SOMNiBUS

DOI: 10.18129/B9.bioc.SOMNiBUS    

Smooth modeling of bisulfite sequencing

Bioconductor version: Release (3.13)

This package aims to analyse count-based methylation data on predefined genomic regions, such as those obtained by targeted sequencing, and thus to identify differentially methylated regions (DMRs) that are associated with phenotypes or traits. The method is built a rich flexible model that allows for the effects, on the methylation levels, of multiple covariates to vary smoothly along genomic regions. At the same time, this method also allows for sequencing errors and can adjust for variability in cell type mixture.

Author: Kaiqiong Zhao [aut], Kathleen Klein [cre]

Maintainer: Kathleen Klein <kathleen.klein at mail.mcgill.ca>

Installation

To install this package, start R (version "4.1") and enter:

if (!requireNamespace("BiocManager", quietly = TRUE))
    install.packages("BiocManager")

BiocManager::install("SOMNiBUS")

For older versions of R, please refer to the appropriate Bioconductor release.

Documentation

To view documentation for the version of this package installed in your system, start R and enter:

browseVignettes("SOMNiBUS")

 

HTML	R Script	Analyzing Targeted Bisulfite Sequencing data with SOMNiBUS
PDF		Reference Manual
Text		NEWS
Text		LICENSE

Details

biocViews	DNAMethylation, DifferentialMethylation, Epigenetics, FunctionalPrediction, Regression, Sequencing, Software
Version	1.0.0
In Bioconductor since	BioC 3.13 (R-4.1) (< 6 months)
License	MIT + file LICENSE
Depends	R (>= 4.1.0)
Imports	graphics, Matrix, mgcv, stats, VGAM
LinkingTo
Suggests	BiocStyle, covr, devtools, dplyr, knitr, magick, rmarkdown, testthat
SystemRequirements
Enhances
URL	https://github.com/kaiqiong/SOMNiBUS
BugReports	https://github.com/kaiqiong/SOMNiBUS/issues
Depends On Me
Imports Me
Suggests Me
Links To Me
Build Report

Package Archives

Follow Installation instructions to use this package in your R session.

Source Package	SOMNiBUS_1.0.0.tar.gz
Windows Binary	SOMNiBUS_1.0.0.zip
macOS 10.13 (High Sierra)	SOMNiBUS_1.0.0.tgz
Source Repository	git clone https://git.bioconductor.org/packages/SOMNiBUS
Source Repository (Developer Access)	git clone git@git.bioconductor.org:packages/SOMNiBUS
Package Short Url	https://bioconductor.org/packages/SOMNiBUS/
Package Downloads Report	Download Stats