M2B {ENmix}R Documentation

Convert methylation M value to methylation beta value.

Description

Convert methylation M value to methylation beta value.

Usage

M2B(x)

Arguments

x

An numeric matrix

Details

Methylation beta value is calculated as beta=M/(M+U+a). M is methylated intensity, U is unmethylated intensity, and a is a constant offset (by default , a=100). M value is calculated as M=log2((M+a)/(U+a)). M or U is usually greater than 1000, so a is negligible for most probes. if a=0, then beta=2^M/(2^M+1).

Value

A matrix of methylation Beta values.

Author(s)

Zongli Xu


[Package ENmix version 1.25.1 Index]