############################################################################## ############################################################################## ### ### Running command: ### ### /home/biocbuild/bbs-3.15-data-experiment/R/bin/R CMD build --keep-empty-dirs --no-resave-data curatedOvarianData ### ############################################################################## ############################################################################## * checking for file ‘curatedOvarianData/DESCRIPTION’ ... OK * preparing ‘curatedOvarianData’: * checking DESCRIPTION meta-information ... OK * installing the package to process help pages * building the PDF package manual Hmm ... looks like a package Converting Rd files to LaTeX ... Creating pdf output from LaTeX ... This is pdfTeX, Version 3.14159265-2.6-1.40.20 (TeX Live 2019/Debian) (preloaded format=pdflatex) restricted \write18 enabled. entering extended mode LaTeX2e <2020-02-02> patch level 2 L3 programming layer <2020-02-14> (./Rd2.tex (/usr/share/texlive/texmf-dist/tex/latex/base/book.cls Document Class: book 2019/12/20 v1.4l Standard LaTeX document class (/usr/share/texlive/texmf-dist/tex/latex/base/bk10.clo)) (/home/biocbuild/bbs-3.15-data-experiment/R/share/texmf/tex/latex/Rd.sty (/usr/share/texlive/texmf-dist/tex/latex/base/ifthen.sty) (/usr/share/texlive/texmf-dist/tex/latex/tools/longtable.sty) (/usr/share/texlive/texmf-dist/tex/latex/tools/bm.sty) (/usr/share/texlive/texmf-dist/tex/latex/base/alltt.sty) (/usr/share/texlive/texmf-dist/tex/latex/tools/verbatim.sty) (/usr/share/texlive/texmf-dist/tex/latex/url/url.sty) (/usr/share/texlive/texmf-dist/tex/latex/base/textcomp.sty) (/usr/share/texlive/texmf-dist/tex/latex/base/fontenc.sty) (/usr/share/texlive/texmf-dist/tex/latex/psnfss/times.sty) (/usr/share/texlive/texmf-dist/tex/latex/inconsolata/zi4.sty `inconsolata-zi4' v1.12, 2019/05/17 Text macros for Inconsolata (msharpe) (/usr/share/texlive/texmf-dist/tex/latex/xkeyval/xkeyval.sty (/usr/share/texlive/texmf-dist/tex/generic/xkeyval/xkeyval.tex (/usr/share/texlive/texmf-dist/tex/generic/xkeyval/xkvutils.tex (/usr/share/texlive/texmf-dist/tex/generic/xkeyval/keyval.tex))))) (/usr/share/texlive/texmf-dist/tex/latex/graphics/color.sty (/usr/share/texlive/texmf-dist/tex/latex/graphics-cfg/color.cfg) (/usr/share/texlive/texmf-dist/tex/latex/graphics-def/pdftex.def)) (/usr/share/texlive/texmf-dist/tex/latex/hyperref/hyperref.sty (/usr/share/texlive/texmf-dist/tex/generic/ltxcmds/ltxcmds.sty) (/usr/share/texlive/texmf-dist/tex/generic/iftex/iftex.sty) (/usr/share/texlive/texmf-dist/tex/latex/pdftexcmds/pdftexcmds.sty (/usr/share/texlive/texmf-dist/tex/generic/infwarerr/infwarerr.sty)) (/usr/share/texlive/texmf-dist/tex/generic/kvsetkeys/kvsetkeys.sty) (/usr/share/texlive/texmf-dist/tex/generic/kvdefinekeys/kvdefinekeys.sty) (/usr/share/texlive/texmf-dist/tex/generic/pdfescape/pdfescape.sty) (/usr/share/texlive/texmf-dist/tex/latex/hycolor/hycolor.sty) (/usr/share/texlive/texmf-dist/tex/latex/letltxmacro/letltxmacro.sty) (/usr/share/texlive/texmf-dist/tex/latex/auxhook/auxhook.sty) (/usr/share/texlive/texmf-dist/tex/latex/kvoptions/kvoptions.sty) (/usr/share/texlive/texmf-dist/tex/latex/hyperref/pd1enc.def) (/usr/share/texlive/texmf-dist/tex/generic/intcalc/intcalc.sty) (/usr/share/texlive/texmf-dist/tex/generic/etexcmds/etexcmds.sty) (/usr/share/texlive/texmf-dist/tex/generic/bitset/bitset.sty (/usr/share/texlive/texmf-dist/tex/generic/bigintcalc/bigintcalc.sty)) (/usr/share/texlive/texmf-dist/tex/generic/atbegshi/atbegshi.sty)) (/usr/share/texlive/texmf-dist/tex/latex/hyperref/hpdftex.def (/usr/share/texlive/texmf-dist/tex/latex/atveryend/atveryend.sty) (/usr/share/texlive/texmf-dist/tex/latex/rerunfilecheck/rerunfilecheck.sty (/usr/share/texlive/texmf-dist/tex/generic/uniquecounter/uniquecounter.sty))) Package hyperref Warning: Option `hyperindex' has already been used, (hyperref) setting the option has no effect on input line 396. 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[3] Overfull \hbox (1107.93701pt too wide) in paragraph at lines 193--193 [] \T1/zi4/m/n/10 Experimenter name: Bentink S, Haibe-Kains B, Risch T, Fan J -B, Hirsch MS, Holton K, Rubio R, April C, Chen J, Wickham-Garcia E, Liu J, Cul hane A, Drapkin R, Quackenbush J, Matulonis UA: Angiogenic mRNA and microRNA ge ne expression signature predicts a novel subtype of serous ovarian cancer. PLoS ONE 2012, 7:e30269.[] Overfull \hbox (146.38962pt too wide) in paragraph at lines 196--196 [] \T1/zi4/m/n/10 Title: Angiogenic mRNA and microRNA gene expression signatu re predicts a novel subtype of serous ovarian cancer.[] (/usr/share/texlive/texmf-dist/tex/latex/inconsolata/ts1zi4.fd) [4] [5] [6] Overfull \hbox (591.34872pt too wide) in paragraph at lines 315--315 [] \T1/zi4/m/n/10 Experimenter name: Partheen K, Levan K, Osterberg L, Horvat h G.Expression analysis of stage III serous ovarian adenocarcinoma distinguishe s a sub-group of survivors. Eur J Cancer. 2006 Nov; 42(16):2846-54.[] Overfull \hbox (134.72977pt too wide) in paragraph at lines 318--318 [] \T1/zi4/m/n/10 Title: Expression analysis of stage III serous ovarian aden ocarcinoma distinguishes a sub-group of survivors.[] [7] Overfull \hbox (34.73999pt too wide) in paragraph at lines 354--354 []\T1/zi4/m/n/10 Binary overall survival summary (definitions of long and shor t provided by study authors):[] [8] Overfull \hbox (1299.59686pt too wide) in paragraph at lines 432--432 [] \T1/zi4/m/n/10 Experimenter name: Yoshihara K, Tajima A, Komata D, Yamamot o T, Kodama S, Fujiwara H, Suzuki M, Onishi Y, Hatae M, Sueyoshi K, Fujiwara H, Kudo Y, Inoue I, Tanaka K.Gene expression profiling of advanced-stage serous o varian cancers distinguishes novel subclasses and implicates ZEB2 in tumor prog ression and prognosis. Cancer Sci. 2009 Aug; 100(8):1421-8.[] [9] Overfull \hbox (379.70932pt too wide) in paragraph at lines 435--435 [] \T1/zi4/m/n/10 Title: Gene expression profiling of advanced-stage serous o varian cancers distinguishes novel subclasses and implicates ZEB2 in tumor prog ression and prognosis.[] [10] [11] Overfull \hbox (861.2976pt too wide) in paragraph at lines 524--524 [] \T1/zi4/m/n/10 Experimenter name: Crijns AP, Fehrmann RS, de Jong S, Gerbe ns F, Meersma GJ, Klip HG, Hollema H, Hofstra RM, te Meerman GJ, de Vries EG, v an der Zee AG.Survival-related profile, pathways, and transcription factors in ovarian cancer. PLoS Med. 2009 Feb 3; 6(2):e24.[] Overfull \hbox (31.41006pt too wide) in paragraph at lines 527--527 [] \T1/zi4/m/n/10 Title: Survival-related profile, pathways, and transcriptio n factors in ovarian cancer.[] [12] [13] [14] Overfull \hbox (636.3385pt too wide) in paragraph at lines 642--642 [] \T1/zi4/m/n/10 Experimenter name: Denkert C, Budczies J, Darb-Esfahani S, Gy??rffy B et al. A prognostic gene expression index in ovarian cancer - valida tion across different independent data sets. J Pathol 2009 Jun;218(2):273-80.[] Overfull \hbox (146.38962pt too wide) in paragraph at lines 645--645 [] \T1/zi4/m/n/10 Title: A prognostic gene expression index in ovarian cancer - validation across different independent data sets.[] [15] Underfull \vbox (badness 10000) has occurred while \output is active [16] Overfull \hbox (3.12666pt too wide) in paragraph at lines 755--756 []\T1/ptm/m/n/10 Advanced-stage ovar-ian can-cer pa-tients are gen-er-ally trea ted with platinum/taxane-based chemother- Overfull \hbox (1289.58664pt too wide) in paragraph at lines 768--768 [] \T1/zi4/m/n/10 Experimenter name: Yoshihara K, Tajima A, Yahata T, Kodama S, Fujiwara H, Suzuki M, Onishi Y, Hatae M, Sueyoshi K, Fujiwara H, Kudo Y, Kot era K, Masuzaki H, Tashiro H, Katabuchi H, Inoue I, Tanaka K.Gene expression pr ofile for predicting survival in advanced-stage serous ovarian cancer across tw o independent datasets. PLoS One. 2010 Mar 12; 5(3):e9615.[] [17] Overfull \hbox (221.38962pt too wide) in paragraph at lines 771--771 [] \T1/zi4/m/n/10 Title: Gene expression profile for predicting survival in a dvanced-stage serous ovarian cancer across two independent datasets.[] [18] Underfull \vbox (badness 10000) has occurred while \output is active [19] Overfull \hbox (1551.22604pt too wide) in paragraph at lines 906--906 [] \T1/zi4/m/n/10 Experimenter name: Mok SC, Bonome T, Vathipadiekal V, Bell A, Johnson ME, Wong KK, Park DC, Hao K, Yip DK, Donninger H, Ozbun L, Samimi G, Brady J, Randonovich M, Pise-Masison CA, Barrett JC, Wong WH, Welch WR, Berkow itz RS, Birrer MJ.A gene signature predictive for outcome in advanced ovarian c ancer identifies a survival factor: microfibril-associated glycoprotein 2. Canc er Cell. 2009 Dec 8; 16(6):521-32.[] Overfull \hbox (293.04947pt too wide) in paragraph at lines 909--909 [] \T1/zi4/m/n/10 Title: A gene signature predictive for outcome in advanced ovarian cancer identifies a survival factor: microfibril-associated glycoprotei n 2.[] [20] [21] Underfull \vbox (badness 10000) has occurred while \output is active [22] Overfull \hbox (904.64798pt too wide) in paragraph at lines 1041--1041 [] \T1/zi4/m/n/10 Experimenter name: Konstantinopoulos PA, Spentzos D, Karlan BY, Taniguchi T et al. Gene expression profile of BRCAness that correlates wit h responsiveness to chemotherapy and with outcome in patients with epithelial o varian cancer. J Clin Oncol 2010 Aug 1;28(22):3555-61.[] Overfull \hbox (353.03925pt too wide) in paragraph at lines 1044--1044 [] \T1/zi4/m/n/10 Title: Gene expression profile of BRCAness that correlates with responsiveness to chemotherapy and with outcome in patients with epithelia l ovarian cancer.[] [23] [24] [25] Overfull \hbox (904.64798pt too wide) in paragraph at lines 1139--1139 [] \T1/zi4/m/n/10 Experimenter name: Konstantinopoulos PA, Spentzos D, Karlan BY, Taniguchi T et al. Gene expression profile of BRCAness that correlates wit h responsiveness to chemotherapy and with outcome in patients with epithelial o varian cancer. J Clin Oncol 2010 Aug 1;28(22):3555-61.[] Overfull \hbox (353.03925pt too wide) in paragraph at lines 1142--1142 [] \T1/zi4/m/n/10 Title: Gene expression profile of BRCAness that correlates with responsiveness to chemotherapy and with outcome in patients with epithelia l ovarian cancer.[] Underfull \vbox (badness 1881) has occurred while \output is active [26] [27] Overfull \hbox (1481.23627pt too wide) in paragraph at lines 1237--1237 [] \T1/zi4/m/n/10 Experimenter name: Meyniel JP, Cottu PH, Decraene C, Stern MH, Couturier J, Lebigot I, Nicolas A, Weber N, Fourchotte V, Alran S, Rapinat A, Gentien D, Roman-Roman S, Mignot L, Sastre-Garau X.A genomic and transcripto mic approach for a differential diagnosis between primary and secondary ovarian carcinomas in patients with a previous history of breast cancer. BMC Cancer. 2 010 May 21; 10:222.[] Overfull \hbox (451.35895pt too wide) in paragraph at lines 1240--1240 [] \T1/zi4/m/n/10 Title: A genomic and transcriptomic approach for a differen tial diagnosis between primary and secondary ovarian carcinomas in patients wit h a previous history of breast cancer.[] [28] [29] Overfull \hbox (101.41006pt too wide) in paragraph at lines 1345--1345 [] \T1/zi4/m/n/10 Experimenter name: EXpression Project for Oncology, Interna tional Genomics Consortium, www.intgen.org[] [30] [31] [32] Overfull \hbox (126.38962pt too wide) in paragraph at lines 1457--1457 [] \T1/zi4/m/n/10 Experimenter name: Mateescu B, Batista L, Mariani O, Meynie l J, Cottu PH, Sastre-Garau X, Mechta-Grigoriou F[] Overfull \hbox (81.39984pt too wide) in paragraph at lines 1460--1460 [] \T1/zi4/m/n/10 Title: miR-141 and miR-200a act on ovarian tumorigenesis by controlling oxidative stress response.[] [33] Underfull \vbox (badness 10000) has occurred while \output is active [34] Overfull \hbox (917.96768pt too wide) in paragraph at lines 1583--1583 [] \T1/zi4/m/n/10 Experimenter name: Bonome T, Levine DA, Shih J, Randonovich M, Pise-Masison CA, Bogomolniy F, Ozbun L, Brady J, Barrett JC, Boyd J, Birrer MJ: A Gene Signature Predicting for Survival in Suboptimally Debulked Patients with Ovarian Cancer. Cancer Research 2008, 68:5478 -5486.[] [35] Overfull \hbox (99.72977pt too wide) in paragraph at lines 1586--1586 [] \T1/zi4/m/n/10 Title: A gene signature predicting for survival in suboptim ally debulked patients with ovarian cancer.[] [36] Underfull \vbox (badness 10000) has occurred while \output is active [37] [38] Overfull \hbox (724.66843pt too wide) in paragraph at lines 1726--1726 [] \T1/zi4/m/n/10 Experimenter name: Gillet JP, Calcagno AM, Varma S, Davidso n B et al. Multidrug resistance-linked gene signature predicts overall survival of patients with primary ovarian serous carcinoma. Clin Cancer Res 2012 Jun 1; 18(11):3197-206.[] Overfull \hbox (218.0597pt too wide) in paragraph at lines 1729--1729 [] \T1/zi4/m/n/10 Title: Multidrug resistance-linked gene signature predicts overall survival of patients with primary ovarian serous carcinoma.[] [39] Underfull \vbox (badness 10000) has occurred while \output is active [40] Overfull \hbox (84.71954pt too wide) in paragraph at lines 1848--1848 [] \T1/zi4/m/n/10 Experimenter name: Ferriss JS, Kim Y, Duska L, Birrer M, Le vine DA, Moskaluk C,Theodorescu D, Lee JK[] Overfull \hbox (299.71954pt too wide) in paragraph at lines 1851--1851 [] \T1/zi4/m/n/10 Title: Multi-gene expression predictors of single drug resp onses to adjuvant chemotherapy in ovarian carcinoma: predicting platinum resist ance.[] [41] [42] Underfull \vbox (badness 10000) has occurred while \output is active [43] [44] Overfull \hbox (834.6582pt too wide) in paragraph at lines 1994--1994 [] \T1/zi4/m/n/10 Experimenter name: Yoshihara K, Tsunoda T, Shigemizu D, Fuj iwara H et al. High-risk ovarian cancer based on 126-gene expression signature is uniquely characterized by downregulation of antigen presentation pathway. Cl in Cancer Res 2012 Mar 1;18(5):1374-85.[] Overfull \hbox (318.04947pt too wide) in paragraph at lines 1997--1997 [] \T1/zi4/m/n/10 Title: High-risk ovarian cancer based on 126-gene expressio n signature is uniquely characterized by downregulation of antigen presentation pathway.[] [45] Underfull \vbox (badness 10000) has occurred while \output is active [46] [47] Overfull \hbox (834.6582pt too wide) in paragraph at lines 2121--2121 [] \T1/zi4/m/n/10 Experimenter name: Yoshihara K, Tsunoda T, Shigemizu D, Fuj iwara H et al. High-risk ovarian cancer based on 126-gene expression signature is uniquely characterized by downregulation of antigen presentation pathway. Cl in Cancer Res 2012 Mar 1;18(5):1374-85.[] Overfull \hbox (318.04947pt too wide) in paragraph at lines 2124--2124 [] \T1/zi4/m/n/10 Title: High-risk ovarian cancer based on 126-gene expressio n signature is uniquely characterized by downregulation of antigen presentation pathway.[] [48] Underfull \vbox (badness 10000) has occurred while \output is active [49] [50] Overfull \hbox (66.39984pt too wide) in paragraph at lines 2251--2251 [] \T1/zi4/m/n/10 Title: COL11A1 promotes tumor progression and predicts poor clinical outcome in ovarian cancer.[] Overfull \hbox (34.73999pt too wide) in paragraph at lines 2287--2287 []\T1/zi4/m/n/10 Binary overall survival summary (definitions of long and shor t provided by study authors):[] [51] [52] Overfull \hbox (456.32828pt too wide) in paragraph at lines 2357--2357 [] \T1/zi4/m/n/10 Experimenter name: Pils D1, Hager G, Tong D, Aust S, Heinze G, Kohl M, Schuster E, Wolf A, Sehouli J, Braicu I, Vergote I, Cadron I, Mahne r S, Hofstetter G, Speiser P, Zeillinger R[] Overfull \hbox (156.3794pt too wide) in paragraph at lines 2360--2360 [] \T1/zi4/m/n/10 Title: Validating the impact of a molecular subtype in ovar ian cancer on outcomes: a study of the OVCAD Consortium.[] [53] [54] [55] Overfull \hbox (139.70932pt too wide) in paragraph at lines 2484--2484 [] \T1/zi4/m/n/10 Experimenter name: Karlan BY, Dering J, Walsh C, Orsulic S, Lester J, Anderson LA, Ginther CL, Fejzo M, Slamon D[] Overfull \hbox (133.06992pt too wide) in paragraph at lines 2487--2487 [] \T1/zi4/m/n/10 Title: POSTN/TGFBI-associated stromal signature predicts po or prognosis in serous epithelial ovarian cancer.[] [56] [57] Underfull \hbox (badness 1337) in paragraph at lines 2605--2605 [] \T1/ptm/m/it/10 Lysophos-pha-tidic acid-induced tran-scrip-tional pro-file r ep-re-sents [58] Overfull \hbox (1007.96768pt too wide) in paragraph at lines 2623--2623 [] \T1/zi4/m/n/10 Experimenter name: Murph MM, Liu W, Yu S, Lu Y, Hall H, Hen nessy BT, Lahad J, Schaner M, Helland A, Kristensen G, Brresen-Dale AL, Mills G B. Lysophosphatidic acid-induced transcriptional profile represents serous epit helial ovarian carcinoma and worsened prognosis. PLoS One. 2009; 4(5):e5583.[] Overfull \hbox (246.39984pt too wide) in paragraph at lines 2626--2626 [] \T1/zi4/m/n/10 Title: Lysophosphatidic acid-induced transcriptional profil e represents serous epithelial ovarian carcinoma and worsened prognosis.[] [59] [60] Overfull \hbox (972.96768pt too wide) in paragraph at lines 2731--2731 [] \T1/zi4/m/n/10 Experimenter name: Ouellet V, Provencher DM, Maugard CM, Le Page C, Ren F, Lussier C, Novak J, Ge B, Hudson TJ, Tonin PN, Mes-Masson A-M: Discrimination between serous low malignant potential and invasive epithelial o varian tumors using molecular profiling. Oncogene 2005, 24:4672-4687.[] [61] [62] Overfull \hbox (929.62753pt too wide) in paragraph at lines 2827--2827 [] \T1/zi4/m/n/10 Experimenter name: Marchini S, Mariani P, Chiorino G, Marra zzo E, Bonomi R, Fruscio R, Clivio L, Garbi A, Torri V, Cinquini M, Dell\TS1/zi 4/m/n/10 '\T1/zi4/m/n/10 Anna T, Apolone G, Broggini M, D\TS1/zi4/m/n/10 '\T1/z i4/m/n/10 Incalci M.Analysis of gene expression in early-stage ovarian cancer. Clin Cancer Res. 2008 Dec 1; 14(23):7850-60.[] [63] [64] Underfull \vbox (badness 10000) has occurred while \output is active [65] Overfull \hbox (1302.91656pt too wide) in paragraph at lines 2953--2953 [] \T1/zi4/m/n/10 Experimenter name: Tothill RW, Tinker AV, George J, Brown R , Fox SB, Lade S, Johnson DS, Trivett MK, Etemadmoghadam D, Locandro B, Trafica nte N, Fereday S, Hung JA, Chiew YE, Haviv I, Gertig D, DeFazio A, Bowtell DD.N ovel molecular subtypes of serous and endometrioid ovarian cancer linked to cli nical outcome. Clin Cancer Res. 2008 Aug 15; 14(16):5198-208.[] Overfull \hbox (94.72977pt too wide) in paragraph at lines 2956--2956 [] \T1/zi4/m/n/10 Title: Novel molecular subtypes of serous and endometrioid ovarian cancer linked to clinical outcome.[] [66] [67] Underfull \vbox (badness 10000) has occurred while \output is active [68] [69] Overfull \hbox (1011.28738pt too wide) in paragraph at lines 3108--3108 [] \T1/zi4/m/n/10 Experimenter name: Berchuck A, Iversen ES, Lancaster JM, Pi ttman J, Luo J, Lee P, Murphy S, Dressman HK, Febbo PG, West M, Nevins JR, Mark s JR.Patterns of gene expression that characterize long-term survival in advanc ed stage serous ovarian cancers. Clin Cancer Res. 2005 May 15; 11(10):3686-96.[ ] Overfull \hbox (153.0597pt too wide) in paragraph at lines 3111--3111 [] \T1/zi4/m/n/10 Title: Patterns of gene expression that characterize long-t erm survival in advanced stage serous ovarian cancers.[] [70] Overfull \hbox (34.73999pt too wide) in paragraph at lines 3149--3149 []\T1/zi4/m/n/10 Binary overall survival summary (definitions of long and shor t provided by study authors):[] [71] [72] Overfull \hbox (1221.25671pt too wide) in paragraph at lines 3231--3231 [] \T1/zi4/m/n/10 Experimenter name: Dressman HK, Berchuck A, Chan G, Zhai J, Bild A, Sayer R, Cragun J, Clarke J, Whitaker RS, Li L, Gray J, Marks J, Ginsb urg GS, Potti A, West M, Nevins JR, Lancaster JM.An integrated genomic-based ap proach to individualized treatment of patients with advanced-stage ovarian canc er. J Clin Oncol. 2007 Feb 10; 25(5):517-25.[] Overfull \hbox (184.72977pt too wide) in paragraph at lines 3234--3234 [] \T1/zi4/m/n/10 Title: An integrated genomic-based approach to individualiz ed treatment of patients with advanced-stage ovarian cancer.[] [73] Underfull \vbox (badness 10000) has occurred while \output is active [74] Overfull \hbox (1237.92679pt too wide) in paragraph at lines 3359--3359 [] \T1/zi4/m/n/10 Experimenter name: Berchuck A, Iversen ES, Luo J, Clarke JP , Horne H, Levine DA, Boyd J, Alonso MA, Secord AA, Bernardini MQ, Barnett JC, Boren T, Murphy SK, Dressman HK, Marks JR, Lancaster JM.Microarray analysis of early stage serous ovarian cancers shows profiles predictive of favorable outco me. Clin Cancer Res. 2009 Apr 1; 15(7):2448-55.[] Overfull \hbox (148.0597pt too wide) in paragraph at lines 3362--3362 [] \T1/zi4/m/n/10 Title: Microarray analysis of early stage serous ovarian ca ncers shows profiles predictive of favorable outcome.[] [75] [76] Underfull \vbox (badness 10000) has occurred while \output is active [77] Overfull \hbox (64.73999pt too wide) in paragraph at lines 3491--3491 [] \T1/zi4/m/n/10 Experimenter name: Integrated genomic analyses of ovarian c arcinoma. Nature 2011, 474:609-615.[] [78] [79] Underfull \vbox (badness 10000) has occurred while \output is active [80] Underfull \vbox (badness 10000) has occurred while \output is active [81] Overfull \hbox (64.73999pt too wide) in paragraph at lines 3667--3667 [] \T1/zi4/m/n/10 Experimenter name: Integrated genomic analyses of ovarian c arcinoma. Nature 2011, 474:609-615.[] [82] [83] Underfull \vbox (badness 10000) has occurred while \output is active [84] [85] Overfull \hbox (64.73999pt too wide) in paragraph at lines 3840--3840 [] \T1/zi4/m/n/10 Experimenter name: Integrated genomic analyses of ovarian c arcinoma. Nature 2011, 474:609-615.[] [86] [87] Underfull \vbox (badness 10000) has occurred while \output is active [88] No file Rd2.ind. [89] (/tmp/Rtmpnd7VRK/Rbuildff44811626336/curatedOvarianData/.Rd2pdf1045576/Rd2.aux) Package rerunfilecheck Warning: File `Rd2.out' has changed. (rerunfilecheck) Rerun to get outlines right (rerunfilecheck) or use package `bookmark'. ) (see the transcript file for additional information){/usr/share/texlive/texmf-d ist/fonts/enc/dvips/inconsolata/i4-ts1.enc}{/usr/share/texlive/texmf-dist/fonts /enc/dvips/base/8r.enc}{/usr/share/texlive/texmf-dist/fonts/enc/dvips/inconsola ta/i4-t1-0.enc} Output written on Rd2.pdf (89 pages, 220431 bytes). Transcript written on Rd2.log. 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[3] [4] Overfull \hbox (1107.93701pt too wide) in paragraph at lines 193--193 [] \T1/zi4/m/n/10 Experimenter name: Bentink S, Haibe-Kains B, Risch T, Fan J -B, Hirsch MS, Holton K, Rubio R, April C, Chen J, Wickham-Garcia E, Liu J, Cul hane A, Drapkin R, Quackenbush J, Matulonis UA: Angiogenic mRNA and microRNA ge ne expression signature predicts a novel subtype of serous ovarian cancer. PLoS ONE 2012, 7:e30269.[] Overfull \hbox (146.38962pt too wide) in paragraph at lines 196--196 [] \T1/zi4/m/n/10 Title: Angiogenic mRNA and microRNA gene expression signatu re predicts a novel subtype of serous ovarian cancer.[] (/usr/share/texlive/texmf-dist/tex/latex/inconsolata/ts1zi4.fd) [5] Underfull \vbox (badness 10000) has occurred while \output is active [6] Overfull \hbox (591.34872pt too wide) in paragraph at lines 315--315 [] \T1/zi4/m/n/10 Experimenter name: Partheen K, Levan K, Osterberg L, Horvat h G.Expression analysis of stage III serous ovarian adenocarcinoma distinguishe s a sub-group of survivors. Eur J Cancer. 2006 Nov; 42(16):2846-54.[] Overfull \hbox (134.72977pt too wide) in paragraph at lines 318--318 [] \T1/zi4/m/n/10 Title: Expression analysis of stage III serous ovarian aden ocarcinoma distinguishes a sub-group of survivors.[] [7] Overfull \hbox (34.73999pt too wide) in paragraph at lines 354--354 []\T1/zi4/m/n/10 Binary overall survival summary (definitions of long and shor t provided by study authors):[] [8] [9] Overfull \hbox (1299.59686pt too wide) in paragraph at lines 432--432 [] \T1/zi4/m/n/10 Experimenter name: Yoshihara K, Tajima A, Komata D, Yamamot o T, Kodama S, Fujiwara H, Suzuki M, Onishi Y, Hatae M, Sueyoshi K, Fujiwara H, Kudo Y, Inoue I, Tanaka K.Gene expression profiling of advanced-stage serous o varian cancers distinguishes novel subclasses and implicates ZEB2 in tumor prog ression and prognosis. Cancer Sci. 2009 Aug; 100(8):1421-8.[] Overfull \hbox (379.70932pt too wide) in paragraph at lines 435--435 [] \T1/zi4/m/n/10 Title: Gene expression profiling of advanced-stage serous o varian cancers distinguishes novel subclasses and implicates ZEB2 in tumor prog ression and prognosis.[] [10] [11] Overfull \hbox (861.2976pt too wide) in paragraph at lines 524--524 [] \T1/zi4/m/n/10 Experimenter name: Crijns AP, Fehrmann RS, de Jong S, Gerbe ns F, Meersma GJ, Klip HG, Hollema H, Hofstra RM, te Meerman GJ, de Vries EG, v an der Zee AG.Survival-related profile, pathways, and transcription factors in ovarian cancer. PLoS Med. 2009 Feb 3; 6(2):e24.[] Overfull \hbox (31.41006pt too wide) in paragraph at lines 527--527 [] \T1/zi4/m/n/10 Title: Survival-related profile, pathways, and transcriptio n factors in ovarian cancer.[] [12] [13] [14] Overfull \hbox (636.3385pt too wide) in paragraph at lines 642--642 [] \T1/zi4/m/n/10 Experimenter name: Denkert C, Budczies J, Darb-Esfahani S, Gy??rffy B et al. A prognostic gene expression index in ovarian cancer - valida tion across different independent data sets. J Pathol 2009 Jun;218(2):273-80.[] Overfull \hbox (146.38962pt too wide) in paragraph at lines 645--645 [] \T1/zi4/m/n/10 Title: A prognostic gene expression index in ovarian cancer - validation across different independent data sets.[] [15] [16] Overfull \hbox (3.12666pt too wide) in paragraph at lines 755--756 []\T1/ptm/m/n/10 Advanced-stage ovar-ian can-cer pa-tients are gen-er-ally trea ted with platinum/taxane-based chemother- [17] Overfull \hbox (1289.58664pt too wide) in paragraph at lines 768--768 [] \T1/zi4/m/n/10 Experimenter name: Yoshihara K, Tajima A, Yahata T, Kodama S, Fujiwara H, Suzuki M, Onishi Y, Hatae M, Sueyoshi K, Fujiwara H, Kudo Y, Kot era K, Masuzaki H, Tashiro H, Katabuchi H, Inoue I, Tanaka K.Gene expression pr ofile for predicting survival in advanced-stage serous ovarian cancer across tw o independent datasets. PLoS One. 2010 Mar 12; 5(3):e9615.[] Overfull \hbox (221.38962pt too wide) in paragraph at lines 771--771 [] \T1/zi4/m/n/10 Title: Gene expression profile for predicting survival in a dvanced-stage serous ovarian cancer across two independent datasets.[] [18] [19] [20] Overfull \hbox (1551.22604pt too wide) in paragraph at lines 906--906 [] \T1/zi4/m/n/10 Experimenter name: Mok SC, Bonome T, Vathipadiekal V, Bell A, Johnson ME, Wong KK, Park DC, Hao K, Yip DK, Donninger H, Ozbun L, Samimi G, Brady J, Randonovich M, Pise-Masison CA, Barrett JC, Wong WH, Welch WR, Berkow itz RS, Birrer MJ.A gene signature predictive for outcome in advanced ovarian c ancer identifies a survival factor: microfibril-associated glycoprotein 2. Canc er Cell. 2009 Dec 8; 16(6):521-32.[] Overfull \hbox (293.04947pt too wide) in paragraph at lines 909--909 [] \T1/zi4/m/n/10 Title: A gene signature predictive for outcome in advanced ovarian cancer identifies a survival factor: microfibril-associated glycoprotei n 2.[] [21] [22] [23] Overfull \hbox (904.64798pt too wide) in paragraph at lines 1041--1041 [] \T1/zi4/m/n/10 Experimenter name: Konstantinopoulos PA, Spentzos D, Karlan BY, Taniguchi T et al. Gene expression profile of BRCAness that correlates wit h responsiveness to chemotherapy and with outcome in patients with epithelial o varian cancer. J Clin Oncol 2010 Aug 1;28(22):3555-61.[] Overfull \hbox (353.03925pt too wide) in paragraph at lines 1044--1044 [] \T1/zi4/m/n/10 Title: Gene expression profile of BRCAness that correlates with responsiveness to chemotherapy and with outcome in patients with epithelia l ovarian cancer.[] [24] [25] Overfull \hbox (904.64798pt too wide) in paragraph at lines 1139--1139 [] \T1/zi4/m/n/10 Experimenter name: Konstantinopoulos PA, Spentzos D, Karlan BY, Taniguchi T et al. Gene expression profile of BRCAness that correlates wit h responsiveness to chemotherapy and with outcome in patients with epithelial o varian cancer. J Clin Oncol 2010 Aug 1;28(22):3555-61.[] Overfull \hbox (353.03925pt too wide) in paragraph at lines 1142--1142 [] \T1/zi4/m/n/10 Title: Gene expression profile of BRCAness that correlates with responsiveness to chemotherapy and with outcome in patients with epithelia l ovarian cancer.[] [26] [27] [28] Overfull \hbox (1481.23627pt too wide) in paragraph at lines 1237--1237 [] \T1/zi4/m/n/10 Experimenter name: Meyniel JP, Cottu PH, Decraene C, Stern MH, Couturier J, Lebigot I, Nicolas A, Weber N, Fourchotte V, Alran S, Rapinat A, Gentien D, Roman-Roman S, Mignot L, Sastre-Garau X.A genomic and transcripto mic approach for a differential diagnosis between primary and secondary ovarian carcinomas in patients with a previous history of breast cancer. BMC Cancer. 2 010 May 21; 10:222.[] Overfull \hbox (451.35895pt too wide) in paragraph at lines 1240--1240 [] \T1/zi4/m/n/10 Title: A genomic and transcriptomic approach for a differen tial diagnosis between primary and secondary ovarian carcinomas in patients wit h a previous history of breast cancer.[] [29] [30] Overfull \hbox (101.41006pt too wide) in paragraph at lines 1345--1345 [] \T1/zi4/m/n/10 Experimenter name: EXpression Project for Oncology, Interna tional Genomics Consortium, www.intgen.org[] [31] [32] Overfull \hbox (126.38962pt too wide) in paragraph at lines 1457--1457 [] \T1/zi4/m/n/10 Experimenter name: Mateescu B, Batista L, Mariani O, Meynie l J, Cottu PH, Sastre-Garau X, Mechta-Grigoriou F[] Overfull \hbox (81.39984pt too wide) in paragraph at lines 1460--1460 [] \T1/zi4/m/n/10 Title: miR-141 and miR-200a act on ovarian tumorigenesis by controlling oxidative stress response.[] [33] [34] [35] Overfull \hbox (917.96768pt too wide) in paragraph at lines 1583--1583 [] \T1/zi4/m/n/10 Experimenter name: Bonome T, Levine DA, Shih J, Randonovich M, Pise-Masison CA, Bogomolniy F, Ozbun L, Brady J, Barrett JC, Boyd J, Birrer MJ: A Gene Signature Predicting for Survival in Suboptimally Debulked Patients with Ovarian Cancer. Cancer Research 2008, 68:5478 -5486.[] Overfull \hbox (99.72977pt too wide) in paragraph at lines 1586--1586 [] \T1/zi4/m/n/10 Title: A gene signature predicting for survival in suboptim ally debulked patients with ovarian cancer.[] [36] [37] [38] Overfull \hbox (724.66843pt too wide) in paragraph at lines 1726--1726 [] \T1/zi4/m/n/10 Experimenter name: Gillet JP, Calcagno AM, Varma S, Davidso n B et al. Multidrug resistance-linked gene signature predicts overall survival of patients with primary ovarian serous carcinoma. Clin Cancer Res 2012 Jun 1; 18(11):3197-206.[] Overfull \hbox (218.0597pt too wide) in paragraph at lines 1729--1729 [] \T1/zi4/m/n/10 Title: Multidrug resistance-linked gene signature predicts overall survival of patients with primary ovarian serous carcinoma.[] [39] [40] [41] Overfull \hbox (84.71954pt too wide) in paragraph at lines 1848--1848 [] \T1/zi4/m/n/10 Experimenter name: Ferriss JS, Kim Y, Duska L, Birrer M, Le vine DA, Moskaluk C,Theodorescu D, Lee JK[] Overfull \hbox (299.71954pt too wide) in paragraph at lines 1851--1851 [] \T1/zi4/m/n/10 Title: Multi-gene expression predictors of single drug resp onses to adjuvant chemotherapy in ovarian carcinoma: predicting platinum resist ance.[] [42] [43] [44] Overfull \hbox (834.6582pt too wide) in paragraph at lines 1994--1994 [] \T1/zi4/m/n/10 Experimenter name: Yoshihara K, Tsunoda T, Shigemizu D, Fuj iwara H et al. High-risk ovarian cancer based on 126-gene expression signature is uniquely characterized by downregulation of antigen presentation pathway. Cl in Cancer Res 2012 Mar 1;18(5):1374-85.[] Overfull \hbox (318.04947pt too wide) in paragraph at lines 1997--1997 [] \T1/zi4/m/n/10 Title: High-risk ovarian cancer based on 126-gene expressio n signature is uniquely characterized by downregulation of antigen presentation pathway.[] [45] [46] [47] Overfull \hbox (834.6582pt too wide) in paragraph at lines 2121--2121 [] \T1/zi4/m/n/10 Experimenter name: Yoshihara K, Tsunoda T, Shigemizu D, Fuj iwara H et al. High-risk ovarian cancer based on 126-gene expression signature is uniquely characterized by downregulation of antigen presentation pathway. Cl in Cancer Res 2012 Mar 1;18(5):1374-85.[] Overfull \hbox (318.04947pt too wide) in paragraph at lines 2124--2124 [] \T1/zi4/m/n/10 Title: High-risk ovarian cancer based on 126-gene expressio n signature is uniquely characterized by downregulation of antigen presentation pathway.[] [48] [49] [50] Overfull \hbox (66.39984pt too wide) in paragraph at lines 2251--2251 [] \T1/zi4/m/n/10 Title: COL11A1 promotes tumor progression and predicts poor clinical outcome in ovarian cancer.[] [51] Overfull \hbox (34.73999pt too wide) in paragraph at lines 2287--2287 []\T1/zi4/m/n/10 Binary overall survival summary (definitions of long and shor t provided by study authors):[] [52] Overfull \hbox (456.32828pt too wide) in paragraph at lines 2357--2357 [] \T1/zi4/m/n/10 Experimenter name: Pils D1, Hager G, Tong D, Aust S, Heinze G, Kohl M, Schuster E, Wolf A, Sehouli J, Braicu I, Vergote I, Cadron I, Mahne r S, Hofstetter G, Speiser P, Zeillinger R[] Overfull \hbox (156.3794pt too wide) in paragraph at lines 2360--2360 [] \T1/zi4/m/n/10 Title: Validating the impact of a molecular subtype in ovar ian cancer on outcomes: a study of the OVCAD Consortium.[] [53] [54] Underfull \vbox (badness 10000) has occurred while \output is active [55] Overfull \hbox (139.70932pt too wide) in paragraph at lines 2484--2484 [] \T1/zi4/m/n/10 Experimenter name: Karlan BY, Dering J, Walsh C, Orsulic S, Lester J, Anderson LA, Ginther CL, Fejzo M, Slamon D[] Overfull \hbox (133.06992pt too wide) in paragraph at lines 2487--2487 [] \T1/zi4/m/n/10 Title: POSTN/TGFBI-associated stromal signature predicts po or prognosis in serous epithelial ovarian cancer.[] [56] [57] Underfull \vbox (badness 10000) has occurred while \output is active [58] Underfull \hbox (badness 1337) in paragraph at lines 2605--2605 [] \T1/ptm/m/it/10 Lysophos-pha-tidic acid-induced tran-scrip-tional pro-file r ep-re-sents Overfull \hbox (1007.96768pt too wide) in paragraph at lines 2623--2623 [] \T1/zi4/m/n/10 Experimenter name: Murph MM, Liu W, Yu S, Lu Y, Hall H, Hen nessy BT, Lahad J, Schaner M, Helland A, Kristensen G, Brresen-Dale AL, Mills G B. Lysophosphatidic acid-induced transcriptional profile represents serous epit helial ovarian carcinoma and worsened prognosis. PLoS One. 2009; 4(5):e5583.[] [59] Overfull \hbox (246.39984pt too wide) in paragraph at lines 2626--2626 [] \T1/zi4/m/n/10 Title: Lysophosphatidic acid-induced transcriptional profil e represents serous epithelial ovarian carcinoma and worsened prognosis.[] [60] [61] Overfull \hbox (972.96768pt too wide) in paragraph at lines 2731--2731 [] \T1/zi4/m/n/10 Experimenter name: Ouellet V, Provencher DM, Maugard CM, Le Page C, Ren F, Lussier C, Novak J, Ge B, Hudson TJ, Tonin PN, Mes-Masson A-M: Discrimination between serous low malignant potential and invasive epithelial o varian tumors using molecular profiling. Oncogene 2005, 24:4672-4687.[] [62] [63] Overfull \hbox (929.62753pt too wide) in paragraph at lines 2827--2827 [] \T1/zi4/m/n/10 Experimenter name: Marchini S, Mariani P, Chiorino G, Marra zzo E, Bonomi R, Fruscio R, Clivio L, Garbi A, Torri V, Cinquini M, Dell\TS1/zi 4/m/n/10 '\T1/zi4/m/n/10 Anna T, Apolone G, Broggini M, D\TS1/zi4/m/n/10 '\T1/z i4/m/n/10 Incalci M.Analysis of gene expression in early-stage ovarian cancer. Clin Cancer Res. 2008 Dec 1; 14(23):7850-60.[] [64] [65] [66] Overfull \hbox (1302.91656pt too wide) in paragraph at lines 2953--2953 [] \T1/zi4/m/n/10 Experimenter name: Tothill RW, Tinker AV, George J, Brown R , Fox SB, Lade S, Johnson DS, Trivett MK, Etemadmoghadam D, Locandro B, Trafica nte N, Fereday S, Hung JA, Chiew YE, Haviv I, Gertig D, DeFazio A, Bowtell DD.N ovel molecular subtypes of serous and endometrioid ovarian cancer linked to cli nical outcome. Clin Cancer Res. 2008 Aug 15; 14(16):5198-208.[] Overfull \hbox (94.72977pt too wide) in paragraph at lines 2956--2956 [] \T1/zi4/m/n/10 Title: Novel molecular subtypes of serous and endometrioid ovarian cancer linked to clinical outcome.[] [67] Underfull \vbox (badness 10000) has occurred while \output is active [68] [69] Overfull \hbox (1011.28738pt too wide) in paragraph at lines 3108--3108 [] \T1/zi4/m/n/10 Experimenter name: Berchuck A, Iversen ES, Lancaster JM, Pi ttman J, Luo J, Lee P, Murphy S, Dressman HK, Febbo PG, West M, Nevins JR, Mark s JR.Patterns of gene expression that characterize long-term survival in advanc ed stage serous ovarian cancers. Clin Cancer Res. 2005 May 15; 11(10):3686-96.[ ] Overfull \hbox (153.0597pt too wide) in paragraph at lines 3111--3111 [] \T1/zi4/m/n/10 Title: Patterns of gene expression that characterize long-t erm survival in advanced stage serous ovarian cancers.[] [70] Overfull \hbox (34.73999pt too wide) in paragraph at lines 3149--3149 []\T1/zi4/m/n/10 Binary overall survival summary (definitions of long and shor t provided by study authors):[] [71] [72] Overfull \hbox (1221.25671pt too wide) in paragraph at lines 3231--3231 [] \T1/zi4/m/n/10 Experimenter name: Dressman HK, Berchuck A, Chan G, Zhai J, Bild A, Sayer R, Cragun J, Clarke J, Whitaker RS, Li L, Gray J, Marks J, Ginsb urg GS, Potti A, West M, Nevins JR, Lancaster JM.An integrated genomic-based ap proach to individualized treatment of patients with advanced-stage ovarian canc er. J Clin Oncol. 2007 Feb 10; 25(5):517-25.[] Overfull \hbox (184.72977pt too wide) in paragraph at lines 3234--3234 [] \T1/zi4/m/n/10 Title: An integrated genomic-based approach to individualiz ed treatment of patients with advanced-stage ovarian cancer.[] [73] [74] [75] Overfull \hbox (1237.92679pt too wide) in paragraph at lines 3359--3359 [] \T1/zi4/m/n/10 Experimenter name: Berchuck A, Iversen ES, Luo J, Clarke JP , Horne H, Levine DA, Boyd J, Alonso MA, Secord AA, Bernardini MQ, Barnett JC, Boren T, Murphy SK, Dressman HK, Marks JR, Lancaster JM.Microarray analysis of early stage serous ovarian cancers shows profiles predictive of favorable outco me. Clin Cancer Res. 2009 Apr 1; 15(7):2448-55.[] Overfull \hbox (148.0597pt too wide) in paragraph at lines 3362--3362 [] \T1/zi4/m/n/10 Title: Microarray analysis of early stage serous ovarian ca ncers shows profiles predictive of favorable outcome.[] [76] [77] [78] Overfull \hbox (64.73999pt too wide) in paragraph at lines 3491--3491 [] \T1/zi4/m/n/10 Experimenter name: Integrated genomic analyses of ovarian c arcinoma. Nature 2011, 474:609-615.[] [79] Underfull \vbox (badness 10000) has occurred while \output is active [80] Underfull \vbox (badness 10000) has occurred while \output is active [81] [82] Overfull \hbox (64.73999pt too wide) in paragraph at lines 3667--3667 [] \T1/zi4/m/n/10 Experimenter name: Integrated genomic analyses of ovarian c arcinoma. Nature 2011, 474:609-615.[] [83] Underfull \vbox (badness 10000) has occurred while \output is active [84] Underfull \vbox (badness 10000) has occurred while \output is active [85] Overfull \hbox (64.73999pt too wide) in paragraph at lines 3840--3840 [] \T1/zi4/m/n/10 Experimenter name: Integrated genomic analyses of ovarian c arcinoma. Nature 2011, 474:609-615.[] [86] [87] Underfull \vbox (badness 10000) has occurred while \output is active [88] Underfull \vbox (badness 10000) has occurred while \output is active [89] No file Rd2.ind. [90] (/tmp/Rtmpnd7VRK/Rbuildff44811626336/curatedOvarianData/.Rd2pdf1045576/Rd2.aux) ) (see the transcript file for additional information){/usr/share/texlive/texmf-d ist/fonts/enc/dvips/inconsolata/i4-ts1.enc}{/usr/share/texlive/texmf-dist/fonts /enc/dvips/base/8r.enc}{/usr/share/texlive/texmf-dist/fonts/enc/dvips/inconsola ta/i4-t1-0.enc} Output written on Rd2.pdf (90 pages, 224192 bytes). Transcript written on Rd2.log. 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[3] [4] Overfull \hbox (1107.93701pt too wide) in paragraph at lines 193--193 [] \T1/zi4/m/n/10 Experimenter name: Bentink S, Haibe-Kains B, Risch T, Fan J -B, Hirsch MS, Holton K, Rubio R, April C, Chen J, Wickham-Garcia E, Liu J, Cul hane A, Drapkin R, Quackenbush J, Matulonis UA: Angiogenic mRNA and microRNA ge ne expression signature predicts a novel subtype of serous ovarian cancer. PLoS ONE 2012, 7:e30269.[] Overfull \hbox (146.38962pt too wide) in paragraph at lines 196--196 [] \T1/zi4/m/n/10 Title: Angiogenic mRNA and microRNA gene expression signatu re predicts a novel subtype of serous ovarian cancer.[] (/usr/share/texlive/texmf-dist/tex/latex/inconsolata/ts1zi4.fd) [5] Underfull \vbox (badness 10000) has occurred while \output is active [6] Overfull \hbox (591.34872pt too wide) in paragraph at lines 315--315 [] \T1/zi4/m/n/10 Experimenter name: Partheen K, Levan K, Osterberg L, Horvat h G.Expression analysis of stage III serous ovarian adenocarcinoma distinguishe s a sub-group of survivors. Eur J Cancer. 2006 Nov; 42(16):2846-54.[] Overfull \hbox (134.72977pt too wide) in paragraph at lines 318--318 [] \T1/zi4/m/n/10 Title: Expression analysis of stage III serous ovarian aden ocarcinoma distinguishes a sub-group of survivors.[] [7] Overfull \hbox (34.73999pt too wide) in paragraph at lines 354--354 []\T1/zi4/m/n/10 Binary overall survival summary (definitions of long and shor t provided by study authors):[] [8] [9] Overfull \hbox (1299.59686pt too wide) in paragraph at lines 432--432 [] \T1/zi4/m/n/10 Experimenter name: Yoshihara K, Tajima A, Komata D, Yamamot o T, Kodama S, Fujiwara H, Suzuki M, Onishi Y, Hatae M, Sueyoshi K, Fujiwara H, Kudo Y, Inoue I, Tanaka K.Gene expression profiling of advanced-stage serous o varian cancers distinguishes novel subclasses and implicates ZEB2 in tumor prog ression and prognosis. Cancer Sci. 2009 Aug; 100(8):1421-8.[] Overfull \hbox (379.70932pt too wide) in paragraph at lines 435--435 [] \T1/zi4/m/n/10 Title: Gene expression profiling of advanced-stage serous o varian cancers distinguishes novel subclasses and implicates ZEB2 in tumor prog ression and prognosis.[] [10] [11] Overfull \hbox (861.2976pt too wide) in paragraph at lines 524--524 [] \T1/zi4/m/n/10 Experimenter name: Crijns AP, Fehrmann RS, de Jong S, Gerbe ns F, Meersma GJ, Klip HG, Hollema H, Hofstra RM, te Meerman GJ, de Vries EG, v an der Zee AG.Survival-related profile, pathways, and transcription factors in ovarian cancer. PLoS Med. 2009 Feb 3; 6(2):e24.[] Overfull \hbox (31.41006pt too wide) in paragraph at lines 527--527 [] \T1/zi4/m/n/10 Title: Survival-related profile, pathways, and transcriptio n factors in ovarian cancer.[] [12] [13] [14] Overfull \hbox (636.3385pt too wide) in paragraph at lines 642--642 [] \T1/zi4/m/n/10 Experimenter name: Denkert C, Budczies J, Darb-Esfahani S, Gy??rffy B et al. A prognostic gene expression index in ovarian cancer - valida tion across different independent data sets. J Pathol 2009 Jun;218(2):273-80.[] Overfull \hbox (146.38962pt too wide) in paragraph at lines 645--645 [] \T1/zi4/m/n/10 Title: A prognostic gene expression index in ovarian cancer - validation across different independent data sets.[] [15] [16] Overfull \hbox (3.12666pt too wide) in paragraph at lines 755--756 []\T1/ptm/m/n/10 Advanced-stage ovar-ian can-cer pa-tients are gen-er-ally trea ted with platinum/taxane-based chemother- [17] Overfull \hbox (1289.58664pt too wide) in paragraph at lines 768--768 [] \T1/zi4/m/n/10 Experimenter name: Yoshihara K, Tajima A, Yahata T, Kodama S, Fujiwara H, Suzuki M, Onishi Y, Hatae M, Sueyoshi K, Fujiwara H, Kudo Y, Kot era K, Masuzaki H, Tashiro H, Katabuchi H, Inoue I, Tanaka K.Gene expression pr ofile for predicting survival in advanced-stage serous ovarian cancer across tw o independent datasets. PLoS One. 2010 Mar 12; 5(3):e9615.[] Overfull \hbox (221.38962pt too wide) in paragraph at lines 771--771 [] \T1/zi4/m/n/10 Title: Gene expression profile for predicting survival in a dvanced-stage serous ovarian cancer across two independent datasets.[] [18] [19] [20] Overfull \hbox (1551.22604pt too wide) in paragraph at lines 906--906 [] \T1/zi4/m/n/10 Experimenter name: Mok SC, Bonome T, Vathipadiekal V, Bell A, Johnson ME, Wong KK, Park DC, Hao K, Yip DK, Donninger H, Ozbun L, Samimi G, Brady J, Randonovich M, Pise-Masison CA, Barrett JC, Wong WH, Welch WR, Berkow itz RS, Birrer MJ.A gene signature predictive for outcome in advanced ovarian c ancer identifies a survival factor: microfibril-associated glycoprotein 2. Canc er Cell. 2009 Dec 8; 16(6):521-32.[] Overfull \hbox (293.04947pt too wide) in paragraph at lines 909--909 [] \T1/zi4/m/n/10 Title: A gene signature predictive for outcome in advanced ovarian cancer identifies a survival factor: microfibril-associated glycoprotei n 2.[] [21] [22] [23] Overfull \hbox (904.64798pt too wide) in paragraph at lines 1041--1041 [] \T1/zi4/m/n/10 Experimenter name: Konstantinopoulos PA, Spentzos D, Karlan BY, Taniguchi T et al. Gene expression profile of BRCAness that correlates wit h responsiveness to chemotherapy and with outcome in patients with epithelial o varian cancer. J Clin Oncol 2010 Aug 1;28(22):3555-61.[] Overfull \hbox (353.03925pt too wide) in paragraph at lines 1044--1044 [] \T1/zi4/m/n/10 Title: Gene expression profile of BRCAness that correlates with responsiveness to chemotherapy and with outcome in patients with epithelia l ovarian cancer.[] [24] [25] Overfull \hbox (904.64798pt too wide) in paragraph at lines 1139--1139 [] \T1/zi4/m/n/10 Experimenter name: Konstantinopoulos PA, Spentzos D, Karlan BY, Taniguchi T et al. Gene expression profile of BRCAness that correlates wit h responsiveness to chemotherapy and with outcome in patients with epithelial o varian cancer. J Clin Oncol 2010 Aug 1;28(22):3555-61.[] Overfull \hbox (353.03925pt too wide) in paragraph at lines 1142--1142 [] \T1/zi4/m/n/10 Title: Gene expression profile of BRCAness that correlates with responsiveness to chemotherapy and with outcome in patients with epithelia l ovarian cancer.[] [26] [27] [28] Overfull \hbox (1481.23627pt too wide) in paragraph at lines 1237--1237 [] \T1/zi4/m/n/10 Experimenter name: Meyniel JP, Cottu PH, Decraene C, Stern MH, Couturier J, Lebigot I, Nicolas A, Weber N, Fourchotte V, Alran S, Rapinat A, Gentien D, Roman-Roman S, Mignot L, Sastre-Garau X.A genomic and transcripto mic approach for a differential diagnosis between primary and secondary ovarian carcinomas in patients with a previous history of breast cancer. BMC Cancer. 2 010 May 21; 10:222.[] Overfull \hbox (451.35895pt too wide) in paragraph at lines 1240--1240 [] \T1/zi4/m/n/10 Title: A genomic and transcriptomic approach for a differen tial diagnosis between primary and secondary ovarian carcinomas in patients wit h a previous history of breast cancer.[] [29] [30] Overfull \hbox (101.41006pt too wide) in paragraph at lines 1345--1345 [] \T1/zi4/m/n/10 Experimenter name: EXpression Project for Oncology, Interna tional Genomics Consortium, www.intgen.org[] [31] [32] Overfull \hbox (126.38962pt too wide) in paragraph at lines 1457--1457 [] \T1/zi4/m/n/10 Experimenter name: Mateescu B, Batista L, Mariani O, Meynie l J, Cottu PH, Sastre-Garau X, Mechta-Grigoriou F[] Overfull \hbox (81.39984pt too wide) in paragraph at lines 1460--1460 [] \T1/zi4/m/n/10 Title: miR-141 and miR-200a act on ovarian tumorigenesis by controlling oxidative stress response.[] [33] [34] [35] Overfull \hbox (917.96768pt too wide) in paragraph at lines 1583--1583 [] \T1/zi4/m/n/10 Experimenter name: Bonome T, Levine DA, Shih J, Randonovich M, Pise-Masison CA, Bogomolniy F, Ozbun L, Brady J, Barrett JC, Boyd J, Birrer MJ: A Gene Signature Predicting for Survival in Suboptimally Debulked Patients with Ovarian Cancer. Cancer Research 2008, 68:5478 -5486.[] Overfull \hbox (99.72977pt too wide) in paragraph at lines 1586--1586 [] \T1/zi4/m/n/10 Title: A gene signature predicting for survival in suboptim ally debulked patients with ovarian cancer.[] [36] [37] [38] Overfull \hbox (724.66843pt too wide) in paragraph at lines 1726--1726 [] \T1/zi4/m/n/10 Experimenter name: Gillet JP, Calcagno AM, Varma S, Davidso n B et al. Multidrug resistance-linked gene signature predicts overall survival of patients with primary ovarian serous carcinoma. Clin Cancer Res 2012 Jun 1; 18(11):3197-206.[] Overfull \hbox (218.0597pt too wide) in paragraph at lines 1729--1729 [] \T1/zi4/m/n/10 Title: Multidrug resistance-linked gene signature predicts overall survival of patients with primary ovarian serous carcinoma.[] [39] [40] [41] Overfull \hbox (84.71954pt too wide) in paragraph at lines 1848--1848 [] \T1/zi4/m/n/10 Experimenter name: Ferriss JS, Kim Y, Duska L, Birrer M, Le vine DA, Moskaluk C,Theodorescu D, Lee JK[] Overfull \hbox (299.71954pt too wide) in paragraph at lines 1851--1851 [] \T1/zi4/m/n/10 Title: Multi-gene expression predictors of single drug resp onses to adjuvant chemotherapy in ovarian carcinoma: predicting platinum resist ance.[] [42] [43] [44] Overfull \hbox (834.6582pt too wide) in paragraph at lines 1994--1994 [] \T1/zi4/m/n/10 Experimenter name: Yoshihara K, Tsunoda T, Shigemizu D, Fuj iwara H et al. High-risk ovarian cancer based on 126-gene expression signature is uniquely characterized by downregulation of antigen presentation pathway. Cl in Cancer Res 2012 Mar 1;18(5):1374-85.[] Overfull \hbox (318.04947pt too wide) in paragraph at lines 1997--1997 [] \T1/zi4/m/n/10 Title: High-risk ovarian cancer based on 126-gene expressio n signature is uniquely characterized by downregulation of antigen presentation pathway.[] [45] [46] [47] Overfull \hbox (834.6582pt too wide) in paragraph at lines 2121--2121 [] \T1/zi4/m/n/10 Experimenter name: Yoshihara K, Tsunoda T, Shigemizu D, Fuj iwara H et al. High-risk ovarian cancer based on 126-gene expression signature is uniquely characterized by downregulation of antigen presentation pathway. Cl in Cancer Res 2012 Mar 1;18(5):1374-85.[] Overfull \hbox (318.04947pt too wide) in paragraph at lines 2124--2124 [] \T1/zi4/m/n/10 Title: High-risk ovarian cancer based on 126-gene expressio n signature is uniquely characterized by downregulation of antigen presentation pathway.[] [48] [49] [50] Overfull \hbox (66.39984pt too wide) in paragraph at lines 2251--2251 [] \T1/zi4/m/n/10 Title: COL11A1 promotes tumor progression and predicts poor clinical outcome in ovarian cancer.[] [51] Overfull \hbox (34.73999pt too wide) in paragraph at lines 2287--2287 []\T1/zi4/m/n/10 Binary overall survival summary (definitions of long and shor t provided by study authors):[] [52] Overfull \hbox (456.32828pt too wide) in paragraph at lines 2357--2357 [] \T1/zi4/m/n/10 Experimenter name: Pils D1, Hager G, Tong D, Aust S, Heinze G, Kohl M, Schuster E, Wolf A, Sehouli J, Braicu I, Vergote I, Cadron I, Mahne r S, Hofstetter G, Speiser P, Zeillinger R[] Overfull \hbox (156.3794pt too wide) in paragraph at lines 2360--2360 [] \T1/zi4/m/n/10 Title: Validating the impact of a molecular subtype in ovar ian cancer on outcomes: a study of the OVCAD Consortium.[] [53] [54] Underfull \vbox (badness 10000) has occurred while \output is active [55] Overfull \hbox (139.70932pt too wide) in paragraph at lines 2484--2484 [] \T1/zi4/m/n/10 Experimenter name: Karlan BY, Dering J, Walsh C, Orsulic S, Lester J, Anderson LA, Ginther CL, Fejzo M, Slamon D[] Overfull \hbox (133.06992pt too wide) in paragraph at lines 2487--2487 [] \T1/zi4/m/n/10 Title: POSTN/TGFBI-associated stromal signature predicts po or prognosis in serous epithelial ovarian cancer.[] [56] [57] Underfull \vbox (badness 10000) has occurred while \output is active [58] Underfull \hbox (badness 1337) in paragraph at lines 2605--2605 [] \T1/ptm/m/it/10 Lysophos-pha-tidic acid-induced tran-scrip-tional pro-file r ep-re-sents Overfull \hbox (1007.96768pt too wide) in paragraph at lines 2623--2623 [] \T1/zi4/m/n/10 Experimenter name: Murph MM, Liu W, Yu S, Lu Y, Hall H, Hen nessy BT, Lahad J, Schaner M, Helland A, Kristensen G, Brresen-Dale AL, Mills G B. Lysophosphatidic acid-induced transcriptional profile represents serous epit helial ovarian carcinoma and worsened prognosis. PLoS One. 2009; 4(5):e5583.[] [59] Overfull \hbox (246.39984pt too wide) in paragraph at lines 2626--2626 [] \T1/zi4/m/n/10 Title: Lysophosphatidic acid-induced transcriptional profil e represents serous epithelial ovarian carcinoma and worsened prognosis.[] [60] [61] Overfull \hbox (972.96768pt too wide) in paragraph at lines 2731--2731 [] \T1/zi4/m/n/10 Experimenter name: Ouellet V, Provencher DM, Maugard CM, Le Page C, Ren F, Lussier C, Novak J, Ge B, Hudson TJ, Tonin PN, Mes-Masson A-M: Discrimination between serous low malignant potential and invasive epithelial o varian tumors using molecular profiling. Oncogene 2005, 24:4672-4687.[] [62] [63] Overfull \hbox (929.62753pt too wide) in paragraph at lines 2827--2827 [] \T1/zi4/m/n/10 Experimenter name: Marchini S, Mariani P, Chiorino G, Marra zzo E, Bonomi R, Fruscio R, Clivio L, Garbi A, Torri V, Cinquini M, Dell\TS1/zi 4/m/n/10 '\T1/zi4/m/n/10 Anna T, Apolone G, Broggini M, D\TS1/zi4/m/n/10 '\T1/z i4/m/n/10 Incalci M.Analysis of gene expression in early-stage ovarian cancer. Clin Cancer Res. 2008 Dec 1; 14(23):7850-60.[] [64] [65] [66] Overfull \hbox (1302.91656pt too wide) in paragraph at lines 2953--2953 [] \T1/zi4/m/n/10 Experimenter name: Tothill RW, Tinker AV, George J, Brown R , Fox SB, Lade S, Johnson DS, Trivett MK, Etemadmoghadam D, Locandro B, Trafica nte N, Fereday S, Hung JA, Chiew YE, Haviv I, Gertig D, DeFazio A, Bowtell DD.N ovel molecular subtypes of serous and endometrioid ovarian cancer linked to cli nical outcome. Clin Cancer Res. 2008 Aug 15; 14(16):5198-208.[] Overfull \hbox (94.72977pt too wide) in paragraph at lines 2956--2956 [] \T1/zi4/m/n/10 Title: Novel molecular subtypes of serous and endometrioid ovarian cancer linked to clinical outcome.[] [67] Underfull \vbox (badness 10000) has occurred while \output is active [68] [69] Overfull \hbox (1011.28738pt too wide) in paragraph at lines 3108--3108 [] \T1/zi4/m/n/10 Experimenter name: Berchuck A, Iversen ES, Lancaster JM, Pi ttman J, Luo J, Lee P, Murphy S, Dressman HK, Febbo PG, West M, Nevins JR, Mark s JR.Patterns of gene expression that characterize long-term survival in advanc ed stage serous ovarian cancers. Clin Cancer Res. 2005 May 15; 11(10):3686-96.[ ] Overfull \hbox (153.0597pt too wide) in paragraph at lines 3111--3111 [] \T1/zi4/m/n/10 Title: Patterns of gene expression that characterize long-t erm survival in advanced stage serous ovarian cancers.[] [70] Overfull \hbox (34.73999pt too wide) in paragraph at lines 3149--3149 []\T1/zi4/m/n/10 Binary overall survival summary (definitions of long and shor t provided by study authors):[] [71] [72] Overfull \hbox (1221.25671pt too wide) in paragraph at lines 3231--3231 [] \T1/zi4/m/n/10 Experimenter name: Dressman HK, Berchuck A, Chan G, Zhai J, Bild A, Sayer R, Cragun J, Clarke J, Whitaker RS, Li L, Gray J, Marks J, Ginsb urg GS, Potti A, West M, Nevins JR, Lancaster JM.An integrated genomic-based ap proach to individualized treatment of patients with advanced-stage ovarian canc er. J Clin Oncol. 2007 Feb 10; 25(5):517-25.[] Overfull \hbox (184.72977pt too wide) in paragraph at lines 3234--3234 [] \T1/zi4/m/n/10 Title: An integrated genomic-based approach to individualiz ed treatment of patients with advanced-stage ovarian cancer.[] [73] [74] [75] Overfull \hbox (1237.92679pt too wide) in paragraph at lines 3359--3359 [] \T1/zi4/m/n/10 Experimenter name: Berchuck A, Iversen ES, Luo J, Clarke JP , Horne H, Levine DA, Boyd J, Alonso MA, Secord AA, Bernardini MQ, Barnett JC, Boren T, Murphy SK, Dressman HK, Marks JR, Lancaster JM.Microarray analysis of early stage serous ovarian cancers shows profiles predictive of favorable outco me. Clin Cancer Res. 2009 Apr 1; 15(7):2448-55.[] Overfull \hbox (148.0597pt too wide) in paragraph at lines 3362--3362 [] \T1/zi4/m/n/10 Title: Microarray analysis of early stage serous ovarian ca ncers shows profiles predictive of favorable outcome.[] [76] [77] [78] Overfull \hbox (64.73999pt too wide) in paragraph at lines 3491--3491 [] \T1/zi4/m/n/10 Experimenter name: Integrated genomic analyses of ovarian c arcinoma. Nature 2011, 474:609-615.[] [79] Underfull \vbox (badness 10000) has occurred while \output is active [80] Underfull \vbox (badness 10000) has occurred while \output is active [81] [82] Overfull \hbox (64.73999pt too wide) in paragraph at lines 3667--3667 [] \T1/zi4/m/n/10 Experimenter name: Integrated genomic analyses of ovarian c arcinoma. Nature 2011, 474:609-615.[] [83] Underfull \vbox (badness 10000) has occurred while \output is active [84] Underfull \vbox (badness 10000) has occurred while \output is active [85] Overfull \hbox (64.73999pt too wide) in paragraph at lines 3840--3840 [] \T1/zi4/m/n/10 Experimenter name: Integrated genomic analyses of ovarian c arcinoma. Nature 2011, 474:609-615.[] [86] [87] Underfull \vbox (badness 10000) has occurred while \output is active [88] Underfull \vbox (badness 10000) has occurred while \output is active [89] (/tmp/Rtmpnd7VRK/Rbuildff44811626336/curatedOvarianData/.Rd2pdf1045576/Rd2.ind [90] LaTeX Font Warning: Font shape `T1/zi4/m/it' undefined (Font) using `T1/zi4/m/n' instead on input line 37. [91] [92]) (/tmp/Rtmpnd7VRK/Rbuildff44811626336/curatedOvarianData/.Rd2pdf1045576/Rd2.aux) Package rerunfilecheck Warning: File `Rd2.out' has changed. (rerunfilecheck) Rerun to get outlines right (rerunfilecheck) or use package `bookmark'. 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[3] [4] Overfull \hbox (1107.93701pt too wide) in paragraph at lines 193--193 [] \T1/zi4/m/n/10 Experimenter name: Bentink S, Haibe-Kains B, Risch T, Fan J -B, Hirsch MS, Holton K, Rubio R, April C, Chen J, Wickham-Garcia E, Liu J, Cul hane A, Drapkin R, Quackenbush J, Matulonis UA: Angiogenic mRNA and microRNA ge ne expression signature predicts a novel subtype of serous ovarian cancer. PLoS ONE 2012, 7:e30269.[] Overfull \hbox (146.38962pt too wide) in paragraph at lines 196--196 [] \T1/zi4/m/n/10 Title: Angiogenic mRNA and microRNA gene expression signatu re predicts a novel subtype of serous ovarian cancer.[] (/usr/share/texlive/texmf-dist/tex/latex/inconsolata/ts1zi4.fd) [5] Underfull \vbox (badness 10000) has occurred while \output is active [6] Overfull \hbox (591.34872pt too wide) in paragraph at lines 315--315 [] \T1/zi4/m/n/10 Experimenter name: Partheen K, Levan K, Osterberg L, Horvat h G.Expression analysis of stage III serous ovarian adenocarcinoma distinguishe s a sub-group of survivors. Eur J Cancer. 2006 Nov; 42(16):2846-54.[] Overfull \hbox (134.72977pt too wide) in paragraph at lines 318--318 [] \T1/zi4/m/n/10 Title: Expression analysis of stage III serous ovarian aden ocarcinoma distinguishes a sub-group of survivors.[] [7] Overfull \hbox (34.73999pt too wide) in paragraph at lines 354--354 []\T1/zi4/m/n/10 Binary overall survival summary (definitions of long and shor t provided by study authors):[] [8] [9] Overfull \hbox (1299.59686pt too wide) in paragraph at lines 432--432 [] \T1/zi4/m/n/10 Experimenter name: Yoshihara K, Tajima A, Komata D, Yamamot o T, Kodama S, Fujiwara H, Suzuki M, Onishi Y, Hatae M, Sueyoshi K, Fujiwara H, Kudo Y, Inoue I, Tanaka K.Gene expression profiling of advanced-stage serous o varian cancers distinguishes novel subclasses and implicates ZEB2 in tumor prog ression and prognosis. Cancer Sci. 2009 Aug; 100(8):1421-8.[] Overfull \hbox (379.70932pt too wide) in paragraph at lines 435--435 [] \T1/zi4/m/n/10 Title: Gene expression profiling of advanced-stage serous o varian cancers distinguishes novel subclasses and implicates ZEB2 in tumor prog ression and prognosis.[] [10] [11] Overfull \hbox (861.2976pt too wide) in paragraph at lines 524--524 [] \T1/zi4/m/n/10 Experimenter name: Crijns AP, Fehrmann RS, de Jong S, Gerbe ns F, Meersma GJ, Klip HG, Hollema H, Hofstra RM, te Meerman GJ, de Vries EG, v an der Zee AG.Survival-related profile, pathways, and transcription factors in ovarian cancer. PLoS Med. 2009 Feb 3; 6(2):e24.[] Overfull \hbox (31.41006pt too wide) in paragraph at lines 527--527 [] \T1/zi4/m/n/10 Title: Survival-related profile, pathways, and transcriptio n factors in ovarian cancer.[] [12] [13] [14] Overfull \hbox (636.3385pt too wide) in paragraph at lines 642--642 [] \T1/zi4/m/n/10 Experimenter name: Denkert C, Budczies J, Darb-Esfahani S, Gy??rffy B et al. A prognostic gene expression index in ovarian cancer - valida tion across different independent data sets. J Pathol 2009 Jun;218(2):273-80.[] Overfull \hbox (146.38962pt too wide) in paragraph at lines 645--645 [] \T1/zi4/m/n/10 Title: A prognostic gene expression index in ovarian cancer - validation across different independent data sets.[] [15] [16] Overfull \hbox (3.12666pt too wide) in paragraph at lines 755--756 []\T1/ptm/m/n/10 Advanced-stage ovar-ian can-cer pa-tients are gen-er-ally trea ted with platinum/taxane-based chemother- [17] Overfull \hbox (1289.58664pt too wide) in paragraph at lines 768--768 [] \T1/zi4/m/n/10 Experimenter name: Yoshihara K, Tajima A, Yahata T, Kodama S, Fujiwara H, Suzuki M, Onishi Y, Hatae M, Sueyoshi K, Fujiwara H, Kudo Y, Kot era K, Masuzaki H, Tashiro H, Katabuchi H, Inoue I, Tanaka K.Gene expression pr ofile for predicting survival in advanced-stage serous ovarian cancer across tw o independent datasets. PLoS One. 2010 Mar 12; 5(3):e9615.[] Overfull \hbox (221.38962pt too wide) in paragraph at lines 771--771 [] \T1/zi4/m/n/10 Title: Gene expression profile for predicting survival in a dvanced-stage serous ovarian cancer across two independent datasets.[] [18] [19] [20] Overfull \hbox (1551.22604pt too wide) in paragraph at lines 906--906 [] \T1/zi4/m/n/10 Experimenter name: Mok SC, Bonome T, Vathipadiekal V, Bell A, Johnson ME, Wong KK, Park DC, Hao K, Yip DK, Donninger H, Ozbun L, Samimi G, Brady J, Randonovich M, Pise-Masison CA, Barrett JC, Wong WH, Welch WR, Berkow itz RS, Birrer MJ.A gene signature predictive for outcome in advanced ovarian c ancer identifies a survival factor: microfibril-associated glycoprotein 2. Canc er Cell. 2009 Dec 8; 16(6):521-32.[] Overfull \hbox (293.04947pt too wide) in paragraph at lines 909--909 [] \T1/zi4/m/n/10 Title: A gene signature predictive for outcome in advanced ovarian cancer identifies a survival factor: microfibril-associated glycoprotei n 2.[] [21] [22] [23] Overfull \hbox (904.64798pt too wide) in paragraph at lines 1041--1041 [] \T1/zi4/m/n/10 Experimenter name: Konstantinopoulos PA, Spentzos D, Karlan BY, Taniguchi T et al. Gene expression profile of BRCAness that correlates wit h responsiveness to chemotherapy and with outcome in patients with epithelial o varian cancer. J Clin Oncol 2010 Aug 1;28(22):3555-61.[] Overfull \hbox (353.03925pt too wide) in paragraph at lines 1044--1044 [] \T1/zi4/m/n/10 Title: Gene expression profile of BRCAness that correlates with responsiveness to chemotherapy and with outcome in patients with epithelia l ovarian cancer.[] [24] [25] Overfull \hbox (904.64798pt too wide) in paragraph at lines 1139--1139 [] \T1/zi4/m/n/10 Experimenter name: Konstantinopoulos PA, Spentzos D, Karlan BY, Taniguchi T et al. Gene expression profile of BRCAness that correlates wit h responsiveness to chemotherapy and with outcome in patients with epithelial o varian cancer. J Clin Oncol 2010 Aug 1;28(22):3555-61.[] Overfull \hbox (353.03925pt too wide) in paragraph at lines 1142--1142 [] \T1/zi4/m/n/10 Title: Gene expression profile of BRCAness that correlates with responsiveness to chemotherapy and with outcome in patients with epithelia l ovarian cancer.[] [26] [27] [28] Overfull \hbox (1481.23627pt too wide) in paragraph at lines 1237--1237 [] \T1/zi4/m/n/10 Experimenter name: Meyniel JP, Cottu PH, Decraene C, Stern MH, Couturier J, Lebigot I, Nicolas A, Weber N, Fourchotte V, Alran S, Rapinat A, Gentien D, Roman-Roman S, Mignot L, Sastre-Garau X.A genomic and transcripto mic approach for a differential diagnosis between primary and secondary ovarian carcinomas in patients with a previous history of breast cancer. BMC Cancer. 2 010 May 21; 10:222.[] Overfull \hbox (451.35895pt too wide) in paragraph at lines 1240--1240 [] \T1/zi4/m/n/10 Title: A genomic and transcriptomic approach for a differen tial diagnosis between primary and secondary ovarian carcinomas in patients wit h a previous history of breast cancer.[] [29] [30] Overfull \hbox (101.41006pt too wide) in paragraph at lines 1345--1345 [] \T1/zi4/m/n/10 Experimenter name: EXpression Project for Oncology, Interna tional Genomics Consortium, www.intgen.org[] [31] [32] Overfull \hbox (126.38962pt too wide) in paragraph at lines 1457--1457 [] \T1/zi4/m/n/10 Experimenter name: Mateescu B, Batista L, Mariani O, Meynie l J, Cottu PH, Sastre-Garau X, Mechta-Grigoriou F[] Overfull \hbox (81.39984pt too wide) in paragraph at lines 1460--1460 [] \T1/zi4/m/n/10 Title: miR-141 and miR-200a act on ovarian tumorigenesis by controlling oxidative stress response.[] [33] [34] [35] Overfull \hbox (917.96768pt too wide) in paragraph at lines 1583--1583 [] \T1/zi4/m/n/10 Experimenter name: Bonome T, Levine DA, Shih J, Randonovich M, Pise-Masison CA, Bogomolniy F, Ozbun L, Brady J, Barrett JC, Boyd J, Birrer MJ: A Gene Signature Predicting for Survival in Suboptimally Debulked Patients with Ovarian Cancer. Cancer Research 2008, 68:5478 -5486.[] Overfull \hbox (99.72977pt too wide) in paragraph at lines 1586--1586 [] \T1/zi4/m/n/10 Title: A gene signature predicting for survival in suboptim ally debulked patients with ovarian cancer.[] [36] [37] [38] Overfull \hbox (724.66843pt too wide) in paragraph at lines 1726--1726 [] \T1/zi4/m/n/10 Experimenter name: Gillet JP, Calcagno AM, Varma S, Davidso n B et al. Multidrug resistance-linked gene signature predicts overall survival of patients with primary ovarian serous carcinoma. Clin Cancer Res 2012 Jun 1; 18(11):3197-206.[] Overfull \hbox (218.0597pt too wide) in paragraph at lines 1729--1729 [] \T1/zi4/m/n/10 Title: Multidrug resistance-linked gene signature predicts overall survival of patients with primary ovarian serous carcinoma.[] [39] [40] [41] Overfull \hbox (84.71954pt too wide) in paragraph at lines 1848--1848 [] \T1/zi4/m/n/10 Experimenter name: Ferriss JS, Kim Y, Duska L, Birrer M, Le vine DA, Moskaluk C,Theodorescu D, Lee JK[] Overfull \hbox (299.71954pt too wide) in paragraph at lines 1851--1851 [] \T1/zi4/m/n/10 Title: Multi-gene expression predictors of single drug resp onses to adjuvant chemotherapy in ovarian carcinoma: predicting platinum resist ance.[] [42] [43] [44] Overfull \hbox (834.6582pt too wide) in paragraph at lines 1994--1994 [] \T1/zi4/m/n/10 Experimenter name: Yoshihara K, Tsunoda T, Shigemizu D, Fuj iwara H et al. High-risk ovarian cancer based on 126-gene expression signature is uniquely characterized by downregulation of antigen presentation pathway. Cl in Cancer Res 2012 Mar 1;18(5):1374-85.[] Overfull \hbox (318.04947pt too wide) in paragraph at lines 1997--1997 [] \T1/zi4/m/n/10 Title: High-risk ovarian cancer based on 126-gene expressio n signature is uniquely characterized by downregulation of antigen presentation pathway.[] [45] [46] [47] Overfull \hbox (834.6582pt too wide) in paragraph at lines 2121--2121 [] \T1/zi4/m/n/10 Experimenter name: Yoshihara K, Tsunoda T, Shigemizu D, Fuj iwara H et al. High-risk ovarian cancer based on 126-gene expression signature is uniquely characterized by downregulation of antigen presentation pathway. Cl in Cancer Res 2012 Mar 1;18(5):1374-85.[] Overfull \hbox (318.04947pt too wide) in paragraph at lines 2124--2124 [] \T1/zi4/m/n/10 Title: High-risk ovarian cancer based on 126-gene expressio n signature is uniquely characterized by downregulation of antigen presentation pathway.[] [48] [49] [50] Overfull \hbox (66.39984pt too wide) in paragraph at lines 2251--2251 [] \T1/zi4/m/n/10 Title: COL11A1 promotes tumor progression and predicts poor clinical outcome in ovarian cancer.[] [51] Overfull \hbox (34.73999pt too wide) in paragraph at lines 2287--2287 []\T1/zi4/m/n/10 Binary overall survival summary (definitions of long and shor t provided by study authors):[] [52] Overfull \hbox (456.32828pt too wide) in paragraph at lines 2357--2357 [] \T1/zi4/m/n/10 Experimenter name: Pils D1, Hager G, Tong D, Aust S, Heinze G, Kohl M, Schuster E, Wolf A, Sehouli J, Braicu I, Vergote I, Cadron I, Mahne r S, Hofstetter G, Speiser P, Zeillinger R[] Overfull \hbox (156.3794pt too wide) in paragraph at lines 2360--2360 [] \T1/zi4/m/n/10 Title: Validating the impact of a molecular subtype in ovar ian cancer on outcomes: a study of the OVCAD Consortium.[] [53] [54] Underfull \vbox (badness 10000) has occurred while \output is active [55] Overfull \hbox (139.70932pt too wide) in paragraph at lines 2484--2484 [] \T1/zi4/m/n/10 Experimenter name: Karlan BY, Dering J, Walsh C, Orsulic S, Lester J, Anderson LA, Ginther CL, Fejzo M, Slamon D[] Overfull \hbox (133.06992pt too wide) in paragraph at lines 2487--2487 [] \T1/zi4/m/n/10 Title: POSTN/TGFBI-associated stromal signature predicts po or prognosis in serous epithelial ovarian cancer.[] [56] [57] Underfull \vbox (badness 10000) has occurred while \output is active [58] Underfull \hbox (badness 1337) in paragraph at lines 2605--2605 [] \T1/ptm/m/it/10 Lysophos-pha-tidic acid-induced tran-scrip-tional pro-file r ep-re-sents Overfull \hbox (1007.96768pt too wide) in paragraph at lines 2623--2623 [] \T1/zi4/m/n/10 Experimenter name: Murph MM, Liu W, Yu S, Lu Y, Hall H, Hen nessy BT, Lahad J, Schaner M, Helland A, Kristensen G, Brresen-Dale AL, Mills G B. Lysophosphatidic acid-induced transcriptional profile represents serous epit helial ovarian carcinoma and worsened prognosis. PLoS One. 2009; 4(5):e5583.[] [59] Overfull \hbox (246.39984pt too wide) in paragraph at lines 2626--2626 [] \T1/zi4/m/n/10 Title: Lysophosphatidic acid-induced transcriptional profil e represents serous epithelial ovarian carcinoma and worsened prognosis.[] [60] [61] Overfull \hbox (972.96768pt too wide) in paragraph at lines 2731--2731 [] \T1/zi4/m/n/10 Experimenter name: Ouellet V, Provencher DM, Maugard CM, Le Page C, Ren F, Lussier C, Novak J, Ge B, Hudson TJ, Tonin PN, Mes-Masson A-M: Discrimination between serous low malignant potential and invasive epithelial o varian tumors using molecular profiling. Oncogene 2005, 24:4672-4687.[] [62] [63] Overfull \hbox (929.62753pt too wide) in paragraph at lines 2827--2827 [] \T1/zi4/m/n/10 Experimenter name: Marchini S, Mariani P, Chiorino G, Marra zzo E, Bonomi R, Fruscio R, Clivio L, Garbi A, Torri V, Cinquini M, Dell\TS1/zi 4/m/n/10 '\T1/zi4/m/n/10 Anna T, Apolone G, Broggini M, D\TS1/zi4/m/n/10 '\T1/z i4/m/n/10 Incalci M.Analysis of gene expression in early-stage ovarian cancer. Clin Cancer Res. 2008 Dec 1; 14(23):7850-60.[] [64] [65] [66] Overfull \hbox (1302.91656pt too wide) in paragraph at lines 2953--2953 [] \T1/zi4/m/n/10 Experimenter name: Tothill RW, Tinker AV, George J, Brown R , Fox SB, Lade S, Johnson DS, Trivett MK, Etemadmoghadam D, Locandro B, Trafica nte N, Fereday S, Hung JA, Chiew YE, Haviv I, Gertig D, DeFazio A, Bowtell DD.N ovel molecular subtypes of serous and endometrioid ovarian cancer linked to cli nical outcome. Clin Cancer Res. 2008 Aug 15; 14(16):5198-208.[] Overfull \hbox (94.72977pt too wide) in paragraph at lines 2956--2956 [] \T1/zi4/m/n/10 Title: Novel molecular subtypes of serous and endometrioid ovarian cancer linked to clinical outcome.[] [67] Underfull \vbox (badness 10000) has occurred while \output is active [68] [69] Overfull \hbox (1011.28738pt too wide) in paragraph at lines 3108--3108 [] \T1/zi4/m/n/10 Experimenter name: Berchuck A, Iversen ES, Lancaster JM, Pi ttman J, Luo J, Lee P, Murphy S, Dressman HK, Febbo PG, West M, Nevins JR, Mark s JR.Patterns of gene expression that characterize long-term survival in advanc ed stage serous ovarian cancers. Clin Cancer Res. 2005 May 15; 11(10):3686-96.[ ] Overfull \hbox (153.0597pt too wide) in paragraph at lines 3111--3111 [] \T1/zi4/m/n/10 Title: Patterns of gene expression that characterize long-t erm survival in advanced stage serous ovarian cancers.[] [70] Overfull \hbox (34.73999pt too wide) in paragraph at lines 3149--3149 []\T1/zi4/m/n/10 Binary overall survival summary (definitions of long and shor t provided by study authors):[] [71] [72] Overfull \hbox (1221.25671pt too wide) in paragraph at lines 3231--3231 [] \T1/zi4/m/n/10 Experimenter name: Dressman HK, Berchuck A, Chan G, Zhai J, Bild A, Sayer R, Cragun J, Clarke J, Whitaker RS, Li L, Gray J, Marks J, Ginsb urg GS, Potti A, West M, Nevins JR, Lancaster JM.An integrated genomic-based ap proach to individualized treatment of patients with advanced-stage ovarian canc er. 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Nature 2011, 474:609-615.[] [83] Underfull \vbox (badness 10000) has occurred while \output is active [84] Underfull \vbox (badness 10000) has occurred while \output is active [85] Overfull \hbox (64.73999pt too wide) in paragraph at lines 3840--3840 [] \T1/zi4/m/n/10 Experimenter name: Integrated genomic analyses of ovarian c arcinoma. Nature 2011, 474:609-615.[] [86] [87] Underfull \vbox (badness 10000) has occurred while \output is active [88] Underfull \vbox (badness 10000) has occurred while \output is active [89] (/tmp/Rtmpnd7VRK/Rbuildff44811626336/curatedOvarianData/.Rd2pdf1045576/Rd2.ind [90] LaTeX Font Warning: Font shape `T1/zi4/m/it' undefined (Font) using `T1/zi4/m/n' instead on input line 37. 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