pairedAlleleSpecificCopyNumbers {aroma.light} | R Documentation |
Calculating tumor-normal paired allele-specific copy number stratified on genotypes. The method is a single-sample (single-pair) method. It requires paired tumor-normal parent-specific copy number signals.
## S3 method for class 'numeric' pairedAlleleSpecificCopyNumbers(thetaT, betaT, thetaN, betaN, muN=callNaiveGenotypes(betaN), ...)
thetaT, betaT |
Theta and allele-B fraction signals for the tumor. |
thetaN, betaN |
Total and allele-B fraction signals for the matched normal. |
muN |
An optional |
... |
Not used. |
Returns a data.frame
with elements CT
, betaT
and muN
.
Pierre Neuvial, Henrik Bengtsson
This definition of calculating tumor-normal paired ASCN is related
to how the normalizeTumorBoost
() method calculates normalized
tumor BAFs.