riskyAlleleCount {gwascat}R Documentation

given a matrix of subjects x SNP calls, count number of risky alleles

Description

given a matrix of subjects x SNP calls, count number of risky alleles for various conditions, relative to NHGRI GWAS catalog

Usage

riskyAlleleCount(
  callmat,
  matIsAB = TRUE,
  chr,
  gwwl,
  snpap = "SNPlocs.Hsapiens.dbSNP144.GRCh37",
  gencode = c("A/A", "A/B", "B/B")
)

Arguments

callmat

matrix with subjects as rows, SNPs as columns; entries can be generic A/A, A/B, B/B, or specific nucleotide calls

matIsAB

logical, FALSE if nucleotide codes are present, TRUE if generic call codes are present; in the latter case, gwascat:::ABmat2nuc will be run

chr

code for chromosome, should work with the SNP annotation getSNPlocs function, so likely "ch[nn]"

gwwl

an instance of {gwaswloc}

snpap

name of a Bioconductor SNPlocs.Hsapiens.dbSNP.* package

gencode

codes used for generic SNP call

Value

matrix with rows corresponding to subjects , columns corresponding to SNP

Examples


## Not run: 
data(gg17N) # translated from GGdata chr 17 calls using ABmat2nuc
data(ebicat37)
library(GenomeInfoDb)
seqlevelsStyle(ebicat37) = "UCSC"
h17 = riskyAlleleCount(gg17N, matIsAB=FALSE, chr="ch17", gwwl=ebicat37)
h17[1:5,1:5]
table(as.numeric(h17))

## End(Not run)


[Package gwascat version 2.22.0 Index]