DEsubs

DOI: 10.18129/B9.bioc.DEsubs    

DEsubs: an R package for flexible identification of differentially expressed subpathways using RNA-seq expression experiments

Bioconductor version: Release (3.15)

DEsubs is a network-based systems biology package that extracts disease-perturbed subpathways within a pathway network as recorded by RNA-seq experiments. It contains an extensive and customizable framework covering a broad range of operation modes at all stages of the subpathway analysis, enabling a case-specific approach. The operation modes refer to the pathway network construction and processing, the subpathway extraction, visualization and enrichment analysis with regard to various biological and pharmacological features. Its capabilities render it a tool-guide for both the modeler and experimentalist for the identification of more robust systems-level biomarkers for complex diseases.

Author: Aristidis G. Vrahatis and Panos Balomenos

Maintainer: Aristidis G. Vrahatis <agvrahatis at upatras.gr>, Panos Balomenos <balomenos at upatras.gr>

Installation

To install this package, start R (version "4.2") and enter:

if (!require("BiocManager", quietly = TRUE))
    install.packages("BiocManager")

BiocManager::install("DEsubs")

For older versions of R, please refer to the appropriate Bioconductor release.

Documentation

To view documentation for the version of this package installed in your system, start R and enter:

browseVignettes("DEsubs")

 

PDF	R Script	DEsubs
PDF		Reference Manual
Text		NEWS

Details

biocViews	DifferentialExpression, GeneExpression, GraphAndNetwork, ImmunoOncology, KEGG, Network, NetworkEnrichment, Normalization, Pathways, RNASeq, Software, SystemsBiology
Version	1.22.0
In Bioconductor since	BioC 3.4 (R-3.3) (6 years)
License	GPL-3
Depends	R (>= 3.3), locfit
Imports	graph, igraph, RBGL, circlize, limma, edgeR, EBSeq, NBPSeq, stats, grDevices, graphics, pheatmap, utils, ggplot2, Matrix, jsonlite, tools, DESeq2, methods
LinkingTo
Suggests	RUnit, BiocGenerics, knitr, rmarkdown
SystemRequirements
Enhances
URL
Depends On Me
Imports Me
Suggests Me
Links To Me
Build Report

Package Archives

Follow Installation instructions to use this package in your R session.

Source Package	DEsubs_1.22.0.tar.gz
Windows Binary	DEsubs_1.22.0.zip (64-bit only)
macOS Binary (x86_64)	DEsubs_1.22.0.tgz
Source Repository	git clone https://git.bioconductor.org/packages/DEsubs
Source Repository (Developer Access)	git clone git@git.bioconductor.org:packages/DEsubs
Package Short Url	https://bioconductor.org/packages/DEsubs/
Package Downloads Report	Download Stats