computeSlope {PharmacoGx} | R Documentation |
Return Slope (normalized slope of the drug response curve) for an experiment of a pSet by taking
its concentration and viability as input.
Description
Return Slope (normalized slope of the drug response curve) for an experiment of a pSet by taking
its concentration and viability as input.
Usage
computeSlope(concentration, viability, trunc = TRUE, verbose = TRUE)
Arguments
concentration |
numeric A concentration range that the AUC should be computed for that range.
Concentration range by default considered as not logarithmic scaled. Converted to numeric by function if necessary.
|
viability |
numeric Viablities corresponding to the concentration range passed as first parameter.
The range of viablity values by definition should be between 0 and 100. But the viabalities greater than
100 and lower than 0 are also accepted.
|
trunc |
logical(1) A flag that identify if the viabality values should be truncated to be in the
range of (0,100)
|
verbose |
logical(1) If 'TRUE' the function will retrun warnings and other infomrative messages.
|
Value
Returns the normalized linear slope of the drug response curve
Examples
dose <- c("0.0025","0.008","0.025","0.08","0.25","0.8","2.53","8")
viability <- c("108.67","111","102.16","100.27","90","87","74","57")
computeSlope(dose, viability)
[Package
PharmacoGx version 2.6.0
Index]