combineTestPvalsMeth {RnBeads} | R Documentation |
combine p-values of multiple tests using (a generalization of) Fisher's method. The parameter setting here is taylored to DNA methylation, but can be adapted. Reference: Makambi, K. (2003). Weighted inverse chi-square method for correlated significance tests. Journal of Applied Statistics, 30(2), 225-234.
combineTestPvalsMeth( pvalues, testWeights = NULL, correlated = FALSE, methExpectedTestCorrelation = 0.8 )
pvalues |
p-values to combine |
testWeights |
weights for the individual tests |
correlated |
are the individual tests correlated |
methExpectedTestCorrelation |
expected correlation. Empirically approximated to the default value of 0.8 for DNA-methylation |
the combined p-value
Fabian Mueller, Christoph Bock
p.vals <- 10^-c(0,1,5) combineTestPvalsMeth(p.vals)