8138485 -2.4947477 40.5891780 88.2343882 82.676633
#> 36 26.9128131 12.3509695 -11.5719312 114.4589612 101.311501
#> 37 4.3678183 7.9662650 -77.8232055 52.5820924 27.245343
#> 38 0.7591905 10.5991350 -62.9418189 51.5951153 32.105695
#> 39 -22.2620935 9.0333851 -42.1467202 7.3309425 NA
#> 40 9.9077787 15.5126880 -136.7295900 58.1588038 202.703951
#> 41 -1.1332547 -9.7426695 -1.9682771 20.8076227 22.675551
#> 42 21.5710846 18.5311351 28.5732539 46.9075185 58.843870
#> 43 41.4569703 4.4037909 -2.6100752 27.4652361 46.826358
#> 44 -22.4060583 -8.6767187 -33.4308289 96.4737422 14.576611
#> 45 16.0121306 -3.4540307 -97.6750924 25.9329505 55.932325
#> 46 -4.5004896 7.8781648 22.2793274 50.6133533 23.112296
#> 47 -19.3222711 10.3351071 -58.4967636 71.3957091 51.654932
#> 48 35.3479625 6.7429662 -14.3967768 33.8985895 30.236715
#> 49 -7.4497148 62.7134198 45.6116458 35.9811633 -5.378230
#> 50 33.7761467 -18.5220958 -85.7595276 56.9763677 44.791794
#> 51 -90.2619688 -170.0000000 100.2558172 61.4874926 -170.000000
#> 52 34.5075893 83.5053260 -63.9974199 110.9799181 125.003901
#> 53 -5.6809311 -7.3737089 52.7155359 -35.2759692 43.017396
#> 54 44.8304481 -76.8192892 -113.8099172 142.9606494 120.846848
#> 55 -44.2659365 -25.9764011 -69.6824044 -170.0000000 NA
#> 56 26.0002107 227.8681584 -34.6425038 7.9320497 72.171204
#> 57 69.7537137 -22.0576437 -64.8558374 55.0857925 19.991316
#> 58 32.4898500 NA -74.5289122 103.3707068 54.610491
#> 59 -37.7941035 12.0652832 -99.3640110 -170.0000000 -170.000000
#> 60 52.1612690 -170.0000000 -116.2850325 95.3531701 168.162510
#> 61 -15.4559127 -4.1757838 -76.8770454 183.7471150 22.095759
#> 62 -7.5526978 -57.7830342 -65.5973382 79.7743928 -61.878134
#> 63 72.4720510 88.2939323 -13.5717974 165.1165368 144.396759
#> 64 35.6889735 127.9956020 -37.1664745 135.4003531 132.533762
#> 65 13.1616221 -170.0000000 -91.2095309 -170.0000000 -170.000000
#> 66 30.4850231 63.9836475 22.9445666 7.7723243 38.905161
#> 67 4.6415586 -28.7840786 -30.7718341 29.0849741 -170.000000
#> 68 NA NA NA NA NA
#> 69 26.1010043 -170.0000000 111.0303854 -93.2069373 NA
#> 70 7.4587786 4.8871485 -93.5381733 -170.0000000 NA
#> 71 -7.3584928 25.9166961 -83.5856069 68.7971067 NA
#> 72 41.9756445 45.6430889 -45.8137092 90.7663868 51.319801
#> 73 18.0445759 -14.5858551 2.2090783 -9.4088197 -47.666244
#> 74 -28.2234806 70.9296569 -69.5295941 59.7068844 64.591385
#> 75 -11.8426858 67.6658614 -63.0952877 81.4814955 NA
#> 76 4.9733411 33.2190311 12.4295408 -4.9501837 72.341966
#> 77 -2.0171607 39.7604414 -82.2810902 72.5061390 50.083563
#> 78 -4.4517034 43.7005346 -100.5557532 65.6321253 91.761604
#> 79 7.9739976 -37.7027381 45.6138331 105.6324389 -170.000000
#> 80 6.8670534 29.8504882 6.6327598 -6.6981704 -75.665889
#> 81 18.6632556 41.0138180 -102.9795698 22.5092684 80.508851
#> 82 -0.6850497 14.0977190 -68.3505329 -18.1687894 -12.595352
#> 83 19.7520058 -4.4487130 68.8238233 29.9643656 47.578771
#> 84 49.9077268 -2.3266603 -60.7539472 50.3621846 27.872753
#> 85 -4.0187302 31.0072344 -97.9757709 46.4212018 35.600458
#> 86 18.2552854 -48.2442169 4.0240459 -3.8901590 -45.086682
#> 87 36.4005779 -41.8240561 -170.0000000 106.8056146 -86.893743
#> 88 -0.2135335 9.7446322 0.9064261 20.6044438 25.999507
#> 89 22.9927948 35.8004982 36.0413329 26.9995467 -35.803103
#> 90 -11.1364207 47.4902106 -82.7070441 -170.0000000 67.202275
#> 91 NA NA NA NA NA
#> 92 34.5767965 -170.0000000 -59.6518874 -170.0000000 NA
#> 93 46.5097657 169.0125152 -107.6952579 155.9960318 254.436751
#> 94 -83.4640096 -11.1492417 -127.2007313 379.7835819 -170.000000
#> 95 28.0340398 -170.0000000 63.9301831 -170.0000000 NA
#> 96 58.1014675 -170.0000000 -2.8239050 -51.7886496 115.387445
#> 97 43.1022556 65.5997468 -36.2745895 97.2251070 -88.739816
#> 98 17.4011471 NA 30.9773586 132.1913921 246.084978
#> 99 9.6263661 224.8399987 -170.0000000 89.2916241 NA
#> 100 14.4682494 -170.0000000 57.3495017 -170.0000000 NA
#> 101 -34.5521088 39.4153060 -75.0715317 42.6427576 57.684953
#> 102 1.9262022 3.3131308 22.5780436 20.7581566 36.101090
#> 103 41.9420882 NA 95.5062909 34.6302718 42.944151
#> 104 14.9392016 NA 12.8637796 -44.6070865 22.895038
#> 105 6.7031586 12.2498148 10.3591320 -0.4318282 45.994270
#> 106 -4.7684893 -27.5132325 -45.4134034 -16.2929914 16.921306
#> 107 -1.6925311 NA -170.0000000 188.4568285 -170.000000
#> 108 26.2732723 NA 79.9907397 27.5812811 54.367435
#> 109 38.9153141 -100.2673110 156.4373886 135.2422789 160.891583
#> 110 33.4713010 78.4878726 53.2335256 53.1272577 51.675792
#> 111 -5.3495470 12.7266594 -14.2029774 -5.9697420 8.615098
#> 112 4.7399261 6.0387472 -40.3165709 51.9713215 22.982054
#> 113 1.0741036 -47.6544633 -134.9338498 -170.0000000 -24.927525
#> 114 27.9791731 9.9696946 -25.6829191 -1.7681512 0.385168
#> 115 31.6458693 8.3622016 -109.7839974 55.4614368 60.685247
#> 116 -1.2220747 24.8916759 12.1698186 77.6287018 40.541277
#> 117 22.1193994 18.2506598 -12.9339581 -6.9530552 67.240579
#> 118 39.3453674 68.4431159 -13.0169879 41.1705940 -114.188306
#> 119 29.3515264 7.4846360 -82.8867520 18.4961756 75.763675
#> 120 2.4787369 -12.6400036 -63.1613768 -21.8441333 103.900911
#> otherimmune__Tc gamma__Tc B__Tc naiveTc__Tc beta__Tc
#> 1 28.7323113 NA NA NA NA
#> 2 -170.0000000 -170.000000 NA NA NA
#> 3 -90.5243355 NA NA NA NA
#> 4 -64.5311364 NA NA NA NA
#> 5 150.6871681 NA NA NA NA
#> 6 28.6409552 NA 29.159592 NA NA
#> 7 -57.9080769 NA NA NA NA
#> 8 263.6375704 -87.278786 NA NA NA
#> 9 NA -170.000000 NA -170.000000 NA
#> 10 56.5566628 NA NA NA NA
#> 11 64.8655401 NA NA NA -64.413981
#> 12 322.4869885 36.521518 NA NA -60.211192
#> 13 225.0745632 NA NA NA -65.947128
#> 14 -71.5625550 NA NA NA -71.121096
#> 15 80.1222457 NA NA NA -89.605268
#> 16 42.5503629 NA NA 25.266669 -45.029929
#> 17 76.8677313 NA NA -170.000000 -87.631080
#> 18 89.5210717 NA NA NA -48.533085
#> 19 49.3265270 NA NA NA -20.920879
#> 20 54.5095460 NA NA NA -65.999522
#> 21 NA NA NA NA -98.280805
#> 22 55.1554954 NA NA NA 10.688559
#> 23 123.5954803 NA NA NA -59.932885
#> 24 93.2164173 NA NA NA 1.857466
#> 25 62.2685854 NA NA NA -48.582528
#> 26 62.0793995 NA NA NA -95.285327
#> 27 37.8312538 NA NA NA -29.186069
#> 28 NA NA NA NA -25.736326
#> 29 -53.7297856 -51.101696 NA -170.000000 -3.667591
#> 30 149.1227028 NA NA NA -72.498392
#> 31 34.7947120 NA NA NA NA
#> 32 82.7407844 NA NA 221.464992 NA
#> 33 23.6724886 24.244458 NA -8.338827 NA
#> 34 58.6198495 NA NA NA NA
#> 35 85.6697817 -50.678107 NA -71.997831 NA
#> 36 54.1201030 NA NA -50.490428 NA
#> 37 28.0163231 -78.512303 NA NA NA
#> 38 16.7710811 -72.559270 NA 46.635476 NA
#> 39 14.2875425 NA NA NA NA
#> 40 29.4658207 NA NA 102.585873 NA
#> 41 16.0271977 NA -59.599021 111.901134 16.408399
#> 42 17.3778920 NA 9.135435 148.581508 NA
#> 43 24.8370494 NA 70.821315 25.038055 1.702759
#> 44 14.8594295 -71.704722 -20.563657 -44.871450 NA
#> 45 36.3163628 -35.281099 74.983468 28.957874 NA
#> 46 8.8553927 NA -44.169352 -15.050702 44.728788
#> 47 49.6633505 NA -43.665535 -36.903629 17.291986
#> 48 -24.4788284 NA 56.458402 86.224257 24.865258
#> 49 5.5139461 NA 53.962910 84.544607 39.111305
#> 50 43.5319382 NA 83.001785 117.997712 NA
#> 51 59.4469833 NA NA NA NA
#> 52 69.9242694 -77.588696 57.857726 172.599717 NA
#> 53 -100.2736898 NA NA -170.000000 NA
#> 54 230.9356924 -6.103126 -170.000000 -38.222575 NA
#> 55 33.1002293 -170.000000 NA NA NA
#> 56 29.7926774 NA NA NA NA
#> 57 156.0776544 NA NA NA NA
#> 58 59.0146677 NA NA -80.083623 NA
#> 59 12.3516375 -170.000000 NA NA NA
#> 60 60.0446935 -45.828040 -170.000000 NA NA
#> 61 86.2873120 NA NA NA -95.570326
#> 62 -33.5506723 NA NA NA -71.026921
#> 63 270.9019625 NA NA NA -47.976669
#> 64 78.7514051 NA NA NA -42.820645
#> 65 12.8275893 NA NA NA -135.609444
#> 66 37.6868494 NA NA NA NA
#> 67 71.3634369 -170.000000 NA NA -36.519225
#> 68 NA NA NA NA NA
#> 69 27.0828615 NA NA NA 89.153977
#> 70 -106.8749916 NA NA NA -48.831386
#> 71 25.2423582 -170.000000 NA NA NA
#> 72 27.4546605 -170.000000 114.475655 138.468246 NA
#> 73 44.9843649 25.782736 NA NA 70.071951
#> 74 73.2825104 NA NA 40.201631 -55.870084
#> 75 9.7724677 24.834369 NA -120.508775 -107.284787
#> 76 -0.2090650 NA NA -44.334124 NA
#> 77 54.8885069 NA NA 104.407919 -85.768703
#> 78 76.5100963 -14.860077 NA -94.434921 -93.364271
#> 79 30.4411695 NA NA -108.341796 36.486489
#> 80 7.1301678 -36.050393 NA NA NA
#> 81 88.7145766 -170.000000 NA -17.338319 NA
#> 82 -2.4666402 NA NA 36.195991 -64.950193
#> 83 -30.0360537 NA NA NA 86.989948
#> 84 46.2973765 -65.065036 57.003729 33.519866 NA
#> 85 23.8169544 -105.523437 NA -24.458188 -50.893350
#> 86 -71.8720401 NA NA NA 29.234291
#> 87 -26.3280280 -170.000000 NA -170.000000 -138.998103
#> 88 11.4387580 -5.271427 -69.686778 -70.375077 NA
#> 89 12.6634296 NA NA NA 6.837306
#> 90 4.7667926 NA NA NA -88.437222
#> 91 NA NA NA NA NA
#> 92 271.3924506 NA NA NA -1.491286
#> 93 58.9434474 NA NA -170.000000 -76.574776
#> 94 241.3387736 NA NA NA -131.835547
#> 95 -170.0000000 NA NA NA 11.582609
#> 96 10.3310692 NA NA NA 126.202061
#> 97 116.0173508 NA NA NA -8.893719
#> 98 27.7683227 NA NA NA 91.551386
#> 99 -170.0000000 NA NA NA -108.181687
#> 100 79.8735465 NA NA NA 69.958780
#> 101 0.1639615 NA NA NA -20.994280
#> 102 20.9121292 NA NA 22.500427 -13.862581
#> 103 -170.0000000 NA NA NA 52.346538
#> 104 10.7036259 NA NA NA NA
#> 105 12.1092547 NA NA 75.864127 -3.839863
#> 106 26.5183682 NA NA NA NA
#> 107 171.0981026 -170.000000 NA -170.000000 -170.000000
#> 108 70.7449219 97.967738 NA 45.481005 66.802771
#> 109 116.0659110 NA 193.830969 191.977005 170.077576
#> 110 77.5198981 NA 101.490405 103.062698 57.911305
#> 111 15.7656835 NA NA NA NA
#> 112 23.7733994 -4.578062 NA NA NA
#> 113 -39.0565847 NA NA NA 16.259148
#> 114 15.4927098 NA NA NA NA
#> 115 -23.5759640 NA NA NA NA
#> 116 87.8313975 -150.069862 NA 71.412158 NA
#> 117 35.6592806 NA 24.408605 NA NA
#> 118 15.4636678 NA NA NA NA
#> 119 58.0505311 NA NA NA NA
#> 120 NA NA NA NA NA
#> ductal__Th acinar__Th neutrophil__Th unknown__Th stromal__Th
#> 1 -0.827142906 -13.04418554 -170.000000 -1.6410500 -89.1896243
#> 2 -19.482200023 -10.43149645 54.160228 10.8483572 83.1202412
#> 3 NA NA NA NA NA
#> 4 -21.310289535 -6.90182777 4.616419 5.1685084 41.6529657
#> 5 43.454524278 -33.16373749 83.515938 32.0207246 -170.0000000
#> 6 -37.659989295 -3.30890827 -64.880880 -15.0407622 -27.6310607
#> 7 15.769558740 0.29440577 2.309669 -0.1574890 92.3792212
#> 8 12.805773460 -9.77719339 51.068000 111.1027378 19.5223260
#> 9 NA NA NA NA NA
#> 10 -27.850341311 -11.91856347 4.445354 -17.3055481 -101.8956465
#> 11 -14.623101921 1.42097941 -15.495280 17.9244054 45.7760614
#> 12 NA NA NA NA NA
#> 13 -9.972702398 -15.24905226 -36.106763 0.4669115 -14.3003206
#> 14 -5.834150521 11.86639830 -57.244861 -4.5543520 2.8813406
#> 15 -7.018907132 -8.77564474 -36.591655 13.3169862 -7.8085925
#> 16 -14.709007680 -2.38929986 -10.105034 -2.0095764 1.6476651
#> 17 4.071392218 7.29556192 -3.320972 21.9578449 17.9105705
#> 18 10.839716093 -6.95452738 -17.257519 -6.0731924 31.5188443
#> 19 -10.305986415 -3.06223688 6.140569 21.2684205 13.3959046
#> 20 -8.006488763 -6.04943466 -13.903595 6.6508652 20.4571387
#> 21 NA NA NA NA NA
#> 22 -6.595657531 18.05676737 NA -38.7222428 30.8237092
#> 23 NA NA NA NA NA
#> 24 25.138545905 -23.32508069 NA 56.2455432 51.8794188
#> 25 -0.172203438 -27.26315819 -170.000000 18.4898921 -39.4365173
#> 26 -30.015780257 -37.75800231 NA 126.3986198 47.7958787
#> 27 -33.070863674 -6.86774349 -170.000000 -9.3926076 -98.2271671
#> 28 NA NA NA NA NA
#> 29 28.913094188 1.10104732 -170.000000 21.3723310 64.3301350
#> 30 NA NA NA NA NA
#> 31 -7.569789944 3.59813693 21.803453 2.4088209 19.6049327
#> 32 -31.815456725 5.64840602 20.260053 6.3546358 -3.5943356
#> 33 -14.315481709 -15.12758457 -33.552190 -21.4491904 -34.7588644
#> 34 -0.359094678 -0.35076048 -28.372106 -13.7019368 24.6077595
#> 35 -34.971035576 -20.11803536 17.215187 -7.2499892 -15.2343696
#> 36 -12.203586314 -8.98044642 22.516245 -1.7678488 -9.7339103
#> 37 -11.564628495 3.58778282 55.093042 20.1975147 51.0421049
#> 38 2.657029573 -10.46267254 11.758633 3.0381620 17.5859393
#> 39 NA NA NA NA NA
#> 40 18.428060138 -53.41732092 -86.455152 -120.4837538 -31.0150588
#> 41 -9.835330116 1.22197825 -170.000000 15.7191337 3.2314871
#> 42 -11.568387318 -8.58448428 -5.386738 17.6149113 18.6709118
#> 43 -30.687414252 -20.15525377 70.939581 47.2676264 -2.5933739
#> 44 -20.212330137 -11.28797508 -14.919008 19.5398713 3.0188011
#> 45 -18.126255404 -8.90480360 68.074332 -0.1423453 -17.0055391
#> 46 -16.866048426 -12.34637880 29.058874 42.1062776 20.9300421
#> 47 -1.055811373 -5.64430266 -41.423704 2.3050402 4.5861223
#> 48 6.242475069 3.74525733 -43.362723 6.3378923 4.9573411
#> 49 -7.152441143 0.35728360 NA 5.6352818 -8.0191352
#> 50 -14.158499151 -9.30523803 64.050865 -9.8709863 -2.7819946
#> 51 -39.016073481 -30.96642563 -170.000000 65.5094407 -121.6689969
#> 52 -14.877307797 -24.05669587 27.754349 16.7068080 21.3196418
#> 53 -8.893717301 4.19993650 -170.000000 -80.9091069 -62.6434617
#> 54 -11.165670923 5.49159534 -170.000000 -0.1000049 144.9163322
#> 55 NA NA NA NA NA
#> 56 -25.630160019 -28.90055534 -1.870017 36.3809130 90.8207140
#> 57 -7.767201745 -8.05244000 -170.000000 60.1808812 20.2717974
#> 58 7.135281808 -0.53696176 -170.000000 62.0879673 66.5032335
#> 59 -12.060593450 -11.96035995 -116.409242 54.7322621 -69.6896622
#> 60 -59.993033128 -45.27627539 -55.632101 54.0485580 105.8757883
#> 61 -29.633523127 11.29219925 1.927094 -2.3445526 -25.3654156
#> 62 -8.709246881 -14.43255027 66.555249 49.7310909 14.3847117
#> 63 -12.545683709 -18.42515063 50.812329 37.9137014 7.6137096
#> 64 -34.533998448 -20.94546700 150.562885 102.2121586 -23.0305116
#> 65 27.713414300 23.49637506 -170.000000 -3.7157957 -170.0000000
#> 66 -80.123701008 -92.49995094 56.895640 13.2055303 48.6889757
#> 67 -10.742659769 -1.43117846 -73.374949 -3.4559918 -56.3653210
#> 68 -22.009011053 -28.45768506 -170.000000 -54.8930956 -13.7846292
#> 69 NA NA NA NA NA
#> 70 NA NA NA NA NA
#> 71 NA NA NA NA NA
#> 72 -22.845988046 -11.24729269 -32.382653 50.7846120 43.9434164
#> 73 -4.212862359 -21.03270239 64.267969 77.3288065 24.2385314
#> 74 0.511630216 -21.31711113 -39.848100 -2.5426960 10.7256868
#> 75 NA NA NA NA NA
#> 76 -30.698740685 -9.20287712 31.092254 23.8211860 -1.7839970
#> 77 -18.602796175 24.29020755 63.401283 -38.6715820 -7.2511642
#> 78 -22.387826894 -27.43618345 48.891635 78.4273223 -11.3553390
#> 79 -9.876148396 26.76754252 -170.000000 -0.7720908 2.1302458
#> 80 2.427202605 13.33470652 -23.932217 -58.5048898 34.7427159
#> 81 7.690691941 6.22040683 32.940788 -7.6601880 19.8358452
#> 82 -4.511943019 -4.74963049 -9.331897 2.4015984 -14.6202257
#> 83 -19.736766038 -18.04344576 -5.611590 -4.0695144 2.6572362
#> 84 -11.652224933 -8.27881992 13.382332 18.9414267 12.0406839
#> 85 -3.543016053 -4.49660940 -16.645505 21.4151129 -11.1778319
#> 86 3.359799865 4.22024524 -60.031254 -28.4373629 6.4616053
#> 87 -10.510109754 -9.47772303 6.099788 -21.6977443 0.2201385
#> 88 -34.841543515 -18.11106984 17.820254 27.5159094 32.5404611
#> 89 -11.995856832 3.64365221 55.445975 -13.6834023 27.1821899
#> 90 -10.526913745 10.46582785 30.567174 -55.6032215 22.4583190
#> 91 NA NA NA NA NA
#> 92 NA NA NA NA NA
#> 93 -6.450230052 -13.59668301 NA 68.7072645 -7.2014798
#> 94 -8.568595532 -16.18063034 -24.198825 97.0447327 164.4767489
#> 95 NA NA NA NA NA
#> 96 -34.971187624 4.33941491 NA -87.5701277 -64.2685539
#> 97 0.941332931 6.08774973 NA -37.2816146 -170.0000000
#> 98 1.621293782 0.97537965 NA 12.0161189 -19.3659963
#> 99 NA NA NA NA NA
#> 100 NA NA NA NA NA
#> 101 -11.290564135 -29.60476298 -48.388310 2.1611500 101.9245527
#> 102 -27.396836272 -31.97263242 16.314605 27.7157761 67.1873478
#> 103 -31.506592126 -7.72571293 -170.000000 64.2580049 -1.1364341
#> 104 -27.420814712 -3.31527719 -96.780731 -32.1998953 105.0895050
#> 105 -25.992524187 -14.20043599 -22.208376 32.5001474 78.7186496
#> 106 -19.914166943 -13.29483340 -24.627097 3.4350273 94.4259389
#> 107 -61.447546802 -48.56624059 46.257958 34.9466697 -46.7526459
#> 108 -33.439028584 -19.20759344 100.975813 25.3958566 106.2382490
#> 109 -25.417931519 -18.21879903 -41.429443 19.8746879 29.8798569
#> 110 -5.682196914 -12.69026219 1.862219 26.6387834 73.0079272
#> 111 -0.008824294 0.03241769 63.960541 19.2257647 -28.9508341
#> 112 -4.698412889 -16.32161963 79.324190 76.2007249 34.4561756
#> 113 -19.208124447 10.04780427 NA -10.7490548 -17.5351858
#> 114 -2.060876887 -7.83448575 -35.864373 9.1571039 65.9763047
#> 115 -2.917841917 -13.87292161 -33.906836 -24.9592129 12.5822014
#> 116 -19.920621942 2.37966496 2.362722 34.2628823 -1.0992300
#> 117 0.439659680 -9.18802876 -1.678726 -8.7860012 88.2443283
#> 118 -36.995381621 -18.19943373 -121.766610 3.4079055 18.3212861
#> 119 -36.244489508 -15.93977763 105.502679 2.7603960 4.5451756
#> 120 -10.410239871 15.35480336 -117.678221 -19.4949104 6.2044464
#> alpha__Th endothelial__Th macrophage__Th delta__Th Tc__Th
#> 1 -24.8961260 73.1436717 34.7207286 69.660358 159.2432355
#> 2 -122.8046266 -51.2502760 1.9732936 -112.377498 160.5145810
#> 3 NA NA NA NA NA
#> 4 -120.6424078 -35.9762140 10.3214585 -96.280685 212.4033564
#> 5 -170.0000000 5.4588940 90.4889874 -170.000000 -170.0000000
#> 6 -134.1585981 -16.6432126 -48.5234956 -170.000000 -170.0000000
#> 7 -170.0000000 13.2118262 -10.0746388 -170.000000 41.5547944
#> 8 -77.5575191 41.7201225 -10.6260675 -119.864239 84.6902427
#> 9 NA NA NA NA NA
#> 10 52.4392299 -65.4497943 -46.0657612 67.027186 -55.5155551
#> 11 -58.8010536 0.8201445 -17.1765249 -16.515536 77.5021920
#> 12 NA NA NA NA NA
#> 13 25.3541606 15.6356504 -57.7185068 19.174033 4.9312011
#> 14 38.3931259 -5.9903597 -49.2844572 36.088237 -29.1715033
#> 15 -99.1641706 2.7358451 -43.9530479 -170.000000 79.0323177
#> 16 -39.5316956 -36.7033608 -29.7994571 -139.100433 -37.5329911
#> 17 -85.5524835 66.9319494 21.1916785 -88.459642 -16.2815947
#> 18 -114.4967789 -58.3703333 -1.1794668 -126.694854 -31.2888388
#> 19 -62.2624189 -22.3288627 21.6373133 -90.633676 11.8745982
#> 20 -27.2359280 10.1287105 11.3578820 -28.621278 84.9534835
#> 21 NA NA NA NA NA
#> 22 -101.4258106 -56.3209008 NA -90.323992 -80.4518975
#> 23 NA NA NA NA NA
#> 24 78.8490734 56.3728108 -170.0000000 96.129336 93.3137072
#> 25 219.1182539 34.5031518 NA -25.394435 20.4544193
#> 26 -147.5420288 49.8379196 468.7525809 -170.000000 53.0144199
#> 27 69.0284933 13.6622944 -170.0000000 253.315736 -170.0000000
#> 28 NA NA NA NA NA
#> 29 -6.0817639 46.3517551 -170.0000000 -67.779923 60.1695193
#> 30 NA NA NA NA NA
#> 31 -86.4762420 33.2033091 48.3033474 -94.032996 -0.8834982
#> 32 -15.3454246 -3.1197910 6.3752585 -56.995358 67.8800134
#> 33 -24.1233926 -54.1856181 -25.6701394 -32.143406 -33.9041782
#> 34 -131.0445067 -40.9327921 -37.0604346 -170.000000 30.3004464
#> 35 -3.0982014 115.0223597 1.6970563 -17.311254 75.7885726
#> 36 92.4184693 49.1821011 -22.9235127 30.511149 102.5474173
#> 37 -134.6066478 3.6237246 36.9664355 -170.000000 32.4459866
#> 38 -77.4231755 -0.1658479 41.4926216 -79.136051 24.4357219
#> 39 NA NA NA NA NA
#> 40 -148.2702602 -89.8036028 -9.8502486 -170.000000 81.4279577
#> 41 40.1435770 -7.3677225 -72.9958514 12.846355 23.2831952
#> 42 9.1568146 33.0360713 1.8036283 30.795194 61.0070531
#> 43 -18.2814594 100.6890760 -43.4768249 -41.883181 47.8748697
#> 44 -41.0676554 10.4933132 5.2913285 -22.899236 5.9706488
#> 45 -69.5352612 32.9224644 -35.8622578 -85.773654 60.9623877
#> 46 0.1890537 12.7903357 16.8273660 16.513750 22.4752142
#> 47 8.0324902 0.1534564 17.6625048 -59.102880 52.6721069
#> 48 -4.0431678 1.0137889 -170.0000000 -51.653687 30.0742971
#> 49 28.4252463 -0.3090178 -14.2559562 42.116087 -8.5380974
#> 50 -67.9482104 -5.5723572 -11.0237607 -95.600634 37.4318727
#> 51 -154.1736309 3.8545795 -92.4669423 -170.000000 -170.0000000
#> 52 -91.9981739 18.5972881 42.6800191 -65.882225 121.4995833
#> 53 32.1558618 -87.0342813 -170.0000000 -27.988402 43.0173964
#> 54 -73.5488010 -23.0213807 -170.0000000 33.297629 120.8468483
#> 55 NA NA NA NA NA
#> 56 -68.0433487 22.7506711 139.7613190 -87.757009 45.9336084
#> 57 -58.1350242 92.8262015 -170.0000000 -170.000000 34.1033949
#> 58 -53.1445139 -39.4581525 NA -83.972521 68.4608890
#> 59 129.8073319 24.9127324 -40.7070775 8.593568 -170.0000000
#> 60 -170.0000000 54.0280262 -170.0000000 -170.000000 170.0719534
#> 61 -67.5410276 -62.6464382 -170.0000000 -32.183023 24.0090092
#> 62 -170.0000000 -127.2422615 245.6527239 -170.000000 -70.8083155
#> 63 -64.5371043 -3.1361636 -66.6525027 -64.855994 148.9968773
#> 64 -146.7368845 40.1021229 86.1813013 -170.000000 129.3283920
#> 65 -33.7247295 -7.7116115 39.3721150 -100.430438 -170.0000000
#> 66 -99.8068252 38.7340847 37.8955712 -104.668238 39.8201453
#> 67 -170.0000000 3.1072959 -170.0000000 -170.000000 -170.0000000
#> 68 -56.6441103 101.9846351 -170.0000000 -58.229585 NA
#> 69 NA NA NA NA NA
#> 70 NA NA NA NA NA
#> 71 NA NA NA NA NA
#> 72 -29.4192556 63.2049298 -17.9708200 -47.654054 54.0360667
#> 73 63.3948913 -42.8932111 -45.6625012 26.252977 -47.6662443
#> 74 24.3046174 1.1478777 153.4489212 -15.706259 61.3897942
#> 75 NA NA NA NA NA
#> 76 -83.3621129 42.3986970 19.1786508 -19.258723 78.3683570
#> 77 -126.1639486 99.1876605 -52.8117942 -170.000000 41.4822786
#> 78 -61.6294869 108.0964273 -10.6142880 -83.739417 105.5353429
#> 79 -170.0000000 -3.3118999 32.9547517 -170.000000 -170.0000000
#> 80 -148.9001719 -0.3404185 -50.5203388 -141.766481 -34.2436686
#> 81 -103.4443504 -3.8462956 37.6975711 -118.798707 73.2165878
#> 82 -9.3857277 8.0423648 2.1037404 -13.498702 -15.6834447
#> 83 143.2892556 69.4795611 -21.7675917 188.965426 45.4201007
#> 84 -32.9335628 25.3434182 21.1106184 -44.851281 32.9623230
#> 85 -11.9474011 -7.8732320 2.8150835 -58.621000 36.1173382
#> 86 -47.8320440 3.2327231 -27.8055581 -18.240779 -49.0163171
#> 87 -1.7261501 -27.3850661 7.4979054 -28.616534 -101.9492669
#> 88 -95.3427005 25.3767142 1.9470238 -94.195658 13.0959637
#> 89 -170.0000000 -47.0422647 -38.4883833 -86.199834 -52.1268788
#> 90 -96.0809483 12.7283926 23.1508871 -90.312798 68.4322643
#> 91 NA NA NA NA NA
#> 92 NA NA NA NA NA
#> 93 74.2106901 97.9369541 445.3865780 -42.170170 252.5721888
#> 94 -87.7184295 40.6717945 112.7602149 -135.140189 -170.0000000
#> 95 NA NA NA NA NA
#> 96 -170.0000000 35.0283933 -170.0000000 -20.473155 115.3874454
#> 97 -99.0468356 -61.6991452 -170.0000000 -111.972817 -102.5085177
#> 98 12.8073636 49.7372173 NA -11.329213 246.5234177
#> 99 NA NA NA NA NA
#> 100 NA NA NA NA NA
#> 101 23.0795823 -27.9568457 103.2936102 -55.910180 51.4828485
#> 102 39.2338943 35.1222572 86.1964504 51.024528 37.6498605
#> 103 144.9336691 62.8896348 NA 136.064831 46.6175973
#> 104 116.1853463 23.4324000 NA 39.367452 25.1321629
#> 105 -25.1896192 -4.1806215 -71.2887302 21.233792 42.5220846
#> 106 -72.3639834 -4.7300641 -96.7724028 -85.825409 2.3054588
#> 107 223.0527952 -45.1434098 NA 83.361957 -170.0000000
#> 108 120.5920885 77.2671885 NA 131.983193 54.3419810
#> 109 189.9264082 62.1398404 -46.5320827 152.518925 160.3367327
#> 110 103.3479399 57.9095551 -170.0000000 83.184406 53.9338701
#> 111 -32.4908709 -16.7593876 -29.1283315 -35.138930 13.8408484
#> 112 -136.4771785 46.9575282 65.9954068 -82.406820 26.3832586
#> 113 -103.4748622 -89.5602700 -170.0000000 -117.658302 2.2199441
#> 114 -87.9288407 -27.0799443 0.2655534 -117.021727 -9.2273746
#> 115 -114.3743214 59.9562042 21.5957276 -141.964830 39.0908665
#> 116 -39.0070835 27.3431120 5.0158099 -38.840323 39.6921039
#> 117 -90.8912338 24.0523338 -45.7652025 -66.949569 66.2623308
#> 118 58.7523180 -43.8307346 -62.9864822 -5.167382 -114.1883061
#> 119 -70.0306576 87.1945833 20.1900847 -86.267962 68.8064309
#> 120 -63.9887705 36.7587325 16.4326487 -69.907326 100.9571772
#> Th__Th otherimmune__Th gamma__Th B__Th naiveTc__Th
#> 1 -170.000000 28.7323113 NA NA NA
#> 2 -170.000000 77.1729955 -170.00000 NA NA
#> 3 NA NA NA NA NA
#> 4 -170.000000 -61.4881071 NA NA NA
#> 5 -170.000000 -170.0000000 NA NA NA
#> 6 -170.000000 -170.0000000 NA -170.00000 NA
#> 7 -170.000000 -170.0000000 NA NA NA
#> 8 113.799803 183.9993596 34.31067 NA NA
#> 9 NA NA NA NA NA
#> 10 -170.000000 16.9145786 NA NA NA
#> 11 138.867302 25.8984467 NA NA NA
#> 12 NA NA NA NA NA
#> 13 -170.000000 60.4144630 NA NA NA
#> 14 -170.000000 91.7195148 NA NA NA
#> 15 56.528453 94.1774378 NA NA NA
#> 16 -46.401732 -9.6928275 NA NA -170.0000000
#> 17 -170.000000 56.8217703 NA NA -22.6264419
#> 18 -170.000000 -31.3055176 NA NA NA
#> 19 64.972890 83.4429425 NA NA NA
#> 20 10.270052 95.1367118 NA NA NA
#> 21 NA NA NA NA NA
#> 22 -170.000000 -170.0000000 NA NA NA
#> 23 NA NA NA NA NA
#> 24 -170.000000 176.2708737 NA NA NA
#> 25 -170.000000 -65.6399223 NA NA NA
#> 26 28.292926 465.5976738 NA NA NA
#> 27 -170.000000 37.7076518 NA NA NA
#> 28 NA NA NA NA NA
#> 29 -170.000000 -75.4674002 -170.00000 NA 71.3126756
#> 30 NA NA NA NA NA
#> 31 59.251327 -47.5992317 NA NA NA
#> 32 60.638691 44.2154876 NA NA 180.5962833
#> 33 6.764534 19.1922560 135.74027 NA -75.3010776
#> 34 13.755668 34.1948398 NA NA NA
#> 35 115.583022 82.2303880 -108.44192 NA -104.2581465
#> 36 109.181355 39.0483552 NA NA -27.2427138
#> 37 -30.216282 110.2218005 -170.00000 NA NA
#> 38 89.449472 24.5167744 -170.00000 NA 0.1150978
#> 39 NA NA NA NA NA
#> 40 -170.000000 -0.1985993 NA NA 304.6626968
#> 41 9.722323 48.3511085 NA 46.02538 49.6261954
#> 42 51.924972 12.4444506 NA 80.87883 170.8718771
#> 43 115.022902 68.0671928 NA 121.94309 7.5415446
#> 44 45.041037 22.5596842 -99.24842 72.00598 12.5213154
#> 45 68.012617 47.4394453 -75.24806 101.15103 87.8349964
#> 46 72.000763 101.0761771 NA -170.00000 164.0895874
#> 47 59.518135 58.9663696 NA -42.87406 22.4896092
#> 48 80.413803 -8.3595381 NA 119.93765 56.7460510
#> 49 -1.035899 -17.3901901 NA -64.28995 -83.9044090
#> 50 -170.000000 8.6271830 NA 42.83488 -40.0471812
#> 51 -11.340435 -115.6852202 NA NA NA
#> 52 116.079546 52.1509273 -107.43725 106.69369 136.9514923
#> 53 -170.000000 -77.3855479 NA NA -170.0000000
#> 54 -170.000000 -42.4070569 20.00051 -170.00000 340.3717724
#> 55 NA NA NA NA NA
#> 56 89.677491 70.4691899 NA NA NA
#> 57 -170.000000 83.4648948 NA NA NA
#> 58 195.339506 -32.1726614 NA NA -170.0000000
#> 59 -18.996263 -49.4690486 194.55527 NA NA
#> 60 -170.000000 -44.4824159 -170.00000 -170.00000 NA
#> 61 -170.000000 77.0327963 NA NA NA
#> 62 -170.000000 204.2500717 NA NA NA
#> 63 102.702566 215.9047832 NA NA NA
#> 64 71.978427 90.8821803 NA NA NA
#> 65 -170.000000 -52.7535512 NA NA NA
#> 66 114.318179 92.7805092 NA NA NA
#> 67 -170.000000 -82.9799396 -170.00000 NA NA
#> 68 -170.000000 35.3353631 NA NA NA
#> 69 NA NA NA NA NA
#> 70 NA NA NA NA NA
#> 71 NA NA NA NA NA
#> 72 91.344526 88.6830225 -66.91040 127.92504 -94.6462114
#> 73 286.050707 259.9687299 44.98436 NA NA
#> 74 68.089675 44.8447250 NA NA 94.2548616
#> 75 NA NA NA NA NA
#> 76 176.591572 134.9353950 NA NA 23.0793915
#> 77 95.881649 145.7445027 NA NA -170.0000000
#> 78 292.858907 214.0361549 44.07081 NA -170.0000000
#> 79 -170.000000 222.3904077 NA NA -170.0000000
#> 80 -170.000000 -46.9985670 -170.00000 NA NA
#> 81 40.932945 113.7419358 -90.27504 NA -89.9936745
#> 82 -66.898942 16.6697335 NA NA 34.7714427
#> 83 156.550942 -10.9043274 NA NA NA
#> 84 72.686513 32.2670461 -72.86899 147.01124 -79.7206976
#> 85 25.908229 18.3770726 -49.50035 NA 0.2115615
#> 86 -81.748927 120.1504529 NA NA NA
#> 87 -24.839765 -52.6728306 -60.39174 NA -5.0750345
#> 88 48.217497 31.5971607 -53.27193 -77.85642 -117.1659059
#> 89 -170.000000 -37.5003035 NA NA NA
#> 90 94.889152 -19.8136127 NA NA NA
#> 91 NA NA NA NA NA
#> 92 NA NA NA NA NA
#> 93 302.738087 138.6385120 NA NA -40.3023369
#> 94 -170.000000 -99.9793388 NA NA NA
#> 95 NA NA NA NA NA
#> 96 66.422701 245.9397869 NA NA NA
#> 97 -170.000000 -170.0000000 NA NA NA
#> 98 327.036051 -61.6818888 NA NA NA
#> 99 NA NA NA NA NA
#> 100 NA NA NA NA NA
#> 101 -170.000000 -55.5823965 NA NA NA
#> 102 140.274505 34.0792358 NA NA 202.0241564
#> 103 -53.171798 -170.0000000 NA NA NA
#> 104 122.495816 99.2140442 NA NA NA
#> 105 105.830234 62.7064381 NA NA 198.5380638
#> 106 -8.627297 53.4882720 NA NA NA
#> 107 210.042936 -170.0000000 -170.00000 NA -170.0000000
#> 108 77.881357 101.3914348 108.29900 NA 188.2454749
#> 109 167.256026 139.0716909 NA 200.41580 237.1984840
#> 110 12.969681 69.2940293 NA 111.93871 141.2074643
#> 111 -24.840880 77.1601937 NA NA NA
#> 112 151.217476 51.5702176 -170.00000 NA NA
#> 113 -170.000000 -170.0000000 NA NA NA
#> 114 46.609544 39.4451736 NA NA NA
#> 115 -103.810586 7.9682381 NA NA NA
#> 116 151.747119 75.9861001 -106.73898 NA -80.3011533
#> 117 86.888949 17.4558043 NA 94.78594 NA
#> 118 23.337379 18.4179111 NA NA NA
#> 119 162.889623 103.3850678 NA NA NA
#> 120 -170.000000 NA NA NA NA
#> beta__Th ductal__otherimmune acinar__otherimmune
#> 1 NA -32.93135177 -24.4174421
#> 2 NA -38.64142065 16.7332564
#> 3 NA -56.83626472 -52.4421043
#> 4 NA -6.40750587 -10.3800500
#> 5 NA -2.98421867 -2.1647725
#> 6 NA -10.54032717 -3.2097915
#> 7 NA -37.05999164 -15.4481693
#> 8 NA -19.44232822 -58.7646900
#> 9 NA NA NA
#> 10 NA -3.78734608 -0.5954928
#> 11 -83.02836115 -11.49777351 0.8544995
#> 12 NA -4.96845667 -8.0031068
#> 13 30.43067292 1.22046345 1.2978268
#> 14 3.09305104 5.20670727 8.9268922
#> 15 -144.44819676 -2.20353970 -6.1827263
#> 16 -84.48255560 -9.53973003 -11.0225784
#> 17 -121.39400516 6.83682469 -0.5934838
#> 18 -129.84045994 -9.26105410 6.2222633
#> 19 -90.87939331 -8.80289164 -5.8067533
#> 20 -61.88574797 -13.94454366 -4.3264594
#> 21 NA NA NA
#> 22 -135.76569530 1.03154460 -15.3225410
#> 23 NA -27.66580833 -11.0411300
#> 24 42.47012593 16.74458203 -37.9262548
#> 25 178.81097555 3.49215245 -39.5012388
#> 26 -148.09853500 -49.28723543 -35.9672841
#> 27 115.87858241 11.44150885 -4.2734410
#> 28 NA NA NA
#> 29 -31.49771490 9.43506578 7.5910365
#> 30 NA -1.84189045 -21.3305445
#> 31 NA -12.94368494 -1.5795147
#> 32 NA -6.89533443 -2.8966637
#> 33 NA -1.55875138 -5.9948310
#> 34 NA -12.83843132 1.5046972
#> 35 NA -15.95212902 -7.2812006
#> 36 NA -7.88971935 -6.8308819
#> 37 NA -1.95429366 -3.2780081
#> 38 NA -2.73546797 0.4725454
#> 39 NA 4.95889073 -5.3053590
#> 40 NA -0.31964908 -3.0754528
#> 41 5.35717094 -7.91657176 -6.8089896
#> 42 NA -7.20406688 -5.9999249
#> 43 -31.87059901 -23.36221422 -9.8740316
#> 44 NA -10.40879435 -11.5817502
#> 45 NA -11.53476950 -5.0044108
#> 46 2.29540882 -12.31180499 -10.9583096
#> 47 -5.39748131 -5.56935835 -8.0544733
#> 48 -14.20037361 -3.32981915 -6.6073731
#> 49 23.21146231 3.38015961 -3.9674491
#> 50 NA -23.15723964 -9.6519875
#> 51 NA -1.53729557 2.1951615
#> 52 NA -15.02056458 -11.7193905
#> 53 NA -9.94937092 -13.7594826
#> 54 NA 43.29362464 -40.0486084
#> 55 NA 9.38600001 -11.5566789
#> 56 NA -30.44115000 21.4034624
#> 57 NA 5.85011940 -17.7516864
#> 58 NA -19.55476689 -16.6112306
#> 59 NA -17.53281116 3.0155525
#> 60 NA -15.48311558 -4.9992191
#> 61 -46.34017447 -10.74849603 10.4727923
#> 62 -170.00000000 -23.40526908 -8.9979083
#> 63 -41.50237987 -30.18655035 -31.5400390
#> 64 -147.28176372 -12.05851631 -9.9383149
#> 65 -58.56275655 23.15341264 12.3615322
#> 66 NA -93.64362448 -102.3899445
#> 67 -68.25290701 2.05809328 8.8109175
#> 68 -83.91632934 -3.90261539 -8.2956718
#> 69 NA 32.79764143 7.4376836
#> 70 NA -10.92812838 1.4656937
#> 71 NA -1.50354220 -3.1230093
#> 72 NA -20.53293303 -9.1223757
#> 73 -0.03993637 -9.16975269 -14.1114268
#> 74 17.52932021 37.17332929 8.1441582
#> 75 NA -7.69204688 -3.4868385
#> 76 NA 6.27558609 4.2974796
#> 77 -149.81081644 9.39354360 7.3588513
#> 78 -170.00000000 -11.04698241 -5.8639411
#> 79 -170.00000000 -8.88817829 7.6791253
#> 80 NA -8.16272726 14.2211327
#> 81 NA 6.36293191 14.2631037
#> 82 -4.91243396 -5.74988910 -11.7630313
#> 83 119.25618379 -13.81239801 -21.5992583
#> 84 NA -2.84164376 -2.7364894
#> 85 -10.44142539 -3.42709427 5.1115126
#> 86 -22.33737358 0.26273946 17.0290368
#> 87 3.35859164 -0.18999386 -8.8367086
#> 88 NA -20.68908337 -12.6289999
#> 89 -86.19983397 -17.29881015 -12.1612372
#> 90 -112.36698270 -24.68808824 -4.0611398
#> 91 NA 31.13268401 0.3754481
#> 92 NA 14.61977802 9.2486942
#> 93 -80.51743045 5.84712855 2.7746808
#> 94 0.57081103 3.63797681 -15.9374932
#> 95 NA -37.69434437 19.5427819
#> 96 -110.72569199 5.92421767 2.3568077
#> 97 -91.10740998 4.45585281 -20.6597863
#> 98 13.34952317 -3.16679268 0.1426191
#> 99 NA -56.81714259 -13.1702074
#> 100 NA 77.33077087 -43.5888207
#> 101 35.42860788 -10.66414957 -2.2165401
#> 102 30.77892545 -11.57840480 -8.2034707
#> 103 124.53801408 -9.15743304 -33.2350576
#> 104 NA 0.04689425 -2.6830368
#> 105 32.43555754 7.19091810 -4.0634463
#> 106 NA -15.01273100 -5.2755168
#> 107 184.23434523 2.10507597 1.2243937
#> 108 127.33721705 -26.81956147 -16.1114625
#> 109 207.80633882 -18.17651141 -9.0770345
#> 110 90.17692113 -7.73173735 -13.9633536
#> 111 NA -10.31285211 -5.3750229
#> 112 NA -8.33387403 3.4047780
#> 113 -170.00000000 9.39205935 4.1122733
#> 114 NA -11.54944123 -4.6738432
#> 115 NA -15.53192294 -6.9059128
#> 116 NA -6.53784941 6.4849911
#> 117 NA -9.09135129 2.7694324
#> 118 NA -27.55831114 -20.0873164
#> 119 NA -18.89183700 -10.9034640
#> 120 NA NA NA
#> neutrophil__otherimmune unknown__otherimmune stromal__otherimmune
#> 1 7.1890749 -62.58082363 26.6270306
#> 2 104.9877532 12.62213636 -170.0000000
#> 3 114.2454066 80.29955254 -170.0000000
#> 4 4.5702126 4.31822933 -85.1833839
#> 5 12.8272508 -31.09948459 111.7959522
#> 6 27.3145788 14.35871421 -84.1080811
#> 7 15.4417990 -41.10115117 59.8557317
#> 8 82.1209693 138.60497092 -170.0000000
#> 9 NA NA NA
#> 10 -58.0544994 -1.75375144 -41.6292288
#> 11 -14.4594797 27.28618760 26.7297131
#> 12 -77.2738098 12.35729283 67.6762928
#> 13 -16.8455660 45.68093617 70.6595491
#> 14 -33.7767788 -53.43080049 52.7974118
#> 15 -3.8572408 34.73245364 8.5695848
#> 16 -8.6628001 -12.21344483 9.0799921
#> 17 20.0562740 31.94174292 24.8492901
#> 18 37.1667852 -0.70350747 2.4873259
#> 19 13.0044787 4.98545284 19.2056900
#> 20 -16.5092504 -23.64563613 -8.9792062
#> 21 NA NA NA
#> 22 NA 56.48331050 46.1582354
#> 23 NA 67.91549190 -18.9726252
#> 24 NA 83.54049953 73.7360498
#> 25 9.8108041 122.09523347 156.7854436
#> 26 NA 162.31841872 99.6245733
#> 27 -170.0000000 27.15891928 4.7601823
#> 28 NA NA NA
#> 29 209.7307321 -28.70539769 -31.2200292
#> 30 NA 91.93218583 13.0956509
#> 31 8.1404003 -4.28203473 -26.3415295
#> 32 25.1444924 20.41151667 -9.3773258
#> 33 -13.1791465 18.85086331 7.6360631
#> 34 -12.7792780 -12.44967975 26.3025988
#> 35 11.8982702 -7.20889904 -5.2434702
#> 36 11.3302890 4.67379607 15.0208324
#> 37 31.4657765 14.80836141 36.8687160
#> 38 -1.1942857 5.84552683 18.7422307
#> 39 7.7726793 13.86678755 3.2970302
#> 40 1.6187753 3.71421903 16.1136445
#> 41 141.8270886 36.10259100 12.0214923
#> 42 25.8321108 10.26655262 -7.9259961
#> 43 33.2564370 33.24138497 1.2818563
#> 44 -3.2733543 17.67681592 4.5822876
#> 45 25.4310371 -5.11197786 6.6272532
#> 46 21.8367292 42.81209747 25.6004353
#> 47 11.3457116 14.05287674 0.5379268
#> 48 5.4897475 -5.36782774 8.5513329
#> 49 NA 7.38977756 -1.6170292
#> 50 -43.5308013 14.91297100 1.1954426
#> 51 86.5496660 -23.23653042 23.6949115
#> 52 38.5211339 2.98499418 24.3529760
#> 53 -76.3539481 9.35290018 -22.1096611
#> 54 -170.0000000 61.85284816 -75.4752061
#> 55 35.3113803 12.89101109 75.6607833
#> 56 47.6583523 -33.04119332 -3.8664404
#> 57 -74.2201024 79.80609505 51.2681910
#> 58 -170.0000000 8.35387323 -41.4997893
#> 59 34.6614913 -11.28186066 126.1792534
#> 60 -57.6399842 61.01991520 17.4179217
#> 61 63.6917879 -9.17184701 49.8627958
#> 62 92.5920907 34.38786538 -36.7163783
#> 63 71.3183926 72.77688309 34.1092509
#> 64 80.1528372 60.80177317 16.2818133
#> 65 -170.0000000 4.26793987 -18.1472248
#> 66 41.9570031 -14.97836606 24.9384827
#> 67 -53.0837244 -5.68882332 87.5723316
#> 68 -21.9810308 33.78350130 -5.3763911
#> 69 99.0357847 13.74750777 38.1276096
#> 70 -1.1007586 0.48887422 6.5889796
#> 71 23.2178750 0.04188478 8.9903108
#> 72 -19.5127926 24.29515310 23.1492354
#> 73 -9.8499959 73.83968749 50.3904252
#> 74 26.9523220 -3.12649806 68.6912752
#> 75 56.0599214 -0.75360474 0.2901424
#> 76 15.9943643 32.27554687 15.2737215
#> 77 23.7575016 8.39661693 4.2647221
#> 78 1.1546973 26.31660639 -10.7761610
#> 79 48.1906768 -8.14073027 12.9361433
#> 80 62.4376290 -2.29918743 20.0403530
#> 81 26.6474195 -12.78376258 10.9119942
#> 82 37.4998092 0.16603410 -4.2842567
#> 83 25.6309313 35.36790418 -23.2894907
#> 84 -0.6046089 10.30173580 -2.6522091
#> 85 19.8157604 8.59659231 -0.2526600
#> 86 -109.5920396 -8.31544141 -17.6453344
#> 87 29.6372622 18.41002719 -18.5696536
#> 88 15.6054197 -4.60397307 -9.9255127
#> 89 -23.3970218 -13.82062147 -26.9024759
#> 90 8.8604401 11.98215939 38.9516257
#> 91 NA -48.66656926 -35.5926580
#> 92 -170.0000000 -62.21587558 10.1977134
#> 93 NA 36.28487214 78.5224398
#> 94 -33.2657639 6.51113173 -9.3081903
#> 95 NA -19.80488469 -56.5367470
#> 96 NA -12.03297943 4.8016799
#> 97 NA 95.96774769 -96.3054230
#> 98 NA 28.20722828 -170.0000000
#> 99 NA -34.99398774 -55.8375543
#> 100 NA 64.95016753 -80.4034792
#> 101 63.7020333 21.91225805 10.9125351
#> 102 58.7956986 25.35810784 31.8645997
#> 103 -170.0000000 -19.23812449 -109.6397789
#> 104 -29.9099984 7.25375018 45.6374863
#> 105 14.4365267 -2.85019315 39.2199396
#> 106 -25.1553867 6.76266432 25.2661989
#> 107 86.3205336 15.70376326 68.9156250
#> 108 62.9272431 23.13828843 114.2773487
#> 109 -38.6273693 26.64297413 40.0583171
#> 110 26.2293635 37.74301893 82.1317496
#> 111 -4.0994970 11.34579148 -20.5219914
#> 112 16.1479750 10.32933979 29.2550844
#> 113 NA 37.54392550 -40.3118284
#> 114 -45.5225710 16.56317385 -9.9953057
#> 115 -88.3916279 24.70785643 36.0956110
#> 116 -12.0791350 6.39220642 24.6210475
#> 117 41.7281090 17.06720641 46.9473876
#> 118 -47.4943786 11.08199973 6.3231691
#> 119 59.1208609 37.16149769 6.2117852
#> 120 NA NA NA
#> alpha__otherimmune endothelial__otherimmune macrophage__otherimmune
#> 1 -148.4169471 24.08461952 7.766899
#> 2 -146.9710158 -70.57594643 -89.116162
#> 3 -56.4617535 121.38233509 -51.289266
#> 4 -41.0723588 -61.22851932 10.720700
#> 5 -85.5913211 71.19536312 8.915950
#> 6 -84.2391113 -50.28134002 12.997674
#> 7 -6.6258110 -65.46325249 20.296305
#> 8 -170.0000000 94.99784006 114.928854
#> 9 NA NA NA
#> 10 -5.7614450 3.86755841 -14.879356
#> 11 -151.5543420 -30.69371482 47.307475
#> 12 -112.7212367 -69.94358719 89.182281
#> 13 -83.9846223 -29.37991503 -7.894009
#> 14 -34.4370364 -40.70974138 -88.979443
#> 15 -56.0253644 -49.75451209 -10.990977
#> 16 -57.1531515 4.00538390 -12.822800
#> 17 -45.7184256 27.44230709 19.814465
#> 18 -63.7818731 9.72719622 53.585302
#> 19 -65.0675510 -10.90727216 16.792335
#> 20 27.7179032 32.57340155 -24.186515
#> 21 NA NA NA
#> 22 17.0115925 -14.72285705 NA
#> 23 -170.0000000 -79.85145850 NA
#> 24 92.6348920 0.27415315 182.615430
#> 25 23.2463749 100.98236120 NA
#> 26 -125.0840576 70.68654451 328.378239
#> 27 0.9485528 32.34469213 54.214618
#> 28 NA NA NA
#> 29 -155.0827680 -70.98670764 -170.000000
#> 30 -47.8434644 186.87623356 NA
#> 31 -17.6092919 -52.75983206 15.194791
#> 32 -29.3994864 -1.30756248 11.661084
#> 33 2.9443661 28.18193309 -1.119025
#> 34 3.5364689 6.36374889 12.539439
#> 35 28.6735378 58.51563307 11.724934
#> 36 12.6924802 26.00237901 19.286782
#> 37 -28.1306696 2.81246485 2.021910
#> 38 -27.9949569 3.94991422 19.939073
#> 39 -11.7896656 1.97398722 34.619086
#> 40 -34.8629797 -9.93286156 20.069125
#> 41 38.3089010 18.64249698 -105.752897
#> 42 -14.0642544 -1.32312863 19.070764
#> 43 -32.6947490 72.46711911 -21.683440
#> 44 -37.8599339 12.59935740 13.753659
#> 45 -70.4328953 5.22611838 -6.148870
#> 46 -68.2635801 12.16283366 45.106769
#> 47 0.1618628 15.23148719 38.768829
#> 48 -23.5233656 -17.94719649 127.239099
#> 49 -23.0457159 17.14026403 -14.016756
#> 50 -55.0564963 33.55629490 6.900735
#> 51 -43.0667238 24.42708350 13.432076
#> 52 -35.4805966 6.56554489 81.858503
#> 53 28.1263117 69.66131035 9.564520
#> 54 -170.0000000 85.80994170 -42.407057
#> 55 -9.4856516 -44.51933663 2.284511
#> 56 -24.3365715 -26.62532158 19.566043
#> 57 -63.4101065 159.50984102 -99.262360
#> 58 -105.8813836 1.60029372 NA
#> 59 -137.2951158 28.35169463 48.109936
#> 60 -170.0000000 49.90311247 -170.000000
#> 61 -97.8372421 -10.92423791 -89.086068
#> 62 -66.3077083 -3.59720788 30.138367
#> 63 -123.8004789 45.64271238 39.843332
#> 64 -92.1552588 10.06823649 56.098935
#> 65 -125.7585553 4.38652066 144.208428
#> 66 -111.1638164 11.36809616 51.525054
#> 67 19.3927609 24.69405129 -34.279606
#> 68 -47.8013708 21.09825368 58.202263
#> 69 -85.7530050 -15.63737342 -110.752866
#> 70 -43.8974859 -36.08923999 10.165539
#> 71 -10.3215558 -11.33450205 2.717223
#> 72 -52.4603817 56.24938947 -25.822938
#> 73 25.4331680 -30.48952951 -170.000000
#> 74 -124.0463019 -39.06025894 57.744270
#> 75 -52.8999236 -13.72556229 69.224711
#> 76 -101.3103039 10.75785812 -99.766301
#> 77 -33.8226789 41.42857233 29.366168
#> 78 -65.0998503 32.60293473 12.498939
#> 79 -95.6226555 -20.13368173 13.358385
#> 80 -37.0914288 -10.63953975 40.657592
#> 81 -112.4616978 -4.45661639 14.693031
#> 82 -46.3140348 -16.80464162 18.458105
#> 83 -50.2531083 -74.45945882 12.336564
#> 84 -46.6019632 29.49776863 -9.329899
#> 85 -54.7753829 15.88051392 13.263457
#> 86 -119.8590710 -81.22673618 202.350100
#> 87 41.9995875 27.94330694 16.902427
#> 88 -72.0429368 21.75317772 -11.668412
#> 89 -109.5224395 -34.32942310 -29.793838
#> 90 -122.5159609 -57.49464960 22.935344
#> 91 21.0057126 -42.38134184 NA
#> 92 -44.4687685 35.08474202 -170.000000
#> 93 30.0798206 -10.73136343 108.930289
#> 94 -27.9355297 -37.83111062 62.149165
#> 95 -34.6159526 -110.16393420 3.047281
#> 96 -98.4832983 45.09591577 -12.353211
#> 97 12.5433581 31.59342872 -23.812908
#> 98 -26.9462165 -39.99845399 NA
#> 99 -170.0000000 -102.91539411 -170.000000
#> 100 -170.0000000 30.77970760 -170.000000
#> 101 6.6365101 11.68883417 -98.636504
#> 102 23.8381592 19.41590366 11.465705
#> 103 -170.0000000 -54.27495439 NA
#> 104 28.9928268 3.89526443 NA
#> 105 -25.9047038 -26.50012226 44.879844
#> 106 28.4547938 14.63269018 -26.930188
#> 107 -122.4955603 -23.66310722 NA
#> 108 141.6937367 67.27687852 NA
#> 109 159.5563991 49.98659787 -100.267311
#> 110 83.8483081 50.29762899 85.691386
#> 111 -73.0063344 -23.33004974 -52.481738
#> 112 -119.7251032 3.95871843 28.582873
#> 113 -32.3532832 18.17631280 86.420907
#> 114 -71.3816192 -22.49439567 13.419279
#> 115 38.4012690 -32.20520073 -31.633677
#> 116 -34.1475257 10.55349483 39.084175
#> 117 -77.7168558 57.09895302 19.814768
#> 118 46.5826965 0.04239457 11.998828
#> 119 -54.3769870 31.54439780 36.159806
#> 120 NA NA NA
#> delta__otherimmune Tc__otherimmune Th__otherimmune otherimmune__otherimmune
#> 1 -170.0000000 -11.8294714 5.421912 278.191192
#> 2 -170.0000000 -170.0000000 77.172995 -170.000000
#> 3 -42.7606224 -85.6973518 NA 200.668027
#> 4 -44.1532583 -68.0522883 -61.488107 -170.000000
#> 5 -87.2608287 142.6596142 -170.000000 -13.694163
#> 6 -90.0963110 31.2103984 -170.000000 -41.471756
#> 7 -60.1408117 -60.6379099 -170.000000 81.194857
#> 8 -170.0000000 252.4138675 124.232326 38.716378
#> 9 NA NA NA NA
#> 10 9.7776688 54.1515046 78.792255 -69.727765
#> 11 -170.0000000 81.9409496 57.329293 82.735514
#> 12 -130.2549153 282.0442723 NA 320.236615
#> 13 -121.0535826 256.7303964 54.300663 -170.000000
#> 14 -60.5498526 -63.5485288 91.719515 -170.000000
#> 15 -38.9011639 71.7893862 86.827575 63.894886
#> 16 -137.4289966 38.0822033 -20.563541 -17.049946
#> 17 -78.6392176 75.6235767 59.830712 -5.641244
#> 18 -100.1902340 92.5190916 -34.526898 70.519565
#> 19 -71.3249648 48.4931884 75.058657 -5.090365
#> 20 74.7690410 66.9211636 101.946195 62.827128
#> 21 NA NA NA NA
#> 22 -8.2591029 58.5293515 -170.000000 -170.000000
#> 23 -170.0000000 127.0654574 NA -170.000000
#> 24 53.3773427 92.3746329 176.270874 135.096562
#> 25 53.7452151 61.6543978 -65.639922 323.048973
#> 26 -170.0000000 85.0731702 464.331018 -170.000000
#> 27 -16.4627281 37.8984510 37.707652 -66.146174
#> 28 NA NA NA NA
#> 29 -170.0000000 -53.4087713 -80.496608 -170.000000
#> 30 -17.1929394 150.3050375 NA -170.000000
#> 31 -26.0653424 30.0325365 -46.705946 28.899807
#> 32 -59.2016514 78.1572684 42.068714 46.100023
#> 33 -31.1255513 18.9405699 34.779101 25.924849
#> 34 17.8672615 60.2345310 39.787987 21.881334
#> 35 22.2597749 85.0352539 81.397231 37.110346
#> 36 17.6530948 55.6838286 39.193284 10.743863
#> 37 -49.2910476 23.0751913 105.390535 83.100810
#> 38 -6.5501099 18.5910702 29.906384 27.710660
#> 39 -9.0313860 13.3213332 NA -41.771102
#> 40 -66.7998954 27.6756691 70.579366 25.528423
#> 41 35.5538868 17.9819774 45.267801 108.798923
#> 42 -22.5451457 19.4293551 13.913805 20.462610
#> 43 -16.1963847 25.4601208 70.662982 49.684064
#> 44 -25.0742847 12.7956574 25.677055 36.802536
#> 45 -73.4980015 34.3869711 40.644275 27.345414
#> 46 -100.7781868 8.2797326 98.987183 99.810063
#> 47 -68.3165141 49.6627909 57.902028 39.514011
#> 48 -28.8970907 -22.6486442 -21.472028 28.269576
#> 49 -43.9098606 2.0058839 -13.903166 -3.292055
#> 50 -71.6931767 45.5509954 7.256734 24.053048
#> 51 -0.6193131 54.0422372 -114.815206 -38.983952
#> 52 11.4360437 72.6077902 55.531108 36.982559
#> 53 8.5362323 -100.2736898 -79.983721 61.523862
#> 54 -99.7623965 230.9356924 -42.407057 271.994920
#> 55 -10.7011344 32.2903457 NA 65.290277
#> 56 -6.9517632 25.7837028 73.674562 37.362057
#> 57 -139.3697033 157.7628548 86.227106 36.953220
#> 58 -107.7410488 47.5474127 -59.534125 -94.242058
#> 59 -170.0000000 5.3362860 -55.851904 51.373948
#> 60 -132.7851789 48.8271353 -44.716244 117.894581
#> 61 96.7692620 83.3499209 71.957185 139.325603
#> 62 3.1795853 -38.4185024 162.994845 84.132141
#> 63 -130.5000348 275.2704742 173.863232 437.952596
#> 64 -100.7664454 76.3414596 91.532178 -2.737984
#> 65 -98.7733856 29.4001771 -61.924334 52.755347
#> 66 -119.7790747 35.7879202 88.559981 -74.822053
#> 67 -87.9567003 69.7274467 -82.979940 79.105884
#> 68 5.3257923 NA 35.335363 173.426811
#> 69 -91.4260918 23.3280832 NA 137.322328
#> 70 -170.0000000 -103.7108840 NA 204.584920
#> 71 -52.7774255 25.8887590 NA 24.144075
#> 72 -46.9489421 41.4259445 93.160800 40.016481
#> 73 5.5339989 44.9843649 259.968730 -170.000000
#> 74 -141.0206476 78.1366272 44.844725 73.166581
#> 75 -68.3644764 8.7334419 NA -15.488840
#> 76 -90.8945581 0.9455248 133.582244 -32.278498
#> 77 -75.2141082 50.4947835 142.891242 14.730080
#> 78 -69.5467201 88.2339618 200.389806 92.215618
#> 79 -27.3166073 31.6996687 222.390408 -31.269041
#> 80 -53.0814029 2.9461706 -43.437510 -98.455311
#> 81 -120.1519026 86.7843928 110.436224 68.019455
#> 82 -84.1183066 -9.4803620 27.621342 20.829951
#> 83 -170.0000000 -40.3012834 7.402535 211.696156
#> 84 -97.0018665 55.1027839 32.013697 50.650969
#> 85 -91.1014100 21.2344042 23.574598 -22.319310
#> 86 -86.8506759 -75.5843549 113.889550 -170.000000
#> 87 -5.0149940 -19.6913810 -43.752566 46.119567
#> 88 -70.0649789 1.7861973 34.312623 7.610408
#> 89 -69.7859089 -6.0742737 -32.730810 6.701079
#> 90 -170.0000000 4.5859118 -41.183088 -170.000000
#> 91 -20.0514704 NA NA -170.000000
#> 92 -13.9442025 271.3924506 NA -170.000000
#> 93 57.4742073 58.4025014 139.748253 11.585951
#> 94 -35.7111231 209.1465649 -107.480069 -58.448604
#> 95 -170.0000000 -170.0000000 NA -170.000000
#> 96 -70.3154366 13.2255444 245.939787 63.002793
#> 97 16.7140468 117.7188423 -170.000000 -62.554535
#> 98 -45.0484878 17.1519907 -67.722723 -19.001157
#> 99 -170.0000000 -170.0000000 NA -170.000000
#> 100 -170.0000000 28.2599732 NA -170.000000
#> 101 58.1045164 0.3091772 -50.716037 28.675674
#> 102 20.7625691 20.0022980 35.295216 48.439398
#> 103 -170.0000000 -170.0000000 -170.000000 -170.000000
#> 104 71.9616820 17.6318625 97.805081 26.427572
#> 105 -33.2905663 10.0921986 63.014889 -11.079469
#> 106 35.4477308 25.4462802 55.514212 -68.441487
#> 107 98.7309374 166.9400391 -170.000000 -170.000000
#> 108 134.3855417 71.7198974 101.397302 97.135849
#> 109 90.6565035 116.0241621 138.885129 94.820260
#> 110 36.1212394 79.9213664 69.723514 75.733443
#> 111 -100.1402059 12.1519274 66.643387 -49.842465
#> 112 -95.7175848 27.8247140 60.924596 -5.911440
#> 113 -6.1837408 -15.7340670 -170.000000 -170.000000
#> 114 -75.0182785 15.3705087 55.106080 5.630200
#> 115 -89.0694345 -25.4927767 12.533728 -65.406388
#> 116 -34.0212839 88.0468630 76.686373 114.353405
#> 117 -96.0105049 40.9316858 24.131641 -95.657357
#> 118 -42.8239259 8.6036529 27.391224 -111.262931
#> 119 -62.3529015 54.4455835 99.131058 19.215061
#> 120 NA NA NA NA
#> gamma__otherimmune B__otherimmune naiveTc__otherimmune beta__otherimmune
#> 1 NA NA NA NA
#> 2 -170.00000 NA NA NA
#> 3 NA NA NA NA
#> 4 NA NA NA NA
#> 5 NA NA NA NA
#> 6 NA 77.68890 NA NA
#> 7 NA NA NA NA
#> 8 -87.27879 NA NA NA
#> 9 NA NA NA NA
#> 10 NA NA NA NA
#> 11 NA NA NA -170.0000000
#> 12 -50.76475 NA NA -120.2754617
#> 13 NA NA NA -111.3708009
#> 14 NA NA NA -31.5468274
#> 15 NA NA NA -101.7159254
#> 16 NA NA -170.00000000 -57.6819916
#> 17 NA NA -78.09643962 -64.4871845
#> 18 NA NA NA -100.1753402
#> 19 NA NA NA -65.6759830
#> 20 NA NA NA -6.9720889
#> 21 NA NA NA NA
#> 22 NA NA NA 34.5575559
#> 23 NA NA NA -170.0000000
#> 24 NA NA NA 51.2125802
#> 25 NA NA NA -4.7281127
#> 26 NA NA NA -132.6383133
#> 27 NA NA NA 3.4750194
#> 28 NA NA NA NA
#> 29 -170.00000 NA -17.38046339 -156.1480392
#> 30 NA NA NA -67.4243747
#> 31 NA NA NA NA
#> 32 NA NA 161.94536363 NA
#> 33 92.83844 NA 30.40540650 NA
#> 34 NA NA NA NA
#> 35 -87.34637 NA -81.24849691 NA
#> 36 NA NA 98.33884929 NA
#> 37 16.04479 NA NA NA
#> 38 -90.96513 NA 70.24256547 NA
#> 39 NA NA NA NA
#> 40 NA NA 75.84475500 NA
#> 41 NA 143.92525 168.77727059 20.4508127
#> 42 NA 41.76901 15.13257590 NA
#> 43 NA 91.64476 45.90355589 -19.2328767
#> 44 -77.10488 43.27955 -59.58771617 NA
#> 45 -46.08976 57.30352 34.27932848 NA
#> 46 NA -84.37641 181.05373603 -73.0906902
#> 47 NA 24.25308 51.12504842 -0.4063682
#> 48 NA -110.34473 -103.66900648 -34.2239896
#> 49 NA -34.62807 28.47460930 -31.9174867
#> 50 NA 83.73652 25.26074625 NA
#> 51 NA NA NA NA
#> 52 16.23325 8.64641 87.66323906 NA
#> 53 NA NA 231.84181851 NA
#> 54 -24.70132 -170.00000 -170.00000000 NA
#> 55 -170.00000 NA NA NA
#> 56 NA NA NA NA
#> 57 NA NA NA NA
#> 58 NA NA -87.35486069 NA
#> 59 -170.00000 NA NA NA
#> 60 -101.85294 -170.00000 NA NA
#> 61 NA NA NA -52.3288808
#> 62 NA NA NA -31.5533200
#> 63 NA NA NA -132.1717404
#> 64 NA NA NA -89.8959425
#> 65 NA NA NA -116.9260490
#> 66 NA NA NA NA
#> 67 -66.39716 NA NA -41.6685660
#> 68 NA NA NA -17.6415422
#> 69 NA NA NA -74.9947753
#> 70 NA NA NA -38.6094254
#> 71 60.22665 NA NA NA
#> 72 -115.32848 72.22065 -115.32848462 NA
#> 73 -170.00000 NA NA -17.9830977
#> 74 NA NA -16.83601237 -127.5084117
#> 75 -24.33868 NA 131.13816557 -63.6224886
#> 76 NA NA 270.25198443 NA
#> 77 NA NA -60.03781952 -47.9575567
#> 78 -24.66179 NA 66.07446702 -84.1211406
#> 79 NA NA -77.51269394 -20.1678285
#> 80 -41.74939 NA NA NA
#> 81 -170.00000 NA -99.08197219 NA
#> 82 NA NA -7.18009562 -78.9368365
#> 83 NA NA NA -51.6609791
#> 84 -131.52633 -35.26206 99.94257457 NA
#> 85 -114.16166 NA -33.26233826 -28.2287672
#> 86 NA NA NA -81.6812817
#> 87 59.90437 NA 75.89106980 40.5601402
#> 88 -51.22956 44.39369 -97.51222089 NA
#> 89 NA NA NA -68.5148560
#> 90 NA NA NA -110.6488165
#> 91 NA NA NA 20.2543093
#> 92 NA NA NA 41.6091562
#> 93 NA NA -49.92329658 20.2827317
#> 94 NA NA NA -17.4000845
#> 95 NA NA NA -83.3501319
#> 96 NA NA NA -82.8523297
#> 97 NA NA NA 23.3274044
#> 98 NA NA NA -9.2834037
#> 99 NA NA NA -170.0000000
#> 100 NA NA NA -122.1200890
#> 101 NA NA NA 40.5976457
#> 102 NA NA 48.00032177 20.9407618
#> 103 NA NA NA -170.0000000
#> 104 NA NA NA NA
#> 105 NA NA 18.37183262 9.4571068
#> 106 NA NA NA NA
#> 107 70.36026 NA -170.00000000 -144.1413535
#> 108 -27.54031 NA 84.10443644 123.9675662
#> 109 NA 159.36336 165.17372566 190.4871039
#> 110 NA 174.08348 165.14611799 77.0713474
#> 111 NA NA NA NA
#> 112 -75.73924 NA NA NA
#> 113 NA NA NA -170.0000000
#> 114 NA NA NA NA
#> 115 NA NA NA NA
#> 116 -50.38423 NA -0.01469692 NA
#> 117 NA 71.51983 NA NA
#> 118 NA NA NA NA
#> 119 NA NA NA NA
#> 120 NA NA NA NA
#> ductal__gamma acinar__gamma neutrophil__gamma unknown__gamma stromal__gamma
#> 1 NA NA NA NA NA
#> 2 -16.821322 -16.5682263 -95.469540 -62.130154 -34.457052
#> 3 NA NA NA NA NA
#> 4 NA NA NA NA NA
#> 5 NA NA NA NA NA
#> 6 NA NA NA NA NA
#> 7 NA NA NA NA NA
#> 8 -14.856381 -30.4040244 -54.603777 4.088383 -89.062422
#> 9 8.611292 1.2351657 -87.481425 72.080073 -170.000000
#> 10 NA NA NA NA NA
#> 11 NA NA NA NA NA
#> 12 -12.834586 -21.9569582 -70.937349 64.715146 -1.002420
#> 13 NA NA NA NA NA
#> 14 NA NA NA NA NA
#> 15 NA NA NA NA NA
#> 16 NA NA NA NA NA
#> 17 NA NA NA NA NA
#> 18 NA NA NA NA NA
#> 19 NA NA NA NA NA
#> 20 NA NA NA NA NA
#> 21 NA NA NA NA NA
#> 22 NA NA NA NA NA
#> 23 NA NA NA NA NA
#> 24 NA NA NA NA NA
#> 25 NA NA NA NA NA
#> 26 NA NA NA NA NA
#> 27 NA NA NA NA NA
#> 28 NA NA NA NA NA
#> 29 -103.757791 -90.6774398 -170.000000 -50.008902 94.831855
#> 30 NA NA NA NA NA
#> 31 NA NA NA NA NA
#> 32 NA NA NA NA NA
#> 33 -28.655483 -13.9160531 -57.471007 24.627772 -96.646530
#> 34 NA NA NA NA NA
#> 35 18.213349 -16.1678137 -95.674342 42.977014 -86.060305
#> 36 NA NA NA NA NA
#> 37 7.010892 -10.0993946 18.753018 8.231648 -56.513038
#> 38 -41.067535 -61.3577301 -39.791069 -33.847320 -134.654532
#> 39 NA NA NA NA NA
#> 40 NA NA NA NA NA
#> 41 NA NA NA NA NA
#> 42 NA NA NA NA NA
#> 43 NA NA NA NA NA
#> 44 -3.982718 -17.3176669 -89.360127 -25.715159 -35.893314
#> 45 -22.937746 -26.0861987 -56.108244 -4.057091 -22.213610
#> 46 NA NA NA NA NA
#> 47 NA NA NA NA NA
#> 48 NA NA NA NA NA
#> 49 NA NA NA NA NA
#> 50 NA NA NA NA NA
#> 51 NA NA NA NA NA
#> 52 4.757941 7.6701828 -21.423494 26.560711 -6.585331
#> 53 NA NA NA NA NA
#> 54 -26.132768 -28.3913195 -41.253255 -46.888945 25.428557
#> 55 -59.771556 1.9444691 -170.000000 -54.405335 -9.067060
#> 56 NA NA NA NA NA
#> 57 NA NA NA NA NA
#> 58 NA NA NA NA NA
#> 59 -8.538084 -22.5041035 -170.000000 19.713256 -74.330486
#> 60 -15.780240 -23.2328082 -13.117791 -24.057595 20.065678
#> 61 NA NA NA NA NA
#> 62 NA NA NA NA NA
#> 63 NA NA NA NA NA
#> 64 NA NA NA NA NA
#> 65 NA NA NA NA NA
#> 66 NA NA NA NA NA
#> 67 27.976124 4.4255238 -59.658684 -34.331007 -116.635458
#> 68 NA NA NA NA NA
#> 69 NA NA NA NA NA
#> 70 NA NA NA NA NA
#> 71 -79.797960 -87.8973820 -170.000000 -60.504241 -40.407392
#> 72 -20.492391 -31.6044110 -74.082419 6.915262 -11.629759
#> 73 -56.067336 -77.2018131 -170.000000 87.274259 -42.074039
#> 74 NA NA NA NA NA
#> 75 9.848712 -6.5466292 -3.434741 20.605051 33.646996
#> 76 NA NA NA NA NA
#> 77 NA NA NA NA NA
#> 78 12.471587 -10.6802912 -55.906992 36.125134 -10.112258
#> 79 NA NA NA NA NA
#> 80 -8.937821 -34.5847017 -101.601850 57.480260 -58.466160
#> 81 -43.855599 -31.4800181 -114.491816 -60.402905 -134.022381
#> 82 NA NA NA NA NA
#> 83 NA NA NA NA NA
#> 84 1.698423 -11.0210129 -36.558254 -50.815532 -42.232485
#> 85 -22.258388 -46.8188723 -37.622478 -63.559134 17.798290
#> 86 NA NA NA NA NA
#> 87 -27.496765 -31.7326008 -52.815886 -28.051959 -19.227999
#> 88 10.350753 -0.1554752 -1.411425 -6.616905 -30.831845
#> 89 NA NA NA NA NA
#> 90 NA NA NA NA NA
#> 91 NA NA NA NA NA
#> 92 NA NA NA NA NA
#> 93 NA NA NA NA NA
#> 94 NA NA NA NA NA
#> 95 NA NA NA NA NA
#> 96 NA NA NA NA NA
#> 97 NA NA NA NA NA
#> 98 NA NA NA NA NA
#> 99 NA NA NA NA NA
#> 100 NA NA NA NA NA
#> 101 NA NA NA NA NA
#> 102 NA NA NA NA NA
#> 103 NA NA NA NA NA
#> 104 NA NA NA NA NA
#> 105 NA NA NA NA NA
#> 106 NA NA NA NA NA
#> 107 -8.212793 -17.8082984 -89.879914 -83.780563 -127.174013
#> 108 -28.435912 3.5940548 -49.427987 -2.960992 93.357120
#> 109 NA NA NA NA NA
#> 110 NA NA NA NA NA
#> 111 NA NA NA NA NA
#> 112 -31.203882 -19.1187447 -170.000000 -19.201156 -51.697243
#> 113 NA NA NA NA NA
#> 114 NA NA NA NA NA
#> 115 NA NA NA NA NA
#> 116 -37.761553 -5.1388663 -127.483980 -61.492601 -54.862034
#> 117 NA NA NA NA NA
#> 118 NA NA NA NA NA
#> 119 NA NA NA NA NA
#> 120 NA NA NA NA NA
#> alpha__gamma endothelial__gamma macrophage__gamma delta__gamma Tc__gamma
#> 1 NA NA NA NA NA
#> 2 125.148973 11.602562 -108.4371805 40.798804 -170.000000
#> 3 NA NA NA NA NA
#> 4 NA NA NA NA NA
#> 5 NA NA NA NA NA
#> 6 NA NA NA NA NA
#> 7 NA NA NA NA NA
#> 8 191.302909 -46.022255 -106.1581357 204.817714 -67.589211
#> 9 4.823686 -170.000000 -125.1726541 13.723231 -170.000000
#> 10 NA NA NA NA NA
#> 11 NA NA NA NA NA
#> 12 105.640588 -113.593595 7.4077050 153.789604 47.013964
#> 13 NA NA NA NA NA
#> 14 NA NA NA NA NA
#> 15 NA NA NA NA NA
#> 16 NA NA NA NA NA
#> 17 NA NA NA NA NA
#> 18 NA NA NA NA NA
#> 19 NA NA NA NA NA
#> 20 NA NA NA NA NA
#> 21 NA NA NA NA NA
#> 22 NA NA NA NA NA
#> 23 NA NA NA NA NA
#> 24 NA NA NA NA NA
#> 25 NA NA NA NA NA
#> 26 NA NA NA NA NA
#> 27 NA NA NA NA NA
#> 28 NA NA NA NA NA
#> 29 155.137351 52.739387 -170.0000000 240.897081 -50.919871
#> 30 NA NA NA NA NA
#> 31 NA NA NA NA NA
#> 32 NA NA NA NA NA
#> 33 -79.715611 -87.900649 -85.9927574 20.851493 13.819817
#> 34 NA NA NA NA NA
#> 35 -62.004639 -99.396116 -170.0000000 -170.000000 -45.709538
#> 36 NA NA NA NA NA
#> 37 162.265753 -16.944457 -23.3366960 152.855017 -77.783853
#> 38 293.449886 -1.298882 -97.0543256 236.037093 -72.559270
#> 39 NA NA NA NA NA
#> 40 NA NA NA NA NA
#> 41 NA NA NA NA NA
#> 42 NA NA NA NA NA
#> 43 NA NA NA NA NA
#> 44 183.863681 -84.822414 -50.5036511 210.887654 -65.024273
#> 45 145.712236 26.587585 -111.2368354 117.686239 -29.237985
#> 46 NA NA NA NA NA
#> 47 NA NA NA NA NA
#> 48 NA NA NA NA NA
#> 49 NA NA NA NA NA
#> 50 NA NA NA NA NA
#> 51 NA NA NA NA NA
#> 52 215.472438 -135.056873 -17.3459748 210.674180 -65.533510
#> 53 NA NA NA NA NA
#> 54 246.825025 -29.731573 -72.6283148 227.193077 -5.777568
#> 55 -56.887289 -45.744772 -0.7061672 -9.353518 -170.000000
#> 56 NA NA NA NA NA
#> 57 NA NA NA NA NA
#> 58 NA NA NA NA NA
#> 59 172.085815 -62.345069 -128.1190986 56.505606 -170.000000
#> 60 191.602504 -14.760775 -45.8073142 185.863185 -44.171136
#> 61 NA NA NA NA NA
#> 62 NA NA NA NA NA
#> 63 NA NA NA NA NA
#> 64 NA NA NA NA NA
#> 65 NA NA NA NA NA
#> 66 NA NA NA NA NA
#> 67 8.842019 -93.076493 -170.0000000 -170.000000 -170.000000
#> 68 NA NA NA NA NA
#> 69 NA NA NA NA NA
#> 70 NA NA NA NA NA
#> 71 170.721920 -19.599427 8.8779706 14.486487 -170.000000
#> 72 139.444452 -40.711359 -77.9912881 370.640049 -170.000000
#> 73 224.690065 65.837824 -98.2137116 335.927355 26.743450
#> 74 NA NA NA NA NA
#> 75 -13.647583 1.804889 -54.7532468 159.754507 24.834369
#> 76 NA NA NA NA NA
#> 77 NA NA NA NA NA
#> 78 31.041627 -5.560094 -72.0473317 32.183560 -2.107678
#> 79 NA NA NA NA NA
#> 80 92.835417 29.735962 -4.2696811 127.333466 -36.050393
#> 81 127.816826 -103.558183 -132.0933079 -33.636938 -170.000000
#> 82 NA NA NA NA NA
#> 83 NA NA NA NA NA
#> 84 60.728498 -19.184784 -60.0557962 116.196369 -68.276137
#> 85 134.454024 38.943203 -22.1312531 341.160979 -93.652335
#> 86 NA NA NA NA NA
#> 87 250.757910 -5.318063 -53.9530640 158.036876 -170.000000
#> 88 58.409862 -22.840184 -9.1385951 129.624299 -4.658459
#> 89 NA NA NA NA NA
#> 90 NA NA NA NA NA
#> 91 NA NA NA NA NA
#> 92 NA NA NA NA NA
#> 93 NA NA NA NA NA
#> 94 NA NA NA NA NA
#> 95 NA NA NA NA NA
#> 96 NA NA NA NA NA
#> 97 NA NA NA NA NA
#> 98 NA NA NA NA NA
#> 99 NA NA NA NA NA
#> 100 NA NA NA NA NA
#> 101 NA NA NA NA NA
#> 102 NA NA NA NA NA
#> 103 NA NA NA NA NA
#> 104 NA NA NA NA NA
#> 105 NA NA NA NA NA
#> 106 NA NA NA NA NA
#> 107 -113.490898 -98.255269 NA 70.360257 -170.000000
#> 108 86.253942 38.141658 NA 98.961213 97.011803
#> 109 NA NA NA NA NA
#> 110 NA NA NA NA NA
#> 111 NA NA NA NA NA
#> 112 170.346445 -20.196486 -71.6792094 182.227378 -4.578062
#> 113 NA NA NA NA NA
#> 114 NA NA NA NA NA
#> 115 NA NA NA NA NA
#> 116 -88.685451 -74.902747 -112.3067535 -64.913183 -150.986258
#> 117 NA NA NA NA NA
#> 118 NA NA NA NA NA
#> 119 NA NA NA NA NA
#> 120 NA NA NA NA NA
#> Th__gamma otherimmune__gamma gamma__gamma B__gamma naiveTc__gamma
#> 1 NA NA NA NA NA
#> 2 -170.00000 -170.00000 478.29704 NA NA
#> 3 NA NA NA NA NA
#> 4 NA NA NA NA NA
#> 5 NA NA NA NA NA
#> 6 NA NA NA NA NA
#> 7 NA NA NA NA NA
#> 8 36.73289 -60.77218 206.01820 NA NA
#> 9 NA NA -170.00000 NA -170.000000
#> 10 NA NA NA NA NA
#> 11 NA NA NA NA NA
#> 12 NA -37.49381 264.60340 NA NA
#> 13 NA NA NA NA NA
#> 14 NA NA NA NA NA
#> 15 NA NA NA NA NA
#> 16 NA NA NA NA NA
#> 17 NA NA NA NA NA
#> 18 NA NA NA NA NA
#> 19 NA NA NA NA NA
#> 20 NA NA NA NA NA
#> 21 NA NA NA NA NA
#> 22 NA NA NA NA NA
#> 23 NA NA NA NA NA
#> 24 NA NA NA NA NA
#> 25 NA NA NA NA NA
#> 26 NA NA NA NA NA
#> 27 NA NA NA NA NA
#> 28 NA NA NA NA NA
#> 29 -170.00000 -170.00000 430.40701 NA -170.000000
#> 30 NA NA NA NA NA
#> 31 NA NA NA NA NA
#> 32 NA NA NA NA NA
#> 33 187.18701 99.04313 560.71729 NA -170.000000
#> 34 NA NA NA NA NA
#> 35 -111.07842 -87.69436 434.49442 NA -170.000000
#> 36 NA NA NA NA NA
#> 37 -170.00000 16.04479 185.83125 NA NA
#> 38 -170.00000 -90.68402 81.59088 NA -72.559270
#> 39 NA NA NA NA NA
#> 40 NA NA NA NA NA
#> 41 NA NA NA NA NA
#> 42 NA NA NA NA NA
#> 43 NA NA NA NA NA
#> 44 -96.63108 -71.84980 227.12871 -83.03931 -70.363839
#> 45 -62.93478 -39.27488 185.73506 -102.77096 58.575705
#> 46 NA NA NA NA NA
#> 47 NA NA NA NA NA
#> 48 NA NA NA NA NA
#> 49 NA NA NA NA NA
#> 50 NA NA NA NA NA
#> 51 NA NA NA NA NA
#> 52 -99.95006 33.01139 -170.00000 -170.00000 -64.363255
#> 53 NA NA NA NA NA
#> 54 20.00051 -24.70132 201.85944 -170.00000 -7.557854
#> 55 NA -170.00000 -170.00000 NA NA
#> 56 NA NA NA NA NA
#> 57 NA NA NA NA NA
#> 58 NA NA NA NA NA
#> 59 194.55527 -170.00000 283.01121 NA NA
#> 60 -170.00000 -101.58383 157.22970 29.87595 NA
#> 61 NA NA NA NA NA
#> 62 NA NA NA NA NA
#> 63 NA NA NA NA NA
#> 64 NA NA NA NA NA
#> 65 NA NA NA NA NA
#> 66 NA NA NA NA NA
#> 67 -170.00000 -33.00297 829.78438 NA NA
#> 68 NA NA NA NA NA
#> 69 NA NA NA NA NA
#> 70 NA NA NA NA NA
#> 71 NA 60.22665 693.72607 NA NA
#> 72 -66.91040 -115.32848 600.82418 -170.00000 -170.000000
#> 73 44.98436 -170.00000 282.41260 NA NA
#> 74 NA NA NA NA NA
#> 75 NA -21.62111 657.04702 NA -170.000000
#> 76 NA NA NA NA NA
#> 77 NA NA NA NA NA
#> 78 75.92142 -12.22377 359.97913 NA -170.000000
#> 79 NA NA NA NA NA
#> 80 -170.00000 -30.04794 316.49082 NA NA
#> 81 -86.22456 -170.00000 390.91483 NA -170.000000
#> 82 NA NA NA NA NA
#> 83 NA NA NA NA NA
#> 84 -76.62631 -129.93417 271.78149 -83.97026 -170.000000
#> 85 -44.56336 -108.81106 303.39154 NA -170.000000
#> 86 NA NA NA NA NA
#> 87 -60.39174 59.90437 -14.99052 NA 201.068965
#> 88 -48.65489 -38.67679 -45.41260 63.00299 -170.000000
#> 89 NA NA NA NA NA
#> 90 NA NA NA NA NA
#> 91 NA NA NA NA NA
#> 92 NA NA NA NA NA
#> 93 NA NA NA NA NA
#> 94 NA NA NA NA NA
#> 95 NA NA NA NA NA
#> 96 NA NA NA NA NA
#> 97 NA NA NA NA NA
#> 98 NA NA NA NA NA
#> 99 NA NA NA NA NA
#> 100 NA NA NA NA NA
#> 101 NA NA NA NA NA
#> 102 NA NA NA NA NA
#> 103 NA NA NA NA NA
#> 104 NA NA NA NA NA
#> 105 NA NA NA NA NA
#> 106 NA NA NA NA NA
#> 107 -170.00000 70.36026 167.30493 NA -16.763997
#> 108 109.08044 -29.64881 -170.00000 NA 171.029153
#> 109 NA NA NA NA NA
#> 110 NA NA NA NA NA
#> 111 NA NA NA NA NA
#> 112 -170.00000 -75.73924 522.30043 NA NA
#> 113 NA NA NA NA NA
#> 114 NA NA NA NA NA
#> 115 NA NA NA NA NA
#> 116 -105.32048 -74.87623 1052.28030 NA -170.000000
#> 117 NA NA NA NA NA
#> 118 NA NA NA NA NA
#> 119 NA NA NA NA NA
#> 120 NA NA NA NA NA
#> beta__gamma ductal__B acinar__B neutrophil__B unknown__B stromal__B
#> 1 NA NA NA NA NA NA
#> 2 NA NA NA NA NA NA
#> 3 NA NA NA NA NA NA
#> 4 NA NA NA NA NA NA
#> 5 NA NA NA NA NA NA
#> 6 NA -26.794117 -14.326824 30.28726 -68.648995 -170.0000000
#> 7 NA NA NA NA NA NA
#> 8 NA NA NA NA NA NA
#> 9 NA NA NA NA NA NA
#> 10 NA NA NA NA NA NA
#> 11 NA NA NA NA NA NA
#> 12 151.17013 NA NA NA NA NA
#> 13 NA NA NA NA NA NA
#> 14 NA NA NA NA NA NA
#> 15 NA NA NA NA NA NA
#> 16 NA NA NA NA NA NA
#> 17 NA NA NA NA NA NA
#> 18 NA NA NA NA NA NA
#> 19 NA NA NA NA NA NA
#> 20 NA NA NA NA NA NA
#> 21 NA NA NA NA NA NA
#> 22 NA NA NA NA NA NA
#> 23 NA NA NA NA NA NA
#> 24 NA NA NA NA NA NA
#> 25 NA NA NA NA NA NA
#> 26 NA NA NA NA NA NA
#> 27 NA NA NA NA NA NA
#> 28 NA NA NA NA NA NA
#> 29 140.73111 NA NA NA NA NA
#> 30 NA NA NA NA NA NA
#> 31 NA NA NA NA NA NA
#> 32 NA NA NA NA NA NA
#> 33 NA NA NA NA NA NA
#> 34 NA NA NA NA NA NA
#> 35 NA NA NA NA NA NA
#> 36 NA NA NA NA NA NA
#> 37 NA NA NA NA NA NA
#> 38 NA NA NA NA NA NA
#> 39 NA NA NA NA NA NA
#> 40 NA NA NA NA NA NA
#> 41 NA 4.792701 10.146237 290.44239 33.235292 4.0096530
#> 42 NA -30.680828 -39.598334 32.92367 1.369774 -45.1390173
#> 43 NA -42.145033 -29.496846 100.15328 71.669075 -17.0360373
#> 44 NA -27.608523 -17.129463 -44.82363 46.238226 15.3241358
#> 45 NA -44.420527 -34.269977 64.43055 8.274828 -27.1567407
#> 46 NA 19.259114 -8.070419 -170.00000 -59.511049 -0.2341264
#> 47 NA -28.412406 -13.706603 -170.00000 48.848514 31.2662284
#> 48 NA -3.305005 4.584307 -170.00000 66.068839 -15.1552691
#> 49 NA 4.232492 -69.125816 NA -18.737005 12.1565338
#> 50 NA -49.208262 -32.027038 -22.67195 19.501978 -37.5882318
#> 51 NA NA NA NA NA NA
#> 52 NA -104.921885 -78.511577 -170.00000 60.046012 55.3292064
#> 53 NA NA NA NA NA NA
#> 54 NA -26.293572 25.688127 -170.00000 -49.888261 18.6473486
#> 55 NA NA NA NA NA NA
#> 56 NA NA NA NA NA NA
#> 57 NA NA NA NA NA NA
#> 58 NA NA NA NA NA NA
#> 59 NA NA NA NA NA NA
#> 60 NA 40.587609 -1.175205 -170.00000 -10.586338 -44.7691339
#> 61 NA NA NA NA NA NA
#> 62 NA NA NA NA NA NA
#> 63 NA NA NA NA NA NA
#> 64 NA NA NA NA NA NA
#> 65 NA NA NA NA NA NA
#> 66 NA NA NA NA NA NA
#> 67 -27.36168 NA NA NA NA NA
#> 68 NA NA NA NA NA NA
#> 69 NA NA NA NA NA NA
#> 70 NA NA NA NA NA NA
#> 71 NA NA NA NA NA NA
#> 72 NA -24.342246 -11.594949 15.98533 66.942109 40.4105353
#> 73 282.57900 NA NA NA NA NA
#> 74 NA NA NA NA NA NA
#> 75 -67.19142 NA NA NA NA NA
#> 76 NA NA NA NA NA NA
#> 77 NA NA NA NA NA NA
#> 78 -57.27343 NA NA NA NA NA
#> 79 NA NA NA NA NA NA
#> 80 NA NA NA NA NA NA
#> 81 NA NA NA NA NA NA
#> 82 NA NA NA NA NA NA
#> 83 NA NA NA NA NA NA
#> 84 NA -27.585026 -34.648849 28.04773 30.553526 14.2719308
#> 85 146.31697 NA NA NA NA NA
#> 86 NA NA NA NA NA NA
#> 87 229.34693 NA NA NA NA NA
#> 88 NA -16.834343 -7.239792 58.37779 -7.831955 -61.7451652
#> 89 NA NA NA NA NA NA
#> 90 NA NA NA NA NA NA
#> 91 NA NA NA NA NA NA
#> 92 NA NA NA NA NA NA
#> 93 NA NA NA NA NA NA
#> 94 NA NA NA NA NA NA
#> 95 NA NA NA NA NA NA
#> 96 NA NA NA NA NA NA
#> 97 NA NA NA NA NA NA
#> 98 NA NA NA NA NA NA
#> 99 NA NA NA NA NA NA
#> 100 NA NA NA NA NA NA
#> 101 NA NA NA NA NA NA
#> 102 NA NA NA NA NA NA
#> 103 NA NA NA NA NA NA
#> 104 NA NA NA NA NA NA
#> 105 NA NA NA NA NA NA
#> 106 NA NA NA NA NA NA
#> 107 -83.31389 NA NA NA NA NA
#> 108 66.61028 NA NA NA NA NA
#> 109 NA -31.673569 -14.976682 -141.34652 31.637878 25.9792547
#> 110 NA -10.379462 -18.837284 93.72951 73.381786 180.8615741
#> 111 NA NA NA NA NA NA
#> 112 NA NA NA NA NA NA
#> 113 NA NA NA NA NA NA
#> 114 NA NA NA NA NA NA
#> 115 NA NA NA NA NA NA
#> 116 NA NA NA NA NA NA
#> 117 NA 3.462221 -10.263237 24.59548 61.287635 19.4047964
#> 118 NA NA NA NA NA NA
#> 119 NA NA NA NA NA NA
#> 120 NA NA NA NA NA NA
#> alpha__B endothelial__B macrophage__B delta__B Tc__B Th__B
#> 1 NA NA NA NA NA NA
#> 2 NA NA NA NA NA NA
#> 3 NA NA NA NA NA NA
#> 4 NA NA NA NA NA NA
#> 5 NA NA NA NA NA NA
#> 6 -147.20010 -122.72980 13.302991 78.802201 9.23735 -170.00000
#> 7 NA NA NA NA NA NA
#> 8 NA NA NA NA NA NA
#> 9 NA NA NA NA NA NA
#> 10 NA NA NA NA NA NA
#> 11 NA NA NA NA NA NA
#> 12 NA NA NA NA NA NA
#> 13 NA NA NA NA NA NA
#> 14 NA NA NA NA NA NA
#> 15 NA NA NA NA NA NA
#> 16 NA NA NA NA NA NA
#> 17 NA NA NA NA NA NA
#> 18 NA NA NA NA NA NA
#> 19 NA NA NA NA NA NA
#> 20 NA NA NA NA NA NA
#> 21 NA NA NA NA NA NA
#> 22 NA NA NA NA NA NA
#> 23 NA NA NA NA NA NA
#> 24 NA NA NA NA NA NA
#> 25 NA NA NA NA NA NA
#> 26 NA NA NA NA NA NA
#> 27 NA NA NA NA NA NA
#> 28 NA NA NA NA NA NA
#> 29 NA NA NA NA NA NA
#> 30 NA NA NA NA NA NA
#> 31 NA NA NA NA NA NA
#> 32 NA NA NA NA NA NA
#> 33 NA NA NA NA NA NA
#> 34 NA NA NA NA NA NA
#> 35 NA NA NA NA NA NA
#> 36 NA NA NA NA NA NA
#> 37 NA NA NA NA NA NA
#> 38 NA NA NA NA NA NA
#> 39 NA NA NA NA NA NA
#> 40 NA NA NA NA NA NA
#> 41 -112.91822 -44.59671 -170.000000 -126.106213 -61.42184 41.67477
#> 42 -98.99016 68.02202 -94.564548 -95.414466 12.90000 50.75815
#> 43 -87.42327 155.26116 -35.724615 -18.920139 74.43265 125.02312
#> 44 -59.36642 29.47835 -14.637496 -9.099126 -27.06023 83.74242
#> 45 -130.98552 44.89693 -12.081894 -138.997312 62.73439 82.90678
#> 46 -124.14797 31.68052 -93.125952 -170.000000 -47.35364 -170.00000
#> 47 13.74074 -110.95939 5.831471 -170.000000 -43.66553 -42.87406
#> 48 -109.48835 51.83771 -170.000000 -170.000000 59.68086 123.81727
#> 49 118.46292 -10.95697 34.257454 -6.066877 54.40621 -65.35793
#> 50 -67.66884 99.91654 -26.619614 -77.495015 80.83881 52.81940
#> 51 NA NA NA NA NA NA
#> 52 -170.00000 259.30748 -170.000000 -170.000000 92.52927 125.96566
#> 53 NA NA NA NA NA NA
#> 54 -170.00000 -57.20089 -170.000000 -170.000000 -170.00000 -170.00000
#> 55 NA NA NA NA NA NA
#> 56 NA NA NA NA NA NA
#> 57 NA NA NA NA NA NA
#> 58 NA NA NA NA NA NA
#> 59 NA NA NA NA NA NA
#> 60 134.98106 -107.51801 -170.000000 -3.570260 -170.00000 -170.00000
#> 61 NA NA NA NA NA NA
#> 62 NA NA NA NA NA NA
#> 63 NA NA NA NA NA NA
#> 64 NA NA NA NA NA NA
#> 65 NA NA NA NA NA NA
#> 66 NA NA NA NA NA NA
#> 67 NA NA NA NA NA NA
#> 68 NA NA NA NA NA NA
#> 69 NA NA NA NA NA NA
#> 70 NA NA NA NA NA NA
#> 71 NA NA NA NA NA NA
#> 72 -98.69150 103.35472 7.843863 1.548984 118.32189 130.08883
#> 73 NA NA NA NA NA NA
#> 74 NA NA NA NA NA NA
#> 75 NA NA NA NA NA NA
#> 76 NA NA NA NA NA NA
#> 77 NA NA NA NA NA NA
#> 78 NA NA NA NA NA NA
#> 79 NA NA NA NA NA NA
#> 80 NA NA NA NA NA NA
#> 81 NA NA NA NA NA NA
#> 82 NA NA NA NA NA NA
#> 83 NA NA NA NA NA NA
#> 84 39.74618 25.61953 58.850572 -55.809684 57.00373 141.88722
#> 85 NA NA NA NA NA NA
#> 86 NA NA NA NA NA NA
#> 87 NA NA NA NA NA NA
#> 88 -87.42433 -24.94227 -42.561868 -85.576802 -91.29044 -90.14027
#> 89 NA NA NA NA NA NA
#> 90 NA NA NA NA NA NA
#> 91 NA NA NA NA NA NA
#> 92 NA NA NA NA NA NA
#> 93 NA NA NA NA NA NA
#> 94 NA NA NA NA NA NA
#> 95 NA NA NA NA NA NA
#> 96 NA NA NA NA NA NA
#> 97 NA NA NA NA NA NA
#> 98 NA NA NA NA NA NA
#> 99 NA NA NA NA NA NA
#> 100 NA NA NA NA NA NA
#> 101 NA NA NA NA NA NA
#> 102 NA NA NA NA NA NA
#> 103 NA NA NA NA NA NA
#> 104 NA NA NA NA NA NA
#> 105 NA NA NA NA NA NA
#> 106 NA NA NA NA NA NA
#> 107 NA NA NA NA NA NA
#> 108 NA NA NA NA NA NA
#> 109 232.38001 73.04015 -170.000000 184.349361 193.79931 200.38594
#> 110 71.51151 96.16584 -170.000000 31.342019 110.97315 111.93871
#> 111 NA NA NA NA NA NA
#> 112 NA NA NA NA NA NA
#> 113 NA NA NA NA NA NA
#> 114 NA NA NA NA NA NA
#> 115 NA NA NA NA NA NA
#> 116 NA NA NA NA NA NA
#> 117 -133.27723 30.02596 9.473353 -137.398880 21.48348 88.48432
#> 118 NA NA NA NA NA NA
#> 119 NA NA NA NA NA NA
#> 120 NA NA NA NA NA NA
#> otherimmune__B gamma__B B__B naiveTc__B beta__B ductal__naiveTc
#> 1 NA NA NA NA NA NA
#> 2 NA NA NA NA NA NA
#> 3 NA NA NA NA NA NA
#> 4 NA NA NA NA NA NA
#> 5 NA NA NA NA NA NA
#> 6 33.81603 NA -170.000000 NA NA NA
#> 7 NA NA NA NA NA NA
#> 8 NA NA NA NA NA NA
#> 9 NA NA NA NA NA 25.6412757
#> 10 NA NA NA NA NA NA
#> 11 NA NA NA NA NA NA
#> 12 NA NA NA NA NA NA
#> 13 NA NA NA NA NA NA
#> 14 NA NA NA NA NA NA
#> 15 NA NA NA NA NA NA
#> 16 NA NA NA NA NA 21.3654422
#> 17 NA NA NA NA NA -22.6215338
#> 18 NA NA NA NA NA NA
#> 19 NA NA NA NA NA NA
#> 20 NA NA NA NA NA NA
#> 21 NA NA NA NA NA NA
#> 22 NA NA NA NA NA NA
#> 23 NA NA NA NA NA NA
#> 24 NA NA NA NA NA NA
#> 25 NA NA NA NA NA NA
#> 26 NA NA NA NA NA NA
#> 27 NA NA NA NA NA NA
#> 28 NA NA NA NA NA NA
#> 29 NA NA NA NA NA 0.8291537
#> 30 NA NA NA NA NA NA
#> 31 NA NA NA NA NA NA
#> 32 NA NA NA NA NA -44.1448803
#> 33 NA NA NA NA NA 21.0859644
#> 34 NA NA NA NA NA NA
#> 35 NA NA NA NA NA 10.2597533
#> 36 NA NA NA NA NA -6.6551325
#> 37 NA NA NA NA NA NA
#> 38 NA NA NA NA NA 8.9151530
#> 39 NA NA NA NA NA NA
#> 40 NA NA NA NA NA 19.4726265
#> 41 140.94768 NA 176.979678 -170.00000 -133.09352 -49.2687377
#> 42 17.04361 NA 304.710354 -170.00000 NA -33.0776612
#> 43 91.90453 NA 217.733164 67.36692 -60.81320 -20.5851402
#> 44 48.26143 -96.92808 8.258481 49.21575 NA 4.3893187
#> 45 50.50670 -113.94400 121.140834 52.06573 NA -14.5364809
#> 46 -95.07385 NA -170.000000 -170.00000 -170.00000 -25.1582091
#> 47 24.25308 NA -170.000000 -27.40338 179.06686 -2.3767983
#> 48 -93.39541 NA -170.000000 274.66802 -60.07512 -18.1342485
#> 49 -27.45435 NA 175.352468 84.19208 147.05388 16.3712242
#> 50 82.96332 NA 143.703976 109.27851 NA -29.9503379
#> 51 NA NA NA NA NA NA
#> 52 36.23918 -170.00000 -170.000000 47.82039 NA -4.5249699
#> 53 NA NA NA NA NA -63.8211608
#> 54 -170.00000 -170.00000 340.371772 -170.00000 NA -20.9901733
#> 55 NA NA NA NA NA NA
#> 56 NA NA NA NA NA NA
#> 57 NA NA NA NA NA NA
#> 58 NA NA NA NA NA -44.5799706
#> 59 NA NA NA NA NA NA
#> 60 -170.00000 35.05072 -170.000000 NA NA NA
#> 61 NA NA NA NA NA NA
#> 62 NA NA NA NA NA NA
#> 63 NA NA NA NA NA NA
#> 64 NA NA NA NA NA NA
#> 65 NA NA NA NA NA NA
#> 66 NA NA NA NA NA NA
#> 67 NA NA NA NA NA NA
#> 68 NA NA NA NA NA NA
#> 69 NA NA NA NA NA NA
#> 70 NA NA NA NA NA NA
#> 71 NA NA NA NA NA NA
#> 72 77.15658 -170.00000 115.120960 -68.90228 NA -22.7816121
#> 73 NA NA NA NA NA NA
#> 74 NA NA NA NA NA 6.1912145
#> 75 NA NA NA NA NA 14.4587978
#> 76 NA NA NA NA NA 11.9343650
#> 77 NA NA NA NA NA 45.8422849
#> 78 NA NA NA NA NA 8.6031795
#> 79 NA NA NA NA NA -6.7187553
#> 80 NA NA NA NA NA NA
#> 81 NA NA NA NA NA 62.4566017
#> 82 NA NA NA NA NA -24.2532830
#> 83 NA NA NA NA NA NA
#> 84 -37.46543 -83.97026 -170.000000 -170.00000 NA 5.8387347
#> 85 NA NA NA NA NA 10.6713522
#> 86 NA NA NA NA NA NA
#> 87 NA NA NA NA NA -7.2787276
#> 88 39.69387 38.07150 184.193013 -170.00000 NA -7.3777045
#> 89 NA NA NA NA NA NA
#> 90 NA NA NA NA NA NA
#> 91 NA NA NA NA NA NA
#> 92 NA NA NA NA NA NA
#> 93 NA NA NA NA NA 27.1199043
#> 94 NA NA NA NA NA NA
#> 95 NA NA NA NA NA NA
#> 96 NA NA NA NA NA NA
#> 97 NA NA NA NA NA NA
#> 98 NA NA NA NA NA NA
#> 99 NA NA NA NA NA NA
#> 100 NA NA NA NA NA NA
#> 101 NA NA NA NA NA NA
#> 102 NA NA NA NA NA -39.7410640
#> 103 NA NA NA NA NA NA
#> 104 NA NA NA NA NA NA
#> 105 NA NA NA NA NA -24.8499470
#> 106 NA NA NA NA NA NA
#> 107 NA NA NA NA NA -4.7413983
#> 108 NA NA NA NA NA -33.5524939
#> 109 159.59133 NA 260.970310 258.20812 246.69709 -41.5472251
#> 110 174.46374 NA -170.000000 202.96986 91.76042 -10.5226692
#> 111 NA NA NA NA NA NA
#> 112 NA NA NA NA NA NA
#> 113 NA NA NA NA NA NA
#> 114 NA NA NA NA NA NA
#> 115 NA NA NA NA NA NA
#> 116 NA NA NA NA NA -17.4341970
#> 117 64.31352 NA -170.000000 NA NA NA
#> 118 NA NA NA NA NA NA
#> 119 NA NA NA NA NA NA
#> 120 NA NA NA NA NA NA
#> acinar__naiveTc neutrophil__naiveTc unknown__naiveTc stromal__naiveTc
#> 1 NA NA NA NA
#> 2 NA NA NA NA
#> 3 NA NA NA NA
#> 4 NA NA NA NA
#> 5 NA NA NA NA
#> 6 NA NA NA NA
#> 7 NA NA NA NA
#> 8 NA NA NA NA
#> 9 -0.8261836 145.017356 -11.5858127 37.159304
#> 10 NA NA NA NA
#> 11 NA NA NA NA
#> 12 NA NA NA NA
#> 13 NA NA NA NA
#> 14 NA NA NA NA
#> 15 NA NA NA NA
#> 16 -2.4746786 37.050074 32.5975568 49.682203
#> 17 9.7523146 6.785968 -134.8426580 -119.237549
#> 18 NA NA NA NA
#> 19 NA NA NA NA
#> 20 NA NA NA NA
#> 21 NA NA NA NA
#> 22 NA NA NA NA
#> 23 NA NA NA NA
#> 24 NA NA NA NA
#> 25 NA NA NA NA
#> 26 NA NA NA NA
#> 27 NA NA NA NA
#> 28 NA NA NA NA
#> 29 10.5371932 -170.000000 -54.5333906 -28.389065
#> 30 NA NA NA NA
#> 31 NA NA NA NA
#> 32 -10.8494715 39.986196 42.0500098 15.074838
#> 33 1.6015152 -75.301078 39.9811425 -75.301078
#> 34 NA NA NA NA
#> 35 19.5001211 52.558689 11.6261907 9.826770
#> 36 -5.3542895 -17.622283 0.2253307 -32.464378
#> 37 NA NA NA NA
#> 38 -7.0381139 -49.479085 11.7754568 -6.081245
#> 39 NA NA NA NA
#> 40 -9.4446782 -71.251408 -65.6184174 29.611709
#> 41 -26.6019431 -170.000000 9.7467576 10.917864
#> 42 -12.9035135 -73.307386 27.1927801 43.710432
#> 43 -9.6990630 47.589630 20.6281981 -2.634070
#> 44 12.3860025 -124.682721 -24.0716941 13.499437
#> 45 -11.4044459 31.341524 -0.8186101 -13.542511
#> 46 -10.3634413 147.247771 73.5733007 74.940855
#> 47 8.6140471 -64.988744 1.9899273 13.122614
#> 48 4.4172682 -170.000000 17.8776674 -19.871549
#> 49 -38.5126315 NA -17.9532287 37.586711
#> 50 0.2105752 -6.727467 -12.6151292 -34.666586
#> 51 NA NA NA NA
#> 52 -20.7879908 35.656912 15.7107567 38.328613
#> 53 -41.8956423 -170.000000 11.8759595 -19.915204
#> 54 9.2823747 -170.000000 32.3689530 59.035399
#> 55 NA NA NA NA
#> 56 NA NA NA NA
#> 57 NA NA NA NA
#> 58 25.6399211 -170.000000 -68.3892612 -73.299679
#> 59 NA NA NA NA
#> 60 NA NA NA NA
#> 61 NA NA NA NA
#> 62 NA NA NA NA
#> 63 NA NA NA NA
#> 64 NA NA NA NA
#> 65 NA NA NA NA
#> 66 NA NA NA NA
#> 67 NA NA NA NA
#> 68 NA NA NA NA
#> 69 NA NA NA NA
#> 70 NA NA NA NA
#> 71 NA NA NA NA
#> 72 4.1353373 -50.151030 -15.3565385 8.370023
#> 73 NA NA NA NA
#> 74 20.9148601 304.799986 -40.5948918 -3.557348
#> 75 -7.2847779 51.331485 -52.3759487 45.851953
#> 76 -18.1752283 -50.345633 -25.7085438 23.629912
#> 77 36.4408375 -170.000000 12.8845992 -26.998999
#> 78 -2.4984155 25.267448 -108.9449166 -39.377860
#> 79 -6.9987143 -170.000000 -12.2586446 -78.702741
#> 80 NA NA NA NA
#> 81 29.4013576 -2.433148 6.7307719 -31.163303
#> 82 -11.1057750 3.579532 21.6246738 -59.162373
#> 83 NA NA NA NA
#> 84 -26.0212493 13.044147 3.2221160 -44.976799
#> 85 9.8810627 8.468511 17.5210534 -11.766519
#> 86 NA NA NA NA
#> 87 -12.9592874 36.950930 -62.8344279 -11.510986
#> 88 23.7011473 -77.173867 -57.5969985 3.030627
#> 89 NA NA NA NA
#> 90 NA NA NA NA
#> 91 NA NA NA NA
#> 92 NA NA NA NA
#> 93 -10.4911037 NA 106.8201329 -27.923328
#> 94 NA NA NA NA
#> 95 NA NA NA NA
#> 96 NA NA NA NA
#> 97 NA NA NA NA
#> 98 NA NA NA NA
#> 99 NA NA NA NA
#> 100 NA NA NA NA
#> 101 NA NA NA NA
#> 102 -82.2744243 -63.115215 51.0714734 84.430882
#> 103 NA NA NA NA
#> 104 NA NA NA NA
#> 105 -34.2597035 23.633623 55.7535009 102.247220
#> 106 NA NA NA NA
#> 107 19.7230706 -170.000000 -113.3131364 -6.524350
#> 108 -21.5998155 -49.427987 48.9137356 115.743801
#> 109 -26.4886356 -170.000000 25.0992933 50.253246
#> 110 -21.6626922 189.332103 5.4201531 165.795509
#> 111 NA NA NA NA
#> 112 NA NA NA NA
#> 113 NA NA NA NA
#> 114 NA NA NA NA
#> 115 NA NA NA NA
#> 116 -22.7302650 -104.134465 13.2147935 78.585779
#> 117 NA NA NA NA
#> 118 NA NA NA NA
#> 119 NA NA NA NA
#> 120 NA NA NA NA
#> alpha__naiveTc endothelial__naiveTc macrophage__naiveTc delta__naiveTc
#> 1 NA NA NA NA
#> 2 NA NA NA NA
#> 3 NA NA NA NA
#> 4 NA NA NA NA
#> 5 NA NA NA NA
#> 6 NA NA NA NA
#> 7 NA NA NA NA
#> 8 NA NA NA NA
#> 9 -137.709823 58.960823 64.380045 -170.000000
#> 10 NA NA NA NA
#> 11 NA NA NA NA
#> 12 NA NA NA NA
#> 13 NA NA NA NA
#> 14 NA NA NA NA
#> 15 NA NA NA NA
#> 16 -85.737151 -63.021083 16.204913 -170.000000
#> 17 -5.306108 12.618191 4.104604 28.324679
#> 18 NA NA NA NA
#> 19 NA NA NA NA
#> 20 NA NA NA NA
#> 21 NA NA NA NA
#> 22 NA NA NA NA
#> 23 NA NA NA NA
#> 24 NA NA NA NA
#> 25 NA NA NA NA
#> 26 NA NA NA NA
#> 27 NA NA NA NA
#> 28 NA NA NA NA
#> 29 -170.000000 -79.676075 -170.000000 -170.000000
#> 30 NA NA NA NA
#> 31 NA NA NA NA
#> 32 -16.970427 1.472821 -15.836557 -117.642129
#> 33 -31.473128 82.773547 -54.271478 -170.000000
#> 34 NA NA NA NA
#> 35 -104.428233 -65.406782 0.380660 -170.000000
#> 36 -55.810116 24.364489 43.821499 -70.488148
#> 37 NA NA NA NA
#> 38 3.830221 -6.920177 -23.791630 82.686201
#> 39 NA NA NA NA
#> 40 -135.491919 -36.001082 22.136612 -170.000000
#> 41 114.041936 31.589476 -170.000000 30.079227
#> 42 -22.930793 36.060694 -51.494407 0.930008
#> 43 -35.472699 39.440822 -58.112928 -72.651544
#> 44 -61.838474 58.909917 83.810868 -77.833481
#> 45 18.559178 52.469352 -50.896322 -21.959115
#> 46 -170.000000 -73.967002 -95.097334 -170.000000
#> 47 -32.683522 61.460030 13.428033 -53.468897
#> 48 -60.711784 32.441622 -170.000000 -170.000000
#> 49 84.131229 -7.188647 160.403965 108.485389
#> 50 -14.766706 55.974582 -73.341234 -52.364273
#> 51 NA NA NA NA
#> 52 -63.608152 25.459217 95.585350 -36.624786
#> 53 175.256639 218.509198 -170.000000 136.186187
#> 54 -170.000000 -93.918268 -170.000000 -29.524793
#> 55 NA NA NA NA
#> 56 NA NA NA NA
#> 57 NA NA NA NA
#> 58 -97.293510 35.887888 NA -113.609135
#> 59 NA NA NA NA
#> 60 NA NA NA NA
#> 61 NA NA NA NA
#> 62 NA NA NA NA
#> 63 NA NA NA NA
#> 64 NA NA NA NA
#> 65 NA NA NA NA
#> 66 NA NA NA NA
#> 67 NA NA NA NA
#> 68 NA NA NA NA
#> 69 NA NA NA NA
#> 70 NA NA NA NA
#> 71 NA NA NA NA
#> 72 -21.125284 -39.906409 -8.028109 -115.328485
#> 73 NA NA NA NA
#> 74 -109.827689 57.327120 -19.418868 -83.061943
#> 75 -58.400353 29.395734 -27.191234 -87.000693
#> 76 -170.000000 -30.536337 -170.000000 -170.000000
#> 77 -56.310240 -59.820732 -170.000000 -73.500446
#> 78 -26.727308 -80.331002 -170.000000 -55.368043
#> 79 28.414355 -170.000000 29.711378 -33.387195
#> 80 NA NA NA NA
#> 81 -74.104491 71.212242 -89.525855 -115.454775
#> 82 -6.713974 -4.257628 -35.295860 -27.634455
#> 83 NA NA NA NA
#> 84 -115.275743 -40.531740 14.668809 -170.000000
#> 85 -145.795018 -60.166157 -3.921229 -170.000000
#> 86 NA NA NA NA
#> 87 23.324279 -34.702103 -55.084377 -31.355303
#> 88 -116.278841 -130.645221 -66.191887 -98.742488
#> 89 NA NA NA NA
#> 90 NA NA NA NA
#> 91 NA NA NA NA
#> 92 NA NA NA NA
#> 93 -111.997442 33.984960 -170.000000 -40.302337
#> 94 NA NA NA NA
#> 95 NA NA NA NA
#> 96 NA NA NA NA
#> 97 NA NA NA NA
#> 98 NA NA NA NA
#> 99 NA NA NA NA
#> 100 NA NA NA NA
#> 101 NA NA NA NA
#> 102 59.572670 89.724103 241.929163 125.679454
#> 103 NA NA NA NA
#> 104 NA NA NA NA
#> 105 92.655281 -22.168376 -170.000000 147.924156
#> 106 NA NA NA NA
#> 107 -137.696896 48.279358 NA -170.000000
#> 108 115.464665 120.896261 NA 139.739145
#> 109 307.641452 78.632307 -170.000000 250.137333
#> 110 76.866987 76.539065 -170.000000 80.195785
#> 111 NA NA NA NA
#> 112 NA NA NA NA
#> 113 NA NA NA NA
#> 114 NA NA NA NA
#> 115 NA NA NA NA
#> 116 75.384272 -36.972372 -85.776222 41.515373
#> 117 NA NA NA NA
#> 118 NA NA NA NA
#> 119 NA NA NA NA
#> 120 NA NA NA NA
#> Tc__naiveTc Th__naiveTc otherimmune__naiveTc gamma__naiveTc B__naiveTc
#> 1 NA NA NA NA NA
#> 2 NA NA NA NA NA
#> 3 NA NA NA NA NA
#> 4 NA NA NA NA NA
#> 5 NA NA NA NA NA
#> 6 NA NA NA NA NA
#> 7 NA NA NA NA NA
#> 8 NA NA NA NA NA
#> 9 -170.000000 NA NA -170.000000 NA
#> 10 NA NA NA NA NA
#> 11 NA NA NA NA NA
#> 12 NA NA NA NA NA
#> 13 NA NA NA NA NA
#> 14 NA NA NA NA NA
#> 15 NA NA NA NA NA
#> 16 31.647434 -170.000000 -170.0000000 NA NA
#> 17 -170.000000 -22.626442 -77.3366574 NA NA
#> 18 NA NA NA NA NA
#> 19 NA NA NA NA NA
#> 20 NA NA NA NA NA
#> 21 NA NA NA NA NA
#> 22 NA NA NA NA NA
#> 23 NA NA NA NA NA
#> 24 NA NA NA NA NA
#> 25 NA NA NA NA NA
#> 26 NA NA NA NA NA
#> 27 NA NA NA NA NA
#> 28 NA NA NA NA NA
#> 29 -170.000000 30.135668 -36.3107153 -170.000000 NA
#> 30 NA NA NA NA NA
#> 31 NA NA NA NA NA
#> 32 232.864323 180.596283 172.8977391 NA NA
#> 33 -2.929999 -53.733030 44.2300583 -170.000000 NA
#> 34 NA NA NA NA NA
#> 35 -77.862814 -108.595862 -87.6211642 -170.000000 NA
#> 36 -50.458101 -27.242714 103.3362043 NA NA
#> 37 NA NA NA NA NA
#> 38 46.181830 10.832989 79.4935629 -72.559270 NA
#> 39 NA NA NA NA NA
#> 40 55.651498 414.805343 58.3711819 NA NA
#> 41 117.212127 49.626195 169.7947742 NA -170.00000
#> 42 149.791489 170.871877 16.7989746 NA -170.00000
#> 43 20.643118 3.095748 43.5515057 NA 49.05692
#> 44 -50.671853 16.099461 -33.6015338 -75.664560 49.21575
#> 45 37.534586 96.252979 43.2893997 51.392614 74.82991
#> 46 -13.963998 177.334204 188.2119971 NA -170.00000
#> 47 -33.336557 25.239656 53.9264211 NA -27.40338
#> 48 90.799535 63.157358 -92.7111671 NA 274.66802
#> 49 90.648841 -76.772182 39.3801345 NA 93.41321
#> 50 129.789012 -13.371476 31.0394451 NA 120.61987
#> 51 NA NA NA NA NA
#> 52 177.719106 154.419193 93.3769708 -77.588696 26.14730
#> 53 -170.000000 -170.000000 231.8418185 NA NA
#> 54 -38.222575 340.371772 -170.0000000 -7.557854 -170.00000
#> 55 NA NA NA NA NA
#> 56 NA NA NA NA NA
#> 57 NA NA NA NA NA
#> 58 -47.232667 -170.000000 -71.4732560 NA NA
#> 59 NA NA NA NA NA
#> 60 NA NA NA NA NA
#> 61 NA NA NA NA NA
#> 62 NA NA NA NA NA
#> 63 NA NA NA NA NA
#> 64 NA NA NA NA NA
#> 65 NA NA NA NA NA
#> 66 NA NA NA NA NA
#> 67 NA NA NA NA NA
#> 68 NA NA NA NA NA
#> 69 NA NA NA NA NA
#> 70 NA NA NA NA NA
#> 71 NA NA NA NA NA
#> 72 137.095629 -82.106757 -115.3284846 -170.000000 -71.52035
#> 73 NA NA NA NA NA
#> 74 37.593374 69.992945 -25.0068457 NA NA
#> 75 -120.508775 NA 131.1381656 -170.000000 NA
#> 76 -45.817836 -8.508365 247.4177909 NA NA
#> 77 101.801855 -170.000000 -44.4847267 NA NA
#> 78 -75.164424 -170.000000 65.3131619 -170.000000 NA
#> 79 -108.341796 -170.000000 -77.5126939 NA NA
#> 80 NA NA NA NA NA
#> 81 -17.338319 -80.792347 -96.4546159 -170.000000 NA
#> 82 20.274482 12.812772 -25.3021959 NA NA
#> 83 NA NA NA NA NA
#> 84 7.607076 -93.246723 70.5252955 -170.000000 -170.00000
#> 85 -24.818727 1.077085 -33.8511579 -170.000000 NA
#> 86 NA NA NA NA NA
#> 87 -170.000000 -16.000452 77.2745825 201.068965 NA
#> 88 -84.292118 -116.718107 -77.1804630 -170.000000 -170.00000
#> 89 NA NA NA NA NA
#> 90 NA NA NA NA NA
#> 91 NA NA NA NA NA
#> 92 NA NA NA NA NA
#> 93 -170.000000 -40.302337 -49.9232966 NA NA
#> 94 NA NA NA NA NA
#> 95 NA NA NA NA NA
#> 96 NA NA NA NA NA
#> 97 NA NA NA NA NA
#> 98 NA NA NA NA NA
#> 99 NA NA NA NA NA
#> 100 NA NA NA NA NA
#> 101 NA NA NA NA NA
#> 102 21.228390 203.045233 44.0843414 NA NA
#> 103 NA NA NA NA NA
#> 104 NA NA NA NA NA
#> 105 84.420736 216.266086 31.0216251 NA NA
#> 106 NA NA NA NA NA
#> 107 -170.000000 -170.000000 -170.0000000 56.124839 NA
#> 108 47.081093 190.540113 84.1197412 171.029153 NA
#> 109 191.984108 237.222278 165.3888351 NA 258.27989
#> 110 114.293311 142.104777 178.9749508 NA 202.96986
#> 111 NA NA NA NA NA
#> 112 NA NA NA NA NA
#> 113 NA NA NA NA NA
#> 114 NA NA NA NA NA
#> 115 NA NA NA NA NA
#> 116 73.097020 -80.506361 -0.3434108 -170.000000 NA
#> 117 NA NA NA NA NA
#> 118 NA NA NA NA NA
#> 119 NA NA NA NA NA
#> 120 NA NA NA NA NA
#> naiveTc__naiveTc beta__naiveTc ductal__beta acinar__beta neutrophil__beta
#> 1 NA NA NA NA NA
#> 2 NA NA NA NA NA
#> 3 NA NA NA NA NA
#> 4 NA NA NA NA NA
#> 5 NA NA NA NA NA
#> 6 NA NA NA NA NA
#> 7 NA NA NA NA NA
#> 8 NA NA NA NA NA
#> 9 -170.000000 NA NA NA NA
#> 10 NA NA NA NA NA
#> 11 NA NA -17.428017 -29.718985 -33.671756
#> 12 NA NA -39.506924 -48.554810 -49.845323
#> 13 NA NA -63.963843 -65.670494 -92.456641
#> 14 NA NA -56.263655 -64.280559 -69.128582
#> 15 NA NA -30.657677 -37.531888 -31.829474
#> 16 -170.000000 -34.785048 -11.071241 -19.781910 -15.053862
#> 17 -170.000000 -5.714903 -68.348626 -74.573835 -80.811497
#> 18 NA NA -51.779852 -63.259107 -52.479748
#> 19 NA NA -21.127679 -37.590302 -25.311410
#> 20 NA NA -25.510499 -29.653593 -27.830464
#> 21 NA NA -47.197935 -51.463587 NA
#> 22 NA NA -21.971523 -42.838996 NA
#> 23 NA NA -4.565037 -46.792993 NA
#> 24 NA NA -19.494066 -73.692077 NA
#> 25 NA NA -28.319138 -42.367849 -170.000000
#> 26 NA NA -40.620950 -58.979254 NA
#> 27 NA NA -16.594859 -48.291566 -170.000000
#> 28 NA NA -39.982939 -47.752022 NA
#> 29 -170.000000 -170.000000 -66.840898 -67.353969 -170.000000
#> 30 NA NA -59.866926 -52.021592 NA
#> 31 NA NA NA NA NA
#> 32 -170.000000 NA NA NA NA
#> 33 -170.000000 NA NA NA NA
#> 34 NA NA NA NA NA
#> 35 -170.000000 NA NA NA NA
#> 36 189.840250 NA NA NA NA
#> 37 NA NA NA NA NA
#> 38 -170.000000 NA NA NA NA
#> 39 NA NA NA NA NA
#> 40 -170.000000 NA NA NA NA
#> 41 -170.000000 117.774341 -54.548158 -59.945866 -170.000000
#> 42 -170.000000 NA NA NA NA
#> 43 -110.386489 21.781689 -29.990362 -48.706639 -41.180105
#> 44 -170.000000 NA NA NA NA
#> 45 -61.306187 NA NA NA NA
#> 46 471.457319 -170.000000 -41.245960 -36.479884 -104.871649
#> 47 -5.343612 -23.897001 -31.169636 -30.877099 -118.261516
#> 48 86.729199 -26.050013 -31.797592 -37.551499 -133.041927
#> 49 60.234979 52.698095 -25.346699 -56.496686 NA
#> 50 162.724080 NA NA NA NA
#> 51 NA NA NA NA NA
#> 52 191.043463 NA NA NA NA
#> 53 306.321379 NA NA NA NA
#> 54 -170.000000 NA NA NA NA
#> 55 NA NA NA NA NA
#> 56 NA NA NA NA NA
#> 57 NA NA NA NA NA
#> 58 -170.000000 NA NA NA NA
#> 59 NA NA NA NA NA
#> 60 NA NA NA NA NA
#> 61 NA NA -15.299916 -10.059545 -63.342486
#> 62 NA NA -57.949204 -49.872939 -73.363506
#> 63 NA NA -38.784243 -51.293566 -143.396777
#> 64 NA NA -16.703242 -39.267052 -109.593731
#> 65 NA NA -58.518433 -60.357501 -80.358753
#> 66 NA NA NA NA NA
#> 67 NA NA 3.135065 -5.481735 -50.139184
#> 68 NA NA -29.471927 -35.191162 -42.508304
#> 69 NA NA -57.152167 -58.067894 -99.837938
#> 70 NA NA -3.161169 -31.826406 -92.025500
#> 71 NA NA NA NA NA
#> 72 -170.000000 NA NA NA NA
#> 73 NA NA -32.599570 -56.077695 -170.000000
#> 74 544.269026 -124.114210 -84.147705 -84.979771 -47.441947
#> 75 -170.000000 -57.361451 -45.284757 -63.382354 -143.450839
#> 76 -170.000000 NA NA NA NA
#> 77 -170.000000 -123.740769 -68.794587 -79.687452 -103.943114
#> 78 -170.000000 -29.746984 -66.796212 -71.308694 -127.373085
#> 79 -170.000000 100.763823 -39.650637 -42.079886 -143.887312
#> 80 NA NA NA NA NA
#> 81 -170.000000 NA NA NA NA
#> 82 -170.000000 -6.234549 -20.966382 -30.689981 -77.494768
#> 83 NA NA -27.998465 -28.273297 -24.004955
#> 84 -170.000000 NA NA NA NA
#> 85 -21.679263 -68.306137 -34.979759 -44.647385 -66.731344
#> 86 NA NA -21.247301 -28.962636 -119.755448
#> 87 36.679312 60.183211 -30.926251 -31.228098 -54.730242
#> 88 -170.000000 NA NA NA NA
#> 89 NA NA -26.430736 -30.120926 -37.964981
#> 90 NA NA -18.286215 -31.337632 -73.893527
#> 91 NA NA -25.322696 -30.056968 NA
#> 92 NA NA -18.392613 -46.908116 -170.000000
#> 93 -170.000000 -29.003775 16.754783 -15.695269 NA
#> 94 NA NA -9.189373 -37.528192 -121.119936
#> 95 NA NA -33.510839 -39.831355 NA
#> 96 NA NA 3.629000 -32.387637 NA
#> 97 NA NA -36.927187 -57.084041 NA
#> 98 NA NA -26.804919 -55.146972 NA
#> 99 NA NA -27.817154 -36.803621 NA
#> 100 NA NA -5.801650 -56.640006 NA
#> 101 NA NA -47.175887 -41.833119 2.809774
#> 102 318.349184 30.980635 -73.406578 -84.469200 -76.605120
#> 103 NA NA -39.307433 -20.815155 -111.766353
#> 104 NA NA NA NA NA
#> 105 272.363809 214.506007 -27.964574 -57.408673 -77.033851
#> 106 NA NA NA NA NA
#> 107 -170.000000 -125.670435 -41.636075 -31.049852 60.163982
#> 108 -170.000000 174.315781 -53.544882 -32.611028 78.597142
#> 109 228.002222 298.096036 -38.978383 -31.737194 -170.000000
#> 110 -170.000000 81.365547 -52.777186 -43.913042 -66.067191
#> 111 NA NA NA NA NA
#> 112 NA NA NA NA NA
#> 113 NA NA 13.261075 15.871595 NA
#> 114 NA NA NA NA NA
#> 115 NA NA NA NA NA
#> 116 -170.000000 NA NA NA NA
#> 117 NA NA NA NA NA
#> 118 NA NA NA NA NA
#> 119 NA NA NA NA NA
#> 120 NA NA NA NA NA
#> unknown__beta stromal__beta alpha__beta endothelial__beta macrophage__beta
#> 1 NA NA NA NA NA
#> 2 NA NA NA NA NA
#> 3 NA NA NA NA NA
#> 4 NA NA NA NA NA
#> 5 NA NA NA NA NA
#> 6 NA NA NA NA NA
#> 7 NA NA NA NA NA
#> 8 NA NA NA NA NA
#> 9 NA NA NA NA NA
#> 10 NA NA NA NA NA
#> 11 9.8015124 -15.3056893 172.34006 17.408521 -46.095936
#> 12 0.4664874 -25.1932866 170.05457 -55.666116 -52.002554
#> 13 -22.2072185 -81.4002019 129.77261 25.779023 -105.209287
#> 14 -12.6622913 -35.3434013 128.92518 52.591848 -57.988236
#> 15 -20.6751051 -52.8659634 145.91723 41.952495 -62.537784
#> 16 -6.4265326 -21.0932321 136.30445 65.167857 -36.906652
#> 17 -47.8474564 -49.7224302 170.64192 -36.763500 -110.551173
#> 18 -36.5105418 4.6551257 191.14814 -1.540860 -67.484955
#> 19 -38.7316943 -31.4936973 175.34066 28.990409 -40.675224
#> 20 -6.5908964 -18.3412738 147.42425 41.641137 -11.854025
#> 21 25.6754189 10.4955098 163.75114 35.643981 NA
#> 22 20.7473173 4.1676939 150.10641 59.620731 NA
#> 23 6.3198158 -42.5605583 189.39609 -5.932611 NA
#> 24 36.0322090 12.4810347 200.24136 56.048990 -129.071274
#> 25 9.0952966 -0.9344785 216.32461 29.945239 NA
#> 26 -43.8947151 7.7343265 151.59382 26.990377 -170.000000
#> 27 31.1330482 -8.0826115 242.00105 22.167566 -13.965735
#> 28 -20.1684233 -1.9521622 196.04042 25.407200 NA
#> 29 -6.5710230 53.8080968 151.44443 49.359435 -29.360724
#> 30 -6.8207469 13.0796353 145.37080 -44.299656 NA
#> 31 NA NA NA NA NA
#> 32 NA NA NA NA NA
#> 33 NA NA NA NA NA
#> 34 NA NA NA NA NA
#> 35 NA NA NA NA NA
#> 36 NA NA NA NA NA
#> 37 NA NA NA NA NA
#> 38 NA NA NA NA NA
#> 39 NA NA NA NA NA
#> 40 NA NA NA NA NA
#> 41 12.6383258 -8.5962742 164.32308 66.306457 -58.972478
#> 42 NA NA NA NA NA
#> 43 -16.0185324 -3.3308347 211.31857 -12.932554 -34.384658
#> 44 NA NA NA NA NA
#> 45 NA NA NA NA NA
#> 46 -45.4714047 -50.8809776 277.97868 33.194188 -80.131775
#> 47 21.6562262 -9.9576770 185.58972 -19.722616 -2.012979
#> 48 -8.4200015 -48.7209504 162.61724 66.976299 -170.000000
#> 49 16.1686211 15.0605335 177.89317 -6.351611 91.839085
#> 50 NA NA NA NA NA
#> 51 NA NA NA NA NA
#> 52 NA NA NA NA NA
#> 53 NA NA NA NA NA
#> 54 NA NA NA NA NA
#> 55 NA NA NA NA NA
#> 56 NA NA NA NA NA
#> 57 NA NA NA NA NA
#> 58 NA NA NA NA NA
#> 59 NA NA NA NA NA
#> 60 NA NA NA NA NA
#> 61 -26.7268506 -64.0861082 144.21288 -48.511993 -136.738008
#> 62 15.0501176 -56.2863939 181.67144 17.060728 -109.217142
#> 63 -33.2240791 -46.1242293 196.44825 -18.912218 -126.771918
#> 64 -42.9719842 -40.6911053 215.22112 -20.916782 -75.032796
#> 65 -16.4209228 -19.6513598 122.57473 -35.079593 -170.000000
#> 66 NA NA NA NA NA
#> 67 3.4820679 4.0912354 154.24226 -15.582448 -20.091950
#> 68 18.2513014 46.4190364 252.56462 27.928786 15.986983
#> 69 -26.9757738 -55.0981681 165.70569 -19.065807 -80.345451
#> 70 -18.8851560 7.7999168 156.10988 -26.052803 -59.988823
#> 71 NA NA NA NA NA
#> 72 NA NA NA NA NA
#> 73 68.7790109 -36.5947472 190.05495 76.748371 -62.320567
#> 74 -26.3385873 -61.0256895 95.88185 26.633263 -52.666212
#> 75 18.0005817 -50.4873595 200.38703 4.250009 -129.239102
#> 76 NA NA NA NA NA
#> 77 -21.9217363 -53.6606598 92.92165 3.440566 -73.454211
#> 78 0.6940717 -56.2694491 160.54212 36.567846 -105.156248
#> 79 20.7847822 -30.4195221 82.03091 -55.646778 -3.148065
#> 80 NA NA NA NA NA
#> 81 NA NA NA NA NA
#> 82 5.4071827 -72.0055849 170.19527 34.190765 -34.008243
#> 83 16.9251257 27.3485176 199.88113 45.421605 -20.296226
#> 84 NA NA NA NA NA
#> 85 34.9535069 -36.9299846 193.33964 33.261938 -40.289178
#> 86 53.9636438 49.7962983 205.35969 -16.692871 -123.428249
#> 87 -18.4292843 -32.8795993 233.74581 -9.264151 -42.778157
#> 88 NA NA NA NA NA
#> 89 6.5494452 16.6085056 151.61476 68.866314 9.857970
#> 90 11.0983650 -22.8420119 160.08576 50.192447 -49.662346
#> 91 6.4258213 -64.2888729 184.58778 83.641209 NA
#> 92 13.0442264 -74.6754492 145.97355 68.120748 -154.327038
#> 93 -3.5386270 -111.3046635 35.42182 -7.001429 -129.741860
#> 94 -51.2116618 -53.7267115 153.44255 5.755116 19.675961
#> 95 50.5594301 -33.5259815 174.43244 90.495950 -12.108516
#> 96 -57.4919233 -54.6222202 169.27474 70.120444 -170.000000
#> 97 -17.3932695 -128.2866479 157.97962 79.820203 -93.695260
#> 98 10.9344732 -20.6155596 172.16843 79.230989 NA
#> 99 -7.2715242 -47.1996435 131.96031 37.486768 -86.162866
#> 100 -2.6244353 29.9895293 183.15276 68.341703 -138.141240
#> 101 16.8400890 3.2838285 240.57305 39.243516 -170.000000
#> 102 4.7753285 26.1390626 232.46407 36.755263 -38.463484
#> 103 -41.4948238 -37.8637390 174.18637 41.821481 NA
#> 104 NA NA NA NA NA
#> 105 5.6657919 58.8657122 198.42388 -59.967044 53.286367
#> 106 NA NA NA NA NA
#> 107 20.3257774 9.7847445 164.22764 -28.314227 NA
#> 108 42.9717308 126.3635579 185.67931 95.089486 NA
#> 109 19.2894151 24.8568475 278.60492 82.617401 -170.000000
#> 110 59.0024041 45.3908397 173.48045 38.536030 -170.000000
#> 111 NA NA NA NA NA
#> 112 NA NA NA NA NA
#> 113 -65.6669300 -101.9592039 -170.00000 -15.512284 38.412574
#> 114 NA NA NA NA NA
#> 115 NA NA NA NA NA
#> 116 NA NA NA NA NA
#> 117 NA NA NA NA NA
#> 118 NA NA NA NA NA
#> 119 NA NA NA NA NA
#> 120 NA NA NA NA NA
#> delta__beta Tc__beta Th__beta otherimmune__beta gamma__beta
#> 1 NA NA NA NA NA
#> 2 NA NA NA NA NA
#> 3 NA NA NA NA NA
#> 4 NA NA NA NA NA
#> 5 NA NA NA NA NA
#> 6 NA NA NA NA NA
#> 7 NA NA NA NA NA
#> 8 NA NA NA NA NA
#> 9 NA NA NA NA NA
#> 10 NA NA NA NA NA
#> 11 182.19334 -62.634714 -83.08982219 -170.000000 NA
#> 12 188.59769 -54.633308 NA -114.741098 151.17013
#> 13 128.64045 -63.397991 32.44142084 -102.144007 NA
#> 14 119.27182 -70.648020 3.09305104 -31.461700 NA
#> 15 164.73058 -86.217317 -140.67154631 -99.968422 NA
#> 16 194.70267 -39.538754 -71.81618124 -56.599394 NA
#> 17 191.50174 -87.153318 -121.46168811 -64.398524 NA
#> 18 183.12347 -48.125798 -128.39025266 -98.304034 NA
#> 19 225.26617 -19.220035 -95.72547511 -57.707585 NA
#> 20 180.41265 -64.952639 -60.54499005 -6.844898 NA
#> 21 199.66181 -91.777835 NA NA NA
#> 22 152.11054 13.025935 -135.76569530 37.373195 NA
#> 23 192.82198 -58.662963 NA -170.000000 NA
#> 24 173.07569 2.981815 44.84854916 51.712584 NA
#> 25 230.24802 -47.055561 178.81097555 -4.728113 NA
#> 26 165.78164 -87.837132 -143.19289401 -126.365308 NA
#> 27 238.78859 -28.612353 115.87858241 3.642633 NA
#> 28 220.63109 -24.544665 NA NA NA
#> 29 153.58663 -2.758334 -31.49771490 -155.369696 140.73111
#> 30 157.36108 -69.947204 NA -63.626762 NA
#> 31 NA NA NA NA NA
#> 32 NA NA NA NA NA
#> 33 NA NA NA NA NA
#> 34 NA NA NA NA NA
#> 35 NA NA NA NA NA
#> 36 NA NA NA NA NA
#> 37 NA NA NA NA NA
#> 38 NA NA NA NA NA
#> 39 NA NA NA NA NA
#> 40 NA NA NA NA NA
#> 41 174.79454 21.658018 8.08219792 21.594703 NA
#> 42 NA NA NA NA NA
#> 43 55.30705 4.166203 -30.73796966 -18.379860 NA
#> 44 NA NA NA NA NA
#> 45 NA NA NA NA NA
#> 46 296.76331 48.032194 3.14152490 -71.912532 NA
#> 47 108.82984 18.710160 -4.87891644 1.533325 NA
#> 48 230.68464 28.111553 -8.13601164 -27.744406 NA
#> 49 215.26226 44.363138 30.52542232 -27.416694 NA
#> 50 NA NA NA NA NA
#> 51 NA NA NA NA NA
#> 52 NA NA NA NA NA
#> 53 NA NA NA NA NA
#> 54 NA NA NA NA NA
#> 55 NA NA NA NA NA
#> 56 NA NA NA NA NA
#> 57 NA NA NA NA NA
#> 58 NA NA NA NA NA
#> 59 NA NA NA NA NA
#> 60 NA NA NA NA NA
#> 61 117.78988 -94.312262 -48.77328223 -53.277611 NA
#> 62 198.36205 -71.026921 -170.00000000 -30.716443 NA
#> 63 207.06524 -47.650604 -41.50237987 -131.222386 NA
#> 64 228.26210 -42.465717 -144.37147069 -85.265580 NA
#> 65 123.13853 -128.719533 -71.18889729 -115.720473 NA
#> 66 NA NA NA NA NA
#> 67 199.40372 -36.026631 -57.55728736 -38.144687 -33.14325
#> 68 279.57968 NA -83.91632934 -17.116830 NA
#> 69 133.64928 89.296828 NA -74.830450 NA
#> 70 178.84077 -47.126135 NA -38.395865 NA
#> 71 NA NA NA NA NA
#> 72 NA NA NA NA NA
#> 73 284.76827 70.793179 -0.03993637 -17.983098 282.57900
#> 74 104.93168 -54.254072 17.79184502 -125.338793 NA
#> 75 271.75001 -107.268511 NA -63.577213 -67.19142
#> 76 NA NA NA NA NA
#> 77 109.40502 -84.796770 -149.81081644 -47.184729 NA
#> 78 149.05575 -92.290424 -170.00000000 -80.751675 -57.27343
#> 79 278.88083 38.418988 -170.00000000 -19.992760 NA
#> 80 NA NA NA NA NA
#> 81 NA NA NA NA NA
#> 82 168.26203 -58.770149 -0.75536585 -72.944047 NA
#> 83 229.08007 89.539695 120.28142703 -51.660979 NA
#> 84 NA NA NA NA NA
#> 85 210.29276 -48.232056 -6.22341397 -26.944876 146.17745
#> 86 199.30490 36.009010 -19.18434320 -72.503095 NA
#> 87 221.03694 -132.619603 3.64444017 41.123292 229.34660
#> 88 NA NA NA NA NA
#> 89 179.20405 11.554013 -71.99644335 -64.946670 NA
#> 90 190.14456 -82.168572 -107.05839409 -99.875315 NA
#> 91 203.27317 NA NA 20.857946 NA
#> 92 168.47400 1.294909 NA 40.584073 NA
#> 93 221.02016 -76.429945 -79.92745826 20.704816 NA
#> 94 181.92280 -136.163377 0.63705907 -17.616937 NA
#> 95 152.40954 14.307857 NA -78.240598 NA
#> 96 214.99285 126.202061 -110.72569199 -82.852330 NA
#> 97 198.94552 -8.693008 -81.86475895 23.327404 NA
#> 98 181.63742 92.342431 14.01961280 -5.494710 NA
#> 99 193.84452 -112.886323 NA -170.000000 NA
#> 100 172.26811 70.784264 NA -109.396763 NA
#> 101 249.55075 -19.397377 35.42860788 41.620106 NA
#> 102 176.92644 -9.742642 37.91090133 21.447014 NA
#> 103 185.56032 54.494129 124.64891238 -170.000000 NA
#> 104 NA NA NA NA NA
#> 105 153.39902 5.450118 56.32094486 27.107245 NA
#> 106 NA NA NA NA NA
#> 107 73.97318 -170.000000 183.91711920 -137.799477 -78.32599
#> 108 177.65124 69.477943 129.13751534 125.049316 69.27391
#> 109 30.65347 170.090151 207.81296930 190.490075 NA
#> 110 197.00806 59.008473 90.88932874 77.871374 NA
#> 111 NA NA NA NA NA
#> 112 NA NA NA NA NA
#> 113 -95.97766 59.121940 -170.00000000 -170.000000 NA
#> 114 NA NA NA NA NA
#> 115 NA NA NA NA NA
#> 116 NA NA NA NA NA
#> 117 NA NA NA NA NA
#> 118 NA NA NA NA NA
#> 119 NA NA NA NA NA
#> 120 NA NA NA NA NA
#> B__beta naiveTc__beta beta__beta
#> 1 NA NA NA
#> 2 NA NA NA
#> 3 NA NA NA
#> 4 NA NA NA
#> 5 NA NA NA
#> 6 NA NA NA
#> 7 NA NA NA
#> 8 NA NA NA
#> 9 NA NA NA
#> 10 NA NA NA
#> 11 NA NA 196.1278
#> 12 NA NA 199.9677
#> 13 NA NA 169.5648
#> 14 NA NA 199.2250
#> 15 NA NA 168.2514
#> 16 NA -17.952541 201.4576
#> 17 NA -5.714903 214.1323
#> 18 NA NA 232.9403
#> 19 NA NA 214.2957
#> 20 NA NA 187.9209
#> 21 NA NA 194.6381
#> 22 NA NA 159.1182
#> 23 NA NA 193.3519
#> 24 NA NA 213.2010
#> 25 NA NA 237.5827
#> 26 NA NA 165.2063
#> 27 NA NA 255.6190
#> 28 NA NA 200.1806
#> 29 NA -170.000000 167.6774
#> 30 NA NA 167.9263
#> 31 NA NA NA
#> 32 NA NA NA
#> 33 NA NA NA
#> 34 NA NA NA
#> 35 NA NA NA
#> 36 NA NA NA
#> 37 NA NA NA
#> 38 NA NA NA
#> 39 NA NA NA
#> 40 NA NA NA
#> 41 -129.17608 117.774341 180.8940
#> 42 NA NA NA
#> 43 -60.44252 24.604651 266.1468
#> 44 NA NA NA
#> 45 NA NA NA
#> 46 -170.00000 -170.000000 298.6349
#> 47 179.06686 -21.772632 248.0636
#> 48 -50.19337 -20.645486 208.3409
#> 49 161.55526 54.983846 209.5530
#> 50 NA NA NA
#> 51 NA NA NA
#> 52 NA NA NA
#> 53 NA NA NA
#> 54 NA NA NA
#> 55 NA NA NA
#> 56 NA NA NA
#> 57 NA NA NA
#> 58 NA NA NA
#> 59 NA NA NA
#> 60 NA NA NA
#> 61 NA NA 202.3878
#> 62 NA NA 229.7082
#> 63 NA NA 194.4476
#> 64 NA NA 228.5318
#> 65 NA NA 124.5445
#> 66 NA NA NA
#> 67 NA NA 191.6432
#> 68 NA NA 245.6459
#> 69 NA NA 169.3467
#> 70 NA NA 174.6546
#> 71 NA NA NA
#> 72 NA NA NA
#> 73 NA NA 107.4522
#> 74 NA -119.394765 109.9929
#> 75 NA -57.361451 314.8335
#> 76 NA NA NA
#> 77 NA -121.511236 125.4899
#> 78 NA -18.526755 228.3028
#> 79 NA 100.763823 340.5294
#> 80 NA NA NA
#> 81 NA NA NA
#> 82 NA -5.729840 172.4228
#> 83 NA NA 239.1906
#> 84 NA NA NA
#> 85 NA -62.050791 179.9384
#> 86 NA NA 206.5403
#> 87 NA 60.183211 222.8283
#> 88 NA NA NA
#> 89 NA NA 205.6083
#> 90 NA NA 203.5996
#> 91 NA NA 176.8820
#> 92 NA NA 147.9724
#> 93 NA -29.003775 230.0317
#> 94 NA NA 195.0803
#> 95 NA NA 169.8109
#> 96 NA NA 217.1322
#> 97 NA NA 173.2726
#> 98 NA NA 188.7857
#> 99 NA NA 183.0495
#> 100 NA NA 175.7658
#> 101 NA NA 275.0372
#> 102 NA 53.622286 259.9500
#> 103 NA NA 183.6854
#> 104 NA NA NA
#> 105 NA 211.946102 350.0675
#> 106 NA NA NA
#> 107 NA -141.446157 174.4394
#> 108 NA 174.146625 192.9140
#> 109 246.75829 298.096036 338.0315
#> 110 91.92835 81.474100 198.1470
#> 111 NA NA NA
#> 112 NA NA NA
#> 113 NA NA -170.0000
#> 114 NA NA NA
#> 115 NA NA NA
#> 116 NA NA NA
#> 117 NA NA NA
#> 118 NA NA NA
#> 119 NA NA NA
#> 120 NA NA NAAgain, we obtain a spicy object which outlines the result of the mixed effects
models performed for each pairwise combination of cell types.
We can represent this as a bubble plot using the signifPlot() function by
providing it the spicy object obtained. Here, we can observe that the most
significant relationships occur between pancreatic beta and delta cells, suggesting
that the 2 cell types are far more localised during diabetes onset compared to
non-diabetics.
signifPlot(
spicyTest,
breaks = c(-3, 3, 1),
marksToPlot = c(
"alpha", "beta", "gamma", "delta",
"B", "naiveTc", "Th", "Tc", "neutrophil", "macrophage"
)
)
If we’re interested and wish to examine a specific cell type-cell type
relationship in more detail, we can use spicyBoxPlot, specifying the relationship
we want to examine.
In the bubble plot above, we can see that the most significant relationship is
between beta and delta islet cells in the pancreas. To examine this further, we
can specify either from = beta and to = delta or rank = 1 parameters in
spicyBoxPlot.
spicyBoxPlot(results = spicyTest,
# from = "beta",
# to = "delta",
rank = 1)
4.3 Mixed effects modelling for custom metrics
spicyR can also be applied to custom distance or abundance metrics. Here, we
provide an example where we apply the spicy function to a custom abundance
metric.
We first obtain the custom abundance metric by converting the a SpatialExperiment
object from the existing SingleCellExperiment object. A KNN interactions graph
is then generated with the function buildSpatialGraph from the imcRtools package.
This generates a colPairs object inside of the SpatialExperiment object.
spicyR provides the function convPairs for converting a colPairs object stored
within a SingleCellExperiment object into an abundance matrix by effectively
calculating the average number of nearby cells types for every cell type.
For example, if there exists on average 5 neutrophils for every macrophage in
image 1, the column neutrophil__macrophage would have a value of 5 for image 1.
spicy can take any input of pairwise cell type combinations across
multiple images and run a mixed effects model to determine collective differences
across conditions.
diabetesData_SPE <- SpatialExperiment(diabetesData_SCE,
colData = colData(diabetesData_SCE))
spatialCoords(diabetesData_SPE) <- data.frame(colData(diabetesData_SPE)$x, colData(diabetesData_SPE)$y) |> as.matrix()
spatialCoordsNames(diabetesData_SPE) <- c("x", "y")
diabetesData_SPE <- imcRtools::buildSpatialGraph(diabetesData_SPE, img_id = "imageID", type = "knn", k = 20, coords = c("x", "y"))
#> 'sample_id's are duplicated across 'SpatialExperiment' objects to cbind; appending sample indices.
#> The returned object is ordered by the 'imageID' entry.
pairAbundances <- convPairs(diabetesData_SPE,
colPair = "knn_interaction_graph")
head(pairAbundances["delta__delta"])
#> delta__delta
#> P15 2.863636
#> Q06 2.217391
#> Q20 8.148148
#> P36 3.076923
#> P34 3.166667
#> Q01 1.230769spicy can take any input of pairwise cell type combinations across
multiple images and run a mixed effects model to determine collective differences
across conditions. To check out other custom distance metrics which can be used,
feel free to check out the Statial package.
spicyTestColPairs <- spicy(
diabetesData_SPE,
condition = "stage",
subject = "case",
alternateResult = pairAbundances,
weights = FALSE
)
#> Cell count weighting set to FALSE for alternate results
#> Testing for spatial differences across conditions accounting for multiple images per subject
topPairs(spicyTestColPairs)
#> intercept coefficient p.value adj.pvalue
#> naiveTc__otherimmune 8.017516e+00 -3.93041769 0.002045249 0.1536382
#> gamma__Th 1.524442e-03 0.01185203 0.002963771 0.1536382
#> macrophage__beta -2.026981e-17 0.19829545 0.004005448 0.1536382
#> Th__delta 3.206950e-01 0.63170349 0.004202172 0.1536382
#> neutrophil__otherimmune 6.533208e+00 -2.57419094 0.004481884 0.1536382
#> B__Th 1.200000e+00 5.09868056 0.004819383 0.1536382
#> endothelial__stromal 1.982832e-01 0.60998756 0.005951482 0.1536382
#> B__delta 3.560011e-01 0.65020515 0.006006260 0.1536382
#> alpha__otherimmune 9.231300e+00 -3.41564695 0.006416430 0.1536382
#> otherimmune__Th 8.673736e-04 0.01574398 0.006775857 0.1536382
#> from to
#> naiveTc__otherimmune naiveTc otherimmune
#> gamma__Th gamma Th
#> macrophage__beta macrophage beta
#> Th__delta Th delta
#> neutrophil__otherimmune neutrophil otherimmune
#> B__Th B Th
#> endothelial__stromal endothelial stromal
#> B__delta B delta
#> alpha__otherimmune alpha otherimmune
#> otherimmune__Th otherimmune ThAgain, we can present this spicy object as a bubble plot using the
signifPlot() function by providing it with the spicy object.
signifPlot(
spicyTestColPairs,
marksToPlot = c(
"alpha", "acinar", "ductal", "naiveTc", "neutrophil", "Tc",
"Th", "otherimmune"
)
)
5 sessionInfo()
sessionInfo()
#> R version 4.3.2 Patched (2023-11-13 r85521)
#> Platform: x86_64-pc-linux-gnu (64-bit)
#> Running under: Ubuntu 22.04.3 LTS
#>
#> Matrix products: default
#> BLAS: /home/biocbuild/bbs-3.18-bioc/R/lib/libRblas.so
#> LAPACK: /usr/lib/x86_64-linux-gnu/lapack/liblapack.so.3.10.0
#>
#> locale:
#> [1] LC_CTYPE=en_US.UTF-8 LC_NUMERIC=C
#> [3] LC_TIME=en_GB LC_COLLATE=C
#> [5] LC_MONETARY=en_US.UTF-8 LC_MESSAGES=en_US.UTF-8
#> [7] LC_PAPER=en_US.UTF-8 LC_NAME=C
#> [9] LC_ADDRESS=C LC_TELEPHONE=C
#> [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C
#>
#> time zone: America/New_York
#> tzcode source: system (glibc)
#>
#> attached base packages:
#> [1] stats4 stats graphics grDevices utils datasets methods
#> [8] base
#>
#> other attached packages:
#> [1] imcRtools_1.8.0 SpatialExperiment_1.12.0
#> [3] SingleCellExperiment_1.24.0 SummarizedExperiment_1.32.0
#> [5] Biobase_2.62.0 GenomicRanges_1.54.1
#> [7] GenomeInfoDb_1.38.5 IRanges_2.36.0
#> [9] S4Vectors_0.40.2 BiocGenerics_0.48.1
#> [11] MatrixGenerics_1.14.0 matrixStats_1.2.0
#> [13] ggplot2_3.4.4 spicyR_1.14.3
#> [15] BiocStyle_2.30.0
#>
#> loaded via a namespace (and not attached):
#> [1] splines_4.3.2 later_1.3.2
#> [3] bitops_1.0-7 svgPanZoom_0.3.4
#> [5] tibble_3.2.1 polyclip_1.10-6
#> [7] lifecycle_1.0.4 sf_1.0-15
#> [9] rstatix_0.7.2 vroom_1.6.5
#> [11] lattice_0.22-5 MASS_7.3-60
#> [13] MultiAssayExperiment_1.28.0 backports_1.4.1
#> [15] magrittr_2.0.3 sass_0.4.8
#> [17] rmarkdown_2.25 jquerylib_0.1.4
#> [19] yaml_2.3.8 httpuv_1.6.13
#> [21] ClassifyR_3.6.2 sp_2.1-2
#> [23] spatstat.sparse_3.0-3 DBI_1.2.0
#> [25] minqa_1.2.6 RColorBrewer_1.1-3
#> [27] abind_1.4-5 zlibbioc_1.48.0
#> [29] purrr_1.0.2 ggraph_2.1.0
#> [31] RCurl_1.98-1.14 tweenr_2.0.2
#> [33] GenomeInfoDbData_1.2.11 ggrepel_0.9.4
#> [35] RTriangle_1.6-0.13 spatstat.utils_3.0-4
#> [37] terra_1.7-65 pheatmap_1.0.12
#> [39] units_0.8-5 goftest_1.2-3
#> [41] spatstat.random_3.2-2 DelayedMatrixStats_1.24.0
#> [43] svglite_2.1.3 codetools_0.2-19
#> [45] DelayedArray_0.28.0 scuttle_1.12.0
#> [47] DT_0.31 ggforce_0.4.1
#> [49] tidyselect_1.2.0 raster_3.6-26
#> [51] farver_2.1.1 lme4_1.1-35.1
#> [53] viridis_0.6.4 spatstat.explore_3.2-5
#> [55] jsonlite_1.8.8 BiocNeighbors_1.20.2
#> [57] e1071_1.7-14 ellipsis_0.3.2
#> [59] tidygraph_1.3.0 survival_3.5-7
#> [61] systemfonts_1.0.5 tools_4.3.2
#> [63] Rcpp_1.0.12 glue_1.6.2
#> [65] gridExtra_2.3 SparseArray_1.2.3
#> [67] xfun_0.41 mgcv_1.9-1
#> [69] EBImage_4.44.0 dplyr_1.1.4
#> [71] HDF5Array_1.30.0 scam_1.2-14
#> [73] shinydashboard_0.7.2 withr_2.5.2
#> [75] numDeriv_2016.8-1.1 BiocManager_1.30.22
#> [77] fastmap_1.1.1 boot_1.3-28.1
#> [79] rhdf5filters_1.14.1 fansi_1.0.6
#> [81] digest_0.6.33 R6_2.5.1
#> [83] mime_0.12 colorspace_2.1-0
#> [85] tensor_1.5 jpeg_0.1-10
#> [87] spatstat.data_3.0-3 utf8_1.2.4
#> [89] tidyr_1.3.0 generics_0.1.3
#> [91] data.table_1.14.10 class_7.3-22
#> [93] graphlayouts_1.0.2 htmlwidgets_1.6.4
#> [95] S4Arrays_1.2.0 pkgconfig_2.0.3
#> [97] gtable_0.3.4 XVector_0.42.0
#> [99] htmltools_0.5.7 carData_3.0-5
#> [101] bookdown_0.37 fftwtools_0.9-11
#> [103] scales_1.3.0 png_0.1-8
#> [105] knitr_1.45 tzdb_0.4.0
#> [107] reshape2_1.4.4 rjson_0.2.21
#> [109] nlme_3.1-164 nloptr_2.0.3
#> [111] proxy_0.4-27 cachem_1.0.8
#> [113] rhdf5_2.46.1 stringr_1.5.1
#> [115] KernSmooth_2.23-22 parallel_4.3.2
#> [117] vipor_0.4.7 concaveman_1.1.0
#> [119] pillar_1.9.0 grid_4.3.2
#> [121] vctrs_0.6.5 promises_1.2.1
#> [123] ggpubr_0.6.0 car_3.1-2
#> [125] beachmat_2.18.0 distances_0.1.10
#> [127] xtable_1.8-4 beeswarm_0.4.0
#> [129] evaluate_0.23 readr_2.1.4
#> [131] magick_2.8.2 cli_3.6.2
#> [133] locfit_1.5-9.8 compiler_4.3.2
#> [135] rlang_1.1.2 crayon_1.5.2
#> [137] ggsignif_0.6.4 labeling_0.4.3
#> [139] classInt_0.4-10 plyr_1.8.9
#> [141] ggbeeswarm_0.7.2 stringi_1.8.3
#> [143] viridisLite_0.4.2 deldir_2.0-2
#> [145] BiocParallel_1.36.0 nnls_1.5
#> [147] cytomapper_1.14.0 lmerTest_3.1-3
#> [149] munsell_0.5.0 tiff_0.1-12
#> [151] spatstat.geom_3.2-7 Matrix_1.6-4
#> [153] hms_1.1.3 bit64_4.0.5
#> [155] sparseMatrixStats_1.14.0 Rhdf5lib_1.24.1
#> [157] shiny_1.8.0 highr_0.10
#> [159] igraph_1.6.0 broom_1.0.5
#> [161] bslib_0.6.1 bit_4.0.5