gtoxHillACXX {GladiaTOX} | R Documentation |
These functions solve for Hill model parameters.
gtoxHillACXX(XX, tp, ga, gw, bt = 0) gtoxHillConc(val, tp, ga, gw, bt = 0) gtoxHillVal(logc, tp, ga, gw, bt = 0)
XX |
Numeric, the activity level (percentage of the top value) |
tp |
Numeric, the top value from the Hill model |
ga |
Numeric, the logAC50 value from the Hill model |
gw |
Numeric, the Hill coefficient from the Hill model |
bt |
Numierc, the bottom value from the Hill model |
val |
Numeric, the activity value |
logc |
Numeric, the log concentration |
gtoxHillVal
computes the value of the Hill model for a given log
concentration.
gtoxHillACXX
computes the activity concentration for a Hill model for
a given activity level.
gtoxHillConc
computes the Hill model concentration for a
given value.
None
## The following code gives examples for a Hill model with a top of 50, ## bottom of 0, AC50 of 1 and Hill coefficient of 1. ## gtoxHillVal calculates activity value given a concentration. gtoxHillVal ## will return the tp/2 when logc equals ga: gtoxHillVal(logc = 1, tp = 50, ga = 1, gw = 1, bt = 0) ## Here, gtoxHillConc returns the concentration where the value equals 20 gtoxHillConc(val = 20, tp = 50, ga = 1, gw = 1, bt = 0) ## Note how this differs from gtoxHillACXX: gtoxHillACXX(XX = 20, tp = 50, ga = 1, gw = 1, bt = 0) ## gtoxHillACXX is based on the top value and allows the user to calculate ## specifc activity concentrations based on a percentage of the top value ## For example, we can calculate the value for the concentration 0.25, then ## use that value to check the other two functions. value <- gtoxHillVal(logc = 0.25, tp = 50, ga = 1, gw = 1, bt = 0) c1 <- gtoxHillConc(val = value, tp = 50, ga = 1, gw = 1, bt = 0) c2 <- gtoxHillACXX(XX = value/50*100, tp = 50, ga = 1, gw = 1, bt = 0) all.equal(0.25, c1, c2) ## Notice, the value had to be transformed to a percentage of the top value ## when using gtoxHillACXX